Patent Grant
10603424
The disclosed subject matter relates generally to the treatment of end stage renal failure and more specifically to devices, methods, systems, improvements, and components for performing peritoneal dialysis.
Peritoneal dialysis is a mature technology that has been in use for many years. It is one of two common forms of dialysis, the other being hemodialysis, which uses an artificial membrane to directly cleanse the blood of a renal patient. Peritoneal dialysis employs the natural membrane of the peritoneum to permit the removal of excess water and toxins from the blood.
In peritoneal dialysis, sterile peritoneal solution is infused into a patient's peritoneal cavity using a catheter that has been inserted through the abdominal wall. The solution remains in the peritoneal cavity for a dwell period. Osmosis exchange with the patient's blood occurs across the peritoneal membrane, removing urea and other toxins and excess water from the blood. Ions that need to be regulated are also exchanged across the membrane. The removal of excess water results in a higher volume of fluid being removed from the patient than is infused. The net excess is called ultrafiltrate, and the process of removal is called ultrafiltration. After the dwell time, the dialysate is removed from the body cavity through the catheter.
Peritoneal dialysis requires the maintenance of strict sterility because of the high risk of peritoneal infection. The risk of infection is particularly high due to the long periods of time that the patient is exposed to the dialysate.
In one form of peritoneal dialysis, an automated cycler is used to infuse and drain dialysate. This form of treatment can be done automatically at night while the patient sleeps. One of the safety mechanisms for such a treatment is the monitoring by the cycler of the quantity of ultrafiltrate. The cycler performs this monitoring function by measuring the amount of fluid infused and the amount removed to compute the net fluid removal.
The treatment sequence usually begins with an initial drain cycle to empty the peritoneal cavity of spent dialysate, except on so-called “dry days” when the patient begins automated treatment without a peritoneum filled with dialysate. The cycler then performs a series of fill, dwell, and drain cycles, typically finishing with a fill cycle.
The fill cycle presents a risk of over-pressurizing the peritoneal cavity, which has a low tolerance for excess pressure. In traditional peritoneal dialysis, a dialysate container is elevated to certain level above the patient's abdomen so that the fill pressure is determined by the height difference. Automated systems sometimes employ pumps that cannot generate a pressure beyond a certain level, but this system is not foolproof since a fluid column height can arise due to a patient-cycler level difference and cause an overpressure. A reverse height difference can also introduce an error in the fluid balance calculation because of incomplete draining.
Modern cyclers may fill by regulating fill volume during each cycle. The volume may be entered into a controller based on a prescription. The prescription, which also determines the composition of the dialysate, may be based upon the patient's size, weight, and other criteria. Due to errors, prescriptions may be incorrect or imperfectly implemented resulting in a detriment to patient well-being and health.
Systems that measure pressure have been proposed. For example, a pressure sensor in contact with a fluid circuit at the cycler has been described. The sensor indicates the pressure at the proximal end of the fill/drain line. During operation, a controller connected to the pressure sensor changes the operation of the peritoneal dialysis machine in response to changes in pressure sensed by the pressure sensor.
Briefly, an automated peritoneal dialysis system provides various features including prescription-driven dialysis fluid preparation, an integrated disposable fluid circuit, and sensor capabilities that allow accurate filing and draining control with high safety margins. Features include a peritoneal fluid circuit with a pressure sensor at either end and methods and devices for using the pressure signals. Other features and embodiments are disclosed.
Objects and advantages of embodiments of the disclosed subject matter will become apparent from the following description when considered in conjunction with the accompanying drawings.
Embodiments will hereinafter be described in detail below with reference to the accompanying drawings, wherein like reference numerals represent like elements. The accompanying drawings have not necessarily been drawn to scale. Where applicable, some features may not be illustrated to assist in the description of underlying features.
Referring to
During a drain cycle, spent dialysate is withdrawn from the patient by flowing in reverse through the fill/drain line back to the cycler 101 and out through a drain 104. The cycler 101 quantifies the volume of fluid that is infused and drained and provides an accounting of the difference to allow the net amount of fluid withdrawn from the patient to be determined.
The pump may be any suitable pump such as a diaphragm pump or a peristaltic pump. Alternatively, the cycler may rely on other fluid conveyance systems such as an over or under-pressurized supply/sump container, gravity feed or any other suitable mechanism.
A controller 116 allows the system to regulate a flow rate to ensure the patient's peritoneal cavity is not over-pressurized. The flow regulation may be accomplished by changing a speed of a pump or by means of a variable flow restrictor or any suitable mechanism conforming to the requirements of the type of fluid conveyance system employed.
Prior art systems have prevented exceeding a safe limit on peritoneal pressure by a variety of mechanisms, including measuring pressure in the fill line using a pressure sensor located on the PD cycler and applying feedback control of the pump to ensure a limit is not exceeded. Another prior art device for preventing over-pressurization of the peritoneal cavity limits the total head pressure by employing a gravitational feed.
An alternative may employ a pressure detection device 110 located at the end of a fill line 112, adjacent the patient 108, or at the access 114 itself, to take pressure readings close to the patient. By using pressure measurements from this location, the error in pressure measurement of the peritoneal cavity due to pressure loss in the fill line during filling of the cavity is eliminated. In this way the flow rate can be controlled by a continuous feedback loop to maintain the cavity pressure below a desired safety threshold. Locating the pressure sensor close to the patient also eliminates another source of error which may arise from a level difference between the supply side of the fill line 112 and the catheter end of the fill line. That is, if the cycler 101 is located higher than the patient access, the gravitational head pressure of the fill line could cause a greater pressure than indicated by a prior art pressure sensor located at the PD cycler which may not otherwise be accounted for, causing excessive pressure to be applied. A low cycler may cause inadequate pressure and slow fill cycles.
In the embodiment of
The pod 10 is primarily made of two parts, a fluid-side shell 30 and an air-side shell 17, that, together, form an enclosure 5 that defines the fluid and air chambers 60 and 45. The ratio of the minimum to the maximum volume of the air chamber 45, including the volume of the line 40 and port 12, is proportional to the total pressure variation that can be measured by the transducer attached to the line 40.
Referring now to
Thus, in the present embodiments, the pressures at each end of the fill/drain line 306 may be determined by a controller that operates the cycler at all times during operation of the PD cycler 318 and applied as continuous input signals to the controller during fill and drain operations. As discussed below, these inputs can be used to allow the capture and storage of vital signs, detection of flow restrictions and kinks in the fill/drain line 306, and allow the regulation of flow rate while managing the pressure within the peritoneum.
Referring now to
The embodiment of
Referring now to
A variation of any of the foregoing embodiments may be fill/drain lines with separated fill and drain lines, each having a respective lumen. The lines may be connected to the cycler by separate attachments, merged by a T or Y junction at the cycler, merged at the peritoneal catheter or a combination of these.
Referring now to
The procedure of
More sophisticated analysis may be done in S28 as well, for example, by fitting the measured data curves to curves that characterize identifiable conditions, such as dangerous conditions. For example, a leak may be indicated by a sharp drop in pressure at the distal location along with a gradual trend of ebbing pressure. The profile templates that characterize events may be may be determined via experiment or modeling or simply by judgment and stored in a memory of the controller. Other events that may be identified, for example by comparing distal and proximal pressure readings, are kinks or flow restrictions in the fill/drain line or changes in the properties of fluid, for example such as may evidence peritoneal infection. The latter may be detected by identifying an excessive pressure drop in the fill/drain line during a drain operation, which may be caused by excessive viscosity in the spent dialysate.
In S30, events detected in the profile data, current pressure values, historical data, and reliability estimates are updated. Current data, for example, may be stored in a location representing current values and historical data may be stored in memory locations representing historical values along with time and date values. For example, a memory location may hold a current estimate of patency of the fill/drain line. The event detection results may be represented as status flags and associated reliability estimates or other metrics such as a measure of goodness of fit to a characteristic curve or instantaneous value.
Referring to
Archived data may be transferred to a data store for combination with data of multiple patients, for example via an internet connection, for analysis and comparison purposes.
The conditions detected in S46, S48, S50 may include, for example:
Referring now to
The fluid conveyor and circuit switch 616 is a fluid circuit element with one or more sensors, actuators, and/or pumps which is effective to convey fluid between selected lines 642, 644, 646, 648, 650 and 618 responsively to control signals from the controller 610. Example embodiments are described herein, but many details are known from the prior art for making such a device so it is not elaborated here.
A multiple-container unit 641 includes a pre-filled, pre-sterilized osmotic agent container for osmotic agent concentrate 602 and another electrolyte container with electrolyte concentrate 604. The unit 641 also contains an empty batch container 606 which is large enough to hold a sufficient volume of dialysis solution for the completion of at least one fill cycle of an automated peritoneal dialysis treatment. The containers 602, 604, and 606 may be flexible bag-type containers that collapse when fluid is drawn from them and therefore, do not require any means to vent air into them when drained.
Osmotic agent container 602, electrolyte container 604, and batch container 606 are all connected by respective lines 642, 648, 644, and 646 to the fluid conveyor and circuit switch 616. The fill/drain line (or multiple lines) 650 and a spent fluid drain line 618 with a conductivity sensor 628 may also be connected to the fluid conveyor and circuit switch 616. The fluid conveyor and circuit switch 616 also has a fill line 631 for receiving water. The water purifier 620 may be a purifier or any source of sterile and pure water including a presterilized container of water or multiple containers. In a preferred configuration, water purifier 620 may be configured as described in WO2007/118235 (PCT/US2007/066251) hereby incorporated by reference in its entirety and attached to the provisional application. For example, the water purifier 620 may include the flow circuit components of
In an alternative embodiment, part of the water (less than the total used for dilution as discussed below with reference to
Referring now to
The relative amounts of water, osmotic agent, and electrolyte may be defined based on the ratiometric proportioning properties of the pump. Since a single tube is used to convey all the liquids into the batch container, most sources of offset from predicted pumping rate (based on shaft rotations, for example) to actual pumping rate affect all the fluids roughly equally.
Referring now to
Referring now to
In addition to mass or conductance measurements, other types of measures may be used to measure proportions of dialysis fluid components and dilution. For example, tracer chemicals such as radioactive tracers or dyes may be used.
Although gravimetric and tracer/conductance sensing were described as devices for ensuring proper proportioning and dilution rates for achieving target prescriptions, it should be clear that the system may employ ratiometric proportioning as well, particularly where positive displacement pumping is employed. Ratiometric proportioning takes advantage of the volumetric repeatability and predictability of certain pumps. For example, a particular pump can deliver a highly repeatable volume of fluid for a given number of pumping cycles (pump rotations for a peristaltic pump or cycles for a diaphragm pump, for example). If all dialysis solution components (water, osmotic agent concentrate, and electrolyte concentrate, for example) are delivered to the mixing container using the same pump, including, for example, the pumping tube segment of a peristaltic pump, then the volume ratios of the components will, after adjustment for potential flow path and/or viscosity differences as described below, be fully determined by the number of pump cycles used to convey each component.
This proportioning may supplement or substitute for measurement of the fluid conductance or density or other measurements. To convert the number of pump cycles to actual displaced mass or volume, a calibration may be performed and/or flow path (including fluid properties) compensation parameters may be employed. The flow path compensation parameters may be respective to each particular fluid flow path and/or fluid type, or may be identical for all fluid paths and fluid types. To provide enhanced accuracy, one or more pump calibration and/or flow path compensation parameters may be generated through a calibration procedure. Typically, flow path compensation factors will be established during the development of the system and stored in non-volatile memory. Typically, one or more flow path calibration procedures will be performed when the system is used by a patient. The calibration procedure may be performed after each new fluid set is installed, or before each batch preparation cycle, or even multiple times during the preparation of a single batch. A disposable fluid set may be installed every day. The calibration procedure may be done using water. The calibration may sequentially pump fluid through one or more of the following stages:
In the calibration procedure, fluid is pumped between any or all of the paths identified above. A separate calibration coefficient may be generated for each of the paths. The calibration coefficient may be stored in a memory or non-volatile data store, for example, as a parameter representing the number of ml/per pump rotation (or diaphragm pump cycle), or as a proportionality ratio relative to a particular reference flow path. The actual fluid quantity transported during the calibration step may be measured by any suitable device (flow sensor) including volume or mass measurement devices or direct flow rate measurement with integration, for example, using laser Doppler velocimetry, thermal transit time, magnetohydrodynamics, propeller hydrometer, positive displacement flow measurement, differential pressure through a resistance such as a venturi, nozzle, orifice plate, or other flow obstruction, variable area or rotameter, pitot or impact tube, vortex shedding frequency counting, ultrasonic, or other device. Any of the disclosed embodiments may employ a flow sensor in which at least the portion of which that carries fluid is disposable so that the flow rate (or total displaced fluid quantity) can be input to a controller while allowing the use of a disposable fluid circuit. Examples include an ultrasonic soft tube flowmeter made by Strain Measurement Devices SMD that non-invasively measures flow in soft tubing by means of slotted transducers in which a length of tubing can be inserted during fluid circuit installation. For cartridge embodiments, the PD cycler can employ a moving transducer stage that engages an exposed tube length of the cartridge after passive insertion of the cartridge.
The pumping system may also be sufficiently repeatable in a way that allows precise ratios to be established without calibration, depending on the predefined tolerances chosen by the system designer. If the manufacturing tolerances, including materials, are sufficiently controlled, a desired level of control over ratios may be achieved without in situ (point of care) calibration. A particularly sensitive component in terms of guaranteeing repeatability is the pumping tube segment of a peristaltic pump. In a first embodiment, the peristaltic pump tube segment is made from a material whose mechanical and material tolerances are controlled within predefined limits. The lengths of the tubing circuit elements and mechanical parameters are also controlled within respective predefined limits. A calibration may then be done outside the treatment context, e.g., in the laboratory, to calculate precise values to convert pump cycles to fluid quantity transferred for a single lot of replaceable fluid circuits. The calibration may be done for multiple lots. The calibration may also be done for each fluid circuit. The calibration may also be done by the treatment system for each fluid circuit. The calibration may also be done for each batch of fluid prepared by the fluid circuit.
Referring to
Referring now to
The fluid circuit 700 is preferably a disposable unit that has a completely sealed internal volume except for a water inlet connection 730 for connection to a source of purified water, a drain connection 713, and a connection for a patient access 717. The connectors 730, 713, and 717 may be sealed with a removable connector cap and the entire disposable fluid circuit 700 sterilized as a unit. The water inlet line 726 may include a sterile barrier 728 in the form of a sterile filter, for example, one with a pore size of 0.2 microns or smaller to filter out contaminants. Effectively, that leaves only the patient access connection 717 and the drain connection 713 as possible entry paths for contaminants. However, the drain line 712 can incorporate a check valve to prevent inflow of fluids therethrough. It is generally a one-way path as well, so this removes all but the patient access connection 717 as a possible route for contaminants to flow into the sealed volume of the fluid circuit 700.
The fluid circuit 700 includes fluid circuit manifold panels 702 and 704 which each distribute flow along their respective lengths effectively allowing flow between any of the connected respective lines. For example, fluid from the osmotic agent line 724 can flow into the manifold 702 and be pumped through a pump line 706, which is configured to mate with a peristaltic pump, into the manifold 704 and then into a selected one or more of the mixing line 715, drain line 714, and/or fill/drain line 716. The fluid circuit manifolds 702 and 704 may include sensor regions (not indicated).
A variety of alternative manifold and/or actuation devices can be used to implement the methods described herein. For example, referring to
The shell housing is assembled as indicated by the dotted arrows into a partial enclosure. Alternatively the tubing parts and manifold may be attached to a single backplane or inserted in a support on a permanent mounting fixture of a PD cycler.
A window, provided by openings 804 and 815, similarly provides access to a pump tubing segment 816 by a peristaltic pump rotor. The pump tubing segment 816 may be flanked by, and also be size-matched to connected tubing, by pressure pods 814. Pressure pods for fluid pressure measurement are known in the art and the details are not provided herein.
The manifolds of the foregoing figures can be realized using a variety of structures. For example, fluid circuit part 826 uses Y-junctions 828 and connecting segments 827 to interconnect tubing branches 828. This structure may be used in place of manifold part 812B, for example, and a variation for manifold part 812A.
The completed device 800 may form a fluid cartridge that can inserted in a cycler housing like a slice of bread in toaster or may be attached to the actuators in other ways.
Actuator regions 732A-732H allow the selective closing of connections to a respective line such as drain line 716. This allows any of the lines connected to manifold 702 to be connected to a line of manifold 704 through the pumping line 706 by closing all the other lines except the selected lines. In manifold 704, actuator region 732A controls access to patient access line 716. Actuator region 732B controls access to drain line 714. Actuator region 732C controls access to mixing line 715. In manifold 702, actuator region 732D controls access to batch fill line 718. Actuator region 732E controls access to drain line 718. Actuator region 732F controls access to electrolyte fill line 722. Actuator region 732G controls access to osmotic agent fill line 724. Actuator region 732H controls access to the water fill line 726.
The patient access line may include a pressure sensor 735 such as a pressure pod as described above with an air line 734 and a connector 736 for connection to a pressure transducer on a peritoneal dialysis cycler or, alternatively, to a sensor region on the fluid circuit manifold.
Referring now to
The disposable fluid circuit unit 758 has a cassette portion 766 that incorporates manifolds 762 and 764 (corresponding respectively to manifolds 702 and 704 of
A registration area 770 (for example a recess area) of the automated peritoneal dialysis cycler 788 has a peristaltic pump actuator 774. The registration area receives the cassette portion 766 of the disposable fluid circuit unit 758 as shown in
Referring now to
The PD cycler and dialysate preparation module 949 has a controller 907 with a user interface panel 906. The user interface panel has controls 906A, 906B, 906C and a display 906D. The controls and other features of the user interface panel 906 may include an audio output device, LED lamps, touchscreen input, and other devices that may be employed for interacting with digital electronic control systems. Preferably the user interface panel 906 controls 906A, 906B, 906C are a small set of clearly differentiated controls that are color coded and shape-differentiated.
The fluid management set 900A includes disposable batch, electrolyte, and osmotic agent concentrate containers 908, 910, and 912, for example, bags that are connected to respective dialysis solution, electrolyte, and osmotic agent draw lines 916, 915, 914. The batch container 908 is preferably an empty presterilized flexible container that is delivered empty of air or fluid and permanently attached to the dialysis solution draw line and a batch fill line 917, the batch fill line 917 being used to add fluid to the bag and the dialysis solution draw line 916 being used to draw contents from the bag. Electrolyte and osmotic agent concentrate containers 910 and 912 store, respectively, electrolyte and osmotic agent concentrate and are also permanently attached to osmotic agent and electrolyte draw lines 914 and 915. The containers and lines are preattached and provided in a sterile condition. The batch container 908 is eventually filled with a mix of sterile water, osmotic agent and electrolytes to form a dialysis solution prescription. The batch container 908 has two lines while the other containers have a single line. The osmotic agent and electrolyte containers 912 and 910 may be fitted with non-reopening clamps 953.
The batch container 908 may be configured to accommodate sufficient dialysis solution for a single peritoneal dialysis fill cycle or it may be large enough for multiple fill cycles. Thus a preparation cycle may generate enough dialysate for a complete treatment (for example a nocturnal treatment cycle including multiple drain-fill cycles).
The batch, electrolyte concentrate, and osmotic agent concentrate containers 908, 910, and 912 may rest on a heater and/or scale 902 indicated by dashed lines. Temperature sensors 904 and 905 may be provided on the surface of the heater and/or scale 902 to provide temperature signals to the controller 907, which controls the heater and/or scale 902. The controller may be configured to warm the dialysate in the batch container 908, which rests directly on the heater and/or scale 902. The temperature sensors 904 and 905 may be positioned to ensure the batch container 908 rests directly on the temperature sensors 904 and 905. The combination of free convection in the large batch container 908 (multiple liters), thin wall of the batch container 908, and the compliance of the wall help to ensure a reading of the temperature sensors 904 and 905 that reflects the temperature of the contents of the batch container 908. Note while the temperature sensors 904 and 905 are shown positioned remote from the batch, electrolyte, and osmotic agent containers 908, 910, 912, it is intended that they be located immediately adjacent to the batch container 908.
The draw lines 914, 915, and 916 and the fill line 917 connect to a manifold module 911 with two valve headers 941 and 946, separated by a barrier section 842, and interconnected by a pump tubing segment 944. The flow between the valve headers 941 and 946 occurs only through the pump segment 944 or through an external connection between the lines linked to it, such as by flowing through the batch container 908 via the valve headers 941 and 946 draw and fill lines 916 and 917. The manifold module 911 in combination with a peristaltic pump actuator 943 and valve actuators 929, 930, 928, 931, 932, 933, 934, and 935 provides and regulates the flow of fluid between selected pairs of the tubing lines 914, 915, and 916, the fill line 917, drain lines 920A and 920B, product water line 919 and a patient line 945. The manifold module 911 also has sensor regions 936 and respective pressure transducers 924 and 925 to generate pressure signals reflecting pressure on either side of the pump tubing segment 944.
The manifold module 911 also has chambers 913A and 913B and respective pressure transducers 926 and 927 to generate pressure signals reflecting pressure on proximal and distal ends of the patient line 945. The pressure chamber 913B is connected to a pneumatic signal line 909 which is in turn connected to a pressure pod 951 configured to transmit the pressure in the patient line 945 distal end through the pneumatic signal line 909 to the chamber 913B. Chamber 913A is in communication with the end of the patient line 945 that is closest to it and conveys the pressure to the transducer 926 to generate a signal representing the pressure at the proximal end of the patient line 945. The controller 907 is connected to control the peristaltic pump actuator 943 and valve actuators 929, 930, 928, 931, 932, 933, 934, and 935 and receive pressure signals from the pressure transducers 924 through 927. The manifold module 911 may be pressed against the valve actuators 929, 930, 928, 931, 932, 933, 934, and 935 by means of a door 973 which may have a hinge and latch as shown in the figures.
An alternative embodiment has a direct pressure-to-electrical transducer in place of the pressure pod 951, which obviates the need in such embodiment for chamber 913B. A direct pressure-to-electrical transducer may take the form of an immersible strain gauge which is bulk-mode deformable so as to provide negative and positive pressure values or either one as required. An electrical lead or wireless channel may convey a pressure signal to the controller 907. Such a transducer may be integrated into a connector for the patient access. Alternatively, the direct pressure-to-electrical transducer may be a pressure catheter, such as one integrated with the peritoneal catheter, as described elsewhere in the present document.
The manifold module 911 has respective box shaped valve headers 941 and 946. Each header has a plurality of valve structures that is actuated by a respective one of the valve actuators 929, 930, 928, 931, 932, 933, 934, and 935. The valve actuators 929, 930, 928, 931, 932, 933, 934, and 935 may be solenoid hammers, linear motors, pneumatic hammers or any suitable device for applying a force to press on a respective one of the header valves (one of the valves being indicated at 140). Referring to
The product water line 919 connects to a water purification system (line continues to a line labeled with the same joining symbol A in
A sterile filter 939 is provided to sterile-filter product water provided in product water line 919. During, prior to, or after preparation of a batch of dialysis solution, the filter may be tested for leaks by performing a bubble point or pressure decay test. A delta-pressure transducer (two pressure sensors separated by the membrane) or a single pressure transducer on the air side of a wetted membrane. In the present embodiment, a transducer at 919 measures the pressure in an air chamber 948 which is in communication with an air side of a wetted membrane of the sterile filter 939. The pressure transducer 919 is used to detect pressure decay (or in other embodiments, a transmembrane pressure TMP decay profile) to determine if the filter integrity is within expected limits. In the present embodiment, an air pump 917 draws air through a filter 921 and selectively pumps it through a control valve 923 and a pressure sensor. The pump 917 may run continuously using a pressure regulated valve 918 to maintain a desired pressure supply to the valve 923 and the valve 922 which may be opened selectively to deliver air into chamber 913B and/or 948. The purpose of flowing air into chamber 948 is to perform a bubble or pressure decay test which is done after making a batch of dialysis solution and to confirm that the filter integrity was maintained during transfer of product water. The flowing of air into chamber 948 is done for the purpose of resetting the volume of the air-side chamber of the pressure pod 951. Air may be selectively leaked from and pumped into the pressure pod to avoid the diaphragm being pinned against one side or the other of its range of travel thereby preventing false readings. So to summarize, valves 918, 923, and 922 are controlled by controller 907 to regulate pressure (by bypassing flow), and selectively allow air to flow to chambers 913B and/or 945 for the described functions.
Referring now particularly to
A permanent filtration subsystem 952 contains a pump, 990 the ultraviolet lamp 982, sensor modules 984 and 985, automatic shutoff valve 988 for the reverse osmosis system, pressure sensors 992, 981, 953, 989 and valves 991 and 993.
Drain fluid from drain line 920 passes through a connector 978 and into a pair of sensor modules 984 and 985 which detect and measure conductivity and temperature, respectively. The sensor modules 984 and 985 provide redundancy as a protection against an error in one of the modules. Safety may be ensured, for example, by enforcing a requirement that the serially interconnected sensor modules 984 and 985 provide signals that are always in agreement and in the event of a disagreement, depending on the operating state, an alarm may be generated or some other action taken. A urea sensor 953 may be used to generate a signal indicating level of urea. The drain line in some modes carries spent dialysate and urea content can be recorded or otherwise used to ensure correct treatment of renal dialysis patients according to known principles. The urea level may be displayed on the display 906D or recorded in a data store of the controller 907 or stored also or alternatively on an Internet server or other external data store (not shown). A check valves 987 at various locations prevent backflow. One check valve 987 in the drain line may be used to prevent backflow into the peritoneal dialysis system 900. Another check valve 987 prevents draining fluid backflowing into reverse osmosis filters 975 and another prevents prefiltered water flowing from the reverse osmosis filters 975 from flowing in reverse. Another check valve 987 prevents primary water entering the system upstream of the particle filter 994 from flowing in reverse.
In addition to the sensor modules 984 and 985, or alternatively, a fluid quantity measurement module may be provided. Primary water enters the water purification system 901 through a connector 978 and check valve 987 and into a particle filter 994. Filtered water passes through a pressure control valve 996, through air vent 999 to a connector 978 connecting it to the permanent filtration subsystem 952. A speed regulated pump 990 draws water through a valve 993. Pressures, upstream and downstream of the pump 990, are measured by sensors 992 and 989 respectively. A bypass valve 991 allows water to be recirculated to control pressure. The bypass valve 991 is controlled by the controller 955 to regulate pressure exiting the pump 990.
An automatic shutoff valve 988 feeds water to the carbon and RO subsystem 997 with respective waste water connection, product water connection and feed water connections 978. Feed water passes through a conductivity sensor 977, which applies a conductivity signal to the controller 955, and then through an activated carbon filter bed.
After passing through RO membranes 975, product water flows through check valve 987 through a line 957 to a pressure sensor 981, through the automatic shutoff valve 988 to an ultraviolet filter after which product water leaves the permanent filtration subsystem 952 through a connector 978. The connector 978 receiving product water from the permanent filtration subsystem 952 is a part of a disposable filter module 970 containing carbon 963, segregated bed deionization filters 959 (each with a cation bed 965 and an anion bed 964) and a mixed bed deionization filter 966. The disposable filter module 970 also contains a pair of separated ultrafilters 958 with air vents 956. Conductivity sensor 968A detects early breakthrough of contaminants which may be used by the controller 955 to generate an indication that the filter module 970 needs to be changed. The indication of expiration of the filter module 970 may be output via the user interface panel 906 or an independent one (not shown). The ultrafilters 958 are separated to sterilize and prevent grow-through contamination. A check valve 969 prevents back flow. A fuse 960 is blown when the filter module 970 is first connected. The controller 955 prevents the reconnection of filter modules 970 with blown fuses, thereby preventing reuse of previously used filter modules 970. A wetness sensor 938 is connected to the controller 955 and generates a signal, applied to the controller 955, when a leak wets it.
As may be seen, lines 1010, 1011, 1012, and 1013 connect the dialysis solution bags 1002 to the manifold module 911. At least one of the dialysis solution bags 1002 is attached to a different one of the two valve headers 941 and 946 to allow transfer of dialysis solution between bags, which in turn may allow priming of the tubing set 1000 and other functions. Also note that line 1010 is coupled to the line 945 to allow fluid from either of valve headers 941 and 946 to be pumped into the patient line 945. The functions enabled by this configuration include, for example, to allow fluid to be conveyed to one of the dialysis solution bags 1002 indicated at 1020 which may be rested on the heater 903, from any of the other bags 1002. Then, once bag 1020 is emptied, fluid can be transferred from one of the other bags 1002 to fill it and the bag 1020 heated prior to infusion. Inspection of the tubing set 1000 and valve headers 941 and 946 make it clear that these functions are enabled simply by appropriate sequencing of the 929, 930, 928, 931, 932, 933, 934, and 935. Each of the dialysis solution bags 1002 is provided with a non-reopenable clamp 1005, a needle free port 1007, and mating connectors 1006 and 1007 on the bag 1002 and tubing set 1000.
At S18, a self-testing procedure may be performed, for example, to do a pump calibration, check pressure ranges, perform bubble point or pressure decay tests on the sterile filter membrane, etc. The patient access is then connected to the patient line and a drain cycle S22 followed by a fill cycle S24 performed. The drain and fill cycles may be repeated until a treatment completed check S26 indicates that a complete set of drain and fill cycles has been performed. Remaining fluid in the bags 1002 may be drained S28 and the access, bags, and fluid sets may be disconnected and disposed of S30 and S32.
Still referring to
The following description applies to a generic PD system and the elements can be configured according to any of a variety of design and technology approaches. For example, the manifold/pumping arrangement 208 may pump fluid using a diaphragm arrangement or a centrifugal pump and incorporate flow control of any of a variety of sorts including permanent valves, flow switches, line clamps etc. The containers batch container 202, osmotic agent concentrate container 204, and electrolyte concentrate container 206 may be rigid or bag type containers and may be disposable or permanent with a sterilization plant provided therewith.
In
In
In the embodiments of
In any of the foregoing embodiments, the osmotic agent concentrate may include a predefined portion of electrolyte concentrate permitting the quantity or concentration of osmotic agent to be determined by measuring the electrolyte concentration using a conductivity cell. The final electrolyte concentration is achieved by proportioning the electrolyte concentrate based on the known amount delivered with the osmotic agent concentrate.
Pressure profile data stored on data store 836 may be obtained from a data store 841 attached to the disposable unit or may be downloaded from a server based on identifying information on such a data store 841. Alternatively pressure profile data may be stored on the 836 periodically and specific data to be used for a treatment selected from a user interface of the controller during treatment, for example data for a particular patient identified through the user interface and whose profile data is obtained from a repository of patient-specific treatment data. The pressure profile data may include a single pressure value representing a maximum pressure at the point of the pressure sensor 834 indicating a maximum pressure and serving as a limit on the pumping rate by pump 840 as controlled by the controller 830 as described according to any of the foregoing embodiments. The pressure profile data may include multiple pressure values representing respective phases of a peritoneal dialysis fill cycle. For example, the pressure values may correlate volume and pressure or number of pump rotations and pressure thus defining a profile. In example, the rate may be ramped progressively up toward a maximum and then slowed gradually to balance the desires of speedy throughput and patient comfort.
In the second column, Pump Operation, the letters A, B, C, etc. refer to predefined values. For example, a peristaltic pump may rotate once for every 2 ml. pumped so the values may correspond to an amount of fluid pumped. The columns labeled Valve State refer to the status of the valve as labeled in
In any of the disclosed and/or claimed method, control, or system embodiments, in which the batch container is emptied, a negative pumping pressure may be applied to the container for a period of time to ensure complete emptying. Also, in any of the disclosed and/or claimed embodiments, the batch container may be positioned on an angled base with its drain opening at a lowest point, also to help in fully emptying the batch container. Other embodiments may be formed by providing a mechanism for jostling or vibrating the batch container and/or the other fluid containers to help ensure fluid is not trapped.
In any of the foregoing manifold embodiments, the drain line can be split to valves on both sides of the pump tube, as in the embodiments of
In any of the foregoing embodiments, separate fill and drain lines can be used instead of a single fill/drain line. In embodiments with separate fill and drain lines, a pressure pod may be carried on the fill line alone, the drain line alone, or pressure pods may be provided on both the fill and the drain line. The same is true for other pressure measurement embodiments of peritoneal treatment lines. As will be evident, the pressure measurement capabilities may be used for the detection of spent dialysis fluid properties and for the regulation of filling flow rate and other purposes described herein.
In the present and any of the other embodiments, a sufficient amount of fluid may be drained in order to contact the conductivity sensor to form a reliable reading. For example, an amount in the range of 25 to 100 ml or preferably an amount in the range of 50-70 ml. may be used.
In any of the described embodiments, the osmotic agent may be, or include, glucose, L-carnitine, glycerol, icodextrin, or any other suitable agents. Further, the components combined to make a peritoneal dialysis solution may vary in number and any of the embodiments described could be made from single concentrate components or any other number of concentrate components by straightforward modifications of the embodiments. For example, a buffer (e.g., acetate, bicarb, lactate) may be separate from an electrolyte which may be separate from an osmotic agent.
In any of the disclosed embodiments that employ direct attachment of diluted fluids, for example, the embodiment of
In any of the disclosed embodiments, pressure signals that proximal and distal ends of the peritoneal line may be generated while a no-flow, or low-flow, condition exists. This may be controlled to occur at a certain point in preparation for, or during treatment, to generate indications of static hydraulic head in the line. For example, if a patient falls out of bed, and a sudden height difference between the proximal and distal ends arises, a pressure difference may be detected. The detection may trigger an alarm or other output and may instantiate a change in machine status for example a shutdown. Another inference from an out of bounds pressure difference during low or no flow is abnormal set up the system. In embodiments, the conversion of pump cycles to total transferred flow may be governed by assumed system configuration which may include a certain range of height differences between the proximal and distal ends of the peritoneal line. The following table shows some possible behaviors.
In the table above, ranges identified by letter may represent pressure profiles, that is pressure values (upper and lower limits or just upper or just lower limits) that change during a progressive process. For example, pressure range C may ramp up with the number of pump cycles. The range data may be stored in a memory of the controller and/or may be stored on a memory device of the replaceable tubing set and/or may be read from a remote server or derived by any other suitable system. The pressure range data may be respective to a particular tubing set model, treatment type, and/or patient and selection may be automated or made manually through a user interface. The term misconfiguration can refer to kinks, obstructions, leaks, disconnections, or other types of line problems. In the table, anywhere alarm or other output is indicated as an action, this may include, or be in the alternative, instructing the user to take some action to verify the problem or a detailed explanation of what the action might be, for example, if a misconfiguration of the connection is indicated.
In any of the disclosed embodiments, the distal pressure sensor may be located within a peritoneal cycler machine or on the tubing set leading to the patient and close to the machine. The distal pressure sensor may be located near the patient and on the tubing set or within a peritoneal catheter. It may also be separated from the tubing set and positioned within the peritoneum. In such an embodiment, the pressure sensor lines may be attached to the tubing set. For example, metallized surface of the tubing or a co-extrusion (wire insulation and tubing being coextruded) or simply attached to the tube at points therealong.
In any of the disclosed embodiments, an osmotic agent, concentrated or dilute, or a peritoneal dialysis solution or concentrate thereof containing glucose or any other precursor of a dialysis solution may contain glucose that has not been treated with heat. In any of these embodiments, the glucose concentrate or solution or dialysis solution or precursor containing glucose may be sterile filtered as it is stored in a sterile container without using heat sterilization at all. This avoids heat sterilization byproducts of glucose that are toxic. In a method embodiment, the a sterile package including a bag has an inline sterilizing filter (e.g., 0.1 micron porosity sterilizing filter) at a filling port thereof. The port may be elongate and have a nonreopenable closure on the filling port. Another port, sealed at the time of filling, may be used to access the contents. Before filling, the sealed container is sterilized by gamma sterilization or heat sterilization. Then the glucose solution is pumped into the container through the inline sterile filter and the nonreopenable closure feature is closed. The nonreopenable feature can be just a weldable tube neck which is sealed by thermoplastic welding. Other sealing devices may be used.
According to embodiments, the disclosed subject matter includes a method of performing a dialysis treatment. The method uses a dialysate supply line that has proximal end into which peritoneal dialysis fluid is supplied and from which spent dialysate is withdrawn and a distal end which is connected to a patient's peritoneal access. The method includes generating proximal and distal pressure signals using pressure detectors located at both the proximal and distal ends, respectively, of the supply line. The method further includes supplying peritoneal dialysis fluid at a rate that is responsive to the distal and pressure signals. For example, the peritoneal dialysis fluid may be supplied at a variable rate which is adjusted by a controller responsively to both (i.e., a combination of) the distal and proximal pressure signals. For example, the pressure drop may be calculated by the controller and that pressure drop used to regulate flow. For example, the pressure drop may represent a viscosity characteristic or a kink in the fluid lines. The viscosity characteristic could be viscosity which might indicate a disease such as peritonitis. Another example is that a pressure difference may arise as a result of the patient being at a very high or low position relative to the peritoneal dialysis cycler unit. In the latter case, the fall of a patient off his bed may be indicated and this indication used to generate an alarm. So the controller may have predefined operating limits of pressure difference, each limit may be tied to a particular flow range or flow rate or status of the machine and used to infer some status that is either normal or erroneous. Thus, the methods disclosed include ones in which the aforementioned supplying operation includes calculating a characteristic of the dialysate supply line and supplying peritoneal dialysis fluid at a rate that is responsive to the characteristic. The methods disclosed also include ones in which the aforementioned supplying operation includes calculating a characteristic of the dialysate supply line and generating an output that is responsive to the characteristic. The outputs may be a text or audible output using a user interface of the cycler and connected to a controller. Outputs can also be sent to remote locations such as a clinic that monitors home treatment or an automated cellular phone message or call. The disclosed methods may thus also include those where the supplying includes calculating a height of a fluid column responsively to the difference in the proximal and distal pressures and supplying peritoneal dialysis fluid at a rate that is responsive to the height. The supplying may include varying a rate of pumping of dialysate responsively to a difference between the proximal and distal pressure signals such that an input pressure of fluid at a point of entry into the peritoneum is maintained, the input pressure corresponding to a predefined pressure stored in a controller that controls a rate of the supplying. The supplying may be effective to limit a pressure difference determined by a controller between the proximal and distal pressure signals. The supplying may be effective to limit a pressure indicated by the distal pressure signal received by a controller that controls a rate of pumping.
According to embodiments, the disclosed subject matter includes a method of performing a dialysis treatment in which a pump and a dialysate supply line are used. The supply line has a proximal end into which peritoneal dialysis fluid is supplied and from which spent dialysate withdrawn. Note that the method may be used with a dual lumen line. The distal is connected to a patient's peritoneal access. The method includes supplying peritoneal dialysis fluid to the peritoneum of a live patient while generating proximal and distal pressure signals, the generating including using pressure detectors positioned at both the proximal and distal ends. The method includes reducing the flow rate of dialysis fluid or halting the flow of dialysis fluid when the difference between the proximal and distal pressure signals rises above a threshold value. The reducing may include using a controller to calculate, from the proximal and distal pressure signals, a characteristic associated with a difference in the proximal and distal pressure signals and reducing the flow rate responsively to the characteristic or generating an alarm indication indicating a problem with the supply line responsively to the proximal and distal pressure signals when the difference between the proximal and distal pressure signals rises above the threshold value. Alternatively it may include reducing the flow rate of the supplying responsively to the proximal and distal pressure signals when the difference between the proximal and distal pressure signals rises above the threshold value; halting the flow rate of the supplying responsively to the proximal and distal pressure signals when the difference between the proximal and distal pressure signals rises above the threshold value; and/or recording a digital record of an error event in a non-volatile data store responsively to the proximal and distal pressure signals.
According to embodiments, the disclosed subject matter includes a method of performing a dialysis treatment using a pump and a dialysate supply line to transport peritoneal dialysis fluid. The supply line has a proximal end into which peritoneal dialysis fluid is supplied and from which spend dialysate is withdrawn (or a combination line with two lumens, one for filling and one for draining), and a distal end which is connected to a patient's peritoneal access. The method includes generating proximal and distal pressure signals using pressure detectors located at both the proximal and distal ends, respectively, of the supply line. The method may include, during a drain cycle in which spent dialysate is pumped from the patient, responsively to the proximal and distal pressure signals, detecting a characteristic of a pressure difference between the distal and proximal ends whose magnitude is determined by a predicted change in dialysate properties, and responsively to the characteristic, generating a signal indicating the change in dialysate properties.
The change in dialysate properties may include an increase in viscosity that causes an increase in pressure drop and the method may include generating a display indicating a change in viscosity, the indication of a possible disease condition or other kind of message or alarm. The method may include recording in a non-volatile data store, an indicator of a pathology event including an identifier of the dialysate properties and an identifier of a patient or transmitting a message to a care provider service, the message indicating the pathology event.
According to embodiments, the disclosed subject matter includes a medical treatment device employing a treatment machine configured to pump a medicament to a patient. The treatment machine has a flow line having a proximal end located at the treatment machine and a distal end attachable to a patient access. A proximal pressure sensor is positioned to detect a pressure in the flow line proximal end. A distal pressure sensor is positioned to detect pressure in the flow line at the distal end. The distal pressure sensor includes an in-line pressure pod at the distal end with an air line running parallel to, and attached at multiple points along, the flow line. The air line is connected at one end to the pressure pod and at the other end to a pressure sensing assembly located at the treatment machine. The air line may be tubing line filled with air. Alternatively, the pressure pod and air line may employ a different working fluid from air, for example, a gas or liquid. The treatment machine may be a peritoneal cycler configured to provide automated peritoneal dialysis. The treatment machine may include a controller configured to implement any of the described methods.
According to embodiments, the disclosed subject matter includes a medical treatment device the includes a treatment machine configured to pump a medicament to a patient. A flow line with a proximal end located at the treatment machine and a distal end attachable to a patient access has a proximal pressure sensor positioned to detect a pressure in the flow line proximal end. A distal pressure sensor is positioned to detect pressure in the flow line at the distal end. The distal pressure sensor includes a distal pressure transducer at the distal end. The distal pressure transducer includes a semiconductor that is subjected to pressure from fluid in the fluid line on at least one side thereof and thereby arranged to detect a pressure at the distal end of the fluid line. The pressure transducer may be arranged to be fully immersed in fluid when the fluid line is conveying fluid. The treatment machine may be a peritoneal cycler. The treatment machine may include a controller configured to implement any of the disclosed methods.
According to embodiments, the disclosed subject matter includes a method of performing a dialysis treatment using a pump and a dialysate supply line, where the supply line has a proximal end into which peritoneal dialysis fluid is supplied and from which spent dialysate is withdrawn, and a distal end connected to a patient's peritoneal access. The method includes supplying peritoneal dialysate to the peritoneum of a live patient to generate a pressure signal, using a pressure detector connected to the supply line. The method further includes generating an indicator signal indicating a presence of the respiratory or heart rate or indicating a magnitude of the respiratory or heart rate and/or an alarm condition responsively to the pressure signal. The generating may include applying a characteristic of the pressure signal to a classifier and using the classifier, comparing the characteristic signal to at least one predefined parameter; and generating the indicator signal responsively to a result of the comparing.
According to embodiments, the disclosed subject matter includes a method of performing a dialysis treatment using a pump and a dialysate supply line, the supply line having a proximal end into which peritoneal dialysis fluid is supplied and from which spent dialysate is withdrawn, and a distal end connected to a patient's peritoneal access. The method includes filling the supply line with peritoneal dialysis solution and detecting a patient's respiratory or heart rate from the distal pressure signal using a pressure detector located at the distal end of the supply line and outputting a signal responsive thereto. The filling may include flowing peritoneal dialysis fluid through the supply line. The method may include applying the status signal to a controller and using the controller, altering a rate of the flowing responsively to the signal.
According to embodiments, the disclosed subject matter includes a method of performing a dialysis treatment using a pump, filling a supply line with peritoneal dialysis solution, the supply line having a proximal end into which dialysis fluid is supplied and from which spent dialysate is withdrawn, and a distal end which is connected to a patient's peritoneum. The method includes generating proximal and distal pressure signals using pressure detectors located at both the proximal and distal ends, respectively, of the supply line. The method further includes responsively to the proximal and distal pressure signals, detecting a patient's breathing or blood pulse to generate respective proximal and distal respiration signals. The method further includes recording data responsive to at least one of the proximal and distal respiration signals on a non-volatile data store. The supply line may include a peritoneal catheter and the distal end coincides with the peritoneal catheter. The generating the distal pressure signal may include using a pressure detector located on a peritoneal catheter.
According to embodiments, the disclosed subject matter includes a method of performing a dialysis treatment using a pump and a dialysate supply line, the supply line having a proximal end into which peritoneal dialysis fluid is supplied and from which spent dialysate is withdrawn, and a distal end which is connected to a patient's peritoneal access. The method includes generating proximal and distal pressure signals using pressure detectors located at both the proximal and distal ends, respectively, of the supply line. The method further includes, responsively to the proximal and distal pressure signal, detecting a patient's breathing or blood pulse to generate respective proximal and distal respiration signals, and generating an alarm signal responsive to a combination of the proximal and distal respiration signals. The combination may be a difference between levels of the proximal and distal respiration signals and the alarm signal indicates a loss of patency in the supply line. The recording may include recording a reliability metric corresponding to the data, the reliability being responsive to a level of the corresponding respiration signal.
According to embodiments, the disclosed subject matter includes a medical treatment device that includes a treatment machine configured to pump a medicament to a patient and a flow line having a proximal end located at the treatment machine and a distal end attachable to a patient access. A proximal pressure sensor is positioned to detect a pressure in the flow line proximal end. A distal pressure sensor is positioned to detect pressure in the flow line at the distal end. The distal pressure sensor includes a distal pressure transducer at the distal end, the distal pressure transducer including a semiconductor that is subjected to pressure from fluid in the fluid line on at least one side thereof and thereby arranged to detect a pressure at the distal end of the fluid line.
According to embodiments, the disclosed subject matter includes a method of performing a peritoneal dialysis treatment that begins with connecting a disposable unit to a source of water where the disposable unit includes at least a first container holding a sterile concentrate containing an osmotic agent, a second container holding a sterile concentrate containing electrolytes, an empty sterile mixing container, and a tubing set with a pre-attached peritoneal fill/drain line. The method includes receiving a prescription command by a controller, indicating at least the fill volume and desired final concentration of the osmotic agent to be used for a current fill cycle under the treatment. The method further includes using the controller, pumping a quantity of the concentrated osmotic agent that is at least sufficient to achieve the desired final concentration into the mixing container, mixing the contents of the mixing container, and further diluting or further adding concentrated osmotic agent to the mixing container. The method also includes flowing fluid from the mixing container to a patient. Prior to the pumping a quantity of the concentrated osmotic agent and responsively to the prescription command, the controller may be used to pump a volume of water from the source of water into the mixing container. After the mixing, the concentration of osmotic agent in the mixing container may be detected. The first container may hold a sterile concentrate containing both an osmotic agent and a predefined mixture containing electrolytes, the mixture serving as a marker for the purpose of establishing a conductivity versus concentration characteristic that is monotonic within a range suitable for closed-loop control. The method may include pumping into the mixing container a quantity of the concentrated electrolytes from the second container that, in combination with the selected quantity of concentrate pumped from the first container, will result, upon further dilution, in the desired final dialysis fluid formulation.
The method may further include mixing the contents of the mixing container, detecting the total concentration of electrolytes in the mixing container, further diluting or further adding concentrated electrolytes to the mixing container, and flowing fluid from the mixing container to a patient. The electrolyte marker may be the same species as the electrolyte concentrate held in the second container. The detecting the concentration of osmotic agent may include detecting the concentration of the electrolyte marker using a conductivity sensor, whereby the concentration of the osmotic agent is inferred from an attending concentration of electrolyte. The electrolyte marker and osmotic agent may have been proportioned such that only concentrate from the first container is needed when the prescription command calls for the maximum desired concentration (typically 4.25% for osmotic agent). The disposable unit may also include a third container holding a buffer. The pH of the concentrated osmotic agent held in the first container may be less than 4.0 and the pH of the concentrates held in the second and/or third containers is such that the pH of the final formulation will be in the range of 6.0 to 8.0. The osmotic agent may include glucose. The disposable unit may include a sterilizing-grade filter. The method may include passing water from the source through the sterilizing-grade filter prior to flowing into the mixing container and confirming the integrity of the filter prior to supplying fluid to a patient. The method may further include passing the contents of the first and second containers, through the sterilizing-grade filter prior to flowing into the mixing container, and confirming the integrity of the filter prior to supplying fluid to a patient. The volume of water may be initially less than 110%, and preferably less than 100%, of the prescribed fill volume. The dialysis treatment may include multiple fill cycles, and the fill volumes and desired final concentrations of the osmotic agent may vary from cycle to cycle.
According to embodiments, the disclosed subject matter includes another method of creating a batch of peritoneal dialysate. The method includes providing a container pre-filled with a first concentrate containing an osmotic agent combined with electrolytes in a predefined ratio and transferring a quantity of the first concentrate from the container to a batch mixing container. The method further includes measuring the concentration of electrolyte in the batch mixing container and correcting it by diluting or adding further amounts of the first concentrate to the batch container. The correcting may include diluting the mixture in the batch container. The method may further include receiving a prescription command indicating an amount of osmotic agent to be used for a treatment. The correcting may be responsive to the prescription command. The receiving a prescription command may include detecting and storing parameters of spent dialysate from a prior treatment of a current patient to be treated, reading the stored parameters, and generating the prescription command responsively to the stored parameters.
According to embodiments, the disclosed subject matter includes a peritoneal dialysis disposable unit. The unit has a manifold unit containing a mechanism for selectively interconnecting a first array of fluid paths, respectively, with a second array of fluid paths, the interconnecting being completed through a pumping portion and a primary inlet fluid path of the first array of the manifold unit being connected to a source of purified water. The unit further includes respective fluid paths of the second array of the manifold unit being connected to a first container holding a sterile, concentrated osmotic agent and an empty sterile mixing container and a fluid path of the first array of the manifold unit being connected to a tubing set that includes a pre-attached peritoneal fill/drain line. The first container may contain a mixture of a sterile osmotic agent and electrolytes in a predefined concentration ratio effective to permit a concentration of the electrolytes to be detected and thereby function as a marker to establish a conductivity versus concentration characteristic that is monotonic within a range of concentrations suitable for peritoneal dialysis. The fluid path that connects to a source of purified water may include an inline sterilizing filter. The fluid paths may define a closed, sterile system, which is accessible to the outside environment only through the primary inlet fluid path and the tubing set, both of which are sealed by a removable seal. In the foregoing system, an air line may connect a pressure pod on the peritoneal fill/drain line with a pressure transducer. The pumping portion may include a pumping tube segment. The pumping portion may include only one pumping tube segment.
According to embodiments, the disclosed subject matter includes a peritoneal dialysis disposable unit that has a manifold portion containing selectably closable portions. A source connector is configured to connect the manifold to a source of purified water. The unit includes an osmotic agent container filled with osmotic agent, an electrolyte container filled with sterile electrolyte, and an empty sterile mixing container and a tubing set with a pre-attached peritoneal fill/drain line. The osmotic agent container, the electrolyte container, and the empty sterile container are connectable to the source through the manifold. The manifold portion is configured to permit the flowing of fluid between the osmotic agent container, the electrolyte container, and the source connector to the mixing container through the same pumping tube portion, without unsealing making or breaking connections of the disposable unit.
A controller may be configured to control an actuator adapted to flow fluid through the disposable units of any of the foregoing units. The controller may be programmed to calculate respective flow characteristics of respective flow paths connecting the mixing container to the source connector, the osmotic agent container, and the electrolyte container at a first time and later use the calculated flow characteristics to control quantities of fluid from flowed from source connector, the osmotic agent container, and the electrolyte container to the mixing container. The controller may be programmed to calculate the respective flow characteristics of respective flow paths by commanding an actuator mechanism to flow fluid through the disposable unit and recording sensor signals indicating flow rates of the fluid. The controller may be further programmed to detect the connection of the disposable unit and to calculate the respective flow characteristic responsively to a detection of a connection of the disposable unit. The controller may be programmed to calculate the respective flow characteristics by pumping fluid while simultaneously measuring flow rate using a flow sensor connected to a pump outlet.
According to embodiments, the disclosed subject matter includes a peritoneal dialysis device with a disposable tubing set including a fill line with a patient access connector at one end and a dialysis fluid receiving end opposite the patient access connector end. A fill-side pressure measuring sensor is attached at the fill end and forming a disposable component of the tubing set. A patient-side pressure measuring sensor is located at the fluid receiving end. The patient-side and fill-side pressure measuring sensors are adapted for measuring pressure in the fill line at the respective ends thereof. A controller is configured to regulate a rate of flow in the fill line responsively to a signal from the at least the patient-side pressure measuring sensor. The controller may be configured to regulate flow in the fill line responsively to signals from at least the fill-side and patient-side pressure sensing devices.
According to embodiments, the disclosed subject matter includes a peritoneal dialysis device with a disposable tubing set including a fill line with a patient access connector at one end and a dialysis fluid receiving end opposite the patient access connector end. A patient-side pressure measuring sensor is located at the fluid receiving end. The patient-side pressure sensing device is adapted for measuring pressure in the fill line at the patient end of the fill line. The device includes a peritoneal dialysis cycler with a controller configured to regulate a rate of flow in the fill line responsively to a signal from at least the patient-side pressure sensing device. The patient-side pressure sensing device may be positioned at a distance no greater than 20 cm from the access connector. The patient-side pressure sensing device may include a pressure pod type device having an air side and a fluid side, the air side being in fluid communication with a signal line running along the length of the fill line to connect to a pressure transducer at the cycler location. The patient-side pressure sensing device may include a pressure transducer in signal communication with the controller.
According to embodiments, the disclosed subject matter includes a method of performing peritoneal dialysis treatment, including conveying dialysis fluid to a peritoneal cavity through a catheter during a patient fill phase and allowing the dialysis fluid to dwell within the peritoneal cavity during a patient dwell phase. The method further includes conveying dialysis fluid away from the peritoneal cavity through the catheter during a patient drain phase and sensing an intraperitoneal pressure through the catheter via a pressure detecting device located at an end of a fill line and adjacent to the catheter to regulate the amount of fluid conveyed during the patient fill phase, so that the peritoneal cavity is not overpressurized during the treatment. The method may further including repeating the conveying, dwelling, and sensing at least once. At least one of the conveying dialysis fluid to the peritoneal cavity and conveying dialysis fluid away from the peritoneal cavity further may include pumping the dialysis fluid. The sensing may be performed during the fill phase.
According to embodiments, the disclosed subject matter includes a method of performing a dialysis treatment including storing a therapeutic program in a memory of a controller, the program including pressure data characteristic of a target pressure profile having at least two pressure magnitudes, each corresponding to a respective total quantity of dialysis fluid transferred during a peritoneal fill cycle. The method includes using a pump and a dialysis fluid supply line that has a proximal end into which peritoneal dialysis fluid is supplied and from which spent dialysis fluid is withdrawn, and a distal end which is connected to a patient's peritoneal access to retrieve the pressure data and supplying peritoneal dialysis fluid to the peritoneum of a live patient while applying to the controller pressure signals representing pressure of dialysis fluid at the distal end using a pressure detector located at the distal end. A rate of the supplying is responsive to the pressure signals and the pressure data. The rate of the supplying may be responsive to a cumulative quantity of dialysis fluid transferred that is calculated by the controller. The pressure target pressure profile may include data representing a series of pressures that are initially high and fall to a lower rate at higher levels of total dialysis fluid transferred. The supplying may include varying a rate of pumping of dialysate responsively to a difference between the proximal and distal pressure signals so as to maintain a pressure of fluid at a point of entry into the peritoneum that corresponds to fixed head pressure, allowing a patient's peritoneum to be filled to a prescribed volume without exceeding a safe pressure limit, the prescribed volume including the peritoneum's full capacity. The supplying may be effective to limit a pressure difference determined by a controller between the proximal and distal pressure signals. The supplying may be effective to limit a pressure indicated by the distal pressure signal received by a controller that controls a rate of pumping.
According to embodiments, the disclosed subject matter includes a method of performing a dialysis treatment using a pump and a dialysate supply line where the supply line has a proximal end into which peritoneal dialysis fluid is supplied and from which spent dialysate withdrawn, and a distal end which is connected to a patient's peritoneal access. The method includes generating proximal and distal pressure signals using pressure detectors located at both the proximal and distal ends, respectively, of the supply line, and reducing the flow rate or halting the flow of dialysis fluid when the difference between the proximal and distal pressure signals rises above a threshold value. The method may include generating an alarm that indicates a problem with the supply line when the pressure difference between the proximal and distal pressure signals rises above the threshold value or when the difference between the proximal and distal pressure signals rises above a threshold value, reducing the flow rate of the supplying. The method may include, when the difference between the proximal and distal pressure signals rises above the threshold value, halting the supplying. The method may include generating of an alarm indication responsively to a detection of a high pressure drop in the supply line and outputting the an alarm and an indication of the type of the alarm on a digital display. The method may include generating of an alarm indication responsively to a detection of a high pressure drop in the supply line and recording a digital record of an error event in a non-volatile data store.
According to embodiments, the disclosed subject matter includes a method of performing a dialysis treatment using a pump and a dialysate supply line where the supply line has a proximal end into which peritoneal dialysis fluid is supplied and from which spend dialysate is withdrawn, and a distal end which is connected to a patient's peritoneal access. The method includes generating proximal and distal pressure signals using pressure detectors located at both the proximal and distal ends, respectively, of the supply line and during a drain cycle in which spent dialysate is pumped from the patient, responsively to the proximal and distal pressure signals, detecting a pressure difference between the distal and proximal ends resulting from a change in dialysate properties, and generating a signal indicating the change in dialysate properties. The change in dialysate properties may include an increase in viscosity that causes an increase in pressure drop. The method may include generating a display indicating a change in viscosity. The method may include recording in a non-volatile data store, an indicator of a pathology event including an identifier of the dialysate properties and an identifier of a patient. The method may include transmitting a message to a care provider service, the message indicating the pathology event.
According to embodiments, the disclosed subject matter includes a controller programmed to implement a method according to any of the foregoing method claims.
According to embodiments, the disclosed subject matter includes a computer readable medium having recorded thereon a computer implementable procedure according to any of the foregoing method claims.
According to embodiments, the disclosed subject matter includes a system configured to perform, automatically, any of the procedures of any of the foregoing method claims.
According to embodiments, the disclosed subject matter includes a disposable fluid circuit includes a peritoneal dialysis tubing set including connection tube with a connector for a peritoneal catheter at a distal end and a connector configured to connect to a peritoneal cycler at a proximal end. The circuit includes a pressure pod at the distal end, the pressure pod being of the type that has a flow chamber for carrying a liquid and an air chamber separated from the flow chamber by a diaphragm and an air port in fluid communication with the air chamber. The flow chamber is connected in-line with a lumen of the connection tube. The circuit includes a length of tubing running from air-port along the length of the connection tube with a connector at the proximal end configured to connect to a pressure transducer. The fluid circuit may be entirely of polymer, the lumen of the connection tube is sealed at both ends and sterile. The distal end may have a peritoneal catheter with a lumen interconnected to the distal and with the lumen of the peritoneal catheter and the connection tube in flow communication. The fluid circuit may include a fluid container connected to the proximal end of the connection tube. The fluid circuit may include a container with at least one component of a medicament connected to the connection tube lumen at the proximal end thereof. The fluid circuit may include a first empty fluid container connected to the proximal end of the connection tube and a second filled fluid container with at least one component of a medicament connected to the first empty fluid container by at least one valve.
According to embodiments, the disclosed subject matter includes a disposable fluid circuit with a peritoneal dialysis tubing set including connection tube with a connector for a peritoneal catheter at a distal end and a connector configured to connect to a peritoneal cycler at a proximal end. The circuit may include a pressure transducer at the distal end, the sensor having leads for connection to a driver circuit. The pressure transducer is in pressure communication with a lumen of the connection tube. Leads may be attached to and run along the length of the connection tube with a connector on the leads at the proximal end and configured to connect to a driver circuit. The fluid circuit may be sealed at both ends and sterile internally. The distal end may have a peritoneal catheter with a lumen interconnected to the distal and with the lumen of the peritoneal catheter and the connection tube in flow communication. A fluid container may be connected to the proximal end of the connection tube. The fluid circuit may further include a container with at least one component of a medicament connected to the connection tube lumen at the proximal end thereof. The fluid circuit may further include a first empty fluid container connected to the proximal end of the connection tube and a second filled fluid container with at least one component of a medicament connected to the first empty fluid container by at least one valve. The leads may be coaxial and/or RF shielded.
According to embodiments, the disclosed subject matter includes a fluid flow system for peritoneal dialysis with a pump. The pump has an inlet and an outlet and is configured to pump fluid from the inlet to the outlet. First flow paths are selectably connectable to the pump inlet, the first flow paths being connected respectively to respective sources of at least one concentrate and water, and to a dialysis fluid batch container. Second flow paths are selectably connectable to the pump outlet, the second flow paths being connected respectively to the dialysis fluid batch container, a patient access line, and a drain. A controller may be included in the system and configured to operate the pump in a single direction. The first and second flow paths may include control valves connected for control by a controller, the controller being configured to operate the pump and the control valves to flow the at least one concentrate and water into the dialysis fluid batch container, to mix the at least one concentrate. The controller may be further configured to operate the pump and the control valves to transfer fluid from the dialysis fluid batch container to the patient access. The controller may be configured to operate the pump and the control valves to transfer fluid from the patient access to the drain. The system may include a fluid property sensor in the second flow path connecting to the drain, wherein the controller is further configured to operate the pump and the control valves to transfer fluid from the dialysis fluid batch container to the drain and to receive a signal indicating a property of the fluid. The at least one concentrate may include an electrolyte and an osmotic agent. The at least one concentrate may include an electrolyte and osmotic agent.
According to embodiments, the disclosed subject matter includes a peritoneal dialysis system with a peritoneal fill line that includes a peritoneal catheter at a distal end thereof and connected to a source of fluid at a proximal end thereof, the proximal end being opposite the distal end. The system has a controller and a distal pressure sensor at the distal end configured to apply a distal pressure signal to the controller as well as a proximal pressure sensor at the proximal end configured to apply a proximal pressure signal to the controller. The controller is configured to detect a condition where a difference in pressures represented by the proximal and distal pressure signals exceed a predefined threshold and to generate a first output responsively thereto. The controller may be further configured to access data indicative of a target flow rate and to maintain a target flow rate responsively to the data, and at least one of the proximal and distal pressure signals. The first output may be an alarm signal. The controller may be configured to regulate a rate of flow of fluid in the peritoneal fill line and further configured such that the first output includes a command to change a flow rate of fluid in the peritoneal fill line. The controller may be configured to regulate a rate of flow of fluid in the peritoneal fill line responsively to a difference in pressures represented by the proximal and distal pressure signals. The controller may be configured to detect a pressure drop characteristic responsive to a difference in pressures represented by the proximal and distal pressure signals and responsive to the flow rate of fluid in the peritoneal fill line and generate a second output responsively to the pressure drop characteristic. The second output may include a UI output on a user interface indicating a peritoneal fill line error condition. The second output may be generated when fluid is flowing from the proximal end to the distal end of the peritoneal fill line. The second output may include a UI output on a user interface indicating a patient health condition. The second output may be generated when fluid is flowing from the distal end to the proximal end of the peritoneal fill line.
According to embodiments, the disclosed subject matter includes a fluid flow system for peritoneal dialysis with a cycler unit configured with a pump actuator, a controller, and valve actuators. The controller is configured to operate the pump actuator and valve actuators to control flow in first and second disposable circuits. The first disposable fluid circuit includes valve portions configured to engage with the valve actuators, pump portions configured to engage with the pump actuator, and respective connections for water, at least one source of concentrate, one batch container, and a peritoneal fill line. The second disposable fluid circuit includes valve portions configured to engage with the valve actuators, pump portions configured to engage with the pump actuator, and respective connections for at least one source of dialysis fluid and a peritoneal fill line. The controller and cycler are configured to prepare a batch of peritoneal dialysis fluid using the first disposable fluid circuit and perform an automatic therapeutic treatment with the batch. The controller and cycler unit are further configured to use the second disposable fluid circuit to perform an automatic therapeutic treatment with fluid from a source of dialysis fluid. The controller may be configured to operate the pump in a single direction. The controller may be further configured to operate the pump and the control valves to transfer fluid from the dialysis fluid batch container to the peritoneal fill line. The controller may be further configured to operate the pump and the control valves to transfer fluid from the peritoneal fill line to a drain. A fluid property sensor may be provided in the second flow path connecting to the drain, wherein the controller is further configured to operate the pump and the control valves to transfer fluid from the dialysis fluid batch container to the drain and to receive a signal indicating a property of the fluid. The second disposable fluid circuit respective connector(s) for peritoneal dialysis fluid may include inline sterile filters.
While the present invention has been described in conjunction with a number of embodiments, the invention is not to be limited to the description of the embodiments contained herein, but rather is defined by the claims appended hereto and their equivalents. It is further evident that many alternatives, modifications, and variations would be or are apparent to those of ordinary skill in the applicable arts. Accordingly, Applicant intends to embrace all such alternatives, modifications, equivalents, and variations that are within the spirit and scope of this invention.
In any of the foregoing embodiments, methods and systems and devices may be implemented using well-known digital systems. It will be appreciated that the modules, processes, systems, and sections described and/or suggested herein can be implemented in hardware, hardware programmed by software, software instruction stored on a non-transitory computer readable medium or a combination of the above. For example, a method for controlling the disclosed systems can be implemented, for example, using a processor configured to execute a sequence of programmed instructions stored on a non-transitory computer readable medium. For example, the processor can include, but not be limited to, a personal computer or workstation or other such computing system that includes a processor, microprocessor, microcontroller device, or is comprised of control logic including integrated circuits such as, for example, an Application Specific Integrated Circuit (ASIC). The instructions can be compiled from source code instructions provided in accordance with a programming language such as Java, C++, C#.net or the like. The instructions can also comprise code and data objects provided in accordance with, for example, the Visual Basic™ language, LabVIEW, or another structured or object-oriented programming language. The sequence of programmed instructions and data associated therewith can be stored in a non-transitory computer-readable medium such as a computer memory or storage device which may be any suitable memory apparatus, such as, but not limited to read-only memory (ROM), programmable read-only memory (PROM), electrically erasable programmable read-only memory (EEPROM), random-access memory (RAM), flash memory, disk drive and the like.
Furthermore, the modules, processes, systems, and sections can be implemented as a single processor or as a distributed processor. Further, it should be appreciated that the steps mentioned above may be performed on a single or distributed processor (single and/or multi-core). Also, the processes, modules, and sub-modules described in the various figures of and for embodiments above may be distributed across multiple computers or systems or may be co-located in a single processor or system. Exemplary structural embodiment alternatives suitable for implementing the modules, sections, systems, means, or processes described herein are provided below.
The modules, processors or systems described above can be implemented as a programmed general purpose computer, an electronic device programmed with microcode, a hard-wired analog logic circuit, software stored on a computer-readable medium or signal, an optical computing device, a networked system of electronic and/or optical devices, a special purpose computing device, an integrated circuit device, a semiconductor chip, and a software module or object stored on a computer-readable medium or signal, for example.
Embodiments of the method and system (or their sub-components or modules), may be implemented on a general-purpose computer, a special-purpose computer, a programmed microprocessor or microcontroller and peripheral integrated circuit element, an ASIC or other integrated circuit, a digital signal processor, a hardwired electronic or logic circuit such as a discrete element circuit, a programmed logic circuit such as a programmable logic device (PLD), programmable logic array (PLA), field-programmable gate array (FPGA), programmable array logic (PAL) device, or the like. In general, any process capable of implementing the functions or steps described herein can be used to implement embodiments of the method, system, or a computer program product (software program stored on a non-transitory computer readable medium).
Furthermore, embodiments of the disclosed method, system, and computer program product may be readily implemented, fully or partially, in software using, for example, object or object-oriented software development environments that provide portable source code that can be used on a variety of computer platforms. Alternatively, embodiments of the disclosed method, system, and computer program product can be implemented partially or fully in hardware using, for example, standard logic circuits or a very-large-scale integration (VLSI) design. Other hardware or software can be used to implement embodiments depending on the speed and/or efficiency requirements of the systems, the particular function, and/or particular software or hardware system, microprocessor, or microcomputer being utilized. Embodiments of the method, system, and computer program product can be implemented in hardware and/or software using any known or later developed systems or structures, devices and/or software by those of ordinary skill in the applicable art from the function description provided herein and with a general basic knowledge of control systems and/or computer programming arts.
Moreover, embodiments of the disclosed method, system, and computer program product can be implemented in software executed on a programmed general purpose computer, a special purpose computer, a microprocessor, or the like.
It is, thus, apparent that there is provided, in accordance with the present disclosure, peritoneal dialysis devices, methods and systems. Many alternatives, modifications, and variations are enabled by the present disclosure. Features of the disclosed embodiments can be combined, rearranged, omitted, etc., within the scope of the invention to produce additional embodiments. Furthermore, certain features may sometimes be used to advantage without a corresponding use of other features. Accordingly, Applicants intend to embrace all such alternatives, modifications, equivalents, and variations that are within the spirit and scope of the present invention.
The present application is a continuation of U.S. patent application Ser. No. 15/400,978 filed Jan. 7, 2017 (issued as U.S. Pat. No. 10,046,100 on Aug. 14, 2018), which is a continuation of U.S. patent application Ser. No. 14/006,763 filed Oct. 2, 2013 (issued as U.S. Pat. No. 9,907,897 on Mar. 6, 2018), which is a national stage entry of International Application No. PCT/US2012/030350 filed Mar. 23, 2012, which claims the benefit of U.S. Provisional Application Nos. 61/466,921 filed on Mar. 23, 2011; 61/490,183 filed May 26, 2011; and 61/509,240 filed on Jul. 19, 2011. All of the above applications are hereby incorporated by reference in their entireties.
| Number | Name | Date | Kind |
|---|---|---|---|
| 2369070 | Nielsen | Feb 1945 | A |
| 2575447 | Gossick | Nov 1951 | A |
| 2874351 | John | Feb 1959 | A |
| 3490591 | Jones et al. | Jan 1970 | A |
| 3526834 | Brown | Sep 1970 | A |
| 3786810 | Pannier et al. | Jan 1974 | A |
| 3847809 | Kopf | Nov 1974 | A |
| 4138639 | Hutchins | Feb 1979 | A |
| 4161264 | Malmgren et al. | Jul 1979 | A |
| 4209391 | Lipps et al. | Jun 1980 | A |
| 4338190 | Kraus et al. | Jul 1982 | A |
| 4396382 | Goldhaber | Aug 1983 | A |
| 4412834 | Kulin | Nov 1983 | A |
| 4420752 | Davis et al. | Dec 1983 | A |
| 4432759 | Gross et al. | Feb 1984 | A |
| 4432765 | Oscarsson | Feb 1984 | A |
| 4435171 | Goldberg et al. | Mar 1984 | A |
| 4439179 | Lueders et al. | Mar 1984 | A |
| 4439188 | Dennehey et al. | Mar 1984 | A |
| 4440207 | Genatempo et al. | Apr 1984 | A |
| 4447230 | Gula et al. | May 1984 | A |
| 4479760 | Bilstad et al. | Oct 1984 | A |
| 4489535 | Veltman | Dec 1984 | A |
| 4526572 | Donnan et al. | Jul 1985 | A |
| 4553552 | Vaidespino et al. | Nov 1985 | A |
| 4605895 | Park | Aug 1986 | A |
| 4617115 | Vantard | Oct 1986 | A |
| 4618343 | Polaschegg | Oct 1986 | A |
| 4636204 | Christopherson et al. | Jan 1987 | A |
| 4655742 | Vantard | Apr 1987 | A |
| 4657529 | Prince et al. | Apr 1987 | A |
| 4663006 | Yao et al. | May 1987 | A |
| 4670007 | Wheeldon et al. | Jun 1987 | A |
| 4747822 | Peabody | May 1988 | A |
| 4747950 | Guinn | May 1988 | A |
| 4797191 | Metzner et al. | Jan 1989 | A |
| 4823833 | Hogan et al. | Apr 1989 | A |
| 4825168 | Ogawa et al. | Apr 1989 | A |
| 4846950 | Yao et al. | Jul 1989 | A |
| 4857199 | Cortial | Aug 1989 | A |
| 4876515 | Ball | Oct 1989 | A |
| 4954782 | Ball | Sep 1990 | A |
| 4997570 | Polaschegg | Mar 1991 | A |
| 5004535 | Bosko et al. | Apr 1991 | A |
| 5062774 | Kramer et al. | Nov 1991 | A |
| 5087245 | Doan | Feb 1992 | A |
| 5141493 | Jacobsen et al. | Aug 1992 | A |
| 5225783 | Suzuki et al. | Jul 1993 | A |
| 5326476 | Grogan et al. | Jul 1994 | A |
| 5336173 | Folden | Aug 1994 | A |
| 5344392 | Senninger et al. | Sep 1994 | A |
| 5346472 | Keshaviah et al. | Sep 1994 | A |
| 5442969 | Troutner et al. | Aug 1995 | A |
| 5485083 | Pulice | Jan 1996 | A |
| 5486286 | Peterson et al. | Jan 1996 | A |
| 5522998 | Polaschegg | Jun 1996 | A |
| 5567320 | Goux et al. | Oct 1996 | A |
| 5570026 | Buffaloe, IV et al. | Oct 1996 | A |
| 5628908 | Kamen et al. | May 1997 | A |
| 5631552 | Ogawa et al. | May 1997 | A |
| 5650071 | Brugger et al. | Jul 1997 | A |
| 5674390 | Matthews et al. | Oct 1997 | A |
| 5725773 | Polaschegg | Mar 1998 | A |
| 5800363 | Chandler et al. | Sep 1998 | A |
| 5836933 | Buttitta et al. | Nov 1998 | A |
| 5865764 | Moorhead | Feb 1999 | A |
| 5895578 | Simard et al. | Apr 1999 | A |
| 5900136 | Gotsu et al. | May 1999 | A |
| 5925011 | Faict et al. | Jul 1999 | A |
| 5938634 | Packard | Aug 1999 | A |
| 6036680 | Horne et al. | Mar 2000 | A |
| 6129699 | Haight et al. | Oct 2000 | A |
| 6136201 | Shah et al. | Oct 2000 | A |
| 6139754 | Hartranft et al. | Oct 2000 | A |
| 6156797 | Kubo et al. | Dec 2000 | A |
| 6168578 | Diamond | Jan 2001 | B1 |
| 6196991 | Keilman | Mar 2001 | B1 |
| 6228047 | Dadson | May 2001 | B1 |
| 6241943 | Wieslander et al. | Jun 2001 | B1 |
| 6270673 | Belt et al. | Aug 2001 | B1 |
| 6280634 | Shah et al. | Aug 2001 | B1 |
| 6327895 | Jeppsson et al. | Dec 2001 | B1 |
| 6391404 | Rosenbaum et al. | May 2002 | B1 |
| 6423029 | Elsberry | Jul 2002 | B1 |
| 6460592 | Sano et al. | Oct 2002 | B1 |
| 6463979 | Sano et al. | Oct 2002 | B1 |
| 6471855 | Odak et al. | Oct 2002 | B1 |
| 6488647 | Miura et al. | Dec 2002 | B1 |
| 6489785 | McAllister | Dec 2002 | B2 |
| 6491658 | Miura et al. | Dec 2002 | B1 |
| 6492336 | Mahiout | Dec 2002 | B1 |
| 6503062 | Gray et al. | Jan 2003 | B1 |
| 6537976 | Gupta | Mar 2003 | B1 |
| 6585682 | Haraldsson et al. | Jul 2003 | B1 |
| 6591126 | Roeper et al. | Jul 2003 | B2 |
| 6595948 | Suzuki et al. | Jul 2003 | B2 |
| 6605214 | Taylor | Aug 2003 | B1 |
| 6610206 | Callan et al. | Aug 2003 | B1 |
| 6645191 | Knerr et al. | Nov 2003 | B1 |
| 6648906 | Lasheras et al. | Nov 2003 | B2 |
| 6666842 | Sakai | Dec 2003 | B1 |
| 6689275 | Gupta | Feb 2004 | B1 |
| 6705372 | Sano et al. | Mar 2004 | B2 |
| 6738052 | Manke et al. | May 2004 | B1 |
| 6749580 | Work et al. | Jun 2004 | B2 |
| 6758975 | Peabody et al. | Jul 2004 | B2 |
| 6769231 | Danby | Aug 2004 | B2 |
| 6803363 | Polaschegg | Oct 2004 | B2 |
| 6808369 | Gray et al. | Oct 2004 | B2 |
| 6814869 | Brandl et al. | Nov 2004 | B2 |
| 6861033 | Mullins et al. | Mar 2005 | B2 |
| 6877713 | Gray et al. | Apr 2005 | B1 |
| 6887214 | Levin | May 2005 | B1 |
| 6889713 | Navis | May 2005 | B2 |
| 6911014 | Wentling et al. | Jun 2005 | B2 |
| 6912917 | Brugger et al. | Jul 2005 | B2 |
| 6929751 | Bowman et al. | Aug 2005 | B2 |
| 6981977 | Herweck et al. | Jan 2006 | B2 |
| 6986752 | McGuckin et al. | Jan 2006 | B2 |
| 6995563 | Talutis | Feb 2006 | B2 |
| 7013928 | Navis | Mar 2006 | B2 |
| 7033539 | Krensky et al. | Apr 2006 | B2 |
| 7053059 | Zieske et al. | May 2006 | B2 |
| 7057400 | Gaignet | Jun 2006 | B2 |
| 7067061 | Bosetto et al. | Jun 2006 | B2 |
| 7083719 | Bowman et al. | Aug 2006 | B2 |
| 7119305 | Sano et al. | Oct 2006 | B2 |
| 7138088 | Wariar et al. | Nov 2006 | B2 |
| 7175606 | Bowman, Jr. et al. | Feb 2007 | B2 |
| 7214228 | Crabtree | May 2007 | B2 |
| 7235569 | Hausheer | Jun 2007 | B2 |
| 7243893 | Sobue et al. | Jul 2007 | B2 |
| 7250619 | Taylor et al. | Jul 2007 | B2 |
| 7320676 | Miesel | Jan 2008 | B2 |
| 7354190 | Demers et al. | Apr 2008 | B2 |
| 7410475 | Krensky et al. | Aug 2008 | B2 |
| 7421316 | Gray et al. | Sep 2008 | B2 |
| 7441108 | Fisher et al. | Oct 2008 | B2 |
| 7459054 | Landherr et al. | Dec 2008 | B2 |
| 7544301 | Shah et al. | Jun 2009 | B2 |
| 7559483 | Hickle et al. | Jul 2009 | B2 |
| 7559524 | Gray et al. | Jul 2009 | B2 |
| 7559913 | Jeppsson et al. | Jul 2009 | B1 |
| 7641753 | Gao et al. | Jan 2010 | B2 |
| 7670491 | Callan et al. | Mar 2010 | B2 |
| 7686279 | Nerbonne et al. | Mar 2010 | B2 |
| 7758552 | Zoltan et al. | Jul 2010 | B2 |
| 7763013 | Baldwin et al. | Jul 2010 | B2 |
| 7803628 | Glocker | Sep 2010 | B2 |
| 7837666 | Jensen et al. | Nov 2010 | B2 |
| 7842002 | Mantle | Nov 2010 | B2 |
| 7847564 | Rossi | Dec 2010 | B2 |
| 7857805 | Raines | Dec 2010 | B2 |
| 7862530 | Callan et al. | Jan 2011 | B2 |
| 7867214 | Childers et al. | Jan 2011 | B2 |
| 7883725 | Shah et al. | Feb 2011 | B2 |
| 7892423 | Rohde et al. | Feb 2011 | B2 |
| 7901376 | Steck et al. | Mar 2011 | B2 |
| 7905853 | Chapman et al. | Mar 2011 | B2 |
| 7905855 | Childers | Mar 2011 | B2 |
| 7935074 | Plahey et al. | May 2011 | B2 |
| 7955295 | Lee et al. | Jun 2011 | B2 |
| 7988849 | Biewer et al. | Aug 2011 | B2 |
| 7993050 | Demers et al. | Aug 2011 | B2 |
| 8034017 | Petersen | Oct 2011 | B2 |
| 8083709 | Childers et al. | Dec 2011 | B2 |
| 8088094 | Hamada et al. | Jan 2012 | B2 |
| 8096969 | Roberts et al. | Jan 2012 | B2 |
| 8105487 | Fulkerson et al. | Jan 2012 | B2 |
| 8147696 | Pandya | Apr 2012 | B1 |
| 8178040 | Brauer | May 2012 | B2 |
| 8202547 | Shah et al. | Jun 2012 | B2 |
| 8222229 | Kiribayashi et al. | Jul 2012 | B2 |
| 8287724 | Slepicka et al. | Oct 2012 | B2 |
| 8297954 | Moubayed | Oct 2012 | B2 |
| 8298167 | Peters et al. | Oct 2012 | B2 |
| 8298170 | Lundtveit et al. | Oct 2012 | B2 |
| 8308128 | Mackal | Nov 2012 | B2 |
| 8348904 | Petersen | Jan 2013 | B2 |
| 8361009 | Lee et al. | Jan 2013 | B2 |
| 8367731 | Wieslander et al. | Feb 2013 | B2 |
| 8375797 | Beden et al. | Feb 2013 | B2 |
| 8382447 | Wang et al. | Feb 2013 | B2 |
| 8398590 | Sternberg et al. | Mar 2013 | B2 |
| 8414686 | Gura et al. | Apr 2013 | B2 |
| 8414768 | Shah et al. | Apr 2013 | B2 |
| 8431086 | Lurvey et al. | Apr 2013 | B2 |
| 8444593 | Hamada et al. | May 2013 | B2 |
| 8449496 | Hamada et al. | May 2013 | B2 |
| 8460544 | Völker | Jun 2013 | B2 |
| 8474784 | Kashmirian et al. | Jul 2013 | B2 |
| 8491184 | Kamen et al. | Jul 2013 | B2 |
| 8500676 | Jansson et al. | Aug 2013 | B2 |
| 8501009 | Peterson et al. | Aug 2013 | B2 |
| 8516902 | Beavis et al. | Aug 2013 | B2 |
| 8529496 | Britton et al. | Sep 2013 | B2 |
| 8540886 | Hedmann et al. | Sep 2013 | B2 |
| 8556225 | Gray | Oct 2013 | B2 |
| 8560510 | Brueggerhoff et al. | Oct 2013 | B2 |
| 8587516 | Kopychev et al. | Nov 2013 | B2 |
| 8597229 | Pan | Dec 2013 | B2 |
| 8600772 | Bacon | Dec 2013 | B2 |
| 8613739 | Sobue | Dec 2013 | B2 |
| 8641685 | Mansour et al. | Feb 2014 | B2 |
| 8671996 | Weilhoefer et al. | Mar 2014 | B2 |
| 8678224 | Ayot et al. | Mar 2014 | B2 |
| 8685251 | Smejtek et al. | Apr 2014 | B2 |
| 8698741 | Wang et al. | Apr 2014 | B1 |
| 8708992 | Kobayashi et al. | Apr 2014 | B2 |
| 8728056 | Colantonio et al. | May 2014 | B2 |
| 8731726 | Gray et al. | May 2014 | B2 |
| 8740864 | Hoang et al. | Jun 2014 | B2 |
| 8741131 | Bedingfield et al. | Jun 2014 | B2 |
| 8747370 | Feith et al. | Jun 2014 | B2 |
| 8758626 | Wong | Jun 2014 | B2 |
| 8764702 | Childers et al. | Jul 2014 | B2 |
| 8774885 | Abreu | Jul 2014 | B2 |
| 8777892 | Sandford et al. | Jul 2014 | B2 |
| 8789558 | Volker | Jul 2014 | B2 |
| 8801652 | Landherr et al. | Aug 2014 | B2 |
| 8801677 | Wallin | Aug 2014 | B2 |
| 8808595 | Babrowicz et al. | Aug 2014 | B2 |
| 8813769 | Gastauer et al. | Aug 2014 | B2 |
| 8815095 | Micheli | Aug 2014 | B2 |
| 8828232 | Shah et al. | Sep 2014 | B2 |
| 8834718 | Randall et al. | Sep 2014 | B2 |
| 8834719 | Childers et al. | Sep 2014 | B2 |
| 8838395 | Matsiev et al. | Sep 2014 | B2 |
| 8840581 | McGill et al. | Sep 2014 | B2 |
| 8858792 | Ding et al. | Oct 2014 | B2 |
| 8869612 | Chen et al. | Oct 2014 | B2 |
| 8870812 | Alberti et al. | Oct 2014 | B2 |
| 8682700 | Chapman et al. | Nov 2014 | B2 |
| 8875748 | Beden et al. | Nov 2014 | B2 |
| 8876753 | Roberts et al. | Nov 2014 | B2 |
| 8924458 | Levin et al. | Dec 2014 | B2 |
| 8926550 | Plahey et al. | Jan 2015 | B2 |
| 8926551 | Lo et al. | Jan 2015 | B2 |
| 8930213 | Gotlib et al. | Jan 2015 | B2 |
| 8945042 | Lee et al. | Feb 2015 | B2 |
| 8961444 | Chapman et al. | Feb 2015 | B2 |
| 8961466 | Steinbach | Feb 2015 | B2 |
| 8980070 | Nishio et al. | Mar 2015 | B2 |
| 8989906 | Gray et al. | Mar 2015 | B2 |
| 8992454 | Anand | Mar 2015 | B2 |
| 8992777 | Doyle | Mar 2015 | B2 |
| 9004886 | Beck et al. | Apr 2015 | B2 |
| 9014775 | Bennett et al. | Apr 2015 | B2 |
| 9022969 | Helmore et al. | May 2015 | B2 |
| 9044544 | Lo et al. | Jun 2015 | B2 |
| 9060727 | Saikley et al. | Jun 2015 | B2 |
| 9066968 | Ohta et al. | Jun 2015 | B2 |
| 9067017 | Tan et al. | Jun 2015 | B2 |
| 9069886 | Shimizu et al. | Jun 2015 | B2 |
| 9108031 | Brandenburger et al. | Aug 2015 | B2 |
| 9112245 | Yen | Aug 2015 | B2 |
| 9132220 | Kugelmann et al. | Sep 2015 | B2 |
| 9138523 | Burnett et al. | Sep 2015 | B2 |
| 9152918 | McNair | Oct 2015 | B1 |
| 9153002 | Jones et al. | Oct 2015 | B2 |
| 9162044 | Traversaz | Oct 2015 | B2 |
| 9165112 | Doyle et al. | Oct 2015 | B2 |
| 9180238 | Bedingfield et al. | Nov 2015 | B2 |
| 9198830 | Kugelmann et al. | Dec 2015 | B2 |
| 9199070 | Wegener et al. | Dec 2015 | B2 |
| 9216247 | Callan et al. | Dec 2015 | B2 |
| 9217702 | Sullivan | Dec 2015 | B2 |
| 9242035 | Karoor | Jan 2016 | B2 |
| 9254356 | Shah et al. | Feb 2016 | B2 |
| 9254358 | Volker | Feb 2016 | B2 |
| 9274073 | Nier et al. | Mar 2016 | B2 |
| 9284960 | Chappel et al. | Mar 2016 | B2 |
| 9308309 | Hedmann et al. | Apr 2016 | B2 |
| 9310232 | Heide et al. | Apr 2016 | B2 |
| 9319110 | Kopychev et al. | Apr 2016 | B2 |
| 9320680 | Schröder | Apr 2016 | B2 |
| 9345871 | Guala | May 2016 | B2 |
| 9358332 | McGill et al. | Jun 2016 | B2 |
| 9381290 | Yu et al. | Jul 2016 | B2 |
| 9393356 | Karoor et al. | Jul 2016 | B2 |
| 9408958 | Wang et al. | Aug 2016 | B2 |
| 9427518 | Brueckner | Aug 2016 | B2 |
| 9433768 | Tekeste et al. | Sep 2016 | B2 |
| 9440016 | Lin et al. | Sep 2016 | B2 |
| 9440019 | Falkenhagen et al. | Sep 2016 | B2 |
| 9470220 | Becker | Oct 2016 | B2 |
| 9471754 | Mastalli et al. | Oct 2016 | B2 |
| 9474841 | Volker | Oct 2016 | B2 |
| 9495511 | Harrington et al. | Nov 2016 | B2 |
| 9500188 | Ly et al. | Nov 2016 | B2 |
| 9514131 | Bochenko et al. | Dec 2016 | B1 |
| 9519969 | Kusens | Dec 2016 | B1 |
| 9539387 | Fini et al. | Jan 2017 | B2 |
| 9555232 | Davis et al. | Jan 2017 | B2 |
| 9593679 | Gray et al. | Mar 2017 | B2 |
| 9610518 | Kamen et al. | Apr 2017 | B2 |
| 9616163 | Wong et al. | Apr 2017 | B2 |
| 9629993 | Klewinghaus | Apr 2017 | B2 |
| 9651511 | Howell et al. | May 2017 | B2 |
| 9669145 | Günther et al. | Jun 2017 | B2 |
| 9677555 | Kamen et al. | Jun 2017 | B2 |
| 9687646 | Sobue et al. | Jun 2017 | B2 |
| 9694125 | Piahey et al. | Jul 2017 | B2 |
| 9694126 | Hedmann et al. | Jul 2017 | B2 |
| 9700711 | Grant et al. | Jul 2017 | B2 |
| 9724270 | Bonnal et al. | Aug 2017 | B2 |
| 9724298 | Nilsson et al. | Aug 2017 | B2 |
| 9724505 | Williams et al. | Aug 2017 | B2 |
| 20010005487 | Kamibayashi et al. | Jun 2001 | A1 |
| 20020045851 | Suzuki et al. | Apr 2002 | A1 |
| 20020072718 | Brugger | Jun 2002 | A1 |
| 20020087126 | Quah | Jul 2002 | A1 |
| 20020120227 | Childers et al. | Aug 2002 | A1 |
| 20020123715 | Sorenson et al. | Sep 2002 | A1 |
| 20020162778 | Peabody et al. | Nov 2002 | A1 |
| 20030065284 | Briggs | Apr 2003 | A1 |
| 20030086794 | Gray et al. | May 2003 | A1 |
| 20030143352 | Yang et al. | Jul 2003 | A1 |
| 20030153865 | Connell et al. | Aug 2003 | A1 |
| 20030217976 | Bowman et al. | Nov 2003 | A1 |
| 20030218623 | Krensky et al. | Nov 2003 | A1 |
| 20040019312 | Childers et al. | Jan 2004 | A1 |
| 20040031756 | Suzuki et al. | Feb 2004 | A1 |
| 20040040620 | Brauer et al. | Mar 2004 | A1 |
| 20040078024 | Peluso et al. | Apr 2004 | A1 |
| 20040087890 | Sakai | May 2004 | A1 |
| 20040099521 | Demers et al. | May 2004 | A1 |
| 20040108223 | Jansson | Jun 2004 | A1 |
| 20040111294 | McNally et al. | Jun 2004 | A1 |
| 20040215129 | Edgson et al. | Oct 2004 | A1 |
| 20040215336 | Udipi et al. | Oct 2004 | A1 |
| 20040221643 | Ehwald et al. | Nov 2004 | A1 |
| 20040254513 | Shang et al. | Dec 2004 | A1 |
| 20050006296 | Sullivan et al. | Jan 2005 | A1 |
| 20050020507 | Zieske et al. | Jan 2005 | A1 |
| 20050082226 | Bene et al. | Apr 2005 | A1 |
| 20050089994 | Neftel | Apr 2005 | A1 |
| 20050094483 | Demers et al. | May 2005 | A1 |
| 20050094485 | Demers et al. | May 2005 | A1 |
| 20050095154 | Tracey et al. | May 2005 | A1 |
| 20050126998 | Childers | Jun 2005 | A1 |
| 20050131141 | Poss et al. | Jun 2005 | A1 |
| 20050167363 | Taylor | Aug 2005 | A1 |
| 20050173344 | Bowman et al. | Aug 2005 | A1 |
| 20050202395 | Edrich et al. | Sep 2005 | A1 |
| 20050209563 | Hopping et al. | Sep 2005 | A1 |
| 20050211373 | Tomasetti et al. | Sep 2005 | A1 |
| 20050224372 | Sasso et al. | Oct 2005 | A1 |
| 20050244909 | Hamada et al. | Nov 2005 | A1 |
| 20050283132 | Stanus et al. | Dec 2005 | A1 |
| 20060005886 | Parrino et al. | Jan 2006 | A1 |
| 20060015015 | Kawamoto et al. | Jan 2006 | A1 |
| 20060161107 | Mantle | Jul 2006 | A1 |
| 20060172954 | Jensen et al. | Aug 2006 | A1 |
| 20060189923 | Neftel et al. | Aug 2006 | A1 |
| 20060195064 | Plahey et al. | Aug 2006 | A1 |
| 20070007208 | Brugger et al. | Jan 2007 | A1 |
| 20070043317 | Sugawara | Feb 2007 | A1 |
| 20070048161 | Moubayed | Mar 2007 | A1 |
| 20070088314 | Gollier et al. | Apr 2007 | A1 |
| 20070106197 | Lauman et al. | May 2007 | A1 |
| 20070106247 | Burnett et al. | May 2007 | A1 |
| 20070112297 | Plahey et al. | May 2007 | A1 |
| 20070149913 | Busby et al. | Jun 2007 | A1 |
| 20070179422 | Schnell et al. | Aug 2007 | A1 |
| 20070194792 | Quackenbush et al. | Aug 2007 | A1 |
| 20070213651 | Busby et al. | Sep 2007 | A1 |
| 20070213654 | Lundtveit et al. | Sep 2007 | A1 |
| 20070213665 | Curtin et al. | Sep 2007 | A1 |
| 20070253463 | Perry et al. | Nov 2007 | A1 |
| 20070276328 | Childers et al. | Nov 2007 | A1 |
| 20070287966 | Keeley | Dec 2007 | A1 |
| 20080015492 | Biesel | Jan 2008 | A1 |
| 20080023135 | Ivansons et al. | Jan 2008 | A1 |
| 20080027374 | Jensen et al. | Jan 2008 | A1 |
| 20080031746 | Gray et al. | Feb 2008 | A9 |
| 20080058712 | Plahey | Mar 2008 | A1 |
| 20080065006 | Roger et al. | Mar 2008 | A1 |
| 20080097283 | Plahey | Apr 2008 | A1 |
| 20080101969 | Moubayed | May 2008 | A1 |
| 20080112258 | Demers et al. | May 2008 | A1 |
| 20080125693 | Gavin et al. | May 2008 | A1 |
| 20080138223 | Lanigan et al. | Jun 2008 | A1 |
| 20080161751 | Plahey et al. | Jul 2008 | A1 |
| 20080183126 | Landherr et al. | Jul 2008 | A1 |
| 20080183127 | Landherr et al. | Jul 2008 | A1 |
| 20080200865 | Bedingfield | Aug 2008 | A1 |
| 20080200866 | Prisco et al. | Aug 2008 | A1 |
| 20080200867 | Bedingfield | Aug 2008 | A1 |
| 20080200868 | Alberti et al. | Aug 2008 | A1 |
| 20080200869 | Bedingfield | Aug 2008 | A1 |
| 20080208195 | Shores et al. | Aug 2008 | A1 |
| 20080216898 | Grant et al. | Sep 2008 | A1 |
| 20080240929 | Kamen et al. | Oct 2008 | A1 |
| 20080243211 | Cartwright et al. | Oct 2008 | A1 |
| 20080253427 | Kamen et al. | Oct 2008 | A1 |
| 20080253911 | Demers et al. | Oct 2008 | A1 |
| 20080273996 | Gray et al. | Nov 2008 | A1 |
| 20080275382 | Biesel et al. | Nov 2008 | A1 |
| 20090007642 | Busby et al. | Jan 2009 | A1 |
| 20090008306 | Cicchello et al. | Jan 2009 | A1 |
| 20090009290 | Kneip et al. | Jan 2009 | A1 |
| 20090012447 | Huitt et al. | Jan 2009 | A1 |
| 20090012451 | Sobue et al. | Jan 2009 | A1 |
| 20090012452 | Slepicka et al. | Jan 2009 | A1 |
| 20090012453 | Childers et al. | Jan 2009 | A1 |
| 20090012455 | Childers et al. | Jan 2009 | A1 |
| 20090012458 | Childers et al. | Jan 2009 | A1 |
| 20090012460 | Steck et al. | Jan 2009 | A1 |
| 20090012464 | Martin et al. | Jan 2009 | A1 |
| 20090024096 | Hai et al. | Jan 2009 | A1 |
| 20090054873 | Landherr et al. | Feb 2009 | A1 |
| 20090078592 | Jensen et al. | Mar 2009 | A1 |
| 20090082758 | Gill et al. | Mar 2009 | A1 |
| 20090095679 | Demers et al. | Apr 2009 | A1 |
| 20090098215 | Riser et al. | Apr 2009 | A1 |
| 20090101549 | Kamen et al. | Apr 2009 | A1 |
| 20090112151 | Chapman et al. | Apr 2009 | A1 |
| 20090143723 | Szpara et al. | Jun 2009 | A1 |
| 20090149810 | Ring et al. | Jun 2009 | A1 |
| 20090169872 | Krongauz et al. | Jul 2009 | A1 |
| 20090177149 | Childers et al. | Jul 2009 | A1 |
| 20090182263 | Burbank et al. | Jul 2009 | A1 |
| 20090185920 | Lanigan et al. | Jul 2009 | A1 |
| 20090196776 | Moubayed | Aug 2009 | A1 |
| 20090198170 | Childers et al. | Aug 2009 | A1 |
| 20090206023 | Rohde et al. | Aug 2009 | A1 |
| 20090212178 | Westberg | Aug 2009 | A1 |
| 20090213521 | Bedingfield | Aug 2009 | A1 |
| 20090218290 | Poss et al. | Sep 2009 | A1 |
| 20090222119 | Plahey et al. | Sep 2009 | A1 |
| 20090223899 | Poss et al. | Sep 2009 | A1 |
| 20090232908 | Zhou | Sep 2009 | A1 |
| 20090264854 | Jensen et al. | Oct 2009 | A1 |
| 20090275881 | Lo et al. | Nov 2009 | A1 |
| 20090277276 | Evering et al. | Nov 2009 | A1 |
| 20090294339 | Biewer et al. | Dec 2009 | A1 |
| 20090295591 | Bedingfield | Dec 2009 | A1 |
| 20090299272 | Hopping et al. | Dec 2009 | A1 |
| 20090299273 | Lee et al. | Dec 2009 | A1 |
| 20100004588 | Yeh et al. | Jan 2010 | A1 |
| 20100004589 | Hedmann et al. | Jan 2010 | A1 |
| 20100004590 | Hedmann et al. | Jan 2010 | A1 |
| 20100005416 | Hedmann et al. | Jan 2010 | A1 |
| 20100010423 | Yu et al. | Jan 2010 | A1 |
| 20100010424 | Yu et al. | Jan 2010 | A1 |
| 20100010425 | Yu et al. | Jan 2010 | A1 |
| 20100010426 | Childers et al. | Jan 2010 | A1 |
| 20100010427 | Yu et al. | Jan 2010 | A1 |
| 20100010428 | Yu et al. | Jan 2010 | A1 |
| 20100016802 | Tarribourgi et al. | Jan 2010 | A1 |
| 20100028170 | Schneeberger et al. | Feb 2010 | A1 |
| 20100028208 | Shekalim et al. | Feb 2010 | A1 |
| 20100038322 | Hedmann et al. | Feb 2010 | A1 |
| 20100049158 | Roger | Feb 2010 | A1 |
| 20100051552 | Rohde et al. | Mar 2010 | A1 |
| 20100063445 | Sternberg et al. | Mar 2010 | A1 |
| 20100078387 | Wong | Apr 2010 | A1 |
| 20100084326 | Takesawa | Apr 2010 | A1 |
| 20100087777 | Hopping et al. | Apr 2010 | A1 |
| 20100096329 | Kotanko et al. | Apr 2010 | A1 |
| 20100100027 | Schilthuizen et al. | Apr 2010 | A1 |
| 20100100034 | Wich-Heiter | Apr 2010 | A1 |
| 20100114012 | Sandford et al. | May 2010 | A1 |
| 20100129247 | Lauer | May 2010 | A1 |
| 20100130918 | Elahi | May 2010 | A1 |
| 20100130919 | Elahi | May 2010 | A1 |
| 20100133153 | Beden et al. | Jun 2010 | A1 |
| 20100137782 | Jansson et al. | Jun 2010 | A1 |
| 20100168652 | Landherr et al. | Jul 2010 | A1 |
| 20100169513 | Levin | Jul 2010 | A1 |
| 20100185132 | Han et al. | Jul 2010 | A1 |
| 20100187476 | Yugari et al. | Jul 2010 | A1 |
| 20100191180 | Childers et al. | Jul 2010 | A1 |
| 20100191181 | Childers et al. | Jul 2010 | A1 |
| 20100197817 | Bui et al. | Aug 2010 | A1 |
| 20100204765 | Hall et al. | Aug 2010 | A1 |
| 20100217178 | Lo et al. | Aug 2010 | A1 |
| 20100217179 | Lo et al. | Aug 2010 | A1 |
| 20100217180 | Akonur et al. | Aug 2010 | A1 |
| 20100222735 | Plahey et al. | Sep 2010 | A1 |
| 20100224492 | Ding et al. | Sep 2010 | A1 |
| 20100229978 | Zhou | Sep 2010 | A1 |
| 20100241062 | Morris et al. | Sep 2010 | A1 |
| 20100252702 | Spang et al. | Oct 2010 | A1 |
| 20100258690 | Kleitsch et al. | Oct 2010 | A1 |
| 20100296953 | Gray | Nov 2010 | A1 |
| 20100308243 | Bedingfield | Dec 2010 | A1 |
| 20100312174 | Hoffman | Dec 2010 | A1 |
| 20100314314 | Ding et al. | Dec 2010 | A1 |
| 20100326916 | Wrazel et al. | Dec 2010 | A1 |
| 20100331768 | Hedmann et al. | Dec 2010 | A1 |
| 20110000902 | Hedrnann et al. | Jan 2011 | A1 |
| 20110004152 | Brady et al. | Jan 2011 | A1 |
| 20110010101 | Lo et al. | Jan 2011 | A1 |
| 20110015610 | Plahey et al. | Jan 2011 | A1 |
| 20110017665 | Updyke et al. | Jan 2011 | A1 |
| 20110034866 | Zhang et al. | Feb 2011 | A1 |
| 20110038755 | Pesci et al. | Feb 2011 | A1 |
| 20110040242 | Fallon et al. | Feb 2011 | A1 |
| 20110040243 | Busby et al. | Feb 2011 | A1 |
| 20110040244 | Busby et al. | Feb 2011 | A1 |
| 20110046533 | Stefani et al. | Feb 2011 | A1 |
| 20110054397 | Schneeberger | Mar 2011 | A1 |
| 20110064608 | Lee et al. | Mar 2011 | A1 |
| 20110085923 | Gray et al. | Apr 2011 | A1 |
| 20110092893 | Demers et al. | Apr 2011 | A1 |
| 20110092895 | Yardimci et al. | Apr 2011 | A1 |
| 20110093294 | Elahi et al. | Apr 2011 | A1 |
| 20110098635 | Helmore et al. | Apr 2011 | A1 |
| 20110105979 | Schlaeper et al. | May 2011 | A1 |
| 20110105981 | Wagner et al. | May 2011 | A1 |
| 20110114559 | Fislage et al. | May 2011 | A1 |
| 20110131058 | McNally et al. | Jun 2011 | A1 |
| 20110132838 | Curtis et al. | Jun 2011 | A1 |
| 20110137236 | Prisco et al. | Jun 2011 | A1 |
| 20110137237 | Prisco et al. | Jun 2011 | A1 |
| 20110138936 | Collins et al. | Jun 2011 | A1 |
| 20110141116 | Dalesch et al. | Jun 2011 | A1 |
| 20110144557 | Childers et al. | Jun 2011 | A1 |
| 20110144569 | Britton et al. | Jun 2011 | A1 |
| 20110158823 | Wang et al. | Jun 2011 | A1 |
| 20110160649 | Pan | Jun 2011 | A1 |
| 20110163033 | Chapman et al. | Jul 2011 | A1 |
| 20110166507 | Childers et al. | Jul 2011 | A1 |
| 20110171713 | Bluchel et al. | Jul 2011 | A1 |
| 20110184339 | Tan | Jul 2011 | A1 |
| 20110184340 | Tan et al. | Jul 2011 | A1 |
| 20110186517 | Hedmann et al. | Aug 2011 | A1 |
| 20110189048 | Curtis et al. | Aug 2011 | A1 |
| 20110190691 | Cazzini | Aug 2011 | A1 |
| 20110192796 | Smejtek et al. | Aug 2011 | A1 |
| 20110196289 | Plahey et al. | Aug 2011 | A1 |
| 20110198350 | Meisberger et al. | Aug 2011 | A1 |
| 20110218486 | Huitt et al. | Sep 2011 | A1 |
| 20110224603 | Richter | Sep 2011 | A1 |
| 20110230822 | Lee et al. | Sep 2011 | A1 |
| 20110249916 | Herrenbauer et al. | Oct 2011 | A1 |
| 20110257124 | Fenn et al. | Oct 2011 | A1 |
| 20110262555 | Riser et al. | Oct 2011 | A1 |
| 20110264042 | Shang et al. | Oct 2011 | A1 |
| 20110266221 | Ware et al. | Nov 2011 | A1 |
| 20110275984 | Biewer et al. | Nov 2011 | A1 |
| 20110284377 | Rohde | Nov 2011 | A1 |
| 20110286167 | Winkler | Nov 2011 | A1 |
| 20110288480 | Bedingfield et al. | Nov 2011 | A1 |
| 20110300231 | Peterson et al. | Dec 2011 | A1 |
| 20110309019 | Ahrens | Dec 2011 | A1 |
| 20120001762 | Turner et al. | Jan 2012 | A1 |
| 20120022440 | Childers et al. | Jan 2012 | A1 |
| 20120029325 | Neftel | Feb 2012 | A1 |
| 20120029937 | Neftel et al. | Feb 2012 | A1 |
| 20120030933 | Lanigan et al. | Feb 2012 | A1 |
| 20120031826 | Childers et al. | Feb 2012 | A1 |
| 20120035533 | Britton et al. | Feb 2012 | A1 |
| 20120058328 | Tourvieille et al. | Mar 2012 | A1 |
| 20120065581 | Childers et al. | Mar 2012 | A1 |
| 20120067805 | Childers et al. | Mar 2012 | A1 |
| 20120071815 | Childers et al. | Mar 2012 | A1 |
| 20120071816 | Busby et al. | Mar 2012 | A1 |
| 20120074060 | Lass | Mar 2012 | A1 |
| 20120078168 | Veneroni et al. | Mar 2012 | A1 |
| 20120082576 | Beck et al. | Apr 2012 | A1 |
| 20120089085 | Childers et al. | Apr 2012 | A1 |
| 20120095392 | Jensen et al. | Apr 2012 | A1 |
| 20120105850 | Slepicka | May 2012 | A1 |
| 20120116294 | Boenig et al. | May 2012 | A1 |
| 20120132574 | Ware et al. | May 2012 | A1 |
| 20120145615 | Rohde et al. | Jun 2012 | A1 |
| 20120150102 | Childers et al. | Jun 2012 | A1 |
| 20120179133 | Bedingfield et al. | Jul 2012 | A1 |
| 20120185267 | Kamen et al. | Jul 2012 | A1 |
| 20120185619 | Levin | Jul 2012 | A1 |
| 20120199205 | Eyrard et al. | Aug 2012 | A1 |
| 20120205306 | Reich et al. | Aug 2012 | A1 |
| 20120209169 | Morris et al. | Aug 2012 | A1 |
| 20120211422 | Thys | Aug 2012 | A1 |
| 20120212434 | Bluemler et al. | Aug 2012 | A1 |
| 20120212455 | Kloeffel | Aug 2012 | A1 |
| 20120215151 | Han et al. | Aug 2012 | A1 |
| 20120215159 | Childers et al. | Aug 2012 | A1 |
| 20120226237 | Russo | Sep 2012 | A1 |
| 20120230844 | Farrell et al. | Sep 2012 | A1 |
| 20120232469 | Medina | Sep 2012 | A1 |
| 20120238525 | Leypoldt et al. | Sep 2012 | A1 |
| 20120241367 | Childers et al. | Sep 2012 | A1 |
| 20120248017 | Beiriger et al. | Oct 2012 | A1 |
| 20120259275 | Jensen et al. | Oct 2012 | A1 |
| 20120265145 | Mefti et al. | Oct 2012 | A1 |
| 20120271226 | Farrell et al. | Oct 2012 | A1 |
| 20120271273 | Childers et al. | Oct 2012 | A1 |
| 20120273354 | Orhan et al. | Nov 2012 | A1 |
| 20120283629 | Childers et al. | Nov 2012 | A1 |
| 20120310150 | Brandl et al. | Dec 2012 | A1 |
| 20120318740 | Ekdahl et al. | Dec 2012 | A1 |
| 20130006171 | Griessmann et al. | Jan 2013 | A1 |
| 20130030356 | Ding et al. | Jan 2013 | A1 |
| 20130030404 | Gerlach et al. | Jan 2013 | A1 |
| 20130037142 | Farrell | Feb 2013 | A1 |
| 20130037461 | Biewer et al. | Feb 2013 | A1 |
| 20130037465 | Heyes et al. | Feb 2013 | A1 |
| 20130056419 | Curtis | Mar 2013 | A1 |
| 20130072895 | Kreischer et al. | Mar 2013 | A1 |
| 20130075309 | West et al. | Mar 2013 | A1 |
| 20130079705 | Cazzini | Mar 2013 | A1 |
| 20130079706 | Childers et al. | Mar 2013 | A1 |
| 20130085437 | Deshpande | Apr 2013 | A1 |
| 20130085451 | Sheu | Apr 2013 | A1 |
| 20130106609 | Singh et al. | May 2013 | A1 |
| 20130126430 | Kenley et al. | May 2013 | A1 |
| 20130131581 | Lundtveit et al. | May 2013 | A1 |
| 20130131583 | Chapman et al. | May 2013 | A1 |
| 20130138037 | Lee et al. | May 2013 | A1 |
| 20130150781 | Busby et al. | Jun 2013 | A1 |
| 20130153048 | Schwalm | Jun 2013 | A1 |
| 20130158469 | Hopping et al. | Jun 2013 | A1 |
| 20130165848 | Sebesta et al. | Jun 2013 | A1 |
| 20130167052 | Niesslein et al. | Jun 2013 | A1 |
| 20130172806 | Griessmann et al. | Jul 2013 | A1 |
| 20130177455 | Kamen et al. | Jul 2013 | A1 |
| 20130180905 | Wong | Jul 2013 | A1 |
| 20130186759 | Lin et al. | Jul 2013 | A1 |
| 20130190681 | Jansson et al. | Jul 2013 | A1 |
| 20130193041 | Rohde | Aug 2013 | A1 |
| 20130195792 | Chan et al. | Aug 2013 | A1 |
| 20130204173 | Kelly et al. | Aug 2013 | A1 |
| 20130205873 | Wagner et al. | Aug 2013 | A1 |
| 20130211322 | Degen et al. | Aug 2013 | A1 |
| 20130245530 | Brandl et al. | Sep 2013 | A1 |
| 20130245531 | Brandl et al. | Sep 2013 | A1 |
| 20130248448 | Shah et al. | Sep 2013 | A1 |
| 20130248449 | Kelly et al. | Sep 2013 | A1 |
| 20130263650 | Nier et al. | Oct 2013 | A1 |
| 20130272902 | Chappel | Oct 2013 | A1 |
| 20130277306 | Chapman et al. | Oct 2013 | A1 |
| 20130310726 | Miller et al. | Nov 2013 | A1 |
| 20130310735 | Yu et al. | Nov 2013 | A1 |
| 20130310736 | Hedmann et al. | Nov 2013 | A1 |
| 20130317795 | Akonur et al. | Nov 2013 | A1 |
| 20130324915 | (Krensky) Britton et al. | Dec 2013 | A1 |
| 20130330208 | Ly et al. | Dec 2013 | A1 |
| 20130331774 | Farrell et al. | Dec 2013 | A1 |
| 20130331775 | Britton et al. | Dec 2013 | A1 |
| 20130334138 | Cicchello et al. | Dec 2013 | A1 |
| 20130338102 | Martis et al. | Dec 2013 | A1 |
| 20130345621 | Cicchello et al. | Dec 2013 | A1 |
| 20130346099 | Yu et al. | Dec 2013 | A1 |
| 20130346102 | Yu et al. | Dec 2013 | A1 |
| 20140010691 | Lanigan et al. | Jan 2014 | A1 |
| 20140018272 | Thoea et al. | Jan 2014 | A1 |
| 20140018727 | Burbank et al. | Jan 2014 | A1 |
| 20140021115 | Ellegaard | Jan 2014 | A1 |
| 20140027380 | Childers et al. | Jan 2014 | A1 |
| 20140031631 | Hall et al. | Jan 2014 | A1 |
| 20140046150 | Gagel et al. | Feb 2014 | A1 |
| 20140046248 | Fini et al. | Feb 2014 | A1 |
| 20140052044 | Crnkovich et al. | Feb 2014 | A1 |
| 20140074018 | Childers et al. | Mar 2014 | A1 |
| 20140098359 | Gross et al. | Apr 2014 | A1 |
| 20140129250 | Daniel et al. | May 2014 | A1 |
| 20140148409 | Ohta et al. | May 2014 | A1 |
| 20140188040 | Busby et al. | Jul 2014 | A1 |
| 20140207055 | Junod et al. | Jul 2014 | A1 |
| 20140216994 | Ki | Aug 2014 | A1 |
| 20140217029 | Meyer et al. | Aug 2014 | A1 |
| 20140217030 | Meyer et al. | Aug 2014 | A1 |
| 20140249683 | Gray et al. | Sep 2014 | A1 |
| 20140288947 | Simpson et al. | Sep 2014 | A1 |
| 20140291218 | Bluchel et al. | Oct 2014 | A1 |
| 20140299545 | Wrazel et al. | Oct 2014 | A1 |
| 20140316332 | Lo et al. | Oct 2014 | A1 |
| 20140360594 | Lee et al. | Dec 2014 | A1 |
| 20150005699 | Burbank et al. | Jan 2015 | A1 |
| 20150014249 | Alberti et al. | Jan 2015 | A1 |
| 20150051536 | Mendels et al. | Feb 2015 | A1 |
| 20150088053 | Lundtveit et al. | Mar 2015 | A1 |
| 20150093450 | Riser et al. | Apr 2015 | A1 |
| 20150129055 | Byler | May 2015 | A1 |
| 20150133854 | Zhu et al. | May 2015 | A1 |
| 20150159643 | Koob | Jun 2015 | A1 |
| 20150196698 | Grant et al. | Jul 2015 | A1 |
| 20150197431 | Shiki | Jul 2015 | A1 |
| 20150204807 | Kamen et al. | Jul 2015 | A1 |
| 20150209500 | Lin et al. | Jul 2015 | A1 |
| 20150231571 | Volker | Aug 2015 | A1 |
| 20150233367 | Shimogata et al. | Aug 2015 | A1 |
| 20150276742 | Henrie | Oct 2015 | A1 |
| 20150335808 | White et al. | Nov 2015 | A1 |
| 20150359956 | Gray et al. | Dec 2015 | A1 |
| 20160030654 | Singh et al. | Feb 2016 | A1 |
| 20160051949 | Jansson et al. | Feb 2016 | A1 |
| 20160097382 | Kamen et al. | Apr 2016 | A1 |
| 20160106904 | Cicchello et al. | Apr 2016 | A1 |
| 20160153444 | Chappel et al. | Jun 2016 | A1 |
| 20160193399 | Wallace et al. | Jul 2016 | A1 |
| 20160206804 | Holmer et al. | Jul 2016 | A1 |
| 20160239637 | Miller et al. | Aug 2016 | A1 |
| 20160245277 | Lanigan et al. | Aug 2016 | A1 |
| 20160271312 | Lance et al. | Sep 2016 | A1 |
| 20160310653 | Wang et al. | Oct 2016 | A1 |
| 20160319954 | Smith | Nov 2016 | A1 |
| 20160346451 | Stonger et al. | Dec 2016 | A1 |
| 20160362234 | Peret et al. | Dec 2016 | A1 |
| 20160367794 | Bedingfield | Dec 2016 | A1 |
| 20170043079 | Jensen et al. | Feb 2017 | A1 |
| 20170112992 | Plahey et al. | Apr 2017 | A1 |
| 20170157310 | Scarpaci et al. | Jun 2017 | A1 |
| 20170319769 | Wieslander et al. | Nov 2017 | A1 |
| 20170319770 | Fitzgerald et al. | Nov 2017 | A1 |
| 20170333609 | O'Brien et al. | Nov 2017 | A1 |
| 20180021501 | Gerber et al. | Jan 2018 | A1 |
| 20180043079 | Gerber et al. | Feb 2018 | A1 |
| 20180066648 | Kamen et al. | Mar 2018 | A1 |
| 20180078692 | Cicchello et al. | Mar 2018 | A1 |
| 20180093031 | Crawford et al. | Apr 2018 | A1 |
| 20180106246 | Kamen et al. | Apr 2018 | A1 |
| 20180128259 | Kamen et al. | May 2018 | A1 |
| Number | Date | Country |
|---|---|---|
| 2544144 | Oct 2012 | CA |
| 2791816 | Dec 2013 | CA |
| 2832661 | Aug 2016 | CA |
| 201150709 | Nov 2008 | CN |
| 201710718 | Jan 2011 | CN |
| 201806987 | Apr 2011 | CN |
| 102258942 | Nov 2011 | CN |
| 202116617 | Jan 2012 | CN |
| 102363054 | Feb 2012 | CN |
| 202355628 | Aug 2012 | CN |
| 202379834 | Aug 2012 | CN |
| 202478260 | Oct 2012 | CN |
| 202505852 | Oct 2012 | CN |
| 202542986 | Nov 2012 | CN |
| 102989047 | Mar 2013 | CN |
| 202822485 | Mar 2013 | CN |
| 204723486 | Oct 2015 | CN |
| 105013031 | Nov 2015 | CN |
| 204824277 | Dec 2015 | CN |
| 2838414 | Mar 1980 | DE |
| 4308586 | May 1994 | DE |
| 19546027 | Apr 1997 | DE |
| 29918801 | Mar 2000 | DE |
| 69725104 | Jul 2004 | DE |
| 102007020573 | Nov 2008 | DE |
| 102007053752 | May 2009 | DE |
| 102008045422 | Mar 2010 | DE |
| 102009037917 | Feb 2011 | DE |
| 102010009816 | Sep 2011 | DE |
| 102010033241 | Feb 2012 | DE |
| 102010053903 | Jun 2012 | DE |
| 102011103325 | Dec 2012 | DE |
| 102012004673 | Sep 2013 | DE |
| 102012007412 | Oct 2013 | DE |
| 102013103223 | Oct 2014 | DE |
| 102013013414 | Jan 2015 | DE |
| 102013013415 | Feb 2015 | DE |
| 102013016204 | Apr 2015 | DE |
| 102013018444 | May 2015 | DE |
| 102014201714 | Aug 2015 | DE |
| 102014004476 | Oct 2015 | DE |
| 102014013152 | Mar 2016 | DE |
| 102015010418 | Feb 2017 | DE |
| 100682 | Feb 1984 | EP |
| 0104460 | Apr 1984 | EP |
| 0112104 | Jun 1984 | EP |
| 049673 | Sep 1985 | EP |
| 0265352 | Apr 1988 | EP |
| 0367252 | May 1990 | EP |
| 0611227 | Aug 1994 | EP |
| 0711569 | May 1996 | EP |
| 0763367 | Mar 1997 | EP |
| 0778033 | Jun 1997 | EP |
| 0813880 | Dec 1997 | EP |
| 1187642 | Mar 2002 | EP |
| 1314442 | May 2003 | EP |
| 0846470 | Sep 2003 | EP |
| 1346749 | Sep 2003 | EP |
| 1048316 | Oct 2003 | EP |
| 0971674 | Dec 2003 | EP |
| 0914093 | Feb 2004 | EP |
| 1438981 | Jul 2004 | EP |
| 1438982 | Jul 2004 | EP |
| 0970699 | Sep 2005 | EP |
| 0994739 | Sep 2005 | EP |
| 0958832 | Jan 2006 | EP |
| 1648536 | Apr 2006 | EP |
| 1066068 | Jul 2006 | EP |
| 1677900 | Jul 2006 | EP |
| 1351726 | Feb 2007 | EP |
| 1382359 | Feb 2007 | EP |
| 1110564 | May 2007 | EP |
| 1867359 | Dec 2007 | EP |
| 1938849 | Jul 2008 | EP |
| 1191960 | Sep 2008 | EP |
| 1582227 | Nov 2008 | EP |
| 1218039 | Feb 2009 | EP |
| 1641473 | Apr 2010 | EP |
| 1357958 | Aug 2010 | EP |
| 2289577 | Mar 2011 | EP |
| 1432462 | May 2011 | EP |
| 2350897 | Aug 2011 | EP |
| 2402047 | Jan 2012 | EP |
| 1509231 | Feb 2012 | EP |
| 1465687 | May 2012 | EP |
| 2446910 | May 2012 | EP |
| 1195171 | Aug 2012 | EP |
| 2503150 | Sep 2012 | EP |
| 2510958 | Oct 2012 | EP |
| 2517742 | Oct 2012 | EP |
| 1735028 | Jul 2013 | EP |
| 2656785 | Oct 2013 | EP |
| 2689790 | Jan 2014 | EP |
| 2712648 | Mar 2015 | EP |
| 1878430 | Apr 2016 | EP |
| 2114487 | Apr 2016 | EP |
| 2131891 | Apr 2016 | EP |
| 2173433 | May 2016 | EP |
| 2312055 | Jul 2000 | GB |
| 60155952 | Aug 1985 | JP |
| S61008057 | Jan 1986 | JP |
| 2001511400 | Aug 2001 | JP |
| 2002539896 | Nov 2002 | JP |
| 2003024435 | Jan 2003 | JP |
| 2003205031 | Jul 2003 | JP |
| 2006181386 | Jul 2006 | JP |
| 2006218037 | Aug 2006 | JP |
| 2002355305 | Feb 2008 | JP |
| 2008119509 | May 2008 | JP |
| 03150035 | Apr 2009 | JP |
| 2009131573 | Jun 2009 | JP |
| 2009139091 | Jun 2009 | JP |
| 2009142436 | Jul 2009 | JP |
| 2009533092 | Sep 2009 | JP |
| 2009279110 | Dec 2009 | JP |
| 2009279532 | Dec 2009 | JP |
| 2010042312 | Feb 2010 | JP |
| 2010088759 | Apr 2010 | JP |
| 2010099631 | May 2010 | JP |
| 2010131495 | Jun 2010 | JP |
| 2010175285 | Aug 2010 | JP |
| 2010214132 | Sep 2010 | JP |
| 2010238013 | Oct 2010 | JP |
| 2010279423 | Dec 2010 | JP |
| 2011056395 | Mar 2011 | JP |
| 2011067535 | Apr 2011 | JP |
| 2011120713 | Jun 2011 | JP |
| 2011131209 | Jul 2011 | JP |
| 2011188996 | Sep 2011 | JP |
| 2011189190 | Sep 2011 | JP |
| 2011207867 | Oct 2011 | JP |
| 2011217965 | Nov 2011 | JP |
| 2011241174 | Dec 2011 | JP |
| 2012071287 | Apr 2012 | JP |
| 2012075572 | Apr 2012 | JP |
| 2012075573 | Apr 2012 | JP |
| 2012075574 | Apr 2012 | JP |
| 2012075575 | Apr 2012 | JP |
| 2012210382 | Nov 2012 | JP |
| 2012223248 | Nov 2012 | JP |
| 2012228285 | Nov 2012 | JP |
| 2013006128 | Jan 2013 | JP |
| 2013048894 | Mar 2013 | JP |
| 2013048895 | Mar 2013 | JP |
| 2013202231 | Oct 2013 | JP |
| 2014014645 | Jan 2014 | JP |
| 2014184380 | Oct 2014 | JP |
| 2014184384 | Oct 2014 | JP |
| 2014184410 | Oct 2014 | JP |
| 2014184411 | Oct 2014 | JP |
| 2017000802 | Jan 2017 | JP |
| 2017006538 | Jan 2017 | JP |
| 6080937 | Feb 2017 | JP |
| 2018027256 | Feb 2018 | JP |
| 2018050751 | Apr 2018 | JP |
| 20120118906 | Oct 2012 | KR |
| M411244 | Sep 2011 | TW |
| 1983002060 | Jun 1983 | WO |
| 1984000137 | Jan 1984 | WO |
| 1984000340 | Feb 1984 | WO |
| 9203202 | Mar 1992 | WO |
| 1992003202 | Mar 1992 | WO |
| 1994020154 | Sep 1994 | WO |
| 1996025214 | Aug 1996 | WO |
| 1997007837 | Mar 1997 | WO |
| 1998032480 | Jul 1998 | WO |
| 1999006082 | Feb 1999 | WO |
| 2000057833 | Oct 2000 | WO |
| 2000057935 | Oct 2000 | WO |
| 2001032237 | May 2001 | WO |
| 2001058509 | Aug 2001 | WO |
| 2002066099 | Aug 2002 | WO |
| 2004006992 | Jan 2004 | WO |
| 2004009156 | Jan 2004 | WO |
| 2004043566 | May 2004 | WO |
| 2005009511 | Feb 2005 | WO |
| 2005042139 | May 2005 | WO |
| 2005089832 | Sep 2005 | WO |
| 2007061368 | May 2007 | WO |
| 2007091217 | Aug 2007 | WO |
| 2007103411 | Sep 2007 | WO |
| 2007118235 | Oct 2007 | WO |
| 2007144427 | Dec 2007 | WO |
| 2008086619 | Jul 2008 | WO |
| 2008106440 | Sep 2008 | WO |
| 2008154435 | Dec 2008 | WO |
| 2009005900 | Jan 2009 | WO |
| 2009094182 | Jul 2009 | WO |
| 2009094183 | Jul 2009 | WO |
| 2009094186 | Jul 2009 | WO |
| 2009127683 | Oct 2009 | WO |
| 2009134881 | Nov 2009 | WO |
| 2010002830 | Jan 2010 | WO |
| 2010009867 | Jan 2010 | WO |
| 2010020380 | Feb 2010 | WO |
| 2010024963 | Mar 2010 | WO |
| 2010031424 | Mar 2010 | WO |
| 2010059959 | May 2010 | WO |
| 2010121751 | Oct 2010 | WO |
| 2010143693 | Dec 2010 | WO |
| 2011017215 | Feb 2011 | WO |
| 2011052348 | May 2011 | WO |
| 2011065222 | Jun 2011 | WO |
| 2011091998 | Aug 2011 | WO |
| 2011113615 | Sep 2011 | WO |
| 2011132165 | Oct 2011 | WO |
| 2012049261 | Apr 2012 | WO |
| 2012087798 | Jun 2012 | WO |
| 2012148781 | Nov 2012 | WO |
| 2012163537 | Dec 2012 | WO |
| 2012172818 | Dec 2012 | WO |
| 2012176135 | Dec 2012 | WO |
| 2013000569 | Jan 2013 | WO |
| 2013012744 | Jan 2013 | WO |
| 2013019179 | Feb 2013 | WO |
| 2013040420 | Mar 2013 | WO |
| 2013051927 | Apr 2013 | WO |
| 2013057109 | Apr 2013 | WO |
| 2013110919 | Aug 2013 | WO |
| 2013114063 | Aug 2013 | WO |
| 2013121162 | Aug 2013 | WO |
| 2013135386 | Sep 2013 | WO |
| 2013135388 | Sep 2013 | WO |
| 2013159935 | Oct 2013 | WO |
| 2013163949 | Nov 2013 | WO |
| 2013185080 | Dec 2013 | WO |
| 2013191344 | Dec 2013 | WO |
| 2014009111 | Jan 2014 | WO |
| 2014053858 | Apr 2014 | WO |
| 2014081367 | May 2014 | WO |
| 2014106010 | Jul 2014 | WO |
| 2014124186 | Aug 2014 | WO |
| 2014155120 | Oct 2014 | WO |
| 2014162489 | Oct 2014 | WO |
| 2015050752 | Apr 2015 | WO |
| 2015177606 | Nov 2015 | WO |
| 2015188154 | Dec 2015 | WO |
| 2016059634 | Apr 2016 | WO |
| 2016080883 | May 2016 | WO |
| 2016088072 | Jun 2016 | WO |
| 2016091366 | Jun 2016 | WO |
| 2016095026 | Jun 2016 | WO |
| 2016193930 | Dec 2016 | WO |
| 2016206949 | Dec 2016 | WO |
| 2018115028 | Jun 2018 | WO |
| Entry |
|---|
| Extended European Search Report dated Apr. 2, 2019 for European Patent Application No. 18215332.0. |
| International Search Report and Written Opinion dated Oct. 24, 2018 issued in International Patent Application No. PCT/US2018/039188. |
| English language abstract for Swedish application publication No. SE 198300739 A, published Aug. 13, 1983. |
| Extended European Search Report for European Application No. 17170146 dated Jul. 25, 2017. |
| Extended European Search Report for European Application No. 17170151.9 dated Aug. 22, 2017. |
| Extended European Search Report for European Patent Application No. 12760085.6 dated Sep. 25, 2015. |
| Extended European Search Report for European Patent Application No. 12871735.2 dated Oct. 15, 2015. |
| International Search Report and Written Opinion for International Application No. PCT/US2012/30350 dated Sep. 13, 2012. |
| International Search Report and Written Opinion for International Application No. PCT/US2012/56781 dated Apr. 4, 2013. |
| Office Action for Chinese Patent Application No. 201280015466.8 dated Apr. 20, 2015 (with translation). |
| Office Action for Japanese Patent Application No. 2014-501276 dated Mar. 1, 2016 (with translation). |
| Office Action for Japanese Patent Application No. 2015-503186 dated Jun. 6, 2017 (with translation). |
| Office Action for U.S. Appl. No. 14/006,763 dated Dec. 15, 2016. |
| Office Action for U.S. Appl. No. 14/006,763 dated May 16, 2016. |
| Office Action for U.S. Appl. No. 14/006,763 dated Jul. 12, 2017. |
| Office Action for U.S. Appl. No. 14/348,533 dated Feb. 22, 2017. |
| Office Action for U.S. Appl. No. 15/400,978 dated Sep. 21, 2017. |
| Office Action in Japanese Patent Application No. 2015-503186 dated Aug. 2, 2016 (with translation). |
| Partial Supplementary European Search Report for European Patent Application No. 12760085.6 dated Jun. 1, 2015. |
| Notice of Reasons for Refusal dated Nov. 15, 2018 for Japanese Patent Application No. 2018-071806. |
| Examination Report for United Kingdom Patent Application No. 1316544.4 dated Nov. 1, 2017. |
| Extended European Search Report for European Patent Application No. 19166992.8 dated Aug. 2, 2019. |
| Extended European Search Report issued in EP Application 19173274.2 and dated Jul. 29, 2019. |
| International Search Report and Written Opinion dated Sep. 6, 2019 and issued in International Application No. PCT/US2019/019967. |
| Partial European Search Report issued in application 19167042.1 and dated Jul. 15, 2019. |
| Extended European Search Report dated Oct. 22, 2019 for European Patent Application No. 19167042.1. |
| Number | Date | Country | |
|---|---|---|---|
| 20170203025 A1 | Jul 2017 | US |
| Number | Date | Country | |
|---|---|---|---|
| 61466921 | Mar 2011 | US | |
| 61490183 | May 2011 | US | |
| 61509240 | Jul 2011 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 15400978 | Jan 2017 | US |
| Child | 15476819 | US | |
| Parent | 14006763 | US | |
| Child | 15400978 | US |
