Claims
- 1. A method of down-regulating the immune response via cytokine release and receptor expression by immune and non-immune cells, interleukin-1 (IL-1) release or IL-1 and interleukin-2 (IL-2) release from interleukin-1 and interleukin-2 releasing cells in a living mammal which comprises administering thereto an immunosuppressive amount of calcitonin gene-related peptide (CGRP).
- 2. A method according to claim 1, wherein the human being is suffering from a hyperimmune response-related disease resulting from the cytokine release and the amount of CGRP administered is effective to ameliorate the disease.
- 3. A method according to claim 2, wherein the CGRP is administered by injection.
- 4. A method according to claim 3, wherein the injection is intramuscular.
- 5. A pharmaceutical composition adapted for noningestion systemic administration which comprises per unit dosage an IL-1 release-inhibiting amount of CGRP in admixture with a pharmaceutically acceptable carrier.
- 6. A pharmaceutical composition according to claim 5, adapted for injection.
- 7. A pharmaceutical composition according to claim 6, wherein the admixture is a dry solid which is soluble in water.
Parent Case Info
This is a continuation, of the application Ser. No. 08/125,275 filed Sep. 23, 1993 now U.S. Pat. No. 5,635,478 which is a continuation of Ser. No. 07/408,573, filed Sep. 18, 1989, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5635478 |
Vignery |
Jun 1997 |
|
Non-Patent Literature Citations (4)
Entry |
Nong et al., Journal of Immunology, vol. 143, pp. 45-49, No. 1, Jul. 1, 1989. |
Asahina et al.,Proc. Natl. Acad. Sci. USA, vol. 92, pp. 8323-8327, Aug. 1995. |
Asahina et al., Journal of Immunology, Inhibition of Induction of Hypersensitivity by CGRP, Dec. 94, pp. 3056-3061. |
Palluault et al., "Targeted Expression of Calcitonin Gene Related Peptide to Beta Cells of NOD Mice Prevents Insulin-Dependent Diabetes Mellitus", Yale University, Abs S518, 1995. |
Continuations (2)
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Number |
Date |
Country |
Parent |
125275 |
Sep 1993 |
|
Parent |
408573 |
Sep 1989 |
|