Claims
- 1. A polyazamacrocyclic compound or a salt thereof, the compound having the formula ##STR6## where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=y;
- y is 3 or4;
- R is (CH.sub.2).sub.z P(.dbd.O)OR.sup.1 OR.sup.2 ;
- R.sup.1 is H or CH.sub.3 ;
- R.sup.2 is C.sub.n H.sub.1+2n ;
- z is 1 to 3; and
- n is 4 to 6.
- 2. A polyazamacrocyclic compound-metal complex having the formula ##STR7## where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=y;
- y is 3 or 4;
- R is (CH.sub.2).sub.z P(.dbd.O)OR.sup.1 OR.sup.2 ;
- R.sup.1 is H or CH.sub.3 ;
- R.sup.2 is C.sub.n H.sub.1+2n ;
- z is 1 to 3;
- r is 2 or 3;
- M is a metal ion; and
- n is 4 to 6.
- 3. The compound of claim 1 where y is 3.
- 4. The compound of claim 1 where y is 4.
- 5. The compound of claim 1 where y is 3 and x is 2.
- 6. The compound of claim 1 where y is 4 and x is 2.
- 7. The complex of claim 2 where y is 3.
- 8. The complex of claim 2 where y is 4.
- 9. The complex of claim 2 where y is 3 and x is 2.
- 10. The complex of claim 2 where y is 4 and x is 2.
- 11. The compound of claim 1 where y is 3, p is 1 and q is 2 or p is 2 and q is 1.
- 12. The complex of claim 2 where y is 3, p is 1 and q is 2 or p is 2 and q is 1.
- 13. The compound of claim 1 where y is 4, p is 1 and q is 3, p is 2 and q is 2 or p is 3 and q is 1.
- 14. The complex of claim 2 where y is 4, p is 1 and q is 3, p is 2 and q is 2 or p is 3 and q is 1.
- 15. The compound of claim 1 where z is 1.
- 16. The complex of claim 2 where z is 1.
- 17. The compound of claim 1 where R.sup.2 is C.sub.4 H.sub.9.
- 18. The complex of claim 2 where R.sup.2 is C.sub.4 H.sub.9.
- 19. The complex of claim 2 where M is a lanthanide element.
- 20. The complex of claim 2 where M.sup.+r is Gd.sup.+3.
- 21. A compound or salt thereof, the compound having the formula: ##STR8## where R is C.sub.n H.sub.1+2n ;
- n is 4 to 6; and
- R' is H.
- 22. A compound or salt thereof, the compound having the formula: ##STR9## where R.sup.1 is OC.sub.n H.sub.1+2n ;
- n is 4 to 6; and
- R.sup.2 is H.
- 23. The compound of claim 21 or 22 where n is 4.
- 24. A polyazamacrocyclic compound or a salt thereof, the compound having the formula ##STR10## where x is 2, 3 or a combination of p 2(s) and q 3(s) where p+q=Y;
- y is 3 or 4
- R is (CH.sub.2).sub.z P(.dbd.O)OR.sup.1 OR.sup.2 ;
- R.sup.1 is H;
- R.sup.2 is C.sub.4 H.sub.9 ; and
- z is 1 to 3.
- 25. A polyazamacrocyclic compound-metal complex having the formula ##STR11## where x is 2, 3 or a combination of p 2(s) and q 3 (s) where p+q=y;
- y is 3 or 4;
- R is (CH.sub.2).sub.z P(.dbd.O)OR.sup.1 OR.sup.2 ;
- R.sup.1 is H;
- R.sup.2 is C.sub.4 H.sub.9 ;
- z is 1 to 3;
- r is 2 or 3; and
- M is a metal ion.
- 26. The complex of claim 25 where M.sup.+r is Gd.sup.+3.
- 27. A compound or salt thereof, the compound having the formula: ##STR12##
Parent Case Info
This is a divisional of application Ser. No. 07/923,715 filed Jul. 31, 1992 and issued Nov. 8, 1994 as U.S. Pat. No. 5,362,476 which is a continuation-in-part of U.S. Ser. No. 07/615,619 filed Nov. 19, 1990, issued as U.S. Pat. No. 5,342,60 which is a continuation-in-part of U.S. Ser. No. 07/357,193 filed May 25, 1989 now abandoned, and U.S. Ser. No. 07/291,053 filed Dec.28, 1988, the latter now issued as U.S. Pat. No. 4,983,376 which is a continuation-in-part of application Ser. No. 07/007,729 filed on Jan. 27, 1987, (abandoned) which was a continuation-in-part of application Ser. No. 06/662,075, filed on Oct. 18, 1984, now issued as U.S. Pat. No. 4,639,365. All of the above applications are incorporated by reference herein.
US Referenced Citations (11)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0404605 |
Dec 1990 |
EPX |
Non-Patent Literature Citations (5)
Entry |
Kabachnik, MI, Izv. Akad. Nauk. SSSR, Ser. Khim., (1984) pp. 769-777. |
Desreux, Inorganic Chemistry 19:1319-1324 (1980). |
Geraldes et al., Inorganic Chemistry 24(23):3876 (1985). |
Geraldes et al. Magnetic Resonance in Medicine, 3:242-250 (1986). |
Sherry et al., J. Magnetic Resonance, 66:511-524 (1986). |
Related Publications (1)
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Date |
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291053 |
Dec 1988 |
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Divisions (1)
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Number |
Date |
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Parent |
923715 |
Jul 1992 |
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Continuation in Parts (4)
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Number |
Date |
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Parent |
615619 |
Nov 1990 |
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Parent |
357193 |
May 1989 |
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Parent |
07729 |
Jan 1987 |
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Parent |
662075 |
Oct 1984 |
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