Claims
- 1. A dry formulation adapted for reconstitution with water, comprising:amoxycillin trihydrate and potassium clavulanate active ingredients; and microcrystalline cellulose filler, said microcrystalline cellulose being at least 20% of the weight of the dry formulation.
- 2. The formulation as claimed in claim 1, further comprising a powdered cellulose.
- 3. The formulation as claimed in claim 1, wherein the amount of microcrystalline cellulose is 20 to 70% by weight of the dry formulation.
- 4. The formulation as claimed in claim 1, wherein the amount of active ingredients are 20 to 70% by weight of the dry formulation.
- 5. The formulation as claimed in claim 1, wherein the microcrystalline cellulose has an average particle size of 50 μm.
- 6. The formulation as claimed in claim 1, wherein the ratio between amoxycillin trihydrate and potassium clavulanate is between 1:1 to 20:1, the weights being between expressed as the free parent acids amoxycillin and clavulanic acid.
- 7. A reconstructed aqueous suspensions or dispersion, comprising:water; amoxycillin trihydrate and potassium clavulanate active ingredients; and microcrystalline cellulose filler, said microcrystalline cellulose being greater than 20% of the dry weight of the active ingredients and filler.
- 8. A method for treatment of bacterial infections in a pediatric or adult patient, comprising:administration to a patient in need thereof of an effective amount of a formulation comprising: water; amoxycillin trihydrate and potassium clavulanate active ingredients; and microcrystalline cellulose filler, said microcrystalline cellulose being greater than 20% of the dry weight of the active ingredients and filler.
- 9. The formulation as claimed in claim 6, wherein the ratio between amoxycillin trihydrate and potassium clavulanate is 7:1, the weights being expressed as the free parent acids amoxycillin and clavulanic acid.
- 10. The formulation as claimed in claim 6, wherein the ratio between amoxycillin trihydrate and potassium clavulanate is 14:1, the weights being expressed as the free parent acids amoxycillin and clavulanic acid.
- 11. The formulation as claimed in claim 1, wherein the amount of cellulose is 20 to 60% by weight of the dry formulation.
- 12. The formulation as claimed in claim 1, wherein the amount of cellulose is 35 to 50% by weight of the dry formulation.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9815532 |
Jul 1998 |
GB |
|
Parent Case Info
This is a 371 of PCT/GB99/02295 filed Jul. 15, 1999.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/GB99/02295 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO00/03695 |
1/27/2000 |
WO |
A |
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Number |
Date |
Country |
WO 9634605 |
Nov 1996 |
WO |
WO 9706798 |
Feb 1997 |
WO |
WO 9835672 |
Aug 1998 |
WO |
WO 9836732 |
Aug 1998 |
WO |