Claims
- 1. A compound of the formula: ##SPC10##
- wherein A is such that there is formed together with the carbon atom shown an unsaturated heterocyclic nucleus, said unsaturated heterocyclic nucleus being an imidazole, pyrazole, pyrimidine, pyrazine or pyridazine ring; X.sub.1 is hydrogen, lower alkyl, hydroxy, trifluoromethyl, benzyl, halogen, amino or ##EQU6## in which E' is NH or N-cyano; X.sub.2 is hydrogen or when X.sub.1 is lower alkyl, lower alkyl or halogen; k is 0 to 2 and m is 2 or 3, provided that the sum of k and m is 3 or 4; Y is oxygen, sulphur or NH; E is NR.sub.2 ; R.sub.1 is hydrogen, lower alkyl or di-lower alkylamino-lower alkyl; and R.sub.2 is hydrogen, nitro or cyano, or a pharmaceutically acceptable addition salt thereof with the proviso that X.sub.1 is ##EQU7## only when E is NH or N-cyano.
- 2. A compound of claim 1 wherein Y is oxygen or sulphur.
- 3. A compound of claim 1 wherein Y is NH.
- 4. A compound of claim 1 wherein said unsaturated heterocyclic nucleus is imidazole, pyrazole, pyrimidine pyrazine or pyridazine and R.sub.2 is hydrogen or nitro.
- 5. A compound of claim 4 wherein k is 1 and m is 2.
- 6. A compound of claim 1 wherein said unsaturated heterocyclic nucleus is imidazole.
- 7. A compound of claim 6 wherein X.sub.1 is hydrogen, methyl, bromo, hydroxyl or amino and X.sub.2 is hydrogen; Y is sulphur and R.sub.1 is methyl.
- 8. A compound of claim 1, said compound being N-cyano-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidine.
- 9. A compound of claim 1, said compound being 2-(4-imidazolylmethylthio)ethyleneguanidine sulphate.
- 10. A compound of claim 1, said compound being N-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N'-nitroguanidine.
- 11. A compound of claim 1, said compound being N-cyano-N'-ethyl-N"-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidine
- 12. A compound of claim 1, said compound being N-[2-((4-bromo-5-imidazolyl)methylthio)ethyl]-N'-cyano-N"-methylguanidine.
- 13. A compound of claim 1, said compound being N-cyano-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine.
- 14. A compound of claim 1, said compound being N-cyano-N'-[2-(4-imidazolylmethylthio)ethyl]-N"-methylguanidine.
- 15. A compound of claim 1, said compound being N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)-ethyl]-N"-propylguanidine.
- 16. A compound of claim 1, said compound being N-cyano-N'-methyl-N"-[2-((1-methyl-2-imidazolyl)-methylthio)ethyl]guanidine.
- 17. A compound of claim 1, said compound being N-cyano-N'-[2-(2-imidazolylmethylthio)ethyl]-N"-methylguanidine.
- 18. A compound of claim 1, said compound being N-cyano-N'-methyl-N"-[2-((5-trifluoromethyl-4-imidazolyl)methylthio)ethyl]guanidine.
- 19. A compound of claim 1, said compound being N-cyano-N'-[2-(4-imidazolylmethoxy)ethyl]-N"-methylguanidine.
- 20. A compound of claim 1 said compound being N-cyano-N'-methyl-N"-[2-(3-pyrazolylmethylthio)-ethyl]guanidine.
- 21. A compound of claim 1, said compound being N-cyano-N'-methyl-N"-[2-(2-pyrazinylmethylthio)ethyl]guanidine.
- 22. A compound of claim 1, said compound being N-cyano-N'-methyl-N"-[2-(3-pyridazinylmethylthio)ethyl]guanidine.
Parent Case Info
This application is a continuation-in-part of Ser. No. 290,584 filed Sept. 20, 1972, now abandoned, which is a continuation-in-part of Ser. No. 230,451 filed Feb. 29, 1972, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3354174 |
Bell |
Nov 1967 |
|
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
290584 |
Sep 1972 |
|
Parent |
230451 |
Feb 1972 |
|