Claims
- 1. A compound of the formula ##STR127## including a pharmaceutically acceptable salt thereof wherein: R.sub.1 is straight or branched alkyl of 1 to 4 carbons or ##STR128## R.sub.2 is straight or branched chain alkyl of 1 to 4 carbons, trifluoromethyl, or ##STR129## X is ##STR130## R.sub.3 and R.sub.5 are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons, and an alkali metal salt ion; and
- q is an integer from 1 to 4.
- 2. A compound of the formula ##STR131## including a pharmaceutically acceptable salt thereof wherein: R.sub.1 is straight or branched chain alkyl of 1 to 4 carbons or ##STR132## R.sub.2 is straight or branched alkyl of 1 to 4 carbons, trifluoromethyl, or ##STR133## X is --NH--(CH.sub.2).sub.2 --COOR.sub.5 ; R.sub.3 and R.sub.5 are independently selected from the group consisting of hydrogen, straight or branched chain alkyl of 1 to 4 carbons, and an alkali metal salt ion; and
- q is an integer from 1 to 4.
- 3. A compound of claim 2 wherein:
- R.sub.1 is ##STR134## and R.sub.2 is methyl.
- 4. The compound of claim 3, 4-[[(S)-2-[[hydroxy(2-phenylethyl)phosphinyl]amino]-1-oxo-propyl]amino]benzoic acid, dilithium salt.
- 5. A compound of claim 1 wherein:
- R.sub.1 is methyl; and
- R.sub.2 is ##STR135##
- 6. The compound of claim 5, 4-[[(S)-2-[(hydroxymethylphosphinyl)amino]-1-oxo-3-phenyl-propyl]amino]benzoic acid, dilithium salt.
- 7. The compound of claim 5, (S)-3-[[2-[(hydroxymethylphosphinyl)amino]-1-oxo-3-phenylpropyl]amino]benzoic acid, dilithium salt.
- 8. A compound of claim 5 wherein:
- R.sub.1 is ##STR136## and R.sub.2 is ##STR137##
- 9. The compound of claim 8, 3-[[(S)-2-[[hydroxy(2-phenylethyl)phosphinyl]amino]-1-oxo-3-phenylpropyl]amino]propanoic acid, dilithium salt.
- 10. A compound of claim 2 wherein:
- R.sub.1 is ##STR138## and R.sub.2 is methyl.
- 11. The compound of claim 10, 3-[[(S)-2-[[hydroxy(2-phenylethyl)phosphonyl]amino]-1-oxo-propyl]amino]propanoic acid, dilithium salt.
- 12. A pharmaceutical composition useful for reducing blood pressure and producing diuresis and natriuresis as well as treating congestive heart failure, pain, and/or diarrhea in a mammalian host comprising a pharmaceutically acceptable carrier and an endopeptidase inhibiting compound of the formula ##STR139## wherein X, R.sub.1, R.sub.2, and R.sub.3 are as defined in claim 1.
- 13. A pharmaceutical composition useful for reducing blood pressure and producing diuresis and natriuresis as well as treating congestive heart failure, pain, and/or diarrhea in a mammalian host comprising a pharmaceutically acceptable carrier and an endopeptidase inhibiting compound of the formula ##STR140## wherein X, R.sub.1, R.sub.2 and R.sub.3 are as defined in claim 2.
PRIOR APPLICATIONS
This application is a continuation-in-part of Ser. No. 223,121 filed July 22, 1988, now abandoned which in turn was a continuation-in-part of Ser. No. 95,065 filed Sept. 10, 1987, now abandoned.
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
223121 |
Jul 1988 |
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Parent |
95065 |
Sep 1987 |
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