Claims
- 1. A compound of the formula ##STR9## in which Het is selected from the group consisting of ##STR10## n is an integer from two to five; A is phenyl or phenyl substituted by loer alkyl, lower alkoxy, lower thioalkoxy, halogen or trifluoromethyl; 2-, 3- or 4-pyridinyl or 2-, 3- or 4-pyridinyl substituted by lower alkyl, lower alkoxy or halogen; 2-, 4- or 5-pyrimidinyl, or 2-, 4- or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy or halogen; 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy or halogen; 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen; 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, or 2- or 5-thiazolyl or 2- or 5-thiazolyl substituted by lower alkyl or halogen, or a pharmaceutically acceptable acid addition salt thereof, with the exclusion of the compound wherein Het is ##STR11## and A is phenyl or substituted phenyl.
- 2. A compound according to claim 1, wherein n is the integer three or four.
- 3. A compound according to claim 2, wherein A is phenyl or phenyl substituted by methyl, methoxy, thiomethoxy or chloro; 2-, 3- or 4-pyridinyl, 2-, 3- or 4-pyridinyl substituted by methyl, chloro or bromo; 2-, 4- or 5-pyrimidinyl; 2-pyrazinyl, or 2- or 5-thiazolyl.
- 4. A compound according to claim 3, wherein A is phenyl, 2-, 3- or 4-pyridinyl, 2-, 4- or 5-pyrimidinyl, 2-pyrazinyl, or 2- or 5-thiazolyl.
- 5. A compound according to claim 4 and being 6-[3-(4-phenyl-1-piperazinyl)propoxy]-3-(2H)-benzofuranone.
- 6. A compound according to claim 4 and being 1-[3-[6-benzofuranyloxy]propyl]-4-phenylpiperazine.
- 7. A compound according to claim 4 and being 1-[3-[(3,4-dihydro-2H-1-benzopyran-7-yl)oxy]propyl]-4-phenylpiperazine.
- 8. A compound according to claim 4 and being 6-[3-[4-(2-pyrimidinyl)-1-piperazinyl]propoxy]-2H-1,4-benzoxazine-3(4H)-one.
- 9. A compound according to claim 4 and being 6-[3-[4-(2-pyrimidinyl)-1-piperazinyl]propoxy]-1H-indole.
- 10. A compound according to claim 4 and being 6-[3-(4-phenyl-1-piperazinyl)propoxy]quinoline.
- 11. A compound according to claim 4 and being 6-[4-[4-(2-pyrimidinyl)-1-piperazinyl]-butoxy]quinoline.
- 12. A compound according to claim 4 and being 5-[3-(4-phenylpiperazinyl)propoxy]-1H-benzimidazole.
- 13. A compound according to claim 4 and being 1,3-dihydro-5-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-indol-2-one.
- 14. A compound according to claim 4 and being 5-[3-[4-(2-pyridinyl)-1-piperazinyl]propoxy]isoquinoline.
- 15. A compound according to claim 4 and being 5-[3-(4-phenyl-1-piperazinyl)propoxy]isoquinoline.
- 16. A compound according to claim 4 and being 7-[3-[4-(2-pyridinyl)-1-piperazinyl]propoxy]quinoline.
- 17. A compound according to claim 4 and being 7-[3-(4-phenyl-1-piperazinyl)propoxy]quinoline.
- 18. A compound according to claim 4 and being 5-[3-[4-(2-pyridinyl)-1-piperazinyl]propoxy]-1-isoquinolinol.
- 19. A compound according to claim 4 and being 3,4-dihydro-5-[3-[4-(2-pyridinyl)-1-piperazinyl]propoxy-1(2H)-isoquinoline
- 20. A compound according to claim 4 and being 7-[3-[4-(2-pyridinyl)-1-piperazinyl]propoxy]isoquinoline.
- 21. A pharmaceutical composition comprising an antipsychotic effective amount of a compound as claimed in claim 1 or a pharmaceutically acceptable acid addition salt thereof with a pharmaceutically acceptable carrier.
- 22. A method of treating psychosis in a subject suffering therefrom comprising administering to said subject a pharmaceutical composition according to claim 21 in unit dosage form.
BACKGROUND ON THE INVENTION
This is a divisional of U.S. Ser. No. 924,627, filed Nov. 5, 1986, now U.S. Pat. No. 4,704,390, which is a continuation-in-part of U.S. Ser. No. 829,036, filed Feb. 13, 1986, now abandoned.
US Referenced Citations (5)
Number |
Name |
Date |
Kind |
4613598 |
Fukami et al. |
Sep 1986 |
|
4670439 |
Witte et al. |
Jun 1987 |
|
4701456 |
Dewald et al. |
Oct 1987 |
|
4734416 |
Banno et al. |
Mar 1988 |
|
4746661 |
Lattrell et al. |
May 1988 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2120670 |
Dec 1983 |
GBX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
924627 |
Nov 1986 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
829036 |
Feb 1986 |
|