Claims
- 1. A pharmaceutical composition consisting of a therapeutically effective amount of an otherwise readily oxidizable drug for the treatment of skin contained in a carrier, said carrier consisting of about 40 to 60% liquid paraffin, about 40 to 60% solid paraffin, and about 0.5 to 5% microcrystalline wax, said drug being substantially stable against oxidation when contained in said carrier, said readily oxidizable drug being selected from the group consisting of dithranol, 10-acyl dithranol, chrysarobin, podophyllin, 5-fluorouracil, idoxuridine, benzoylperoxine, and tretinoin.
- 2. A composition according to claim 1 wherein the carrier consists of about 45 to 55% of liquid paraffin, about 45 to 55% of solid paraffin, and about 1 to 3% of microcrystalline wax.
- 3. A composition according to claim 2 wherein the carrier consists of about 48 to 51% of liquid paraffin, about 47 to 50% of solid paraffin, and about 1.5 to 2.5% of microcrystalline wax.
- 4. A composition according to claim 1 wherein said composition is in a stick-shaped form.
- 5. A composition according to claim 1 wherein the melting point of the microcrystalline wax is about 75.degree. to 90.degree. C.
- 6. A composition according to claim 5 wherein the melting point of the microcrystalline wax is about 85.degree. to 88.degree. C.
- 7. A composition according to claim 2 wherein the melting point of the microcrystalline wax is about 75.degree. to 90.degree. C.
- 8. A composition according to claim 3 wherein the melting point of the microcrystalline wax is about 75.degree. to 90.degree. C.
- 9. A composition according to claim 7 wherein the melting point of the microcrystalline wax is about 85.degree. to 88.degree. C.
- 10. A composition according to claim 8 wherein the melting point of the microcrystalline wax is about 85.degree. to 88.degree. C.
- 11. A composition according to claim 2 wherein the drug is dithranol.
- 12. A composition according to claim 2 wherein the drug is 10-acyl dithranol.
- 13. A composition according to claim 12 wherein the carrier consists of about 49.5% of liquid paraffin, about 48.5% of solid paraffin, and about 2.0% of microcrystalline wax whose melting point is about 85.degree. to 88.degree. C.
Priority Claims (1)
Number |
Date |
Country |
Kind |
812177 |
Jul 1981 |
FIX |
|
Parent Case Info
This is a continuation of application Ser. No. 768,172, filed on Aug. 22, 1985 and now abandoned, which is a continuation of application Ser. No. 478,529, filed Mar. 8, 1983, also now abandoned.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/FI82/00026 |
7/8/1982 |
|
|
3/8/1983 |
3/8/1983 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO83/00084 |
1/20/1983 |
|
|
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3957969 |
Fujiyama et al. |
May 1976 |
|
4327114 |
Brickl et al. |
Apr 1982 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
3002089 |
Jul 1981 |
DEX |
Continuations (2)
|
Number |
Date |
Country |
Parent |
768172 |
Aug 1985 |
|
Parent |
478529 |
Mar 1983 |
|