Claims
- 1. A polyethylene glycol ester prodrug comprising a compound selected from the group consisting of a steroidal compound, an antiviral compound, an immunomodulating compound, an anti-tumor compound, a neovascular compound, and a non-steroidal compound, which non-steroidal compound is selected from the group consisting of indomethacin, dideoxyinosine (DDI) and gancyclovir, with said compound linked via an ester linkage to a polyethylene glycol having the formula HO(CH.sub.2 CH.sub.2 O).sub.n H, wherein n=2-12.
- 2. A pharmaceutical composition comprising a prodrug according to claim 1 and a carrier.
- 3. A prodrug according to claim 1 wherein said steroidal compound is selected from the group consisting of triamcinolone acetonide and trihydroxysteroid.
- 4. A prodrug according to claim 1 wherein n=2-6.
- 5. A prodrug according to claim 1 wherein n=3-6.
- 6. A prodrug according to claim 1 wherein said steroidal or non-steroidal compound is linked to said polyethylene glycol by a carbonate group.
- 7. A prodrug according to claim 1, selected from the following compound formulas: ##STR5##
- 8. A prodrug according to claim 1 wherein said immunomodulating compound is cyclosporin.
- 9. A prodrug according to claim 1 wherein said anti-tumor compound is taxol.
- 10. A method of treating a human or animal having a disease condition or symptom comprising administering an effective amount of a prodrug according to claim 1 to said human or animal having such disease condition or symptom.
Parent Case Info
This application is a continuation in part application of Ser. No. 08/162,388, filed Dec. 7, 1993 abandoned upon filing this application, which is a continuation of Ser. No. 08/016,179, filed Feb. 11, 1993, now abandoned which is a continuation of Ser. No. 07/601,644, filed Oct. 23, 1990, now abandoned
US Referenced Citations (11)
Foreign Referenced Citations (2)
Number |
Date |
Country |
1148165 |
Jun 1983 |
CAX |
38 11118C1 |
Oct 1989 |
DEX |
Continuations (2)
|
Number |
Date |
Country |
Parent |
16179 |
Feb 1993 |
|
Parent |
601644 |
Oct 1990 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
162388 |
Dec 1993 |
|