Martin et al., “Discriminant Analysis of the Relationship Between Physical Properties and the Inhibition of Monoamine Oxidase by Aminotetralins and Aminoindans”, J. Med. Chem. (1974) 17(4):409-413 (Exhibit 1). |
Caplus abstract of JP 54132559, Apr. 1978.* |
Chorvat et al. “Acetycholine Release Enhancing Agents: Potential Therapeutics For Alzheimer's Disease”(1995), Drugs of the Future 20(11):1145-1162 (Exhibit 10). |
Cooper et al. “Alzheimer's Disease Drug Treatment” (1993), J. Ger. Drug Ther. 8(2):5-18 (Exhibit 11). |
Cutler et al. “Muscarinic M1-Receptor Agonists” (1995), CNS Drugs 3(6):467-481 (Exhibit 12). |
Davis et al. “Tacrine” (1995), The Lancet 345:625-630 (Exhibit 13). |
Drugs of the Future 1991, 16(1), 16-18 (Exhibit 14). |
Drugs of the Future 1995, 20(1), 77-78 (Exhibit 15). |
Drugs of the Future 1995, 20(3), 248-250 (Exhibit 16). |
Fink et al. “Imino 1,2,3,4-Tetrahydrocyclopent[B]indole Carbamates as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase” (1996), Bioorganic & Medical Chemistry Letters 6(6), 625-630 (Exhibit 17). |
Gabryel et al. Nootropics: Pharmacological Properties and Therapeutic Use (1994), Pol. J. Pharmacol.46:383-394 (Exhibit 18). |
Harvey “The Pharmacology of Galanthamine and its Analogues” (1995), Pharmac. Ther. 68(1):113-128 (Exhibit 19). |
Hori et al. Database CAPLUS on STN®, Chemical Abstracts Service, (Columbus, Ohio), Accession No. 1980:180807, ‘N-containing diphenylethylamine derivatives and acid adducts’, abstract, Japan Kokai Tokkyo Koho JP 54-132559, Oct. 15, 1979, abstract (Exhibit 20). |
Knapp et al. “A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients with Alzheimer's Disease” (1994), JAMA 271(13):985-991 (Exhibit 21). |
Sramek et al. “Safety/Tolerability Trial of SDZ ENA 713 in Patients with Probable Alzheimer's Disease” (1996), Life Sciences 58(15):1201-1207 (Exhibit 22). |
Tariot et al. “Treatment of Alzheimer's Disease: Glimmers of Hope” (1993), Chem. Ind. 20, 801-3, 806-7 (Exhibit 23). |
Terni et al. Database CAPLUS on STN®, Chemical Abstracts Service (Columbus, Ohio),, Accession No. 1996:340192 Preparation of (aminoalkyl) phenyl morpholinoalkylcarbamates and analogs as cholinesterase inhibitors, abstract, WO 96/02524, Feb. 1, 1996, see entire abstract (Exhibit 24); and. |
Weinstock, “The Pharmacotherapy of Alzheimer's Disease Based on the Cholinergic Hypothesis: an Update” (1995), Neurodegeneration 4:349-356 (Exhibit 25). |