Physiological Flow of Liquids Used in Dysphagia Management (previously Tongue-Pressure Timing for Liquid Flow Detection and Control in Swallowing)

Information

  • Research Project
  • 9433634
  • ApplicationId
    9433634
  • Core Project Number
    R01DC011020
  • Full Project Number
    5R01DC011020-06
  • Serial Number
    011020
  • FOA Number
    PA-13-302
  • Sub Project Id
  • Project Start Date
    8/1/2010 - 13 years ago
  • Project End Date
    2/28/2021 - 3 years ago
  • Program Officer Name
    SHEKIM, LANA O
  • Budget Start Date
    3/1/2018 - 6 years ago
  • Budget End Date
    2/28/2019 - 5 years ago
  • Fiscal Year
    2018
  • Support Year
    06
  • Suffix
  • Award Notice Date
    2/20/2018 - 6 years ago

Physiological Flow of Liquids Used in Dysphagia Management (previously Tongue-Pressure Timing for Liquid Flow Detection and Control in Swallowing)

? DESCRIPTION (provided by applicant): The practice of thickening liquids has become one of the most frequently used interventions for swallowing impairment (dysphagia). However, the terminology used to describe thickened liquids (such as nectar-thick and honey-thick) is subjective and we lack empirical evidence about how alterations in liquid consistency affect swallowing function and physiology. The International Dysphagia Diet Standardisation Initiative is a multidisciplinary task force (www.iddsi.org) that has recently developed a new taxonomy of terms to label different levels of liquid consistency used in dysphagia management; these are paired with operational definitions and practical gravity-flow measurement techniques that can be used by caregivers and clinicians to confirm the category of any liquid at the time of preparation or serving. The goal of the current proposal is to measure the in vitro physiological flow of liquids representative of the IDDSI levels of liquid consistency (thin, slightly-thick, milly-thick, moderately-thick and extremely-thick). Physiological measures of liquid flow require an understanding both of the rheological properties of the liquid (gravity-flow; viscosity) and the forces that are applied to the liquid during swallowing (tongue pressure; swallowing muscle contraction). Additional sensory attributes of the bolus (such as slipperiness, graininess and cohesiveness) are also likely to be relevant. We will measure these properties and study bolus flow in healthy adults to establish a reference perspective of expected flow in the context of healthy tongue pressure generation. We will then collect comparative measures in individuals with dysphagia of different etiologies (stroke, acquired brain injury, oropharyngeal cancer, post cervical spine surgery, and neurodegenerative disease) to determine how alterations in swallowing motor function impact liquid flow. These measurements will provide information to guide clinicians in determining optimal levels of thickening to recommend for patients with dysphagia. This research is highly significant because it will establish a new foundation of understanding with respect to the influence of thickened liquids on swallowing. This is essential for advancing clinical practice and setting the stage for future treatment efficacy research.

IC Name
NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
  • Activity
    R01
  • Administering IC
    DC
  • Application Type
    5
  • Direct Cost Amount
    383663
  • Indirect Cost Amount
    30692
  • Total Cost
    414355
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    173
  • Ed Inst. Type
  • Funding ICs
    NIDCD:414355\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    MFSR
  • Study Section Name
    Motor Function, Speech and Rehabilitation Study Section
  • Organization Name
    UNIVERSITY HEALTH NETWORK
  • Organization Department
  • Organization DUNS
    208469486
  • Organization City
    TORONTO
  • Organization State
    ON
  • Organization Country
    CANADA
  • Organization Zip Code
    M5G 2M9
  • Organization District
    CANADA