Claims
- 1. A compound which is a imidazo[5,1-f]-1,2,4-triazine or a derivative thereof of the formula (I): ##STR14## and physiologically acceptable salts thereof in which ##STR15## wherein R.sub.2 represents a hydrogen atom or a straight or branched chain alkyl radical containing from 1 to 6 carbon atoms, or Z can additionally represent a group ##STR16## and R.sub.1, R.sub.3 and R.sub.4, which may be the same or different, each represent a hydrogen atom; a cycloalkyl group, said cycloalkyl group containing from 3 to 7 carbon atoms; a phenyl group which may optionally be substituted by one or more hydroxy, alkoxy or halogen radicals, said alkoxy radical containing from 1 to 4 carbon atoms; or straight or branched alkyl or alkenyl group, said alkyl group containing from 1 to 6 carbon atoms, said alkenyl group containing 2 to 6 carbon atoms, which alkyl or alkenyl group may be substituted with a phenyl group, which phenyl group may optionally be substituted by one or more hydroxy, alkoxy or halogen radicals, said alkoxy radical containing from 1 to 4 carbon atoms.
- 2. A compound as claimed in claim 1 in which Z represents a group of the formula: ##STR17## in which R.sub.1 represents methyl, R.sub.2 represents hydrogen or methyl, R.sub.3 represents methyl, and R.sub.4 represents n-propyl or isobutyl, except that R.sub.4 does not represent isobutyl when R.sub.2 represents hydrogen.
- 3. A compound as claimed in claim 1 in which:
- R.sub.1 is hydrogen, alkyl or phenyl or phenylalkyl;
- R.sub.2 is hydrogen or alkyl;
- R.sub.3 is alkyl or phenyl;
- R.sub.4 is alkyl or cycloalkyl.
- 4. A compound as claimed in claim 3 in which:
- R.sub.1 is hydrogen, methyl, ethyl or isopropyl, phenyl, benzyl or phenethyl;
- R.sub.2 is hydrogen or methyl;
- R.sub.3 is methyl or phenyl;
- R.sub.4 is methyl, propyl or isobutyl, or cyclopentyl.
- 5. A compound as claimed in claim 1 selected from 2,5-dimethyl-7-(2-methylpropyl)imidazo[5,1-f]-1,2,4-triazin-4(3H)-one and physiologically acceptable salts thereof.
- 6. A compound as claimed in claim 1 selected from 3,4-dihydro-2,5-dimethyl-7-propylimidazo[5,1-f]-1,2,4-triazine and physiologically acceptable salts thereof.
- 7. A compound as claimed in claim 1 selected from 3,4-dihydro-7-(2-methylpropyl)-2,4,5-trimethylimidazo[5,1-f]-1,2,4-triazine and physiologically acceptable salts thereof.
- 8. A compound as claimed in claim 1 selected from 2-(1-methylethyl)-5-methyl-7-(2-methylpropyl)imidazo[5,1-f]-1,2,4-triazin-4(3H)-one, and physiologically acceptable salts thereof.
- 9. A pharmaceutical composition comprising at least one compound as claimed in claim 1 in association with a physiologically acceptable carrier.
- 10. A composition as claimed in claim 9 including supplementary medicinal agents.
- 11. A composition as claimed in claim 9 in the form of solid or liquid preparations for oral use, as suppositories or injections or forms suitable for inhalation.
- 12. A composition as claimed in claim 11 in the form of a powder which may be inhaled.
- 13. A composition as claimed in claim 9 in dosage unit form.
- 14. A method for the treatment of a patient suffering from a condition involving constriction of the bronchial muscle which comprises administering an effective amount of a compound as claimed in claim 1.
Priority Claims (2)
Number |
Date |
Country |
Kind |
12598/77 |
Mar 1977 |
GBX |
|
47250/77 |
Nov 1977 |
GBX |
|
Parent Case Info
This is a continuation, of application Ser. No. 888,522, filed Mar. 21, 1978, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3941785 |
Clarke et al. |
Mar 1976 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
1400999 |
Jul 1975 |
GBX |
Continuations (1)
|
Number |
Date |
Country |
Parent |
888522 |
Mar 1979 |
|