Claims
- 1. A method of treating diseases selected from the group consisting of rheumatism and bone metabolic disease, and for inhibiting patient physiological conditions selected from the group consisting of inflammation, interleukin-1 production, interleukin-1-induced cellular response, active oxygen production in neutrophils and bone resorption, comprising administering an effective amount of a methanediphosphonate derivative represented by formula (I): ##STR44## where, X represents H, a straight chain or branched chain alkyl group having 1 to 8 carbon atoms that is either unsubstituted or substituted, an aryl group, or an acyl group,
- Y represents a halogen atom, nitrile group, nitro group, alkyl group, alkoxy group, trifluoromethyl group, hydroxyl group, acyloxy group, acylamino group, acyl group, alkenyl group, aryl group, cycloalkyl group, COOH group, COO-alkyl group, ##STR45## (wherein Z.sup.1 and Z.sup.2 represent, independently of each other, hydrogen atoms or alkyl groups, or Z.sup.1 and Z.sup.2 may form a ring composed of carbon atoms or a ring composed of carbon atoms containing hetero atoms) or ##STR46## (wherein Z.sup.1 and Z.sup.2 represent the same groups as indicated above, and Z.sup.3 represents oxygen or sulfur),
- m represents an integer of 1 to 5, n represents an integer of 0 to 4 (provided that m+n is 5 or less), the m number of XS and the n number of Y may be either identical or different, respectively,
- . . represents a double bond or a single bond,
- A is --(CH.sub.2)a-(D)b-(CH.sub.2)c- (D is sulfur, oxygen, NH, alkyl-substituted N or CH.sub.2, a and c are integers of 0 to 10, and b is 0 or 1), or --(CH.dbd.CH)d-CH.dbd. (d is an integer of 0 to 2, and B does not exist in the case when A represents --(CH.dbd.CH) d-CH.dbd.,
- B represents a hydrogen atom, an alkyl group, amino group, monoalkylamino group, dialkylamino group, acylamino group, hydroxyl group, an alkoxy group, trialkylsiloxy group or acyloxy group, and
- R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different, and are hydrogen atoms, straight or branched chain alkyl groups having 1 to 7 carbon atoms or pharmaceutically acceptable cations.
- 2. The method defined in claim 1 wherein said effective amount is about 0.1 mg-5.0 g once or several times per one day to seven days.
Priority Claims (2)
Number |
Date |
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Kind |
3-226175 |
Sep 1991 |
JPX |
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4-179802 |
Jul 1992 |
JPX |
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Parent Case Info
This application is a division of application Ser No. 08/340,819, filed on Nov. 17, 1994, now U.S. Pat. No. 5,527,940, which is a continuation of application Ser. No. 08/050,084, filed Apr. 28, 1993, now abandoned, which was filed under 35 USC 371 and based upon PCT/JP92/01140, filed Sep. 7, 1992.
US Referenced Citations (11)
Foreign Referenced Citations (6)
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Date |
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0 243 173 A2 |
Oct 1987 |
EPX |
0 407 344 A3 |
Jan 1991 |
EPX |
0 416 689 A3 |
Mar 1991 |
EPX |
0 440 809 A1 |
Aug 1991 |
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3-106893 |
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Divisions (1)
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Number |
Date |
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Parent |
340819 |
Nov 1994 |
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Continuations (1)
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Number |
Date |
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Parent |
50084 |
Apr 1993 |
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