Claims
- 1. A therapeutic composition in dosage unit form effective to inhibit the release of chemical mediators that are responsible for the symptoms of allergic diseases which comprises an effective amount of a compound of the formula: ##STR37## wherein R.sub.1 is at position 4 and either is an alkyl group of 1-6 C or is an --(CH.sub.2).sub.3 -- which is additionally linked to the phenyl at position 3 thereof;
- R.sub.2 is a lower alkyl of 1-3 C or is hydrogen;
- n.sub.1, n.sub.2 and n.sub.3 represent the number of CH.sub.2, C(R.sub.2).sub.2 and CH.sub.2 groups, respectively, wherein n.sub.1 is 2, 3, 4, 5, 6, 8 or 11, n.sub.2 is 0 or 1 and n.sub.3 is 0 and
- R.sub.4 is an alkyl residue of 1-12 C or is selected from phenyl and pyridyl;
- in admixture with an inert pharmaceutically acceptable carrier.
- 2. The composition of claim 1 wherein n.sub.2 and n.sub.3 are zero, and n.sub.1 is 2-8.
- 3. The composition of claim 2 wherein R.sub.1 is t-butyl.
- 4. The composition of claim 1 wherein R.sub.1 is propylene.
- 5. The composition of claim 1 wherein R.sub.4 is selected from H(CH.sub.2).sub.m,wherein m is 1-5; phenyl; and 3-pyridyl.
- 6. The composition of claim 1 wherein the dosage unit form is a tablet or capsule.
- 7. A method to inhibit the release of chemical mediators that are responsible for the symptoms of allergic diseases in an animal in need of such treatment, which method comprises administering to said animal an effective amount of a compound of the formula: ##STR38## wherein R.sub.1 is at position 4 and either is an alkyl group of 1-6 C or is an --(CH.sub.2).sub.3 -- which is additionally linked to the phenyl at position 3 thereof;
- R.sub.2 is a lower alkyl of 1-3 C or is hydrogen;
- n.sub.1, n.sub.2 and n.sub.3 represent the number of CH.sub.2, C(R.sub.2).sub.2 and CH.sub.2 groups, respectively, wherein n.sub.1 is 2, 3, 4, 5, 6, 8, or 11, n.sub.2 is 0 or 1 and n.sub.3 is 0 and
- R.sub.4 is an alkyl residue of 1-12 C or is selected from phenyl and pyridyl.
- 8. The method of claim 7 wherein n.sub.2 and n.sub.3 are zero, and n.sub.1 is 2-8.
- 9. The method of claim 8 wherein R.sub.1 is t-butyl.
- 10. The method of claim 7 wherein R.sub.1 is propylene.
- 11. The method of claim 7 wherein R.sub.4 is selected from H(CH.sub.2).sub.m, wherein m is 1-5; phenyl; and 3-pyridyl.
- 12. A compound of the formula: ##STR39## wherein R.sub.1 is at position 4 and either is an alkyl group of 1-6 C or is an --(CH.sub.2).sub.3 -- which is additionally linked to the phenyl at position 3 thereof;
- R.sub.2 is a lower alkyl of 1-3 C or is hydrogen;
- n.sub.1, n.sub.2 and n.sub.3 represent the number of CH.sub.2, C(R.sub.2).sub.2 and CH.sub.2 groups, respectively, wherein n.sub.1 is 2, 3, 4, 5, 6, 8 or 11, n.sub.2 is 0 or 1 and n.sub.3 is 0 and
- R.sub.4 is an alkyl residue of 1-12 C or is selected from phenyl and pyridyl.
- 13. The compound of claim 12 wherein n.sub.2 and n.sub.3 are zero, and n.sub.1 is 2-8.
- 14. The compound of claim 13 wherein R.sub.1 is t-butyl.
- 15. The compound of claim 12 wherein R.sub.1 is propylene.
- 16. The compound of claim 12 wherein R.sub.4 is selected from H(CH.sub.2).sub.m, wherein m is 1-5; phenyl; and 3-pyridyl.
Parent Case Info
This application is a continuation of Ser. No. 07/195,607 filed May 18, 1988 and now abandoned; which is a division of Ser. No. 07/047,379 filed May 7, 1987 and now issued as U.S. Pat. No. 4,816,491 on Mar. 28, 1989; which is a continuation of Ser. No. 06/551,453 filed Dec. 27, 1983 and now abandoned which is a division of Ser. No. 06/327,141 filed Dec. 3, 1981 and now issued as U.S. Pat. No. 4,451,474 on May 29, 1984; which is a continuation in part of Ser. No. 06/114,183 filed Jan. 22, 1980 and now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4451474 |
Berger et al. |
May 1984 |
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Divisions (2)
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Number |
Date |
Country |
Parent |
47379 |
May 1987 |
|
Parent |
327141 |
Dec 1981 |
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Continuations (2)
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Number |
Date |
Country |
Parent |
195607 |
May 1988 |
|
Parent |
551453 |
Dec 1983 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
114183 |
Jan 1980 |
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