Claims
- 1. A pharmaceutical composition, comprising:
- (A) an effective amount of a 9-cis-retinoic acid-.alpha.-tocopherol ester represented by the formula (I): ##STR2## (B) A synergistic effective amount of at least one compound selected from the group consisting of 1.alpha.,25-dihydroxyvitamin D.sub.3 and 9-cis-retinoic acid; and
- (C) a pharmaceutically acceptable carrier.
- 2. The composition of claim 1, which comprises 1.alpha.,25-dihydroxyvitamin D.sub.3.
- 3. A method for the treatment of leukemia, comprising administering to a patient suffering from leukemia a therapeutically effective amount the composition of claim 1.
- 4. The method of claim 3, wherein the composition comprises 1.alpha.,25-dihydroxyvitamin D.sub.3.
- 5. The method of claim 4, wherein the amount of 1.alpha.,25-dihydroxyvitamin D.sub.3 administered to the patient is sufficiently low so as not to produce side effects.
- 6. The method of claim 5, wherein the amount of 1.alpha.,25-dihydroxyvitamin D.sub.3 administered to the patient is is a daily dose of from 0.005 .mu.g to 5 .mu.g for an adult patient.
- 7. The method of claim 4, wherein the amount of the 9-cis-retinoic acid-.alpha.-tocopherol ester administered to the patient is a daily dose of from 10 mg to 1200 mg for an adult patient.
- 8. The method of claim 3, wherein the amount of the 9-cis-retinoic acid-.alpha.-tocopherol ester administered to the patient is a daily dose of from 10 mg to 1200 mg for an adult patient.
- 9. The method of claim 3, wherein said leukemia is acute promyelocytic leukemia.
- 10. A method of inducing the differentiation of leukemia cells in a patient in need thereof comprising treating the patient with an effective amount of the composition of claim 1, thereby inducing differentiation of the leukemia cells.
- 11. A method of inducing the differentiation of leukemia cells in a patient in need thereof comprising treating the patient with an effective amount of the composition of claim 2, thereby inducing differentiation of the leukemia cells.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8-171028 |
Jul 1996 |
JPX |
|
Parent Case Info
The present application is a Divisional of U.S application Ser. No. 08/884,040 filed Jun. 27, 1997 now U.S. Pat. No. 5,827,878.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3878202 |
Fukawa et al. |
Apr 1975 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
884040 |
Jun 1997 |
|