Photosynthesis based light transduction on a retinal prosthetic chip: Interfacing molecular reactions centers, nano-channel glass, and the retina

Information

  • NSF Award
  • 0243329
Owner
  • Award Id
    0243329
  • Award Effective Date
    10/1/2001 - 23 years ago
  • Award Expiration Date
    12/31/2004 - 20 years ago
  • Award Amount
    $ 329,348.00
  • Award Instrument
    Continuing grant

Photosynthesis based light transduction on a retinal prosthetic chip: Interfacing molecular reactions centers, nano-channel glass, and the retina

This project will study interactions between three distinct systems: (1) photovoltaic molecules and/or membrane structures derived from green plants and artificial photosynthetic systems, (2) micron-scale electrode arrays formed by metal wires in microchannel glass, and (3) the retina. The proposed research will provide a knowledge and technology base necessary to integrate these systems towards the successful development of a novel, energy-efficient retinal prosthesis with a micron scale spatial resolution. More specifically, these objectives will be pursued:<br/> - Investigate interactions between natural and artificial photoactive structures and microchannel glass electrode arrays and to determine methods of attaching the structures to individual microwires.<br/> - Develop methods for depositing conductors throughout the entire length of the microchannels.<br/> - Determine the optimal size and shape for a retinal stimulating electrode.<br/> - Test the biocompatibility of the microchannel glass and photoactivated microchannel glass.<br/>Results of this research are likely to have broader application through improved understanding of metal/molecular interfaces, imaging technology, novel microfabrication techniques, and biological interfacing and testing.

  • Program Officer
    Rajinder P. Khosla
  • Min Amd Letter Date
    4/24/2003 - 22 years ago
  • Max Amd Letter Date
    9/1/2004 - 20 years ago
  • ARRA Amount

Institutions

  • Name
    Doheny Eye Institute
  • City
    Los Angeles
  • State
    CA
  • Country
    United States
  • Address
    1450 San Pablo St, DVRC312
  • Postal Code
    900331088
  • Phone Number
    3234426600

Investigators

  • First Name
    Mark
  • Last Name
    Humayun
  • Email Address
    humayun@usc.edu
  • Start Date
    4/24/2003 12:00:00 AM