Claims
- 1. A pharmaceutical composition for treating viral diseases containing interferon in a stable state which comprises an effective amount of human interferon, 15-60% by weight of glycerin, an organic acid buffer and a conventional pharmaceutical carrier or diluent, and pH of the composition being about 3 to 6.
- 2. A composition according to claim 1, wherein the organic acid buffer is a member selected from the group consisting of citrate buffer, succinate buffer, fumarate buffer, gluconate buffer, oxalate buffer, lactate buffer and acetate buffer and is formulated in an amount of 0.01 to 0.2 mole/kg composition.
- 3. A composition according to claim 1, wherein the composition further includes an anionic surfactant.
- 4. A composition according to claim 3, wherein the anionic surfactant is a member selected from the group consisting of sodium alkyl sulfate, the alkyl group of which has 8 to 18 carbon atoms; sodium polyoxyethylene alkyl ether sulfate, the average number of mole of ethylene oxide added of which is 2 to 4 and the alkyl group of which has 8 to 18 carbon atoms; sodium alkyl sulfosuccinte, the alkyl group of which has 8 to 18 carbon atoms; and a mixture thereof and is formulated in an amount of 0.008 to 4% by weight based on the composition.
- 5. A composition according to claim 1 or 3 in the form for application in the oral cavity.
- 6. A composition according to claim 1 or 3 in the form for topical application to the skin.
- 7. A composition according to claim 1 or 3 in the form for rectal administration.
- 8. A composition according to claim 1 or 3 in the form for vaginal administration.
- 9. A composition according to claim 1 or 3 in the form for urethral administration.
- 10. A composition according to claim 1 or 3 in the form for application to the eye.
- 11. A composition according to claim 1 or 3 in the form for application to the nose.
- 12. A composition according to claim 1 or 3 in the form for application to the throat.
- 13. A composition according to claim 1 or 3, wherein interferon having the specific activity of at least 1.times.10.sup.5 IU/mg protein is formulated in an amount of at least 1.times.10.sup.4 IU per 100 g of the composition.
Priority Claims (5)
Number |
Date |
Country |
Kind |
56-191250 |
Nov 1981 |
JPX |
|
56-191251 |
Nov 1981 |
JPX |
|
56-191252 |
Nov 1981 |
JPX |
|
56-191253 |
Nov 1981 |
JPX |
|
57-049444 |
Mar 1982 |
JPX |
|
Parent Case Info
This application is a continuation-in-part application of pending application Ser. No. 443,620 filed Nov. 22, 1982 now abandoned.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3981991 |
Stewart et al. |
Sep 1976 |
|
4100150 |
Cartwright |
Jul 1978 |
|
4137307 |
Funakoshi et al. |
Jan 1979 |
|
4252791 |
Grossberg et al. |
Feb 1981 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
102519 |
Aug 1980 |
JPX |
164630 |
Dec 1980 |
JPX |
Non-Patent Literature Citations (1)
Entry |
International Publication No. WO83/0119, Publication Date 4/14/83. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
443620 |
Nov 1982 |
|