Claims
- 1. A compound having the formula ##STR27## or a non-toxic, physiologically acceptable salt thereof, wherein R.sub.1 is alkyl, aryl, arylalkyl, cycloalkyl, or cylcoalkylalkyl;
- R.sub.2 and R.sub.4 each is independently hydrogen, alkyl or arylalkyl;
- R.sub.3 is hydrogen or alkyl;
- --R.sub.5 --COOR.sub.4 is ##STR28## R.sub.6 is cycloalkyl or aryl; R.sub.7 and R'.sub.7 together are --S--(CH.sub.2).sub.2 --S--; and
- n is 0 or 1;
- and wherein the term "aryl" refers to phenyl or phenyl substituted with halogen, alkyl, alkoxy, alkylthio, hydroxy, alkanoyl, nitro, amino, dialkylamino, or trifluoromethyl groups; the term "alkyl" refers to groups having 1 to 10 carbon atoms; the term "alkoxy" refers to groups having 1 to 8 carbon atoms; the term "cycloalkyl" refers to groups having 3 to 7 carbon atoms; and the term "alkanoyl" refers to groups having 2 to 9 carbon atoms.
- 2. A compound in accordance with claim 1 wherein n is 0.
- 3. A compound in accordance with claim 1 wherein each of R.sub.2 and R.sub.4 is hydrogen.
- 4. A compound in accordance with claim 1 wherein --R.sub.5 --COOR.sub.4 is ##STR29##
- 5. A compound in accordance with claim 1 wherein --R.sub.5 --COOR.sub.4 is ##STR30##
- 6. The compound in accordance with claim 1, (S)-7-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, or a physiologically acceptable salt thereof.
- 7. The compound in accordance with claim 1, (cis)-4-cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline, or a physiologically acceptable salt thereof.
- 8. The compound in accordance with claim 1, (cis)-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-4-phenyl-L-proline, or a physiologically acceptable salt thereof.
Parent Case Info
This is a division of application Ser. No. 212,911 filed Dec. 4, 1980 now U.S. Pat. No. 4,337,201, issued June 29, 1982.
US Referenced Citations (13)
Foreign Referenced Citations (3)
Number |
Date |
Country |
9183 |
Apr 1980 |
EPX |
2027025 |
Feb 1980 |
GBX |
2028327 |
Mar 1980 |
GBX |
Divisions (1)
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Number |
Date |
Country |
Parent |
212911 |
Dec 1980 |
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