Not Applicable
Not Applicable
Technical Field of the Invention
The present invention is directed to a moisture sensor and more specifically, to a perspiration sensor for quantitatively measuring levels of perspiration. In accordance with some embodiments, the perspiration sensor includes a capacitive sensor that can be coupled to the skin and utilize capacitance to measure perspiration. The perspiration sensor can be shielded and stabilized to reduce noise by electrically coupling the capacitor dielectric material to the skin.
Description of the Prior Art
The prior art perspiration sensors are generally related to devices for determining galvanic skin response. These devices involve the measurement of the electrical resistance of the skin, but do not provide a quantitative indication of the volume or level of perspiration over time.
The present invention is directed to a method and system for obtaining a quantitative measurement of moisture, and more specifically, perspiration. Various embodiments of the invention utilize the dielectric properties of perspiration in a capacitive sensor that includes a pair of ground shielded parallel electrodes sandwiching a moisture absorbent dielectric material (e.g., a microfiber cloth). In accordance with some embodiments, the dielectric material can be electrically coupled (e.g., capacitively coupled) to the skin of the user to provide a more stable signal because the skin is capacitively coupled to earth ground which is weakly capacitively coupled to the ground of signal measurement circuit (e.g., the capacitance to digital signal converter integrated circuit). The method includes a providing a capacitor that includes a dielectric material that absorbs moisture (e.g., perspiration) in contact with the skin, wherein the capacitor includes one or more inlets that enable perspiration released from the skin to become absorbed by the absorbent dielectric material and electrically (e.g., capacitively) coupling the dielectric material to the body.
In accordance with the invention, the perspiration sensor can be constructed having three layers, a first or top layer, a second or middle layer and a third or bottom layer. The bottom layer can include an adhesive or other skin contacting material that maintains contact with and capacitively couples the sensor to the skin. The bottom layer and the top layer include the first and second electrode plates that form the capacitor with dielectric material surrounded by the middle layer sandwiched in between. The bottom layer, middle layer and top layer form a central chamber that encloses the dielectric material and positions it in a dielectric space between the first and second electrodes. The bottom layer can also include one or more pores, inlets or vents that enable perspiration released from the skin to enter central chamber and be absorbed by the dielectric material in the dielectric space. The bottom layer can also include a skin coupling electrode that becomes electrically coupled to the skin when the bottom surface of the bottom layer is adhered to or placed in contact with the skin. The skin coupling electrode can be electrically connected to the central chamber and the dielectric material. When the bottom surface includes an adhesive material, the skin coupling electrode capacitively couples the dielectric material in the central chamber to the skin to provide ground shielding adjacent to the electrodes to minimize environmental noise. In accordance with some embodiments of the invention, the dielectric material can be weakly but consistently (capacitively) coupled to earth ground through the skin.
Each of the layers can be formed from a rigid printed circuit board (PCB) or a flexible PCB, and each of the layers can be laminated together as is well known in the art. The dielectric material can be an absorbent material that rapidly replaces air with perspiration, such as a tufted microfiber cloth. The thickness of the middle layer can be selected to define and control the distance between the sensing electrode plates of the capacitor. In accordance with some embodiments, the middle layer includes a rigid material having a predefined thickness to tightly control the electrode plate spacing and slightly thinner than the thickness of the microfiber cloth causing portions of the cloth to extrude through the pores or inlets of the bottom layer facilitate moisture absorption.
In accordance with some embodiments of the invention, the device can further include a capacitance measurement integrated circuit (e.g., IC chip) mounted to the top layer that enables close proximity measurement of the change in capacitance of the sensor to minimize the introduction of noise. In this configuration, the measured capacitance can be transmitted (e.g., by wire or wirelessly) to a remote system for storing and/or analyzing the capacitance data and determining perspiration rates (e.g., volume and volume over time).
In accordance with some embodiments of the invention, the device can be fully or partially enclosed or encapsulated in polymer or elastomeric material (e.g. PDMS, or silicone) that protects the sensor from the environment. One or more of the layers can include one or more partially or fully enclosed anchor rings projecting from the perimeter of the device such that the polymer material passes through the opening in the anchor rings to more securely anchor the encapsulating material to the outside of the device.
In operation, the bottom of the device is coupled to the skin by an adhesive material and perspiration released by the skin passes through the inlets and become absorbed by the microfiber dielectric material. The capacitance of the first and second electrodes changes as the dielectric material absorbs perspiration. In addition, the bottom of the device includes a skin electrode that is electrically connected to the dielectric material and the central chamber. The skin electrode can be electrically connected to the middle layer by plated through holes or vias in the bottom layer. The vias in the middle layer can include electrodes that directly contact the dielectric material, enabling the dielectric material to be coupled (e.g., capacitively coupled) to the skin through the adhesive. The integrated circuit on the top layer includes a circuit that determines a measure of the capacitance between the first and second electrodes while the skin electrode serves to stabilize the capacitance measurement against noise.
These and other capabilities of the invention, along with the invention itself, will be more fully understood after a review of the following figures, detailed description, and claims.
The accompanying drawings, which are incorporated into this specification, illustrate one or more exemplary embodiments of the inventions and, together with the detailed description, serve to explain the principles and applications of these inventions. The drawings and detailed description are illustrative, and are intended to facilitate an understanding of the inventions and their application without limiting the scope of the invention. The illustrative embodiments can be modified and adapted without departing from the spirit and scope of the inventions.
The present invention is directed to methods and systems for obtaining a quantitative measurement of moisture. One specific application for the invention includes the detection and measurement of perspiration. For purposes of illustration, the invention is described herein in the context of measuring perspiration, however, embodiments of the invention can be used to measure other sources of moisture.
In accordance with some embodiments of the invention, the perspiration sensor includes a pair of ground shielded parallel electrodes sandwiching a moisture absorbent dielectric material (e.g., a microfiber cloth) that forms a capacitor. The sensor allows perspiration to become absorbed by moisture absorbent dielectric material which changes the dielectric constant the dielectric material and is reflected in the measured capacitance of the electrode plates of the perspiration sensor. In accordance with some embodiments of the invention, the dielectric material can be electrically coupled (e.g., capacitively coupled) to the skin of the user to provide for more stable signal measurement. In accordance with some embodiments of the invention, the absorbent dielectric material can be weakly (e.g., 10 pF or less) but consistently (e.g., up to 10% variation) coupled through the skin to earth ground which is weakly coupled to signal ground of capacitance measuring circuit. The method includes providing a capacitor that includes an exposed dielectric material that can absorb moisture (e.g., perspiration) produced by the skin. As perspiration is released from the skin and becomes absorbed by the absorbent dielectric material, the dielectric properties of the material between the electrode plates change resulting in a change in the capacitance of the perspiration sensor. An internal or external measurement component can be connected to the electrodes of the capacitor to measure the changes in capacitance of the perspiration sensor.
The dielectric properties of perspiration closely resemble that of saline which in turn closely resemble that of water. The dielectric constant of water is about 80 times that of air. An air capacitor formed by two parallel plates will increase capacitance significantly when air is replaced with water, saline, or perspiration. The approximate capacitance C of the parallel plates can be determined by
where A is the area of the electrode plate, d is the distance between the plates; ε0 is the dielectric constant of free space and εr is the relative dielectric constant of the material between the plates.
In accordance with the invention, the dielectric material can be selected to rapidly absorb the perspiration. In accordance with some embodiments of the invention, the dielectric material can have predefined wicking or absorbency properties that provide a desired level of perspiration absorption. In operation, the dielectric material is initially in a dry state and has dielectric properties similar to air and produces an initial capacitance level. As the dielectric material is exposed to moisture (e.g., perspiration) the moisture rapidly replaces the air, changing the dielectric properties of the dielectric material and the measured capacitance level of the sensor.
In accordance with some embodiments of the invention, the absorbent dielectric material can include a tufted microfiber cloth. This material has been found to have improved capillary suction and to diffuse perspiration faster and more uniformly than other materials as well as provides higher absorption densities. Other absorbent materials, such as cellulose paper, foamy elastomers, cotton, wool, air, and moisture wicking materials, can be used. The absorbent dielectric material can be configured to have a large surface area to volume ratio of the material that results in capillary suction causing the air filled space to become filled with environmental moisture or perspiration. A capacitance measuring circuit can be provided onboard or in close proximity to the capacitor sensor to minimize noise and convert the capacitance to a digital signal for transmission to a connected device.
As shown in
As shown in
In accordance with some embodiments of the invention, the perspiration sensor 100 can also include one or more anchor rings 220 that project from the peripheral edge of the device as shown in
In accordance with some embodiments, the perspiration sensor can include a capacitive sensor signal measuring integrated circuit that accurately measures the capacitance or capacitive signal and converts it to a digital signal for transmission to a remote device. In accordance with some embodiments of the invention, the capacitive sensor signal measuring integrated circuit can include a ZSSC3123 integrated circuit (ZMDI, Dresden, Germany and Milpitas, Calif.).
In accordance with some embodiments of the invention, the perspiration sensor can be part of system that quantitatively measures perspiration of a user in real time. The sensor can be connected to a data-logging hub (e.g. BioStamp TM by MC10 Inc., a smartphone or data recorder). The perspiration sensor can measure a change in capacitance over time and calculate perspiration moisture volume using a predetermined calibrated curve. The data logging hub can include a computer processor and associated memory that can communicate with the perspiration sensor to receive sensor data. The data logging hub can include additional wired or wireless communication components to enable the sensor data to be stored in a remote database or processed by a remote data processing system.
While some embodiments of the present invention are described in the context of a perspiration sensor, the invention can be used for measuring moisture in other applications. In some embodiments, the moisture sensor can be used to measure perspiration to test the efficacy of anti-perspirant products. In other applications, the moisture sensor can be installed in a helmet worn by an athlete, a soldier or a fighter pilot as well as other areas of the body to provide continuous physiological monitoring, for example, for health, wellness, hydration and/or stress monitoring. In accordance with some embodiments, the central chamber or an adjacent collection chamber can include analyte sensors and/or assays to detecting the presence and/or quantity of components of the absorbed perspiration. For example, a sodium sensor can be included for diagnosis of cystic fibrosis.
Other embodiments are within the scope and spirit of the invention. For example, due to the nature of hardware and software, functions described above can be implemented using software, hardware, firmware, hardwiring, or combinations of any of these. Features implementing functions may also be physically located at various positions, including being distributed such that portions of functions are implemented at different physical locations.
Further, while the description above refers to the invention, the description may include more than one invention.
This application claims any and all benefits as provided by law including benefit under 35 U.S.C. § 119(e) of the U.S. Provisional Application No. 62/127,124, filed Mar. 2, 1015, the contents of which are incorporated herein by reference in its entirety.
Number | Name | Date | Kind |
---|---|---|---|
3716861 | Root | Feb 1973 | A |
3805427 | Epstein | Apr 1974 | A |
4304235 | Kaufman | Dec 1981 | A |
4416288 | Freeman | Nov 1983 | A |
4658153 | Brosh | Apr 1987 | A |
5272375 | Belopolsky | Dec 1993 | A |
5306917 | Black | Apr 1994 | A |
5326521 | East | Jul 1994 | A |
5331966 | Bennett | Jul 1994 | A |
5360987 | Shibib | Nov 1994 | A |
5471982 | Edwards | May 1995 | A |
5454270 | Brown | Oct 1995 | A |
5491651 | Janic | Feb 1996 | A |
5567975 | Walsh | Oct 1996 | A |
5580794 | Allen | Dec 1996 | A |
5617870 | Hastings | Apr 1997 | A |
5811790 | Endo | Sep 1998 | A |
5817008 | Rafert | Oct 1998 | A |
5907477 | Tuttle | May 1999 | A |
6042543 | Warwick | Mar 2000 | A |
6063046 | Allum | May 2000 | A |
6265090 | Nishide | Jul 2001 | B1 |
6282960 | Samuels et al. | Sep 2001 | B1 |
6343514 | Smith | Feb 2002 | B1 |
6387052 | Quinn | May 2002 | B1 |
6410971 | Otey | Jun 2002 | B1 |
6421016 | Phillips | Jul 2002 | B1 |
6450026 | Desarnaud | Sep 2002 | B1 |
6455931 | Hamilton | Sep 2002 | B1 |
6567158 | Falcial | May 2003 | B1 |
6641860 | Kaiserman | Nov 2003 | B1 |
6775906 | Silverbrook | Aug 2004 | B1 |
6784844 | Boakes | Aug 2004 | B1 |
6965160 | Cobbley | Nov 2005 | B2 |
6987314 | Yoshida | Jan 2006 | B1 |
7259030 | Daniels | Aug 2007 | B2 |
7265298 | Maghribi | Sep 2007 | B2 |
7302751 | Hamburgen | Dec 2007 | B2 |
7337012 | Maghribi | Feb 2008 | B2 |
7487587 | Vanfleteren | Feb 2009 | B2 |
7491892 | Wagner | Feb 2009 | B2 |
7521292 | Rogers | Apr 2009 | B2 |
7557367 | Rogers | Jul 2009 | B2 |
7618260 | Daniel | Nov 2009 | B2 |
7622367 | Nuzzo | Nov 2009 | B1 |
7727228 | Abboud | Jun 2010 | B2 |
7739791 | Brandenburg | Jun 2010 | B2 |
7759167 | Vanfleteren | Jul 2010 | B2 |
7960246 | Flamand | Jun 2011 | B2 |
7982296 | Nuzzo | Jul 2011 | B2 |
8097926 | De Graff | Jan 2012 | B2 |
8198621 | Rogers | Jun 2012 | B2 |
8207473 | Axisa | Jun 2012 | B2 |
8217381 | Rogers | Jul 2012 | B2 |
8372726 | De Graff | Feb 2013 | B2 |
8389862 | Arora | Mar 2013 | B2 |
8431828 | Vanfleteren | Apr 2013 | B2 |
8440546 | Nuzzo | May 2013 | B2 |
8536667 | De Graff | Sep 2013 | B2 |
8552299 | Rogers | Oct 2013 | B2 |
8664699 | Nuzzo | Mar 2014 | B2 |
8679888 | Rogers | Mar 2014 | B2 |
8729524 | Rogers | May 2014 | B2 |
8754396 | Rogers | Jun 2014 | B2 |
8865489 | Rogers | Oct 2014 | B2 |
8886334 | Ghaffari | Nov 2014 | B2 |
8905772 | Rogers | Dec 2014 | B2 |
9012784 | Arora | Apr 2015 | B2 |
9082025 | Fastert | Jul 2015 | B2 |
9105555 | Rogers | Aug 2015 | B2 |
9105782 | Rogers | Aug 2015 | B2 |
9119533 | Ghaffari | Sep 2015 | B2 |
9123614 | Graff | Sep 2015 | B2 |
9159635 | Elolampi | Oct 2015 | B2 |
9168094 | Lee | Oct 2015 | B2 |
9171794 | Rafferty | Oct 2015 | B2 |
9186060 | De Graff | Nov 2015 | B2 |
9226402 | Hsu | Dec 2015 | B2 |
9247637 | Hsu | Jan 2016 | B2 |
20010012918 | Swanson | Aug 2001 | A1 |
20010021867 | Kordis | Sep 2001 | A1 |
20020000081 | Hirono et al. | Jan 2002 | A1 |
20020026127 | Balbierz | Feb 2002 | A1 |
20020082515 | Campbell | Jun 2002 | A1 |
20020094701 | Biegelsen | Jul 2002 | A1 |
20020113739 | Howard | Aug 2002 | A1 |
20020128700 | Cross, Jr. | Sep 2002 | A1 |
20020145467 | Minch | Oct 2002 | A1 |
20020151934 | Levine | Oct 2002 | A1 |
20020158330 | Moon | Oct 2002 | A1 |
20030017848 | Engstrom | Jan 2003 | A1 |
20030045025 | Coyle | Mar 2003 | A1 |
20030097165 | Krulevitch | May 2003 | A1 |
20030120271 | Burnside | Jun 2003 | A1 |
20030162507 | Vatt | Aug 2003 | A1 |
20030214408 | Grajales | Nov 2003 | A1 |
20030236455 | Swanson | Dec 2003 | A1 |
20040006264 | Mojarradi | Jan 2004 | A1 |
20040085469 | Johnson | May 2004 | A1 |
20040092806 | Sagon | May 2004 | A1 |
20040106334 | Suzuki | Jun 2004 | A1 |
20040135094 | Niigaki | Jul 2004 | A1 |
20040138558 | Dunki-Jacobs | Jul 2004 | A1 |
20040149921 | Smyk | Aug 2004 | A1 |
20040178466 | Merrill | Sep 2004 | A1 |
20040192082 | Wagner | Sep 2004 | A1 |
20040201134 | Kawai | Oct 2004 | A1 |
20040203486 | Shepherd | Oct 2004 | A1 |
20040221370 | Hannula | Nov 2004 | A1 |
20040243204 | Maghribi | Dec 2004 | A1 |
20050021103 | DiLorenzo | Jan 2005 | A1 |
20050029680 | Jung | Feb 2005 | A1 |
20050067293 | Naito | Mar 2005 | A1 |
20050070778 | Lackey | Mar 2005 | A1 |
20050096513 | Ozguz | May 2005 | A1 |
20050113744 | Donoghue | May 2005 | A1 |
20050139683 | Yi | Jun 2005 | A1 |
20050171524 | Stern | Aug 2005 | A1 |
20050203366 | Donoghue | Sep 2005 | A1 |
20060003709 | Wood | Jan 2006 | A1 |
20060038182 | Rogers | Feb 2006 | A1 |
20060071349 | Tokushige | Apr 2006 | A1 |
20060084394 | Engstrom | Apr 2006 | A1 |
20060106321 | Lewinsky | May 2006 | A1 |
20060128346 | Yasui | Jun 2006 | A1 |
20060154398 | Qing | Jul 2006 | A1 |
20060160560 | Josenhans | Jul 2006 | A1 |
20060248946 | Howell | Nov 2006 | A1 |
20060257945 | Masters | Nov 2006 | A1 |
20060264767 | Shennib | Nov 2006 | A1 |
20060270135 | Chrysler | Nov 2006 | A1 |
20060286785 | Rogers | Dec 2006 | A1 |
20070027514 | Gerber | Feb 2007 | A1 |
20070031283 | Davis | Feb 2007 | A1 |
20070108389 | Makela | May 2007 | A1 |
20070113399 | Kumar | May 2007 | A1 |
20070123756 | Kitajima | May 2007 | A1 |
20070019088 | Dubrow et al. | Aug 2007 | A1 |
20070270672 | Hayter | Nov 2007 | A1 |
20070270674 | Kane et al. | Nov 2007 | A1 |
20080036097 | Ito | Feb 2008 | A1 |
20080046080 | Vanden Bulcke | Feb 2008 | A1 |
20080074383 | Dean | Mar 2008 | A1 |
20080096620 | Lee | Apr 2008 | A1 |
20080139894 | Szydlo-Moore | Jun 2008 | A1 |
20080157235 | Rogers | Jul 2008 | A1 |
20080188912 | Stone | Aug 2008 | A1 |
20080193749 | Thompson | Aug 2008 | A1 |
20080204021 | Leussler | Aug 2008 | A1 |
20080211087 | Mueller-Hipper | Sep 2008 | A1 |
20080237840 | Alcoe | Oct 2008 | A1 |
20080259576 | Johnson | Oct 2008 | A1 |
20080287167 | Caine | Nov 2008 | A1 |
20080313552 | Buehler | Dec 2008 | A1 |
20090000377 | Shipps | Jan 2009 | A1 |
20090001550 | Yonggang | Jan 2009 | A1 |
20090015560 | Robinson | Jan 2009 | A1 |
20090017884 | Rotschild | Jan 2009 | A1 |
20090048556 | Durand | Feb 2009 | A1 |
20090088750 | Hushka | Apr 2009 | A1 |
20090107704 | Vanfleteren | Apr 2009 | A1 |
20090154736 | Lee | Jun 2009 | A1 |
20090184254 | Miura | Jul 2009 | A1 |
20090204168 | Kallmeyer | Aug 2009 | A1 |
20090215385 | Waters | Aug 2009 | A1 |
20090225751 | Koenck | Sep 2009 | A1 |
20090261828 | Nordmeyer-Massner | Oct 2009 | A1 |
20090273909 | Shin | Nov 2009 | A1 |
20090283891 | Dekker | Nov 2009 | A1 |
20090291508 | Babu | Nov 2009 | A1 |
20090294803 | Nuzzo | Dec 2009 | A1 |
20090322480 | Benedict | Dec 2009 | A1 |
20100002402 | Rogers | Jan 2010 | A1 |
20100030167 | Thirstrup et al. | Feb 2010 | A1 |
20100059863 | Rogers | Mar 2010 | A1 |
20100072577 | Nuzzo | Mar 2010 | A1 |
20100073669 | Colvin | Mar 2010 | A1 |
20100087782 | Ghaffari | Apr 2010 | A1 |
20100090781 | Yamamoto | Apr 2010 | A1 |
20100090824 | Rowell | Apr 2010 | A1 |
20100116526 | Arora | May 2010 | A1 |
20100117660 | Douglas | May 2010 | A1 |
20100178722 | De Graff | Jul 2010 | A1 |
20100245011 | Chatzopoulos | Sep 2010 | A1 |
20100271191 | De Graff | Oct 2010 | A1 |
20100298895 | Ghaffari | Nov 2010 | A1 |
20100317132 | Rogers | Dec 2010 | A1 |
20100321161 | Isabell | Dec 2010 | A1 |
20100327387 | Kasai | Dec 2010 | A1 |
20110011179 | Gustafsson | Jan 2011 | A1 |
20110034912 | De Graff | Feb 2011 | A1 |
20110051384 | Kriechbaum | Mar 2011 | A1 |
20110054583 | Litt | Mar 2011 | A1 |
20110101789 | Salter | May 2011 | A1 |
20110121822 | Parsche | May 2011 | A1 |
20110140897 | Purks | Jun 2011 | A1 |
20110175735 | Forster | Jul 2011 | A1 |
20110184320 | Shipps | Jul 2011 | A1 |
20110215931 | Callsen | Sep 2011 | A1 |
20110218756 | Callsen | Sep 2011 | A1 |
20110218757 | Callsen | Sep 2011 | A1 |
20110220890 | Nuzzo | Sep 2011 | A1 |
20110277813 | Rogers | Nov 2011 | A1 |
20110284268 | Palaniswamy | Nov 2011 | A1 |
20110306851 | Wang | Dec 2011 | A1 |
20120016258 | Webster | Jan 2012 | A1 |
20120051005 | Vanfleteren | Mar 2012 | A1 |
20120052268 | Axisa | Mar 2012 | A1 |
20120065937 | De Graff | Mar 2012 | A1 |
20120074546 | Chong | Mar 2012 | A1 |
20120087216 | Keung | Apr 2012 | A1 |
20120091594 | Landesberger | Apr 2012 | A1 |
20120092178 | Callsen | Apr 2012 | A1 |
20120092222 | Kato | Apr 2012 | A1 |
20120101413 | Beetel | Apr 2012 | A1 |
20120101538 | Ballakur | Apr 2012 | A1 |
20120108012 | Yasuda | May 2012 | A1 |
20120126418 | Feng | May 2012 | A1 |
20120015007 | Revol-Cavalier et al. | Jun 2012 | A1 |
20120157804 | Rogers | Jun 2012 | A1 |
20120172697 | Urman | Jul 2012 | A1 |
20120226130 | De Graff | Sep 2012 | A1 |
20120244848 | Ghaffari | Sep 2012 | A1 |
20120256308 | Helin | Oct 2012 | A1 |
20120316455 | Rahman | Dec 2012 | A1 |
20120327608 | Rogers | Dec 2012 | A1 |
20130041235 | Rogers | Feb 2013 | A1 |
20130099358 | Elolampi | Apr 2013 | A1 |
20130100618 | Rogers | Apr 2013 | A1 |
20130012358 | Sarrafzadeh et al. | May 2013 | A1 |
20130118255 | Callsen | May 2013 | A1 |
20130150693 | D'angelo | Jun 2013 | A1 |
20130185003 | Carbeck | Jul 2013 | A1 |
20130019731 | Monty et al. | Aug 2013 | A1 |
20130192356 | De Graff | Aug 2013 | A1 |
20130200268 | Rafferty | Aug 2013 | A1 |
20130211761 | Brandsma | Aug 2013 | A1 |
20130214300 | Lerman | Aug 2013 | A1 |
20130215467 | Fein | Aug 2013 | A1 |
20130225965 | Ghaffari | Aug 2013 | A1 |
20130237150 | Royston | Sep 2013 | A1 |
20130245388 | Rafferty | Sep 2013 | A1 |
20130274562 | Ghaffari | Oct 2013 | A1 |
20130313713 | Arora | Nov 2013 | A1 |
20130316442 | Meurville | Nov 2013 | A1 |
20130316487 | De Graff | Nov 2013 | A1 |
20130320503 | Nuzzo | Dec 2013 | A1 |
20130321373 | Yoshizumi | Dec 2013 | A1 |
20140001058 | Ghaffari | Jan 2014 | A1 |
20140012160 | Ghaffari | Jan 2014 | A1 |
20140012242 | Lee | Jan 2014 | A1 |
20140022746 | Hsu | Jan 2014 | A1 |
20140039290 | De Graff | Feb 2014 | A1 |
20140097944 | Fastert | Apr 2014 | A1 |
20140110859 | Rafferty | Apr 2014 | A1 |
20140140020 | Rogers | May 2014 | A1 |
20140188426 | Fastert | Jul 2014 | A1 |
20140191236 | Nuzzo | Jul 2014 | A1 |
20140216524 | Rogers | Aug 2014 | A1 |
20140240932 | Hsu | Aug 2014 | A1 |
20140249520 | Ghaffari | Sep 2014 | A1 |
20140303452 | Ghaffari | Oct 2014 | A1 |
20140340857 | Hsu | Nov 2014 | A1 |
20140374872 | Rogers | Dec 2014 | A1 |
20140375465 | Fenuccio | Dec 2014 | A1 |
20150001462 | Rogers | Jan 2015 | A1 |
20150019135 | Kacyvenski | Jan 2015 | A1 |
20150035680 | Li | Feb 2015 | A1 |
20150069617 | Arora | Mar 2015 | A1 |
20150099954 | Achmann | Apr 2015 | A1 |
20150099976 | Ghaffari | Apr 2015 | A1 |
20150100135 | Ives | Apr 2015 | A1 |
20150194817 | Lee | Jul 2015 | A1 |
20150237711 | Rogers | Aug 2015 | A1 |
20150241288 | Keen | Aug 2015 | A1 |
20150260713 | Ghaffari | Sep 2015 | A1 |
20150272652 | Ghaffari | Oct 2015 | A1 |
20150286913 | Fastert | Oct 2015 | A1 |
20150320472 | Ghaffari | Nov 2015 | A1 |
20150335254 | Elolampi | Nov 2015 | A1 |
20150342036 | Fastert | Nov 2015 | A1 |
20160027834 | de Graff | Jan 2016 | A1 |
20160045162 | De Graff | Feb 2016 | A1 |
20160081192 | Hsu | Mar 2016 | A1 |
Number | Date | Country |
---|---|---|
102007046886 | Apr 2009 | DE |
0585670 | Mar 1994 | EP |
0779059 | Jun 1997 | EP |
1808124 | Jul 2007 | EP |
2259062 | Dec 2010 | EP |
05-087511 | Apr 1993 | JP |
2009-170173 | Jul 2009 | JP |
WO 1999038211 | Jul 1999 | WO |
WO 2005122285 | Dec 2005 | WO |
WO 2003021679 | Mar 2006 | WO |
WO 2007003019 | Jan 2007 | WO |
WO 2007024983 | Mar 2007 | WO |
WO 2007116344 | Oct 2007 | WO |
WO 2007136726 | Nov 2007 | WO |
WO 2008030960 | Mar 2008 | WO |
WO 2009111641 | Sep 2009 | WO |
WO 2009114689 | Sep 2009 | WO |
WO 2010036807 | Apr 2010 | WO |
WO 2010042653 | Apr 2010 | WO |
WO 2010042957 | Apr 2010 | WO |
WO 2010046883 | Apr 2010 | WO |
WO 2010056857 | May 2010 | WO |
WO 2010081137 | Jul 2010 | WO |
WO 2010082993 | Jul 2010 | WO |
WO 2010102310 | Sep 2010 | WO |
WO 2010132552 | Nov 2010 | WO |
WO 2011003181 | Jan 2011 | WO |
WO 2011041727 | Apr 2011 | WO |
WO 2011084450 | Jul 2011 | WO |
WO 2011084709 | Jul 2011 | WO |
WO 2011127331 | Oct 2011 | WO |
WO 2012125494 | Sep 2012 | WO |
WO 2012166686 | Dec 2012 | WO |
WO 2013010171 | Jan 2013 | WO |
WO 2013022853 | Feb 2013 | WO |
WO 2013033724 | Mar 2013 | WO |
WO 2013034987 | Mar 2013 | WO |
WO 2013049716 | Apr 2013 | WO |
WO 2013052919 | Apr 2013 | WO |
WO 2013170032 | Nov 2013 | WO |
WO 2014007871 | Jan 2014 | WO |
WO 2014058473 | Apr 2014 | WO |
WO 2014059032 | Apr 2014 | WO |
WO 2014106041 | Jul 2014 | WO |
WO 2014110176 | Jul 2014 | WO |
WO 2014130928 | Aug 2014 | WO |
WO 2014130931 | Aug 2014 | WO |
WO 2014186467 | Nov 2014 | WO |
WO 2014197443 | Dec 2014 | WO |
WO 2014205434 | Dec 2014 | WO |
WO 2015021039 | Feb 2015 | WO |
WO 2015054312 | Apr 2015 | WO |
WO 2015077559 | May 2015 | WO |
WO 2015080991 | Jun 2015 | WO |
WO 2015102951 | Jul 2015 | WO |
WO 2015103483 | Jul 2015 | WO |
WO 2015103580 | Jul 2015 | WO |
WO 2015127458 | Aug 2015 | WO |
WO 2015134588 | Sep 2015 | WO |
WO 2015138712 | Sep 2015 | WO |
Entry |
---|
Carvalhal et al., “Electrochemical Detection in a Paper-Based Separation Device”, Analytical Chemistry, vol. 82, No. 3, (1162-1165) (4 pages) (Jan. 7, 2010). |
Demura et al., “Immobilization of Glucose Oxidase with Bombyx mori Silk Fibroin by Only Stretching Treatment and its Application to Glucose Sensor,” Biotechnology and Bioengineering, vol. 33, 598-603 (6 pages) (1989). |
Ellerbee et al., “Quantifying Colorimetric Assays in Paper-Based Microfluidic Devices by Measuring the Transmission of Light through Paper,” Analytical Chemistry, vol. 81, No. 20 8447-8452, (6 pages) (Oct. 15, 2009). |
Halsted, “Ligature and Suture Material,” Journal of the American Medical Association, vol. LX, No. 15, 1119-1126, (8 pages) (Apr. 12, 1913). |
Kim et al., “Complementary Metal Oxide Silicon Integrated Circuits Incorporating Monolithically Integrated Stretchable Wavy Interconnects,” Applied Physics Letters, vol. 93, 044102-044102.3 (3 pages) (Jul. 31, 2008). |
Kim et al., “Dissolvable Films of Silk Fibroin for Ultrathin Conformal Bio-Integrated Electronics,” Nature, 1-8 (8 pages) (Apr. 18, 2010). |
Kim et al., “Materials and Noncoplanar Mesh Designs for Integrated Circuits with Linear Elastic Responses to Extreme Mechanical Deformations,” PNAS, vol. 105, No. 48, 18675-18680 (6 pages) (Dec. 2, 2008). |
Kim et al., “Stretchable and Foldable Silicon Integrated Circuits,” Science, vol. 320, 507-511 (5 pages) (Apr. 25, 2008). |
Kim et al., “Electrowetting on Paper for Electronic Paper Display,” ACS Applied Materials & Interfaces, vol. 2, No. 11, (3318-3323) (6 pages) (Nov. 24, 2010). |
Ko et al., “A Hemispherical Electronic Eye Camera Based on Compressible Silicon Optoelectronics,” Nature, vol. 454, 748-753 (6 pages) (Aug. 7, 2008). |
Lawrence et al., “Bioactive Silk Protein Biomaterial Systems for Optical Devices,” Biomacromolecules, vol. 9, 1214-1220 (7 pages) (Nov. 4, 2008). |
Meitl et al., “Transfer Printing by Kinetic Control of Adhesion to an Elastomeric Stamp,” Nature, vol. 5, 33-38 (6 pages) (Jan. 2006). |
Omenetto et al., “A New Route for Silk,” Nature Photonics, vol. 2, 641-643 (3 pages) (Nov. 2008). |
Omenetto et al., “New Opportunities for an Ancient Material,” Science, vol. 329, 528-531 (5 pages) (Jul. 30, 2010). |
Siegel et al., “Foldable Printed Circuit Boards on Paper Substrates,” Advanced Functional Materials, vol. 20, No. 1, 28-35, (8 pages) (Jan. 8, 2010). |
Tsukada et al., “Structural Changes of Silk Fibroin Membranes Induced by Immersion in Methanol Aqueous Solutions,” Journal of Polymer Science, vol. 32, 961-968 (8 pages) (1994). |
Wang et al., “Controlled Release From Multilayer Silk Biomaterial Coatings to Modulate Vascular Cell Responses” Biomaterials, 29, 894-903 (10 pages) (Nov. 28, 2008). |
Number | Date | Country | |
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20160256070 A1 | Sep 2016 | US |
Number | Date | Country | |
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62127124 | Mar 2015 | US |