Claims
- 1. A cyclopropane derivative of the formula ##STR8## wherein Ar is phenyl or phenyl monosubstituted or polysubstituted by F, Cl, Br, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.2-4 alkenyloxy, C.sub.1-4 alkylthio, OH, SH, CN, methylenedioxy or CF.sub.3 ; and R is H, C.sub.1-4 alkyl or benzyl, or a physiologically acceptable acid addition salt thereof.
- 2. A compound of claim 1 wherein Ar is phenyl or phenyl substituted by F, Cl, CH.sub.3 O, CH.sub.2 .dbd.CHCH.sub.2 O, CH.sub.3 S, OH, SH, CN or CF.sub.3 and R is H, CH.sub.3 or benzyl.
- 3. A compound of claim 1, wherein Ar is m- or p-fluorophenyl, p-chlorophenyl, o-, m- or p-methoxyphenyl, o-allyloxyphenyl, p-methylthiophenyl or p-trifluoromethylphenyl and R is H, CH.sub.3 or benzyl.
- 4. A compound of claim 1 wherein Ar is m- or p-fluorophenyl, p-chlorophenyl, o-, m- or p-methoxyphenyl, o-allyloxyphenyl, p-methylthiophenyl or p-trifluoromethylphenyl and R is H or CH.sub.3.
- 5. A compound of claim 1 wherein Ar is o-methoxyphenyl or p-trifluoromethyl-phenyl and R is H, CH.sub.3 or benzyl.
- 6. A compound of claim 1 wherein Ar is p-trifluoromethylphenyl and R is H, CH.sub.3 or benzyl.
- 7. 1-Methylamino-3-cyclopropyl-3-p-trifluoromethyl-phenoxypropane, a compound of claim 1.
- 8. 1 Dimethylamino-3-cyclopropyl-3-p-trifluoromethylphenoxy-propane, a compound of claim 1, and its hydrochloride.
- 9. A pharmaceutical composition for treating depression, comprising an antidepressantly effective amount of a compound of claim 1 and a pharmaceutically acceptable adjuvant.
- 10. A pharmaceutical composition of claim 9 wherein the amount of active compound is 2-500 mg.
- 11. A method of treating depression in a patient in need of such treatment comprising administering an antidepressantly effective amount of a compound of claim 1 to the patient.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3017812 |
May 1980 |
DEX |
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Parent Case Info
This application is a continuation-in-part of application Ser. No. 261,820, filed 5/8/81 now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3253040 |
Potter et al. |
May 1966 |
|
3928426 |
Welstead, Jr. |
Dec 1975 |
|
4207343 |
Lavagnino et al. |
Jun 1980 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0196386 |
Mar 1958 |
ATX |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
261820 |
May 1981 |
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