Claims
- 1. A pharmaceutical composition suitable for use in producing an anti-inflammatory effect in a warm-blooded animal which comprises a compound of the formula: ##STR20## wherein R.sup.1 is hydroxy, R.sup.2 is fluoro, R.sup.3 and R.sup.5 are hydrogen and R.sup.4 is chloro, bromo or iodo; or R.sup.2 and R.sup.5 are hydrogen, and R.sup.3 and R.sup.4 are each independently chloro, bromo or iodo; and in either case R.sup.6, R.sup.7 and R.sup.8 are hydrogen and X is oxygen; or a pharmaceutically acceptable base-addition salt thereof; together with a pharmaceutically acceptable diluent or carrier.
- 2. The pharmaceutical composition of claim 1 wherein the compound of formula I is selected from the group consisting of 2-(2-fluoro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazin-4-ylacetic acid, 2-(3-chloro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazin-4-ylacetic acid, and the pharmaceutically acceptable base-addition salts thereof.
- 3. The pharmaceutical composition of claim 1 which is in a form suitable for oral administration, said form being one of a tablet, capsule, suspension or solution.
- 4. A method for the production of an anti-inflammatory effect in a warm-blooded animal requiring such treatment which comprises administering to said animal a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable base-addition salt thereof, as defined in claim 1.
- 5. The method of claim 4 wherein said compound is selected from the group consisting of 2-(2-fluoro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazin-4-ylacetic acid, 2-(3-chloro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazine-4-ylacetic acid, and the pharmaceutically acceptable base-addition salts thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
54142/77 |
Dec 1977 |
GBX |
|
Parent Case Info
This is a division of application Ser. No. 964,725, filed Nov. 29, 1978, now U.S. Pat. No. 4,251,528.
US Referenced Citations (7)
Foreign Referenced Citations (1)
Number |
Date |
Country |
1502312 |
Mar 1978 |
GBX |
Non-Patent Literature Citations (2)
Entry |
Jour. Khim. Farm Zh vol. 4, cl 22-26 (1970). |
Chem. Abstracts vol. 73, p. 366 (77173y) 1970. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
964725 |
Nov 1978 |
|