Claims
- 1. A process of preparing a granular pharmaceutical ion exchange resin composition that is readily dispersible in water comprising the step of granulating a mixture of an ion exchange resin, having a pharmaceutically active ingredient bound thereto, and a particulate sugar or sugar alcohol, with an aqueous solution of sugar or sugar alcohol as a granulating medium.
- 2. The process according to claim 1, wherein said aqueous solution of sugar or sugar alcohol is added to said mixture during said granulating step.
- 3. The process according to claim 1 wherein said sugar or sugar alcohol in the aqueous solution thereof is identical to the particulate sugar or sugar alcohol in said mixture.
- 4. The process according to claim 1 wherein said aqueous solution has a concentration of from 40% to 60% w/w of sugar alcohol.
- 5. The process according to claim 1 wherein said sugar or the sugar alcohol in said mixture and/or in said aqueous solution comprises sucrose, dextrose, maltose, fructose, lactose, mannitol, sorbitol or xylitol, preferably xylitol.
- 6. The process according to claim 1 wherein all of the sugar or the sugar alcohol particles have a particle size of 600 microns or less.
- 7. The process according to claim 6, wherein at least 90% (by wt) of the sugar or the sugar alcohol particles have a particle size of 200 microns or less.
- 8. The process according to claim 1 wherein said pharmaceutical composition contains from 25% to 99% (by weight) of the sugar or the sugar alcohol.
- 9. The process according to claim 1 wherein the amount of aqueous solution of sugar or sugar alcohol employed in the granulation is from 1% to 20% (by weight) of the final dry weight of the mixture.
- 10. The process according to claim 1 wherein after said granulating, said composition is dried until its water content is below 0.35% (by weight).
- 11. The process according to claim 1 further comprising the step of filling a capsule or a sachet with said composition.
- 12. The process according to claim 1 wherein said aqueous solution has a concentration of about 50% w/w, of sugar alcohol.
- 13. The process according to claim 1 wherein said composition contains from 70% to 95% (by weight) of the sugar or the sugar alcohol.
- 14. The process according to claim 1 wherein the amount of aqueous solution of sugar or sugar alcohol employed in the granulation is from 4% to 15%, (by weight) of the mixture.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9517883 |
Sep 1995 |
GBX |
|
Parent Case Info
This application is a 371 of PCT/GB96/02156 filed Sep. 2, 1996.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/GB96/02156 |
9/2/1996 |
|
|
5/8/1998 |
5/8/1998 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/09036 |
3/13/1997 |
|
|
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3627583 |
Troy et al. |
Dec 1971 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0200252 |
Dec 1986 |
EPX |