Claims
- 1. A compound of the formula ##STR28## or a pharmaceutically acceptable salt thereof, wherein R.sub.3 and R.sub.4 are each independently selected from the group consisting of hydrogen, alkyl having 1 to 6 carbon atoms, hydroxy, alkoxy having 1 to 6 carbon atoms and halo;
- X is --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.dbd.C-- or HNCO
- m is an integer from 1 to 3; and
- A is the group ##STR29## wherein R.sub.1 is a fully unsaturated heteromonocyclic ring structure having 5 or 6 ring carbon atoms wherein one of the ring carbon atoms is replaced by nitrogen, oxygen or sulfur.
- 2. A compound according to claim 1 which is (.+-.)-cis-6-[4-[4-(aminoiminomethyl)phenyl]butyl]tetrahydro-4(3-pyridinyl)-2H-pyran-2-one, ditrifluoroacetate.
- 3. A pharmaceutical composition useful for inhibiting platelet aggregation comprising an effective amount of a compound according to claim 1 together with one or more non-toxic pharmaceutically acceptable carriers.
- 4. A pharmaceutical composition according to claim 3 wherein the compound is (.+-.)-cis-6-[4-[4-(aminoiminomethyl)phenyl]butyl]tetrahydro-4-(3-pyridinyl)-2H-pyran-2 -one, ditrifluoroacetate.
- 5. A method of treating a mammal to inhibit platelet aggregation comprising administering a therapeutically effective dose of a compound of claim 1 to a mammal in need of said treatment.
- 6. A method according to claim 5 wherein said compound is (.+-.)- cis-6-[4-[4-(aminoiminomethyl)phenyl]butyl]tetrahydro-4-(3-pyridinyl)-2H-pyran-2-one, ditrifluoroacetate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
PCT/US93/05861 |
Jun 1993 |
WOX |
|
Parent Case Info
This is a divisional application of application Ser. No. 08/256,707, filed on Jul. 21, 1994, now U.S. Pat. No. 5,504,106 issued Apr. 2, 1996 which is a 371 application of PCT/US93/05861, filed Jun. 23, 1993.
US Referenced Citations (11)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0275748 |
Jul 1988 |
EPX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
256707 |
Jul 1994 |
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