Claims
- 1. Pyrimido�4,5-b!indoles of the formula (IV) where R.sub.1-2 and R.sub.1-2 are taken together with the attached nitrogen atom to form 1-pyrrolidinyl;
- where R.sub.2-1 and R.sub.2-2 are taken together with the attached nitrogen atom to form 1-pyrrolidiny;
- where n.sub.1 is 1 thru 3;
- where R.sub.3-1 is:
- (1) --H,
- where R.sub.3-2 is:
- (1) --H,
- (2) --CH.sub.2 --�2-pyridinyl!,
- (3) --CH.sub.2 --�3-pyridinyl!,
- (4) --CH.sub.2 --�4-pyridinyl!,
- (5) --CH.sub.2 --�CH(OH)!.sub.4 --CH.sub.2 --OH,
- (8) --OH,
- and where R.sub.3-1 and R.sub.3-2 are taken together with the attached nitrogen atom to form a heterocyclic ring selected from the group consisting of:
- (1) 1-pyrrolidinyl,
- (2) 1-piperidinyl,
- (3) 4-morpholinyl,
- (4) 2-hydroxy-1-pyrrolidinyl,
- (5) 3-hydroxy-1-pyrrolidinyl,
- (6) 1-prolinyl and pharmaceutically acceptable salts thereof.
- 2. Tricyclic amines of formula (IV) according to claim 1 where n.sub.1 is 1.
- 3. Tricyclic amines of formula (IV) according to claim 1 where R.sub.3-1 and R.sub.3-2 are taken together with the attached nitrogen atoms to form 1-pyrrolidinyl.
- 4. Tricyclic amines of formula (IV) according to claim 1 where the pharmaceutically acceptable salts are selected from the group consisting of hydrochloride, sulfate, methanesulfonate, maleate and phosphate.
- 5. Tricyclic amines of formula (IV) according to claim 1 which are selected from the group consisting of:
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, pyrrolidine amide,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, morpholine amide,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, 2-aminomethylpyridine amide,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, amide,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, 1-amino-1-deoxysorbitol amide
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, proline amide,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, glycine amide,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, hydroxylamine amide,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, 3-hydroxypyrrolidine amide,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, 4-amino-1-butanol amide,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, 4-aminobutyric acid amide,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, 2-hydroxypyrrolidine amide.
- 6. Tricyclic amines of formula (IV) according to claim 5 which is
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, pyrrolidine amide.
- 7. Tricyclic amines of formula (IV) according to claim 5 which is
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, pyrrolidine amide, monohydrochloride,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!inol-9-yl)acetic acid, pyrrolidine amide, sulfate,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, pyrrolidine amide, methanesulfonate salt,
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, pyrrolidine amide, maleate salt and
- (2,4-di-1-pyrrolidinyl-9H-pyrimido�4,5-b!indol-9-yl)acetic acid, pyrrolidine amide, phosphate salt.
CROSS REFERENCE TO RELATED APPLICATIONS
This application claims the benefit of U.S. provisional application Ser. Nos. 60/035,223 filed Jan. 8, 1997 and 60/043,749 filed Apr. 9, 1997, under 35 USC .sctn.119(e)(i).
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