The invention relates to the field of ultrasound detection.
In the last decade, there has been an increasing interest in optical techniques for ultrasound detection, as alternative to piezoelectric devices, e.g., in biomedical applications. One of the common optical approaches for ultrasound detection is the use of optical resonators, which can trap light within small volumes and thus facilitate detector miniaturization without loss of sensitivity. When an acoustic wave impinges on an optical resonator, it perturbs its refractive index and deforms its structure, resulting in a modulation of the resonance wavelength. By monitoring the shifts in the resonance wavelength, one can effectively measure the ultrasound-induced pressure within the resonator.
The foregoing examples of the related art and limitations related therewith are intended to be illustrative and not exclusive. Other limitations of the related art will become apparent to those of skill in the art upon a reading of the specification and a study of the figures.
The following embodiments and aspects thereof are described and illustrated in conjunction with systems, tools and methods which are meant to be exemplary and illustrative, not limiting in scope.
There is provided, in an embodiment, a method comprising: generating a pulsed laser beam comprised of non-interfering pulse-pairs having a phase difference, wherein said phase difference changes between each two consecutive cycles of said pulse-pairs; directing said pulsed laser beam at one or more optical resonators, wherein each of said one or more optical resonators is impinged by acoustic waves, to cause said pulsed laser beam to propagate through each of said one or more optical resonators, thereby interfering said pulse-pairs; and calculating shifts in a spectral response of each of said one or more optical resonators based on measuring said interference, wherein said shifts are indicative of a waveform of said acoustic waves.
In some embodiments, each of said cycles of said pulse-pairs comprises one or more consecutive pulse-pairs.
In some embodiments, said calculating is performed with respect to at least two cycles of said pulse-pairs.
In some embodiments, said pulse-pairs have identical wavelengths.
In some embodiments, said one or more optical resonators are selected from the group consisting of: π phase-shifted Bragg grating (π-BG), Fabry-Perot cavity, and optical-ring resonator.
In some embodiments, said generating of said pulse-pairs is performed from a single pulse via an active unbalanced Mach-Zehnder interferometer (MZI) with a phase modulator in one of its arms.
In some embodiments, said phase modulator is configured to induce a constant phase shift during a duration of each of said pulses.
In some embodiments, said measuring further comprises measuring an optical power transmission in said propagated pulsed laser beam, wherein said optical power transmission is indicative of said shifts is said spectral response.
In some embodiments, said measuring of said optical power transmission is performed by at least one photo-detector.
In some embodiments, said acoustic waves are ultrasound acoustic waves.
There is also provided, in an embodiment, a system comprising: one or more optical resonators; and an interferometer configured to generate, from a pulsed laser beam source, a pulsed laser beam comprised of non-interfering pulse-pairs having a phase difference, wherein said phase difference changes between each two consecutive cycles of said pulse-pairs; wherein said pulse-pairs are directed to said one or more optical resonators to propagate said pulse-pairs through said one or more optical resonators, thereby interfering said pulse-pairs.
In some embodiments, said interferometer is further configured to measure said interference when said one or more optical resonators are being impinged by acoustic waves, to calculate shifts in a spectral response of each of said one or more optical resonators based on said measuring; wherein said shifts are indicative of a waveform of said acoustic waves.
In some embodiments, said calculating is performed with respect to at least two cycles of said pulse-pairs.
In some embodiments, each of said cycles of said pulse-pairs comprises one or more consecutive pulse-pairs.
In some embodiments, said pulse-pairs have identical wavelengths.
In some embodiments, said one or more optical resonators are selected from the group consisting of: π phase-shifted Bragg grating (π-BG), Fabry-Perot cavity, and optical-ring resonator.
In some embodiments, said interferometer is an active unbalanced Mach-Zehnder interferometer (MZI) with a phase modulator in one of its arms, configured to generate said pulse-pairs from a single pulse.
In some embodiments, said phase modulator is configured to induce a constant phase shift during a duration of each of said pulses.
In some embodiments, said interferometer is further configured to measure an optical power transmission in said propagated pulsed laser beam, wherein said optical power transmission is indicative of said shifts is said spectral response.
In some embodiments, said measuring of said optical power transmission is performed by at least one photo-detector.
In some embodiments, said acoustic waves are ultrasound acoustic waves.
In addition to the exemplary aspects and embodiments described above, further aspects and embodiments will become apparent by reference to the figures and by study of the following detailed description.
Exemplary embodiments are illustrated in referenced figures. Dimensions of components and features shown in the figures are generally chosen for convenience and clarity of presentation and are not necessarily shown to scale. The figures are listed below.
Disclosed herein are a system and method for ultrasound detection based on pulse interferometry (PI), configured to simultaneously interrogate multiple optical resonators with non-overlapping spectra. In some embodiments, the present disclosure provides for parallel interrogation of up to four resonators with non-overlapping spectra using only a single wave source.
In some embodiments, the present disclosure is based, at least in part, on a phase-modulation (i.e., phase modulation-pulse interferometry, or PM-PI) scheme performed at the output of the source, which couples between the intensity and wavelength at the output of the resonators. In some embodiments, a demodulation algorithm of the present disclosure may be configured to decode ultrasound-induced shifts in the wavelengths of multiple resonators from intensity measurements. Accordingly, in some embodiments, the present disclosure may only require a single photodetector and sampling channel per resonator.
Pulse interferometry has been developed as an alternative approach for interrogating optical resonators, which may potentially overcome some of the limitations that have characterized CW interrogation (see, e.g., A. Rosenthal et al., “Wideband optical sensing using pulse interferometry,” Optics Express, vol. 20, no. 17, p. 19016, August 2012; A. Rosenthal et al., “Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications,” Laser & Photonics Reviews, vol. 8, no. 3, pp. 450-457, 2014; Y. Hazan and A. Rosenthal, “Passive-demodulation pulse interferometry for ultrasound detection with a high dynamic range,” Optics Letters, vol. 43, no. 5, p. 1039, March 2018; 0. Volodarsky, Y. Hazan, and A. Rosenthal, “Ultrasound detection via low-noise pulse interferometry using a free-space Fabry-Perot,” Opt. Express, OE, vol. 26, no. 17, pp. 22405-22418, August 2018).
In PI, the source is based on a pulse laser whose bandwidth is sufficiently wide to cover the entire bandwidth in which the resonances may occur. Previously, this property was used to achieve a high dynamic range and robust operation under volatile environmental conditions. While PI may in principle be used to interrogate several resonators with non-overlapping spectra with a single source, previous demodulation schemes were not scalable, and involved relatively high costs per channel.
With continued reference to
For each phase value, the pulses interfere differently at the output of each resonator 114a-114d, depending on the phase difference in the MZI for the specific resonance wavelength of that resonator. In some embodiments, the duration of each phase value of the modulator corresponded to 5 pulses of the laser. In some embodiments, the output of each resonator 114a-114d is switched between two interferometric states, which together enable monitoring wavelength shifts of its resonance.
In some embodiments, PM 112 has only two phase states that may be experienced by each pulse, wherein the transition between the two states occurs at times when no light passes through the PM. In some embodiments, the electric fields at different positions in PM-PI system 100 are marked with the letters a-c in
e1a=2e(ω),
where ω is the angular frequency. At the two outputs of the first coupler 110a, points (a3) and (a4), the electric fields are given by, respectively
e3a=√{square root over (2)}e(ω),
and
e4a=√{square root over (2)}ie(ω),
wherein at the two inputs of the second coupler 110b, points (b1) and (b2), the following can be obtained:
e1b=√{square root over (2)}e(ω)exp(iφPM+iωnl1/c) (1a)
e2b=√{square root over (2)}ie(ω)exp(iωnl2/c) (1b)
where l1 and l2 are the lengths of the top and bottom arms of the MZI, respectively, n is the refractive index of the fiber, c is the speed of light, and φPM is the phase contribution of the PM, which may be equal to either 0 or
where Δl=l2−l1.
Neglecting global phase accumulation, the electric fields at the output of the second coupler, b3 and b4, are given by:
e3b=e(ω)[exp(iφPM)−exp(iωnΔl/c)] (2a)
e4b=e(ω)[exp(iφPM)+exp(iωnΔl/c)], (2b)
where Δl=l2−l1.
At the final stage of system, 100, the electric fields e3b and e4b can be filtered by the resonators 114a-114d, whose field transmission functions is denoted by Hi(ω), where i=1, . . . , 4.
For each resonator 114a-114d, the central frequency is denoted by ωi and the bandwidth is denoted by Δωi. In such cases, the assumption is that Δl is sufficiently small so that exp(iωnΔl/c) is approximately constant over Δωi (i=1, . . . , 4). In some embodiments, the corresponding mathematical condition can be given by:
ΔωinΔl/c<<2π (3)
In some embodiments, in cases where Eq. (3) is fulfilled, the spectra at the output of the resonators may be approximated by the following expressions:
e1,2c=e1,2H1,2(ω)[exp(iφPM)−exp(iω1,2nΔl/c)] (4a)
e3,4c=e3,4H3,4(ω)[exp(iφPM)+exp(iω3,4nΔl/c)] (4b)
where ei=e(ωi). The power at the output of each π-FBG is thus given by:
Pic=Pi[1−cos(φi+φPM−ωinΔl/c)] (5)
where Pi=2∫|eiHi(ω)|2dω, and where φi=0 for i=1,2 and φi=π for i=3,4. In practice, Δl may not fully fulfill the condition in Eq. (3), leading to the following modification in Eq. (5):
Pic=Pi[1−ηi cos(φi+φPM−ωinΔl/c)], (6)
where ηi≤1 shows the visibility of the interference.
Assuming that the two-phase states of the PM lead to φPM=0 and φPM=π/2, for each channel two expressions are obtained for the measured power, corresponding to the two states:
Pi,0c=Pi[1−ηi cos(φi−ωinΔl/c)] (7a)
Pi,π/2=Pi[1+ηi sin(φi−ωinΔl/c)], (7b)
When Pi and ηi are known from a pre-measurement calibration procedure, the sine and cosine in Eqs. (7a) and (7b) may be readily calculated from Pi,0c and Pi,π/2, and used to calculate the phase ϕi=φi−ωinΔl/c, using the four-quadrant inverse tangent (atan 2) and a phase unwrapping algorithm (see, e.g., J. M. Huntley and H. Saldner, “Temporal phase-unwrapping algorithm for automated interferogram analysis,” Appl. Opt., AO, vol. 32, no. 17, pp. 3047-3052, June 1993).
When an acoustic pulse impinges on a resonator, it leads to a modulation in ωi. Accordingly, ωi(t)=ωidc+ωiac(t) may be defined, where ωidc represents the resonance frequency before the arrival of the acoustic pulse, and ωiac(t) is the ultrasound-induced perturbation to be recovered. Assuming that the MZI is not exposed to the acoustic pulse, the term nΔl may be regarded as constant during the acoustic measurement. Thus, ωiac(t) may be readily recovered from ϕi (t):
In practice, ωiac(t) may be obtained by applying a high-pass filter on the right-hand side of Eq. (8), while ignoring the values of φi and ωidc.
In some embodiments, the output power from each of the π-FBGs 114a-114d is approximately 25 μW when the EDFA 106 is set to 100 mW average power output. In some embodiments, the components in PM-PI system 100 may be implemented with polarization-maintaining fibers to avoid polarization fading in the setup (see, e.g., D. Stowe, D. Moore, and R. Priest, “Polarization fading in fiber interferometric sensors,” IEEE Journal of Quantum Electronics, vol. 18, no. 10, pp. 1644-1647, October 1982).
In some embodiments, the MZI in
In some embodiments, as shown in
In some embodiments, the performance of PM-PI system 100 may be evaluated using an acoustic setup, e.g., as set forth in Rosenthal [2011], Rosenthal [2012], and Hazan [2018]. The π-FBGs 114a-114d may be placed in a water bath briefly, along with an ultrasound transducer with a central frequency of 1 MHz. To maximize the resonance frequency shift in the fibers, the orientation of the transducer may be adjusted to an angle of 30° with respect to the optical fibers, leading to excitation of a guided acoustic wave in the fibers, which has been previously shown to generate a stronger response than normal-incidence waves (see, e.g., A. Rosenthal, M. Á. A. Caballero, S. Kellnberger, D. Razansky, and V. Ntziachristos, Opt. Lett., 37, 3174, (2012); I. A. Veres, P. Burgholzer, T. Berer, A. Rosenthal, G. Wissmeyer, and V. Ntziachristos, J. Acoust. Soc. Am., 135, 1853, (2014)).
In a first measurement, the signal from a single π-FBG may be measured using the present system as well as the original implementation of PI developed in Rosenthal [2012], in which active stabilization of the MZI was used (A-PI). Since A-PI suffers from non-linear signal folding when the acoustic signal is too strong (Hazan [2018]), the magnitude of the ultrasound burst may be chosen to be sufficiently small to fit the linear-operation range of the MZI, i.e., 600 MHz in the present implementation.
In the second measurement, the ability of PM-PI for parallel interrogation is demonstrated with the four π-FBGs whose spectra are shown in
Accordingly, in some embodiments, there is demonstrated a novel scheme for parallel interrogation of resonator-based interferometric detectors of ultrasound. The present disclosure is based on a variation PI, in which the pulses are modulated at the input of the resonators by a PM. The modulation enables the coding in time of two interference states, which facilitates digital demodulation of the desired signals from simple power measurements. While the PM in this work operated at only 10% of the pulse rate, reducing the measurement bandwidth by the same proportion, in an ideal implementation the PM modulation frequency may be set at 50% of the pulse repetition rate. For the pulse laser used in this work, which had a repetition rate of 250 MHz, PM-PI with a modulation frequency of 125 MHz corresponds to an acoustic bandwidth of 62.5 MHz, which is compatible with most imaging applications.
In some embodiments, the present disclosure may overcome a major limitation of interferometric detectors of ultrasound—the inability to simultaneously interrogate several resonators with non-overlapping spectra.
This application is a National Phase of PCT Patent Application No. PCT/IL2019/050923 having International filing date of Aug. 19, 2019, which claims the benefit of priority from U.S. Provisional Patent Application No. 62/719,672, filed on Aug. 19, 2018, the contents of which are all incorporated by reference herein in their entirety.
Filing Document | Filing Date | Country | Kind |
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PCT/IL2019/050923 | 8/19/2019 | WO |
Publishing Document | Publishing Date | Country | Kind |
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WO2020/039427 | 2/27/2020 | WO | A |
Number | Name | Date | Kind |
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20010042410 | Ogawa | Nov 2001 | A1 |
20120156802 | Flagan et al. | Jun 2012 | A1 |
20140114187 | Rozental | Apr 2014 | A1 |
20180003552 | Lewin | Jan 2018 | A1 |
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