Claims
- 1. A pharmaceutical composition comprising a therapeutically effective amount of a compound of the general formula: ##STR48## wherein one of A and B is a group (G) of the formula: ##STR49## and the other is a group R.sup.5 wherein R.sup.1 is an aryl group or a substituted aryl group wherein the substituent is halogen, hydroxy, C.sub.(1-6) lower alkoxy, C.sub.(1-6) lower alkylenedioxy, halo C.sub.(1-6) lower alkyl, cyano, nitro, mono- or di-C.sub.(1-6) alkylamino or C.sub.(1-6) lower alkanoylamino; or a 5-membered or 6-membered C.sub.(1-6) alkyl substituted or unsubstituted heterocyclic group containing a heteroatom selected from oxygen, nitrogen and sulfur, or a condensed heterocyclic group consisting of a heterocycle as defined above and a benzene nucleus, and R.sup.4 and R.sup.5 are both hydrogen or together form a single chemical bond, R.sup.2 and R.sup.2' are independently hydrogen, halogen, nitro, C.sub.(1-6) lower alkyl or C.sub.(1-6) lower alkoxy, and R.sup.3 and R.sup.3' are independently carboxy or its functional derivative, with the proviso that
- when one of A and B is the group (G) and the other is the group R.sup.5 wherein R.sup.4 and R.sup.5 together form a single chemical bond, R.sup.1 is unsubstituted aryl and R.sup.2 and R.sup.2' are independently hydrogen or C.sub.(1-6) lower alkyl, then R.sup.3 and R.sup.3' are independently carboxy or its functional derivative other than methyl ester,
- in association with a pharmaceutically acceptable carrier, diluent or excipient.
- 2. The pharmaceutical composition of claim 1 wherein said compound has the following general formula: ##STR50## wherein R is a residue derived from an alcohol having two or more carbon atoms by removing hydroxy group.
- 3. The pharmaceutical composition of claim 1 wherein said compoiund has the following general formula: ##STR51##
- 4. The pharmaceutical composition of claim 1 wherein said compound has the following general formula: ##STR52## wherein R is phenyl, 2-thienyl, 3-thienyl or 1-methyl2-pyrrolyl.
- 5. A method for treating allergic disease in mammals which method comprises administering to a subject in need of such treatment a therapeutically effective amount of, or a pharmaceutical composition containing therapeutically effective amount of, the compound (I') as set forth in claim 1.
Priority Claims (5)
Number |
Date |
Country |
Kind |
59-22360 |
Feb 1984 |
JPX |
|
59-169702 |
Aug 1984 |
JPX |
|
59-179064 |
Aug 1984 |
JPX |
|
59-195219 |
Sep 1984 |
JPX |
|
59-197836 |
Sep 1984 |
JPX |
|
Parent Case Info
This is a divisional of copending application Ser. No. 697,573, filed on Feb. 1, 1985, now U.S. Pat. No. 4,634,777.
Foreign Referenced Citations (5)
Number |
Date |
Country |
1235324 |
Mar 1967 |
DEX |
2659417 |
Jul 1977 |
DEX |
3209486 |
Sep 1982 |
DEX |
83431 |
Jul 1979 |
JPX |
110081 |
Jul 1981 |
JPX |
Non-Patent Literature Citations (3)
Entry |
Black et al., Australian Journal of Chemistry, vol. 36 (1983), pp. 1133-1140. |
Shepel et al., "N,N'-Malonylbis(aminoterephthalic acid)," Chem. Abstracts, 70, 15:67926v (1969). |
Satoh et al., "Studies on Methodology of Finding Novel Anti-Allergic Agents with the Guidance of Anti-Hyaluronidase Activity," VIIIth Inter. Symposium on Med. Chem., Aug. 27-31, 1984. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
697573 |
Feb 1985 |
|