Claims
- 1. A compound of Formula I or pharmaceutically acceptable salts thereof wherein Formula I is ##STR7## wherein R.sup.1 is H, C.sub.1 -C.sub.6 alkyl, benzyl, phenyl, phenyl substituted with 1 to 5 F, Cl, Br, I, NO.sub.2, OCH.sub.3 or C.sub.1 -C.sub.4 alkyl;
- R.sup.2 is H, C.sub.1 -C.sub.6 alkyl, benzyl, phenyl or phenyl substituted with 1 to 5 F, Cl, Br, I, NO.sub.2, OCH.sub.3 or C.sub.1 -C.sub.4 alkyl;
- Y is hydrogen and
- X is ##STR8##
- 2. The compound of claim 1 which is
- a. Benzenepentanoic acid, .alpha.-(diethoxyphosphinyl)-.delta.-oxo-, ethyl ester
- b. Benzenepentanoic acid, .alpha.-(dimethoxyphosphinyl)-3-fluoro-.delta.-oxo-, methyl ester
- c. Benzenepentanoic acid, .alpha.-(diethoxyphosphinyl)-.delta.-oxo-.gamma.-phenyl-, ethyl ester or
- d. ferrocene, (4-(dimethoxyphosphinyl)-5-methoxy-1,5-dioxopentyl).
- 3. A method for treating inflammation comprising administering an anti-inflammatory effective amount of a compound of Formula I according to claim 1 to an animal, including humans, in need thereof.
- 4. The method of claim 3 wherein said compound is administered to a patient in need thereof in an anti-inflammatory effective amount of from 0.001 mg to 1.0 gram and is administered orally, intramuscularly, intravenously, transdermally, intra-articularly, subcutaneously, or intraperitoneally.
Parent Case Info
This application is a division of application Ser. No. 08/382,240, filed 1 Feb. 1995, now U.S. Pat. No. 5,565,641 which was a continuation of PCT/US93/05365 filed Jun. 9, 1993, which was a continuation of U.S. Ser. No. 07/926,879, filed Aug. 7, 1992, abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3962433 |
Worms et al. |
Jun 1976 |
|
5071840 |
Ebetino et al. |
Dec 1991 |
|
5312814 |
Biller et al. |
May 1994 |
|
Foreign Referenced Citations (4)
Number |
Date |
Country |
A 0 274 158 |
Jul 1988 |
EPX |
A 2 253 527 |
Jul 1975 |
FRX |
A 2 310 450 |
Sep 1974 |
DEX |
PCTUS9205398 |
Jan 1993 |
WOX |
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts, vol. 103, No. 1, Abstract No. 6420d, p. 580 (1985). Abstract for ZH. Obsch. Khim, Khokhlov P. S."Diazotiazation of Alpha-Aminophosphonylacetates", vol. 54, No. 12, pp. 2785-2787 (1984). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
382240 |
Feb 1995 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
926879 |
Aug 1992 |
|