Claims
- 1. A compound of the formula ##STR10## in which Het is selected from the group consisting of ##STR11## n is an integer from two to five; ##STR12## represents a double bond; X is C, and A is phenyl or phenyl substituted by lower alkyl, lower alkoxy, lower thioalkoxy, halogen or trifluoromethyl; 2-, 3- or 4-pyridinyl or 2-, 3- or 4-pyridinyl substituted by lower alkyl, lower alkoxy or halogen; 2-, 4- or 5-pyrimidinyl, or 2-, 4- or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy or halogen; 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy or halogen; 2- or 3-thienyl or 2- or 3-thienyl substituted by lower alkyl or halogen; 2- or 3-furanyl or 2- or 3-furanyl substituted by lower alkyl or halogen, or 2- or 5-thiazolyl or 2- or 5-thiazolyl substituted by lower alkyl or halogen, or a pharmaceutically acceptable acid addition salt thereof, with the exclusion of the compound wherein X is N, Het is ##STR13## or ##STR14## and A is phenyl or substituted phenyl.
- 2. A compound according to claim 1, wherein n is the integer three or four.
- 3. A compound according to claim 2, wherein A is phenyl or phenyl substituted by methyl, methoxy, thiomethoxy or chloro; 2-, 3- or 4-pyridinyl, 2-, 3- or 4-pyridinyl substituted by methyl, chloro or bromo; 2-, 4- or 5-pyrimidinyl; 2-pyrazinyl, or 2- or 5-thiazolyl.
- 4. A compound according to claim 3, wherein A is phenyl, 2-, 3- or 4-pyridinyl, 2-, 4- or 5-pyrimidinyl, 2-pyrazinyl, or 2- or 5-thiazolyl.
- 5. A compound according to claim 4 and being 7-[3-[3,6-dihydro-4-phenyl]-1(2H)-pyridinyl)-propoxy]-2,3-dihydro-2,2-dimethyl-4H-benzopyran-4-one.
- 6. A compound according to claim 4 and being 4-[3-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)propoxy]-1H-indole.
- 7. A compound according to claim 4 and being 4-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butoxy]-1H-indole.
- 8. A compound according to claim 4 and being 5-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butoxy]-1H-indole.
- 9. A compound according to claim 4 and being 6-[3-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)propoxy]-1H-indole.
- 10. A compound according to claim 4 and being 6-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butoxy]quinoline.
- 11. A compound according to claim 4 and being 5-[3-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)propoxy]isoquinoline.
- 12. A pharmaceutical composition comprising an antipsychotic effective amount of a compound as claimed in claim 1 or a pharmaceutically acceptable acid addition salt thereof with a pharmaceutically acceptable carrier.
- 13. A method of treating psychosis in a subject suffering therefrom comprising administering to said subject 12 a pharmaceutical composition according to claim 8 in unit dosage form.
Parent Case Info
This is a continuation-in-part of U.S. application Ser. No. 829,036 filed 2-13-86, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3929793 |
Popelak et al. |
Dec 1975 |
|
4482560 |
Banno et al. |
Nov 1984 |
|
Foreign Referenced Citations (4)
Number |
Date |
Country |
80322 |
May 1982 |
JPX |
145872 |
Sep 1982 |
JPX |
70675 |
Apr 1984 |
JPX |
2071094 |
Sep 1981 |
GBX |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
829036 |
Feb 1986 |
|