Claims
- 1. A pharmaceutical composition comprising as active ingredient an effective amount of at least one alkanolamine selected from compounds of the formula: ##STR41## wherein A is alkylene of from 2 to 12 carbon atoms, wherein R.sup.1 is hydrogen, or alkyl, halogenoalkyl, alkenyl or cycloalkyl each of up to 10 carbon atoms, or aryl of the formula: ##STR42## wherein R.sup.2, R.sup.3, R.sup.12 and R.sup.13, which may be the same or different, each is hydrogen, halogen, hydroxy, amino, nitro or cyano, alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, cycloalkoxy, alkenyloxy, alkynyloxy or alkanoyl each of up to 6 carbon atoms, or aryl, aryloxy or aralkoxy each of up to 12 carbon atoms; wherein R.sup.4 is hydrogen, hydroxy or hydroxymethyl or aralkoxy of up to 12 carbon atoms; wherein R.sup.14 is hydrogen, amino or dialkylamino of up to 12 carbon atoms; wherein X is carbonyl (--CO--) and wherein Y is imino (--NH--), or alkylimino of up to 6 carbon atoms and the acid-addition salts thereof, in association with a pharmaceutically-acceptable diluent or carrier therefor.
- 2. A composition as claimed in claim 1 wherein the active ingredient is selected from compounds of the formula given in claim 1 wherein A is ethylene, 1-methylethylene or 1,1-dimethylethylene, R.sup.1 is phenyl, R.sup.12 is hydrogen, chloro, nitro, methyl or methoxy, R.sup.13 and R.sup.14 are both hydrogen, Y is imino, X is carbonyl, R.sup.2 is hydrogen or chloro, cyano, nitro, methyl, allyl, methoxy or allyloxy in the ortho- or meta- position of the benzene ring and R.sup.3 and R.sup.4 are both hydrogen; and the acid-addition salts thereof.
- 3. A composition as claimed in claim 1 wherein the active ingredient is selected from compounds of the formula given in claim 1 wherein A is ethylene, 1-methylethylene or 1,1-dimethylethylene, R.sup.1 is alkyl or cycloalkyl each of up to 6 carbon atoms or phenyl, R.sup.12 is hydrogen, methyl, methoxy or phenyl, R.sup.13 and R.sup.14 are both hydrogen, Y is imino, X is carbonyl, R.sup.2 is hydrogen or hydroxy, R.sup.3 is hydrogen and R.sup.4 is hydroxy; and the acid-addition salts thereof.
- 4. A composition as claimed in claim 1 wherein the active ingredient is selected from:
- 1-phenoxy-3-.beta.-(3-phenylureido)ethylamino-2-propanol;
- 1-(2-cyanophenoxy)-3-.beta.-(3-phenylureidoethyl)amino-2-propanol;
- 1-phenoxy-3-.beta.-(3-n-butylureidoethyl)amino-2-propanol;
- and the acid-addition salts thereof.
- 5. A composition as claimed in claim 1 wherein the active ingredient is selected from:
- 1-(4-hydroxyphenoxy)-3-.beta.-(3-phenylureido)ethylamino-2-propanol;
- 1-(3,4-dihydroxyphenoxy)-3-.beta.-(3-phenylureido)ethylamino-2-propanol;
- 1-(3-hydroxyphenoxy)-3-.beta.-(3-phenylureido)ethylamino-2-propanol;
- and the acid-addition salts thereof.
- 6. A composition as claimed in claim 1 wherein the acid-addition salt is a hydrochloride, hydrobromide, phosphate, sulphate, oxalate, lactate, tartrate, acetate, salicylate, citrate, benzoate, .beta.-naphthoate, adipate or 1,1-methylene-bis-(2-hydroxy-3-naphthoate), or a salt derived from a sulphonated polystyrene resin.
- 7. A composition as claimed in claim 1 which additionally contains one or more drugs selected from sedatives, vasodilators, diuretics, hypotensive agents, cardiac membrane stabilising agents, agents used in the treatment of Parkinson's disease and other tremors, cardiotonic agents, .alpha.-adrenergic blocking agents and sympathomimetic bronchodilators.
- 8. A method for the treatment or prophylaxis of heart diseases and hypertension in warm-blooded animals which comprises administering to said animals a therapeutically effective amount of at least one alkanolamine or salt thereof as defined in claim 1.
- 9. A method for producing coronary .beta.-adrenergic blockade in warm-blooded animals in need of such blockade which comprises administering to said animals a therapeutically effective amount of at least one alkanolamine or salt thereof defined in claim 1.
- 10. A method for the treatment of acute or chronic heart failure in warm-blooded animals which comprises administering to said animals a therapeutically effective amount of at least one cardiac stimulant alkanolamine or salt thereof, defined in claim 1, which has the formula given in claim 1 wherein one or more of the substituents R.sup.2, R.sup.3 and R.sup.4 is hydroxy and the other substituents are as defined in claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
5790/72 |
Dec 1972 |
GB |
|
43478/73 |
Sep 1973 |
GB |
|
Parent Case Info
This is a division of application Serial No. 738,173 filed November 2, 1976, now U.S. Patent No. 4,083,992 which is a division of application Ser. No. 607,995, filed August 26, 1975, now U.S. patent 4,010,189, which in turn is a division of Serial No. 421,669, filed December 4, 1973, now U.S. patent 3,928,412.
US Referenced Citations (7)
Divisions (3)
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Number |
Date |
Country |
Parent |
738173 |
Nov 1976 |
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Parent |
607995 |
Aug 1975 |
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Parent |
421669 |
Dec 1973 |
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