Claims
- 1. A. compound of the general formula
- 2. A compound according to claim 1, wherein Y is —C(O)— and R4 is 4-methylpiperazinyl.
- 3. A compound according to claim 2, N-[2-Benzoyl-4-(4-methyl-piperazin-1-yl)-phenyl]-2-(3,5 -bis-trifluoromethyl-phenyl)isobutyramide.
- 4. A compound according to claim 1, wherein Y is -O-, and R4 is hydrogen, 4-methylpiperazinyl or morpholinyl.
- 5. A compound according to claim 4, 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(2-phenoxy-phenyl)-isobutyramide.
- 6. A compound according to claim 4, 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(2-o-tolyloxy-phenyl)-isobutyramide.
- 7. A compound according to claim 4, 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[2-(2,4-dichloro-phenoxy)-phenyl]-N-methyl-isobutyramide.
- 8. A compound according to claim 4, N-(3,5-Bis-trifluoromethyl-benzyl)-N-methyl-6-morpholin-4-yl-4-phenoxy-nicotinamide.
- 9. A compound according to claim 4, N-(3,5-Bis-trifluoromethyl-benzyl)-4-(2-chloro-phenoxy)-N-methyl-6-morpholin-4-yl-nicotinamide.
- 10. A compound according to claim 4, N-(3,5-Bis-trifluoromethyl-benzyl)-4-(2-chloro-phenoxy)-N-methyl-6-(4-methyl-piperazin-1-yl)-nicotinamide.
- 11. A compound according to claim 4, N-(3,5-Bis-trifluoromethyl-benzyl)-N-methyl-6-morpholin-4-yl-4-o-tolyloxy-nicotinamide.
- 12. A compound according to claim 1, wherein Y is —N(CH3)— and R4 is hydrogen.
- 13. A compound according to claim 12, 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-[2-(methyl-phenyl-amino)-phenyl]-propionamide.
- 14. A compound according to claim 12, 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-[2-(methyl-phenyl-amino)-phenyl]-isobutyramide.
- 15. A compound according to claim 12, 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[2-(methyl-phenyl-amino)-phenyl]-acetamide.
- 16. A compound according to claim 12, 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-[2-(methyl-phenyl-amino)-phenyl]-acetamide.
- 17. A process for preparing a compound of formula I as defined in claim 1, comprising:
reacting a compound of formula 44with a compound of formula 45to yield a compound of formula 46wherein the definitions of substituents are given in claim 1.
- 18. A process for preparing a compound of formula I as defined in claim 1, comprising:
reducing a compound of formula 47to a compound of formula 48wherein the definitions of substituents are given in claim 1.
- 19. A process for preparing a compound of formula I as defined in claim 1, comprising:
reacting a compound of formula 49with a compound of formula 50to yield a compound of formula 51wherein the definition of substituents is given in claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
99103502.3 |
Feb 1999 |
EP |
|
Parent Case Info
[0001] This application is a divisional application of U.S. Pat. application Ser. No. 09/505,356, filed Feb. 16, 2000.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09505356 |
Feb 2000 |
US |
Child |
10051699 |
Jan 2002 |
US |