Claims
- 1. A compound selected from the groups of phenyl derivatives of the formula: ##STR29## wherein n is an integer of from 6 to 7; R.sub.1 is hydrogen, loweralkyl, trifluoromethyl, chlorine or fluorine R.sub.2 is trifluoromethyl, hydrogen, hydroxy, loweralkyl, alkoxy, trifluoromethylloweralkoxy, chlorine or fluorine; R.sub.3 is hydrogen, lower alkyl, chlorine or fluorine, X is ##STR30## R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are individually hydrogen or lower alkyl; and R.sub.20 is hydrogen or taken together with its attached oxygen atom forms a hydrolizable ether group and R.sub.5 is --COOR.sub.9 ;
- and pharmaceutically acceptable salts thereof.
- 2. The compound of claim 1 wherein --X-- is --O--.
- 3. The compound of claim 2 wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen.
- 4. The compound of claim 3 wherein R.sub.7 and R.sub.8 are methyl.
- 5. The compound of claim 4 wherein said phenyl derivative is (all-E)-3,7-dimethyl-9-[2-[(8-hydroxyoctyl)oxy]phenyl]-2,4,6,8-nonatetraenoic acid.
CROSS REFERENCE TO RELATED APPLICATIONS
This is a division of application Ser. No. 922,430, filed Oct. 23, 1986, now U.S. Pat. No. 4,780,251, which is a divisional of application Ser. No. 746,812, filed June 20, 1985, now U.S. Pat. No. 4,648,996, which is a continuation-in-part of Ser. No. 35,100, filed July 27, 1984, now abandoned.
US Referenced Citations (6)
Foreign Referenced Citations (2)
Number |
Date |
Country |
0059365 |
Sep 1980 |
EPX |
1101396 |
Jun 1965 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Trown Cancer Research 40, 212 (1980). |
Divisions (2)
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Number |
Date |
Country |
Parent |
922430 |
Oct 1986 |
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Parent |
746812 |
Jun 1985 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
635100 |
Jul 1984 |
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