The disclosure relates to a system and method for visual field testing of patients, and in particular, perimetry testing using a video display to present target fixation objects.
Visual field testing is conducted to detect dysfunction in central and peripheral vision due to, for example, glaucoma, stroke, brain tumor, or a neurological problem.
In perimetry visual field testing, the patient fixates or maintains focus on a fixed object directly ahead. While the patient is doing so, a stimulus such as an object or a light is presented elsewhere in the field of vision, and the patient indicates when it is visible to the patient, if at all, at each location in which it is presented. The stimulus is presented at locations that are unpredictable to the patient, until all locations of interest have been tested.
Static perimetry tests the sensitivity of different locations in the field of view by presenting lights of varying brightness in a single location at a time and the patient reports each time the light is seen. In Kinetic perimetry, commonly carried out using a Goldmann or Octopus perimetry device, a stimulus such as a test light is moved by an examiner (perimetrist) or the instrument program from outside the peripheral vision of the patient towards the center of vision or from non-seeing to seeing areas of vision until it is detected by the patient. The test may be repeated using test stimuli of different brightness levels or lights of a different size.
A more complete understanding of the present disclosure, and the attendant advantages and features thereof, will be more readily understood by reference to the following detailed description when considered in conjunction with the accompanying drawings wherein:
As required, detailed embodiments are disclosed herein; however, it is to be understood that the disclosed embodiments are merely examples and that the systems and methods described below can be embodied in various forms. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a basis for the claims and as a representative basis for teaching one skilled in the art to variously employ the present subject matter in virtually any appropriately detailed structure and function. Further, the terms and phrases used herein are not intended to be limiting, but rather, to provide an understandable description of the concepts.
The terms “a” or “an”, as used herein, are defined as one or more than one. The term plurality, as used herein, is defined as two or more than two. The term another, as used herein, is defined as at least a second or more. The terms “including” and “having,” as used herein, are defined as comprising (i.e., open language). The term “coupled,” as used herein, is defined as “connected,” although not necessarily directly, and not necessarily mechanically.
Poor visual field (VF) testing reliability can be a problem, since incorrect or inconsistent results can potentially lead to loss of vision due to failure to timely detect correctable problems. At least, inconsistent results can create a necessity for retesting. For this reason, VF tests are not a sole or primary means of testing children, as children typically have difficulty maintaining concentration and providing reliable feedback during testing. This leads to inconsistent results and challenges in interpreting test results.
In accordance with the disclosure, a visual field tester is provided with a multimedia interface for maintaining the attention of the individual completing VF testing. More particularly, in an embodiment, physically small video images or clips are presented at the location where the test subject is required to maintain focus during the test. In addition, one or more audio sequences or clips are played at appropriate times during testing to educate, direct, and reward the individual before, during, and after testing. The audio clips can be coordinated with the video clips so that it appears that one or more characters in the video clip are speaking.
With reference to
The use and manner of operation of a Humphrey field tester is well known in the art, and a description of such is therefore omitted in the interest of brevity. While a Humphrey field tester by Zeiss is shown, it should be understood that the disclosure can be carried out with other types or styles of automated VF testers, including those made by Zeiss, Oculus, Kowa, Synemed or Octopus, and can further be carried out using a manual system, such as a Goldmann tester, as detailed elsewhere herein.
In the embodiment of
Display 200 can be completely self-contained, wherein a video clip is manually started and stopped during testing. Alternatively, display 200 can be integrated into the computer control system 122 of tester 120, either by a plug-in cable or by a wireless method, such as a near field or BLUETOOTH network. In an embodiment, a portion of display 124 of tester 120 duplicates the video shown by display 200. In this manner, the examiner can verify that the correct video is being presented, and coordinate with the patient if the patient refers to the video. Additionally, the video can be paused by system 122 when testing is paused, and can be otherwise coordinated with the test procedure.
Testers 120 are known which include hardware and software to determine when the patient is not looking directly at the fixation target. Such hardware and software can be used in a like fashion to determine if the patient is not looking at display 200, which is positioned at the same location as the standard fixation target. Accordingly, when the patient is not looking at display 200, system 122 can play a video clip on display 200, and a corresponding audio clip, wherein the character depicted in display 200 asks the test subject, advantageously in a playful or amusing way, to continue to look at the display.
In tests carried out by the inventor, an entertaining video was presented upon display 200 during testing of children, and a statistically significant improvement in test reliability indices was noted, indicating increased attention and consistency of responses to test stimuli, which leads to increased VF test reliability. More particularly, children between ages 5 and 8 who are glaucoma suspects or have low vision were randomized to complete Humphrey VF testing with the video/audio intervention of the disclosure (‘the intervention’, n=4) versus without carrying out the disclosure, using standard equipment and methods (‘usual care’, n=3), and for each eye, at two visits about 1 week apart. A system as shown and described in
Results were analyzed, and mean false positive responses during VF testing at both visits were statistically significantly greater by 10% on average in children randomized to usual care testing compared to those who received the intervention (95% CI: 1 to 18%; p=0.03) after adjusting for age group and eye. At the second visit, false negatives were slightly greater in usual care controls by 16% on average in the second eye that was tested at the session when compared to those who received the intervention (95% CI: −2 to 34%; p=0.07).
From the results, it can be concluded that since false positives affect the accuracy and reliability of VF results, and that reductions in false positives using a test procedure in accordance with the disclosure can translate to improved diagnosis and care of young children with regard to potential peripheral vision loss. It should be noted that the disclosure can be used with any individual who, for whatever reason, has difficulty focusing on the fixation target, maintaining interest or concentration with respect to identifying stimuli, or otherwise participating in the test procedure in a reliable or repeatable way.
In an embodiment, video clips of about 10 minutes each are selected, and a different clip can be used when testing each eye. Video clips can be selected to be of greatest interest to the age and personality of the test subject. To maintain interest, the main character can be changed periodically, for example, every one to two minutes. Cartoon clips can be selected, for example, which feature close-ups of a character positioned centrally for several seconds as the character waves, smiles, or slightly moves around, in order to keep children engaged and fixated centrally, which may not be the case where multiple characters are present or the figures are changing locations.
A professional voice impersonator can be used to record a set of audio directions and feedback in an appropriate and engaging voice, such as a cartoon-type voice, which can be prepared and presented for each of the various cartoon characters, while the video is played during VF testing. During the VF test, the operator can use a computer or tablet device that contains these audio clips, which are advantageously organized into the following 6 categories, based on content:
(1) positive reinforcement to encourage the patient to continue to exert efforts for reliable test results (e.g. “Good Work!”);
(2) repositioning instructions, to promote proper and comfortable posture and body positioning of the patient (e.g. “Sit up, look straight at me, and we can start having fun!”);
(3) encouragement to reduce fatigue and positive emotions with respect to completing the test (e.g. “Almost done, you're doing so well, we'll be finished in no time!”);
(4) fixation instructions to keep the patient focused on the fixation target to improve reliability and reproducibility of the test (e.g. “Mr. Bunny hopes you'll watch him closely the whole time!”);
(5) stability instructions to maintain a consistent patient orientation to promote reliability and reproducibility of the test (e.g. “Please try to sit very still and look straight at me, so that you can get a high score!”); and
(6) instructional messages to advise the patient of what will take place, and what is expected of the patient (e.g. “Press the button when you see the dot appear, and Mr. Bunny gets another carrot!”).
While the visual field test is ongoing, the operator selects the appropriate type of audio clip to play based on the child's performance and behavior, as related to the 6 possible categories. Additional or fewer categories can be used, as determined by the medical practitioner.
With reference to
An eye orientation detector 112, such as a camera, is positioned so that the patient's eye can be observed by the operator on display 124 of the tester, or so that the eye can be electronically observed, in order to identify when the patient is not focused on the fixation target. An aperture 128 (shown in
In
In
Flexible display 250 can be fabricated using a rollable TFT-driven OLED display technology as demonstrated by SONY in partnership with RIKEN, or as developed by Arizona State University. Other examples of display technology that can be applied to perimeter 110, or which can be formed to create perimeter 110, are an organic thin film transistor (OTFT) technology color display by PLASTIC LOGIC, or a flexible AMOLED display by SAMSUNG. Alternatively, an electronic paper can be used, such as developed between HP and ASU using the Self-Aligned Imprint Lithography (SAIL) process. Other technologies may be hereinafter developed, which can alternatively be used to form flexible display 250. Further, it may be possible to manufacture flexible display 250 in the correct perimeter shape for system 100.
Flexible display 250 need only flex a single time, when it is applied to the interior or exterior curved surface of perimeter 110, or a similarly shaped mold, and is then held in place, for example using adhesive. As such, it may be possible to flex the display more than a recommended amount, as there will be no reverse flexing, or repeated flexing. If the selected display technology is limited in its ability to flex along more than one plane, multiple strips may be applied to perimeter 110. Likewise, if a single display for the selected technology cannot economically be made large enough to cover the desired peripheral diameter, multiple displays can be placed edge to edge to form a sufficiently large surface. It is advantageous for the display technology to be color enabled, although certain limited vision testing could be conducted with a grayscale display, if necessary. In an embodiment, strips which only bend along one plane or dimension can be used, provided that displayed stimulus objects are an equal or predetermined distance from the patient's eye.
Reported display curvatures are listed in Wikipedia (‘Flexible Display’), as reproduced in Table 1.
It may be seen that the Samsung Round in particular, and also the LG G Flex, exhibit sufficient curvature to form a typical perimeter 110 diameter (e.g. 16 to 28 inches). If multiple flexible displays 250 are to be combined to form a radius of perimeter 110, the maximum radius of curvature of a single display can be larger than the total radius of the perimeter to be formed.
With reference to
In
In
The stimulus target 304 can be displayed at any number of different brightness levels. While three brightness levels are illustrated in
Accordingly, the disclosure can enable the development of new tests, which have the potential to detect disorders earlier, and to track their progress with greater precision, thereby improving a quality of life for patients using the disclosure.
Referring now to
In
In
In the embodiment of
Instructions can be provided upon display 770 of device 700 as to where to move second display 200A (or where to position a manual stimulus). In an embodiment, second display 200A includes a battery, controller, a motor, and wheels, gears, or other mechanical elements which enable display 200A to move along perimeter band 162 under control of device 700, in order to carry out a test of a patient, whereby the entire testing process is automated.
In
The embodiments of
In subsequent testing of the device of
The study suggests that the intervention function as hypothesized and use of device 100 was very well received by the study participants. Mean false positive responses during VF testing at both visits were statistically significantly greater by 8% on average in children randomized to usual care testing compared to those who received the video/audio intervention (95% CI: 1-15%; p=0.03) after adjusting for age group, low vision, and eye. A previous publication suggested that VF results with false positive errors>20% should not be considered reliable [Vingrys & Demirel 1998]; none of the subjects with the video/audio intervention exceeded that rate. At the second visit, the video/audio intervention group subjects had 6% fewer false negatives for the second eye tested compared to the first eye, whereas usual care controls had 8% greater false negatives for the second eye (95% CI: −2%, 30%; p=0.07). This finding indicates that the usual care controls were more likely to be non-responsive to stimuli by the time they were completing the second eye, whereas the video/audio intervention group was more engaged and responsive on average.
The study team did not find any significant differences for these outcomes or acceptability of the intervention when comparing children with low vision compared to those with normal vision. Qualitative notes by the VF test operator indicated that the usual care controls typically had trouble sitting still during testing, required several pauses, tired quickly, thought it was boring, felt sleepy, did not like the test, and complained during testing. In contrast, the notes for the video/audio intervention group indicated that they were very cooperative, very interested, did not need breaks, were excited to play the ‘game’, said it was fun, liked doing the test, gave it a thumbs up at the end and actively wanted to come back to take the test again.
Example Computing System
Computer system 700 includes at least one central processing unit (CPU) 705, or server, which may be implemented with a conventional microprocessor, a random access memory (RAM) 710 for temporary storage of information, and a read only memory (ROM) 715 for permanent storage of information. A memory controller 720 is provided for controlling RAM 710.
A bus 730 interconnects the components of computer system 700. A bus controller 725 is provided for controlling bus 730. An interrupt controller 735 is used for receiving and processing various interrupt signals from the system components.
Mass storage may be provided by DVD ROM 747, or flash or rotating hard disk drive 752, for example. Data and software, including software 400 of the disclosure, may be exchanged with computer system 700 via removable media such as diskette, CD ROM, DVD, Blu Ray, or other optical media 747 connectable to an Optical Media Drive 746 and Controller 745. Alternatively, other media, including for example a media stick, for example a solid state USB drive, may be connected to an External Device Interface 741, and Controller 740. Additionally, another computing device can be connected to computer system 700 through External Device Interface 741, for example by a USB connector, BLUETOOTH connector, Infrared, or WiFi connector, although other modes of connection are known or may be hereinafter developed. A hard disk 752 is part of a fixed disk drive 751 which is connected to bus 730 by controller 750. It should be understood that other storage, peripheral, and computer processing means may be developed in the future, which may advantageously be used with the disclosure.
User input to computer system 700 may be provided by a number of devices. For example, a keyboard 756 and mouse 757 are connected to bus 730 by controller 755. An audio transducer 796, which may act as both a microphone and a speaker, is connected to bus 730 by audio controller 797, as illustrated. It will be obvious to those reasonably skilled in the art that other input devices, such as a pen and/or tablet, Personal Digital Assistant (PDA), mobile/cellular phone and other devices, may be connected to bus 730 and an appropriate controller and software, as required. DMA controller 760 is provided for performing direct memory access to RAM 710. A visual display is generated by video controller 765 which controls video display 770. Computer system 700 also includes a communications adapter 790 which allows the system to be interconnected to a local area network (LAN) or a wide area network (WAN), schematically illustrated by bus 791 and network 795.
Operation of computer system 700 is generally controlled and coordinated by operating system software, such as a Windows system, commercially available from Microsoft Corp., Redmond, Wash. The operating system controls allocation of system resources and performs tasks such as processing scheduling, memory management, networking, and I/O services, among other things. In particular, an operating system resident in system memory and running on CPU 705 coordinates the operation of the other elements of computer system 700. The present disclosure may be implemented with any number of commercially available operating systems.
One or more applications, such as an HTML page server, or a commercially available communication application, may execute under the control of the operating system, operable to convey information to a user.
All references cited herein are expressly incorporated by reference in their entirety. It will be appreciated by persons skilled in the art that the present disclosure is not limited to what has been particularly shown and described herein above. In addition, unless mention was made above to the contrary, it should be noted that all of the accompanying drawings are not to scale. There are many different features to the present disclosure and it is contemplated that these features may be used together or separately. Thus, the disclosure should not be limited to any particular combination of features or to a particular application of the disclosure. Further, it should be understood that variations and modifications within the spirit and scope of the disclosure might occur to those skilled in the art to which the disclosure pertains. Accordingly, all expedient modifications readily attainable by one versed in the art from the disclosure set forth herein that are within the scope and spirit of the present disclosure are to be included as further embodiments of the present disclosure.
Filing Document | Filing Date | Country | Kind |
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PCT/US2017/019896 | 2/28/2017 | WO | 00 |
Number | Date | Country | |
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62301776 | Mar 2016 | US |