Photoplethysmography-based Blood Pressure Monitoring Device

Abstract

A blood pressure monitoring device includes a wrist strap, a case, and a display. The strap portion is adapted to fasten the device to the wrist without occluding blood flow. At least one sensor modality is arranged within the case for obtaining sensor data from an artery in the wrist. In a preferred embodiment photoplethysmography sensors are incorporated in the case to generate PPG waveform data. A processor within the case is operable to compute mean arterial pressure, and optionally diastolic and systolic blood pressure based on extracted and computed features of the sensor data. Related methods and systems are also described.

Description

Claims

1. A blood pressure monitoring device for computing mean arterial pressure of a user comprising: a case and a strap adapted to hold the case against the wrist of the patient;a first PPG sensor within the case and aimed at an artery in the wrist when the case is strapped to the wrist;a second PPG sensor spaced from the first PPG sensor within the case and aimed at the artery in the wrist when the case is strapped to the wrist; anda processor arranged within the case and operable to: compute a plurality of features from PPG waveform data generated by the PPG sensors; andcompute the mean arterial pressure (MAP) based on the plurality of features.

2. The blood pressure monitoring device of claim 1, wherein computing MAP is further based on a predetermined proportionality coefficient associated with the user, wherein the proportionality coefficient is initially computed and based on measuring blood pressure using a second type of blood pressure measurement device.

3. The blood pressure monitoring device of claim 1, wherein one of the plurality of features comprises: diastolic velocity, systolic velocity, systolic volume, diastolic volume, diastolic distance, systolic distance, heart rate, diastolic time, and/or systolic time.

4. The blood pressure monitoring device of claim 1, wherein the processor is further operable to compute diastolic blood pressure (DBP).

5. The blood pressure monitoring device of claim 1, wherein the processor is further operable to compute systolic blood pressure based on the computed the MAP and DBP.

6. The blood pressure monitoring device of claim 1, wherein the case further houses a battery, memory, and PPG electronics.

7. The blood pressure monitoring device of claim 1, further comprising a trained machine learning model for determining the MAP based on the plurality of features extracted from the PPG waveform data.

8. The blood pressure monitoring device of claim 1, further comprising a display, and wherein the strap, case and display collectively form a wrist watch-like shape.

9. The blood pressure monitoring device of claim 1, further comprising a location module for alerting the user to an optimal position on the wrist to strap the case thereto as the user adjusts the position of the case along the user’s wrist.

10. The blood pressure monitoring device of claim 1, wherein the MAP computing is performed without use of ECG data.

11. A blood pressure monitoring system for computing mean arterial pressure of a user comprising: a case and a window adapted to be held against the skin of the patient;at least one sensor modality arranged within the case; anda processor arranged operable to: compute a plurality of features from data arising from the sensor modality; andcompute the mean arterial pressure (MAP) based on the plurality of features.

12. The blood pressure monitoring system of claim 11, wherein the at least one sensor modality comprises a PPG sensor modality comprising a first PPG sensor and second PPG sensor aimed through the window towards the artery.

13. The blood pressure monitoring system of claim 12, wherein computing the MAP is performed without use of ECG data.

14. The blood pressure monitoring system of claim 11, wherein one of the plurality of features comprises: diastolic velocity, systolic velocity, systolic volume, diastolic volume, diastolic distance, systolic distance, heart rate, diastolic time, and/or systolic time.

15. The blood pressure monitoring system of claim 11, wherein computing MAP is further based on a predetermined proportionality coefficient associated with the user, wherein the proportionality coefficient is initially computed and based on measuring blood pressure using a second type of blood pressure measurement device.

16. The blood pressure monitoring system of claim 11, further comprising an adhesive to bond the case to the skin.

17. A method for monitoring mean arterial pressure (MAP) of a person based on PPG data comprising: arranging a first PPG sensor and second PPG sensor on a wrist of the person, wherein the second PPG sensor is spaced a fixed distance from the first PPG sensor;obtaining PPG data from the first PPG sensor and the second PPG sensor corresponding to blood flow in a vessel of the person;extracting a plurality of features from the PPG data; andcomputing the mean arterial pressure (MAP) based on the plurality of features.

18. The method of claim 17, further comprising sending the MAP to a portable computing device.

19. The method of claim 17, wherein computing the MAP is performed without use of ECG data.

20. The method of claim 17, further comprising computing diastolic blood pressure (DBP).

21. The method of claim 17, further comprising computing systolic blood pressure.

22. The method of claim 17, further comprising alerting the user to an optimal position on the wrist to strap the case thereto as the user adjusts and moves the case along the user’s wrist.

23. The method of claim 17, wherein one of the plurality of features comprises: diastolic velocity, systolic velocity, systolic volume, diastolic volume, diastolic distance, systolic distance, heart rate, diastolic time, and /or systolic time.

24. The method of claim 17, wherein the step of computing MAP is performed using a BP algorithm, and wherein the BP algorithm is calibrated using an ancillary BP measuring device, optionally a pressure cuff-type device.

25. The method of claim 24, wherein the computing MAP is performed compression-free subsequent to being calibrated.

26. The method of claim 24, wherein the computing MAP is performed continuously subsequent to being calibrated.

27. The blood pressure monitoring system of claim 11, further comprising an umbilical cord extending from the case for transmitting information to and from the case to another device, and optionally, to transmit power to the case from another device.

28. The blood pressure monitoring system of claim 12, wherein the data arising from the sensor modality is velocity and/or volumetric flow data of the patient.

29. The blood pressure monitoring system of claim 28, wherein the features are computed from the flow data.

30. The blood pressure monitoring system of claim 29, wherein the MAP is computed without the use of database, atlas or general population-type information.

31. The blood pressure monitoring system of claim 12, wherein all the sensors are aimed at the same anatomical body part, and spaced less than 50 mm from one another.