Claims
- 1. A compound having the formula ##STR19## wherein R.sup.1 is hydrogen or lower alkyl;
- R.sup.2 is C.sub.3-7 alkyl or C.sub.3-7 cycloalkyl;
- R.sup.3 is hydrogen, lower alkyl, carboxyloweralkyl, lower alkoxycarbonyl, lower alkoxycarbonyl loweralkyl, C.sub.6-10 aryl or C.sub.12-16 aralkyl;
- R.sup.4 is hydrogen, C.sub.1-8 alkyl or ##STR20## B is a bond, NH or O; Y is O or S;
- R.sup.5 may be hydrogen when B is NH, or
- R.sup.5 is lower alkyl, C.sub.3-8 cycloalkyl, C.sub.6-10, aryl, substituted C.sub.6-10 aryl, C.sub.12-16 aralkyl, substituted C.sub.12-16 aralkyl wherein the substituent for the forgoing substituted aryl is selected from lower alkyl and oxo, C.sub.12-16 aralkenyl, C.sub.18-26 aralkenylalkyl, --(CH.sub.2).sub.n NR.sup.1 R.sup.1,
- n is 0-5;
- the dotted line represents an optional double bond;
- or a pharmacologically acceptable salt thereof.
- 2. A compound as claimed in claim 1 wherein ##STR21## wherein R.sup.1 is C.sub.1-3 alkyl;
- R.sup.2 is C.sub.4-6 alkyl or C.sub.5-6 cycloalkyl;
- R.sup.3 is C.sub.1-3 alkyl or C.sub.12-16 aralkyl;
- R.sup.4 is ##STR22## B is a bond or NH; R.sup.5 is hydrogen when B is NH; or aralkyl.
- 3. A compound as claimed in claim 1 wherein ##STR23## wherein R.sup.1 is lower alkyl;
- R.sup.2 is n-butyl or cyclopentyl;
- R.sup.3 is methyl;
- R.sup.4 is ##STR24## R.sup.5 is hydrogen or aralkyl.
- 4. The compound of claim 1, having the name 5-[3-(cyclopentyloxy)-4-methoxyphenyl[-3-pyrazolidinone.
- 5. The compound of claim 1, having the name 5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-methyl-3-pyrazolidinone.
- 6. The compound of claim 1, having the name 5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1,2-dimethyl-3-pyrazolidinone, hydriodide.
- 7. The compound of claim 1, having the name 5-[3-(cyclopentyloxy)-4-methoxyphenyl]-3-oxo-1-pyrazolidineacetic acid methyl ester.
- 8. The compound of claim 1, having the name 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-5-oxo)-1-pyrazolidinecarboxamide.
- 9. The compound of claim 1, having the name 5-[3-(cyclopentyloxy)-4-methoxyphenyl]-3 -oxo- 1 -pyrazolidinecarboxylic acid methyl ester.
- 10. The compound of claim 1, having the name 5-[3-(cyclopentyloxy)-4-methoxyphenyl]-3-oxo-l-pyrazolidinecarboxylic acid.
- 11. The compound of claim 1, having the name 3-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-pyrazolidinecarboxamide, hydrochloride.
- 12. The compound of claim 1, having the name 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-N-methyl-1 -pyrazolidinecarboxamide, hemihydrate.
- 13. The compound of claim 1, having the name 5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1,2-dihydro- 1 -methyl-3H-pyrazol- 3-one.
- 14. The compound of claim 1, having the name 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2,5-dihydro-2-methyl-5-oxo-1H-pyrazole-1-carboxamide.
- 15. The compound of claim 1, having the name (S)-3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-N-[1-(1-naphthalenyl)ethyl]-5-oxo-1-pyrazolidine carboxamide.
- 16. The compound of claim 1, having the name N-butyl-3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-1-pyrazolidinecarboxamide hydrochloride.
- 17. The compound of claim 1, having the name 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-N-ethyl-2-methyl-5-oxo-1-pyrazolidinecarboxamide hydrochloride, hydrate.
- 18. The compound of claim 1, having the name 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-N-phenyl-1-pyrazolidine carboxamide hydrochloride.
- 19. The compound of claim 1, having the name 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-N-(phenylmethyl)-1-pyrazolidinecarboxamide hydrochloride.
- 20. The compound of claim 1, having the name N-cyclohexyl-3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-l-pyrazolidine carboxamide hydrochloride.
- 21. The compound of claim 1, having the name 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-N-(4-methoxyphenyl)-2-methyl-5-oxo-1-pyrazolidinecarboxamide.
- 22. The compound of claim 1, having the name 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-N-[(4-fluorophenyl)methyl]-2-methyl-5-oxo-1-pyrazolidinecarbothioamide.
- 23. The compound of claim 1, having the name 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-N-[(4-methoxyphenyl)methyl]-2-methyl-5-oxo-1-pyrazolidinecarbothioamide.
- 24. The compound of claim 1, having the name 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-N-(4-fluorophenyl)-2-methyl-5-oxo-1-pyrazolidinecarboxamide.
- 25. The compound of claim 1, having the name 3-[3-(cyclopentyloxy)-4-methoxyphenyl]-5-oxo-2-(phenylmethyl)-1-pyrazolidinecarboxamide.
- 26. The compound of claim 1, having the name 5-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-heptyl-1-methyl-3-pyrazolidinone hydrochloride.
- 27. The compound of claim 1, having the name 2-acetyl-5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-methyl-3-pyrazolidinone hydrochloride.
- 28. The compound of claim 1, having the name 5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-(phenylmethyl)-3-pyrazolidinone.
- 29. The compound of claim 1, having the name 5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-ethyl-3-pyrazolidinone.
- 30. The compound of claim 1, having the name 3-(3-cyclopentyloxy-4-methoxyphenyl)-2-methyl-5-oxo-pyrazolidine-1-carboxylic acid 2-(diethyl-amino) ethylamide.
Parent Case Info
This is a continuation-in-part of U.S. patent application Ser. No. 07/694,197, filed May 1, 1991 now U.S. Pat. No. 5,191,084 issued Mar. 2, 1993.
Non-Patent Literature Citations (1)
Entry |
Allen et al. CA 71(7):30028y, 1969. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
694197 |
May 1991 |
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