Claims
- 1. A pharmaceutical formulation for oral administration with controlled release of a pharmaceutically active substance and with improved bioadhesion characteristics, comprising scleroglucan and a pharmaceutically active substance in an amount of between 5 and 60% by weight and a pharmaceutically acceptable excipient in an amount of between 5 and 40% by weight, said formulation being prepared in form of tablets and capsule granulates by a) mechanically mixing said scleroglucan, said active substance and said pharmaceutically acceptable excipient in solid state and directly compressing to form a formulation in tablet form and b) mechanically disintegrating the tablets obtained in the step a) to form a capsule granulate.
- 2. The pharmaceutical formulation for oral administration as claimed in claim 1 wherein said pharmaceutically acceptable excipient is at least one member selected from the group consisting of polyethyleneglycol, gum arabic, calcium chloride, sodium borate and stearic acid.
- 3. The pharmaceutical formulation for oral administration as claimed in claim 1 wherein said capsule granulate has a particle size of between 0, 1 and 1 mm.
- 4. A method for providing controlled release of a pharmaceutically active substance in a pharmaceutical formulation which comprises a) mechanically mixing scleroglucan, a pharmaceutically active substance and a pharmaceutically acceptable excipient in a solid state, b) directly compressing the obtained mixture to form a tablet and c) mechanically disintegrating said tablet to form a capsule granulate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
19816 A/88 |
Mar 1988 |
ITX |
|
Parent Case Info
This application is a division of copending application Ser. No. 07/324,736, filed on Mar. 17, 1989 and now U.S. Pat. No. 5,068,111. The entire contents of which are hereby incorporated by reference.
US Referenced Citations (11)
Divisions (1)
|
Number |
Date |
Country |
Parent |
324736 |
Mar 1989 |
|