PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY

Abstract

This disclosure relates to picolinamides of Formula I and their use as fungicides.

Description

BACKGROUND & SUMMARY

Fungicides are compounds, of natural or synthetic origin, which act to protect and/or cure plants against damage caused by agriculturally relevant fungi. Generally, no single fungicide is useful in all situations. Consequently, research is ongoing to produce fungicides that may have better performance, are easier to use, and cost less.

The present disclosure relates to picolinamides and their use as fungicides. The compounds of the present disclosure may offer protection against ascomycetes, basidiomycetes, deuteromycetes and oomycetes.

One embodiment of the present disclosure may include compounds of Formula I:

• • in which: X is hydrogen or C(O)R₅;
  • Y is hydrogen, C(O)R₅, or Q; Q is

• • wherein: Z is N or CH;
  • R₁ is hydrogen or alkyl, each optionally substituted with 0, 1 or multiple R₈;
  • R₂ is methyl;
  • R₃ is chosen from aryl or heteroaryl, each optionally substituted with 0, 1 or multiple R₈;
  • R₄ is chosen from hydrogen, halo, hydroxyl, alkyl or alkoxy;
  • R₅ is chosen from alkoxy or benzyloxy, each optionally substituted with 0, 1, or multiple R₈;
  • R₆ is chosen from hydrogen, alkoxy, or halo, each optionally substituted with 0, 1, or multiple R₈;
  • R₇ is chosen from hydrogen, —C(O)R₉, or —CH₂OC(O)R₉;
  • R₈ is chosen from hydrogen, alkyl, aryl, acyl, halo, alkenyl, alkynyl, alkoxy, cyano or heterocyclyl, each optionally substituted with 0, 1, or multiple R₁₀;
  • R₉ is chosen from alkyl, alkoxy, or aryl, each optionally substituted with 0, 1, or multiple R₈;
  • R₁₀ is chosen from hydrogen, alkyl, aryl, acyl, halo, alkenyl, alkoxy, or heterocyclyl;
  • R₁₁ is chosen from hydrogen or alkyl, substituted with 0, 1, or multiple R₈;
  • R₁₂ is chosen from aryl or heteroaryl, each optionally substituted with 0, 1 or multiple R₈.

Another embodiment of the present disclosure may include a fungicidal composition for the control or prevention of fungal attack comprising the compounds described above and a phytologically acceptable carrier material.

Yet another embodiment of the present disclosure may include a method for the control or prevention of fungal attack on a plant, the method including the steps of applying a fungicidally effective amount of one or more of the compounds described above to at least one of the fungus, the plant, and an area adjacent to the plant.

It will be understood by those skilled in the art that the following terms may include generic “R”-groups within their definitions, e.g., “the term alkoxy refers to an —OR substituent”. It is also understood that within the definitions for the following terms, these “R” groups are included for illustration purposes and should not be construed as limiting or being limited by substitutions about Formula I.

The term “alkyl” refers to a branched, unbranched, or saturated cyclic carbon chain, including, but not limited to, methyl, ethyl, propyl, butyl, isopropyl, isobutyl, tertiary butyl, pentyl, hexyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and the like.

The term “alkenyl” refers to a branched, unbranched or cyclic carbon chain containing one or more double bonds including, but not limited to, ethenyl, propenyl, butenyl, isopropenyl, isobutenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, and the like.

The term “alkynyl” refers to a branched or unbranched carbon chain containing one or more triple bonds including, but not limited to, propynyl, butynyl, and the like.

The terms “aryl” and “Ar” refer to any aromatic ring, mono- or bi-cyclic, containing 0 heteroatoms.

The term “heterocyclyl” refers to any aromatic or non-aromatic ring, mono- or bi-cyclic, containing one or more heteroatoms.

The term “alkoxy” refers to an —OR substituent.

The term “acyloxy” refers to an —OC(O)R substituent.

The term “cyano” refers to a —C≡N substituent.

The term “hydroxyl” refers to an —OH substituent.

The term “amino” refers to a —N(R)₂ substituent.

The term “arylalkoxy” refers to —O(CH₂)_nAr where n is an integer selected from the list 1, 2, 3, 4, 5, or 6.

The term “haloalkoxy” refers to an —OR—X substituent, wherein X is Cl, F, Br, or I, or any combination thereof.

The term “haloalkyl” refers to an alkyl, which is substituted with Cl, F, I, or Br or any combination thereof.

The term “halogen” or “halo” refers to one or more halogen atoms, defined as F, Cl, Br, and I.

The term “nitro” refers to a —NO₂ substituent.

The term thioalkyl refers to an —SR substituent.

Throughout the disclosure, reference to the compounds of Formula I is read as also including all stereoisomers, for example diastereomers, enantiomers, and mixtures thereof. In another embodiment, Formula I is read as also including salts or hydrates thereof. Exemplary salts include, but are not limited to: hydrochloride, hydrobromide, hydroiodide, trifluoroacetate, and trifluoromethane sulfonate.

It is also understood by those skilled in the art that additional substitution is allowable, unless otherwise noted, as long as the rules of chemical bonding and strain energy are satisfied and the product still exhibits fungicidal activity.

Another embodiment of the present disclosure is a use of a compound of Formula I, for protection of a plant against attack by a phytopathogenic organism or the treatment of a plant infested by a phytopathogenic organism, comprising the application of a compound of Formula I, or a composition comprising the compound to soil, a plant, a part of a plant, foliage, and/or roots.

Additionally, another embodiment of the present disclosure is a composition useful for protecting a plant against attack by a phytopathogenic organism and/or treatment of a plant infested by a phytopathogenic organism comprising a compound of Formula I and a phytologically acceptable carrier material.

DETAILED DESCRIPTION

The compounds of the present disclosure may be applied by any of a variety of known techniques, either as the compounds or as formulations comprising the compounds. For example, the compounds may be applied to the roots or foliage of plants for the control of various fungi, without damaging the commercial value of the plants. The materials may be applied in the form of any of the generally used formulation types, for example, as solutions, dusts, wettable powders, flowable concentrate, or emulsifiable concentrates.

Preferably, the compounds of the present disclosure are applied in the form of a formulation, comprising one or more of the compounds of Formula I with a phytologically acceptable carrier. Concentrated formulations may be dispersed in water, or other liquids, for application, or formulations may be dust-like or granular, which may then be applied without further treatment. The formulations can be prepared according to procedures that are conventional in the agricultural chemical art.

The present disclosure contemplates all vehicles by which one or more of the compounds may be formulated for delivery and use as a fungicide. Typically, formulations are applied as aqueous suspensions or emulsions. Such suspensions or emulsions may be produced from water-soluble, water-suspendible, or emulsifiable formulations which are solids, usually known as wettable powders; or liquids, usually known as emulsifiable concentrates, aqueous suspensions, or suspension concentrates. As will be readily appreciated, any material to which these compounds may be added may be used, provided it yields the desired utility without significant interference with the activity of these compounds as antifungal agents.

Wettable powders, which may be compacted to form water-dispersible granules, comprise an intimate mixture of one or more of the compounds of Formula I, an inert carrier and surfactants. The concentration of the compound in the wettable powder may be from about 10 percent to about 90 percent by weight based on the total weight of the wettable powder, more preferably about 25 weight percent to about 75 weight percent. In the preparation of wettable powder formulations, the compounds may be compounded with any finely divided solid, such as prophyllite, talc, chalk, gypsum, Fuller's earth, bentonite, attapulgite, starch, casein, gluten, montmorillonite clays, diatomaceous earths, purified silicates or the like. In such operations, the finely divided carrier and surfactants are typically blended with the compound(s) and milled.

Emulsifiable concentrates of the compounds of Formula I may comprise a convenient concentration, such as from about 1 weight percent to about 50 weight percent of the compound, in a suitable liquid, based on the total weight of the concentrate. The compounds may be dissolved in an inert carrier, which is either a water-miscible solvent or a mixture of water-immiscible organic solvents, and emulsifiers. The concentrates may be diluted with water and oil to form spray mixtures in the form of oil-in-water emulsions. Useful organic solvents include aromatics, especially the high-boiling naphthalenic and olefinic portions of petroleum such as heavy aromatic naphtha. Other organic solvents may also be used, for example, terpenic solvents, including rosin derivatives, aliphatic ketones, such as cyclohexanone, and complex alcohols, such as 2-ethoxyethanol.

Emulsifiers which may be advantageously employed herein may be readily determined by those skilled in the art and include various nonionic, anionic, cationic and amphoteric emulsifiers, or a blend of two or more emulsifiers. Examples of nonionic emulsifiers useful in preparing the emulsifiable concentrates include the polyalkylene glycol ethers and condensation products of alkyl and aryl phenols, aliphatic alcohols, aliphatic amines or fatty acids with ethylene oxide, propylene oxides such as the ethoxylated alkyl phenols and carboxylic esters solubilized with the polyol or polyoxyalkylene. Cationic emulsifiers include quaternary ammonium compounds and fatty amine salts. Anionic emulsifiers include the oil-soluble salts (e.g., calcium) of alkylaryl sulfonic acids, oil-soluble salts or sulfated polyglycol ethers and appropriate salts of phosphated polyglycol ether.

Representative organic liquids which may be employed in preparing the emulsifiable concentrates of the compounds of the present disclosure are the aromatic liquids such as xylene, propyl benzene fractions; or mixed naphthalene fractions, mineral oils, substituted aromatic organic liquids such as dioctyl phthalate; kerosene; dialkyl amides of various fatty acids, particularly the dimethyl amides of fatty glycols and glycol derivatives such as the n-butyl ether, ethyl ether or methyl ether of diethylene glycol, the methyl ether of triethylene glycol, petroleum fractions or hydrocarbons such as mineral oil, aromatic solvents, paraffinic oils, and the like; vegetable oils such as soybean oil, rapeseed oil, olive oil, castor oil, sunflower seed oil, coconut oil, corn oil, cottonseed oil, linseed oil, palm oil, peanut oil, safflower oil, sesame oil, tung oil and the like; esters of the above vegetable oils; and the like. Mixtures of two or more organic liquids may also be employed in the preparation of the emulsifiable concentrate. Organic liquids include xylene, and propyl benzene fractions, with xylene being most preferred in some cases. Surface-active dispersing agents are typically employed in liquid formulations and in an amount of from 0.1 to 20 percent by weight based on the combined weight of the dispersing agent with one or more of the compounds. The formulations can also contain other compatible additives, for example, plant growth regulators and other biologically active compounds used in agriculture.

Aqueous suspensions comprise suspensions of one or more water-insoluble compounds of Formula I, dispersed in an aqueous vehicle at a concentration in the range from about 1 to about 50 weight percent, based on the total weight of the aqueous suspension. Suspensions are prepared by finely grinding one or more of the compounds, and vigorously mixing the ground material into a vehicle comprised of water and surfactants chosen from the same types discussed above. Other components, such as inorganic salts and synthetic or natural gums, may also be added to increase the density and viscosity of the aqueous vehicle.

The compounds of Formula I can also be applied as granular formulations, which are particularly useful for applications to the soil. Granular formulations generally contain from about 0.5 to about 10 weight percent, based on the total weight of the granular formulation of the compound(s), dispersed in an inert carrier which consists entirely or in large part of coarsely divided inert material such as attapulgite, bentonite, diatomite, clay or a similar inexpensive substance. Such formulations are usually prepared by dissolving the compounds in a suitable solvent and applying it to a granular carrier which has been preformed to the appropriate particle size, in the range of from about 0.5 to about 3 mm. A suitable solvent is a solvent in which the compound is substantially or completely soluble. Such formulations may also be prepared by making a dough or paste of the carrier and the compound and solvent, and crushing and drying to obtain the desired granular particle.

Dusts containing the compounds of Formula I may be prepared by intimately mixing one or more of the compounds in powdered form with a suitable dusty agricultural carrier, such as, for example, kaolin clay, ground volcanic rock, and the like. Dusts can suitably contain from about 1 to about 10 weight percent of the compounds, based on the total weight of the dust.

The formulations may additionally contain adjuvant surfactants to enhance deposition, wetting, and penetration of the compounds onto the target crop and organism. These adjuvant surfactants may optionally be employed as a component of the formulation or as a tank mix. The amount of adjuvant surfactant will typically vary from 0.01 to 1.0 percent by volume, based on a spray-volume of water, preferably 0.05 to 0.5 volume percent. Suitable adjuvant surfactants include, but are not limited to ethoxylated nonyl phenols, ethoxylated synthetic or natural alcohols, salts of the esters or sulfosuccinic acids, ethoxylated organosilicones, ethoxylated fatty amines, blends of surfactants with mineral or vegetable oils, crop oil concentrate (mineral oil (85%)+emulsifiers (15%)); nonylphenol ethoxylate; benzylcocoalkyldimethyl quaternary ammonium salt; blend of petroleum hydrocarbon, alkyl esters, organic acid, and anionic surfactant; C₉-C₁₁ alkylpolyglycoside; phosphated alcohol ethoxylate; natural primary alcohol (C₁₂-C₁₆) ethoxylate; di-sec-butylphenol EO-PO block copolymer; polysiloxane-methyl cap; nonylphenol ethoxylate+urea ammonium nitrrate; emulsified methylated seed oil; tridecyl alcohol (synthetic) ethoxylate (8EO); tallow amine ethoxylate (15 EO); PEG(400) dioleate-99. The formulations may also include oil-in-water emulsions such as those disclosed in U.S. patent application Ser. No. 11/495,228, the disclosure of which is expressly incorporated by reference herein.

The formulations may optionally include combinations that contain other pesticidal compounds. Such additional pesticidal compounds may be fungicides, insecticides, herbicides, nematocides, miticides, arthropodicides, bactericides or combinations thereof that are compatible with the compounds of the present disclosure in the medium selected for application, and not antagonistic to the activity of the present compounds. Accordingly, in such embodiments, the other pesticidal compound is employed as a supplemental toxicant for the same or for a different pesticidal use. The compounds of Formula I and the pesticidal compound in the combination can generally be present in a weight ratio of from 1:100 to100:1.

The compounds of the present disclosure may also be combined with other fungicides to form fungicidal mixtures and synergistic mixtures thereof. The fungicidal compounds of the present disclosure are often applied in conjunction with one or more other fungicides to control a wider variety of undesirable diseases. When used in conjunction with other fungicide(s), the presently claimed compounds may be formulated with the other fungicide(s), tank-mixed with the other fungicide(s) or applied sequentially with the other fungicide(s). Such other fungicides may include 2-(thiocyanatomethylthio)-benzothiazole, 2-phenylphenol, 8-hydroxyquinoline sulfate, ametoctradin, amisulbrom, antimycin, Ampelomyces quisqualis, azaconazole, azoxystrobin, Bacillus subtilis, Bacillus subtilis strain QST713, benalaxyl, benomyl, benthiavalicarb-isopropyl, benzovindiflupyr, benzylaminobenzene-sulfonate (BABS) salt, bicarbonates, biphenyl, bismerthiazol, bitertanol, bixafen, blasticidin-S, borax, Bordeaux mixture, boscalid, bromuconazole, bupirimate, calcium polysulfide, captafol, captan, carbendazim, carboxin, carpropamid, carvone, chlazafenone, chloroneb, chlorothalonil, chlozolinate, Coniothyrium minitans, copper hydroxide, copper octanoate, copper oxychloride, copper sulfate, copper sulfate (tribasic), coumoxystrobin, cuprous oxide, cyazofamid, cyflufenamid, cymoxanil, cyproconazole, cyprodinil, dazomet, debacarb, diammonium ethylenebis-(dithiocarbamate), dichlofluanid, dichlorophen, diclocymet, diclomezine, dichloran, diethofencarb, difenoconazole, difenzoquat ion, diflumetorim, dimethomorph, dimoxystrobin, diniconazole, diniconazole-M, dinobuton, dinocap, diphenylamine, dipymetitrone, dithianon, dodemorph, dodemorph acetate, dodine, dodine free base, edifenphos, enestrobin, enestroburin, enoxastrobin, epoxiconazole, ethaboxam, ethoxyquin, etridiazole, famoxadone, fenamidone, fenaminostrobin, fenarimol, fenbuconazole, fenfuram, fenhexamid, fenoxanil, fenpiclonil, fenpropidin, fenpropimorph, fenpyrazamine, fentin, fentin acetate, fentin hydroxide, ferbam, ferimzone, fluazinam, fludioxonil, flufenoxystrobin, flumorph, fluopicolide, fluopyram, fluoroimide, fluoxastrobin, fluquinconazole, flusilazole, flusulfamide, flutianil, flutolanil, flutriafol, fluxapyroxad, folpet, formaldehyde, fosetyl, fosetyl-aluminium, fuberidazole, furalaxyl, furametpyr, guazatine, guazatine acetates, GY-81, hexachlorobenzene, hexaconazole, hymexazol, imazalil, imazalil sulfate, imibenconazole, iminoctadine, iminoctadine triacetate, iminoctadine tris(albesilate), iodocarb, ipconazole, ipfenpyrazolone, iprobenfos, iprodione, iprovalicarb, isofetamid, isoprothiolane, isopyrazam, isotianil, kasugamycin, kasugamycin hydrochloride hydrate, kresoxim-methyl, laminarin, mancopper, mancozeb, mandestrobin, mandipropamid, maneb, mefenoxam, mepanipyrim, mepronil, meptyl-dinocap, mercuric chloride, mercuric oxide, mercurous chloride, metalaxyl, metalaxyl-M, metam, metam-ammonium, metam-potassium, metam-sodium, metconazole, methasulfocarb, methyl iodide, methyl isothiocyanate, metiram, metominostrobin, metrafenone, mildiomycin, myclobutanil, nabam, nitrothal-isopropyl, nuarimol, octhilinone, ofurace, oleic acid (fatty acids), orysastrobin, oxadixyl, oxathiapiprolin, oxine-copper, oxpoconazole fumarate, oxycarboxin, pefurazoate, penconazole, pencycuron, penflufen, pentachlorophenol, pentachlorophenyl laurate, penthiopyrad, phenylmercury acetate, phosphonic acid, phthalide, picarbutrazox, picoxystrobin, polyoxin B, polyoxins, polyoxorim, potassium bicarbonate, potassium hydroxyquinoline sulfate, probenazole, prochloraz, procymidone, propamocarb, propamocarb hydrochloride, propiconazole, propineb, proquinazid, prothioconazole, pyraclostrobin, pyrametostrobin, pyraoxystrobin, pyraziflumid, pyrazophos, pyribencarb, pyributicarb, pyrifenox, pyrimethanil, pyriofenone, pyrisoxazole, pyroquilon, quinoclamine, quinoxyfen, quintozene, Reynoutria sachalinensis extract, sedaxane, silthiofam, simeconazole, sodium 2-phenylphenoxide, sodium bicarbonate, sodium pentachlorophenoxide, spiroxamine, sulfur, SYP-Z048, tar oils, tebuconazole, tebufloquin, tecnazene, tetraconazole, thiabendazole, thifluzamide, thiophanate-methyl, thiram, tiadinil, tolclofos-methyl, tolprocarb, tolylfluanid, triadimefon, triadimenol, triazoxide, triclopyricarb, tricyclazole, tridemorph, trifloxystrobin, triflumizole, triforine, triticonazole, validamycin, valifenalate, valiphenal, vinclozolin, zineb, ziram, zoxamide, Candida oleophila, Fusarium oxysporum, Gliocladium spp., Phlebiopsis gigantea, Streptomyces griseoviridis, Trichoderma spp., (RS)—N-(3,5-dichlorophenyl)-2-(methoxymethyl)-succinimide, 1,2-dichloropropane, 1,3-dichloro-1,1,3,3-tetrafluoroacetone hydrate, 1-chloro-2,4-dinitronaphthalene, 1-chloro-2-nitropropane, 2-(2-heptadecyl-2-imidazolin-1-yl)ethanol, 2,3-dihydro-5-phenyl-1,4-dithi-ine 1,1,4,4-tetraoxide, 2-methoxyethylmercury acetate, 2-methoxyethylmercury chloride, 2-methoxyethylmercury silicate, 3-(4-chlorophenyl)-5-methylrhodanine, 4-(2-nitroprop-1-enyl)phenyl thiocyanateme, ampropylfos, anilazine, azithiram, barium polysulfide, Bayer 32394, benodanil, benquinox, bentaluron, benzamacril, benzamacril-isobutyl, benzamorf, binapacryl, bis(methylmercury) sulfate, bis(tributyltin) oxide, buthiobate, cadmium calcium copper zinc chromate sulfate, carbamorph, CECA, chlobenthiazone, chloraniformethan, chlorfenazole, chlorquinox, climbazole, copper bis(3-phenylsalicylate), copper zinc chromate, cufraneb, cupric hydrazinium sulfate, cuprobam, cyclafuramid, cypendazole, cyprofuram, decafentin, dichlone, dichlozoline, diclobutrazol, dimethirimol, dinocton, dinosulfon, dinoterbon, dipyrithione, ditalimfos, dodicin, drazoxolon, EBP, ESBP, etaconazole, etem, ethirim, fenaminosulf, fenapanil, fenitropan, fluotrimazole, furcarbanil, furconazole, furconazole-cis, furmecyclox, furophanate, glyodine, griseofulvin, halacrinate, Hercules 3944, hexylthiofos, ICIA0858, isopamphos, isovaledione, mebenil, mecarbinzid, metazoxolon, methfuroxam, methylmercury dicyandiamide, metsulfovax, milneb, mucochloric anhydride, myclozolin, N-3,5-dichlorophenyl-succinimide, N-3-nitrophenylitaconimide, natamycin, N-ethylmercurio-4-toluenesulfonanilide, nickel bis(dimethyldithiocarbamate), OCH, phenylmercury dimethyldithiocarbamate, phenylmercury nitrate, phosdiphen, prothiocarb, prothiocarb hydrochloride, pyracarbolid, pyridinitril, pyroxychlor, pyroxyfur, quinacetol, quinacetol sulfate, quinazamid, quinconazole, rabenzazole, salicylanilide, SSF-109, sultropen, tecoram, thiadifluor, thicyofen, thiochlorfenphim, thiophanate, thioquinox, tioxymid, triamiphos, triarimol, triazbutil, trichlamide, urbacid, zarilamid, and any combinations thereof.

Additionally, the compounds described herein may be combined with other pesticides, including insecticides, nematocides, miticides, arthropodicides, bactericides or combinations thereof that are compatible with the compounds of the present disclosure in the medium selected for application, and not antagonistic to the activity of the present compounds to form pesticidal mixtures and synergistic mixtures thereof. The fungicidal compounds of the present disclosure may be applied in conjunction with one or more other pesticides to control a wider variety of undesirable pests. When used in conjunction with other pesticides, the presently claimed compounds may be formulated with the other pesticide(s), tank-mixed with the other pesticide(s) or applied sequentially with the other pesticide(s). Typical insecticides include, but are not limited to: 1,2-dichloropropane, abamectin, acephate, acetamiprid, acethion, acetoprole, acrinathrin, acrylonitrile, afidopyropen, alanycarb, aldicarb, aldoxycarb, aldrin, allethrin, allosamidin, allyxycarb, alpha-cypermethrin, alpha-ecdysone, alpha-endosulfan, amidithion, aminocarb, amiton, amiton oxalate, amitraz, anabasine, athidathion, azadirachtin, azamethiphos, azinphos-ethyl, azinphos-methyl, azothoate, barium hexafluorosilicate, barthrin, bendiocarb, benfuracarb, bensultap, beta-cyfluthrin, beta-cypermethrin, bifenthrin, bioallethrin, bioethanomethrin, biopermethrin, bistrifluron, borax, boric acid, broflanilide, bromfenvinfos, bromocyclen, bromo-DDT, bromophos, bromophos-ethyl, bufencarb, buprofezin, butacarb, butathiofos, butocarboxim, butonate, butoxycarboxim, cadusafos, calcium arsenate, calcium polysulfide, camphechlor, carbanolate, carbaryl, carbofuran, carbon disulfide, carbon tetrachloride, carbophenothion, carbosulfan, cartap, cartap hydrochloride, chlorantraniliprole, chlorbicyclen, chlordane, chlordecone, chlordimeform, chlordimeform hydrochloride, chlorethoxyfos, chlorfenapyr, chlorfenvinphos, chlorfluazuron, chlormephos, chloroform, chloropicrin, chlorphoxim, chlorprazophos, chlorpyrifos, chlorpyrifos-methyl, chlorthiophos, chromafenozide, cinerin I, cinerin II, cinerins, cismethrin, clacyfos, cloethocarb, closantel, clothianidin, copper acetoarsenite, copper arsenate, copper naphthenate, copper oleate, coumaphos, coumithoate, crotamiton, crotoxyphos, crufomate, cryolite, cyanofenphos, cyanophos, cyanthoate, cyantraniliprole, cyclaniliprole, cyclethrin, cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin, cyphenothrin, cyromazine, cythioate, DDT, decarbofuran, deltamethrin, demephion, demephion-O, demephion-S, demeton, demeton-methyl, demeton-O, demeton-O-methyl, demeton-S, demeton-S-methyl, demeton-S-methylsulphon, diafenthiuron, dialifos, diatomaceous earth, diazinon, dicapthon, dichlofenthion, dichlorvos, dicloromezotiaz, dicresyl, dicrotophos, dicyclanil, dieldrin, diflubenzuron, dilor, dimefluthrin, dimefox, dimetan, dimethoate, dimethrin, dimethylvinphos, dimetilan, dinex, dinex-diclexine, dinoprop, dinosam, dinotefuran, diofenolan, dioxabenzofos, dioxacarb, dioxathion, disulfoton, dithicrofos, d-limonene, DNOC, DNOC-ammonium, DNOC-potassium, DNOC-sodium, doramectin, ecdysterone, emamectin, emamectin benzoate, EMPC, empenthrin, endosulfan, endothion, endrin, EPN, epofenonane, eprinomectin, esdepalldthrine, esfenvalerate, etaphos, ethiofencarb, ethion, ethiprole, ethoate-methyl, ethoprophos, ethyl formate, ethyl-DDD, ethylene dibromide, ethylene dichloride, ethylene oxide, etofenprox, etrimfos, EXD, famphur, fenamiphos, fenazaflor, fenchlorphos, fenethacarb, fenfluthrin, fenitrothion, fenobucarb, fenoxacrim, fenoxycarb, fenpirithrin, fenpropathrin, fensulfothion, fenthion, fenthion-ethyl, fenvalerate, fipronil, flometoquin, flonicamid, flubendiamide, flucofuron, flucycloxuron, flucythrinate, flufenerim, flufenoxuron, flufenprox, flufiprole, fluhexafon, flupyradifurone, fluvalinate, fonofos, formetanate, formetanate hydrochloride, formothion, formparanate, formparanate hydrochloride, fosmethilan, fospirate, fosthietan, furathiocarb, furethrin, gamma-cyhalothrin, gamma-HCH, halfenprox, halofenozide, HCH, HEOD, heptachlor, heptafluthrin, heptenophos, heterophos, hexaflumuron, HHDN, hydramethylnon, hydrogen cyanide, hydroprene, hyquincarb, imidacloprid, imiprothrin, indoxacarb, iodomethane, IPSP, isazofos, isobenzan, isocarbophos, isodrin, isofenphos, isofenphos-methyl, isoprocarb, isoprothiolane, isothioate, isoxathion, ivermectin, jasmolin I, jasmolin II, jodfenphos, juvenile hormone I, juvenile hormone II, juvenile hormone III, kappa-bifenthrin, kappa-tefluthrin, kelevan, kinoprene, lambda-cyhalothrin, lead arsenate, lepimectin, leptophos, lindane, lirimfos, lufenuron, lythidathion, malathion, malonoben, mazidox, mecarbam, mecarphon, menazon, mephosfolan, mercurous chloride, mesulfenfos, metaflumizone, methacrifos, methamidophos, methidathion, methiocarb, methocrotophos, methomyl, methoprene, methoxychlor, methoxyfenozide, methyl bromide, methyl isothiocyanate, methylchloroform, methylene chloride, metofluthrin, metolcarb, metoxadiazone, mevinphos, mexacarbate, milbemectin, milbemycin oxime, mipafox, mirex, molosultap, momfluorothrin, monocrotophos, monomehypo, monosultap, morphothion, moxidectin, naftalofos, naled, naphthalene, nicotine, nifluridide, nitenpyram, nithiazine, nitrilacarb, novaluron, noviflumuron, omethoate, oxamyl, oxydemeton-methyl, oxydeprofos, oxydisulfoton, para-dichlorobenzene, parathion, parathion-methyl, penfluron, pentachlorophenol, permethrin, phenkapton, phenothrin, phenthoate, phorate, phosalone, phosfolan, phosmet, phosnichlor, phosphamidon, phosphine, phoxim, phoxim-methyl, pirimetaphos, pirimicarb, pirimiphos-ethyl, pirimiphos-methyl, potassium arsenite, potassium thiocyanate, pp′-DDT, prallethrin, precocene I, precocene II, precocene III, primidophos, profenofos, profluralin, promacyl, promecarb, propaphos, propetamphos, propoxur, prothidathion, prothiofos, prothoate, protrifenbute, pyflubumide, pyraclofos, pyrafluprole, pyrazophos, pyresmethrin, pyrethrin I, pyrethrin II, pyrethrins, pyridaben, pyridalyl, pyridaphenthion, pyrifluquinazon, pyrimidifen, pyriminostrobin, pyrimitate, pyriprole, pyriproxyfen, quassia, quinalphos, quinalphos-methyl, quinothion, rafoxanide, resmethrin, rotenone, ryania, sabadilla, schradan, selamectin, silafluofen, silica gel, sodium arsenite, sodium fluoride, sodium hexafluorosilicate, sodium thiocyanate, sophamide, spinetoram, spinosad, spiromesifen, spirotetramat, sulcofuron, sulcofuron-sodium, sulfluramid, sulfotep, sulfoxaflor, sulfuryl fluoride, sulprofos, tau-fluvalinate, tazimcarb, TDE, tebufenozide, tebufenpyrad, tebupirimfos, teflubenzuron, tefluthrin, temephos, TEPP, terallethrin, terbufos, tetrachloroethane, tetrachlorvinphos, tetramethrin, tetramethylfluthrin, tetraniliprole, theta-cypermethrin, thiacloprid, thiamethoxam, thicrofos, thiocarboxime, thiocyclam, thiocyclam oxalate, thiodicarb, thiofanox, thiometon, thiosultap, thiosultap-disodium, thiosultap-monosodium, thuringiensin, tioxazafen, tolfenpyrad, tralomethrin, transfluthrin, transpermethrin, triarathene, triazamate, triazophos, trichlorfon, trichlormetaphos-3, trichloronat, trifenofos, triflumezopyrim, triflumuron, trimethacarb, triprene, vamidothion, vaniliprole, XMC, xylylcarb, zeta-cypermethrin, zolaprofos, and any combinations thereof.

Additionally, the compounds described herein may be combined with herbicides that are compatible with the compounds of the present disclosure in the medium selected for application, and not antagonistic to the activity of the present compounds to form pesticidal mixtures and synergistic mixtures thereof. The fungicidal compounds of the present disclosure may be applied in conjunction with one or more herbicides to control a wide variety of undesirable plants. When used in conjunction with herbicides, the presently claimed compounds may be formulated with the herbicide(s), tank-mixed with the herbicide(s) or applied sequentially with the herbicide(s). Typical herbicides include, but are not limited to: 4-CPA; 4-CPB; 4-CPP; 2,4-D; 3,4-DA; 2,4-DB; 3,4-DB; 2,4-DEB; 2,4-DEP; 3,4-DP; 2,3,6-TBA; 2,4,5-T; 2,4,5-TB; acetochlor, acifluorfen, aclonifen, acrolein, alachlor, allidochlor, alloxydim, allyl alcohol, alorac, ametridione, ametryn, amibuzin, amicarbazone, amidosulfuron, aminocyclopyrachlor, aminopyralid, amiprofos-methyl, amitrole, ammonium sulfamate, anilofos, anisuron, asulam, atraton, atrazine, azafenidin, azimsulfuron, aziprotryne, barban, BCPC, beflubutamid, benazolin, bencarbazone, benfluralin, benfuresate, bensulfuron, bensulide, bentazone, benzadox, benzfendizone, benzipram, benzobicyclon, benzofenap, benzofluor, benzoylprop, benzthiazuron, bicyclopyrone, bifenox, bilanafos, bispyribac, borax, bromacil, bromobonil, bromobutide, bromofenoxim, bromoxynil, brompyrazon, butachlor, butafenacil, butamifos, butenachlor, buthidazole, buthiuron, butralin, butroxydim, buturon, butylate, cacodylic acid, cafenstrole, calcium chlorate, calcium cyanamide, cambendichlor, carbasulam, carbetamide, carboxazole, chlorprocarb, carfentrazone, CDEA, CEPC, chlomethoxyfen, chloramben, chloranocryl, chlorazifop, chlorazine, chlorbromuron, chlorbufam, chloreturon, chlorfenac, chlorfenprop, chlorflurazole, chlorflurenol, chloridazon, chlorimuron, chlornitrofen, chloropon, chlorotoluron, chloroxuron, chloroxynil, chlorpropham, chlorsulfuron, chlorthal, chlorthiamid, cinidon-ethyl, cinmethylin, cinosulfuron, cisanilide, clethodim, cliodinate, clodinafop, clofop, clomazone, clomeprop, cloprop, cloproxydim, clopyralid, cloransulam, CMA, copper sulfate, CPMF, CPPC, credazine, cresol, cumyluron, cyanatryn, cyanazine, cycloate, cyclopyrimorate, cyclosulfamuron, cycloxydim, cycluron, cyhalofop, cyperquat, cyprazine, cyprazole, cypromid, daimuron, dalapon, dazomet, delachlor, desmedipham, desmetryn, di-allate, dicamba, dichlobenil, dichloralurea, dichlormate, dichlorprop, dichlorprop-P, diclofop, diclosulam, diethamquat, diethatyl, difenopenten, difenoxuron, difenzoquat, diflufenican, diflufenzopyr, dimefuron, dimepiperate, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, dimexano, dimidazon, dinitramine, dinofenate, dinoprop, dinosam, dinoseb, dinoterb, diphenamid, dipropetryn, diquat, disul, dithiopyr, diuron, DMPA, DNOC, DSMA, EBEP, eglinazine, endothal, epronaz, EPTC, erbon, esprocarb, ethalfluralin, ethametsulfuron, ethidimuron, ethiolate, ethofumesate, ethoxyfen, ethoxysulfuron, etinofen, etnipromid, etobenzanid, EXD, fenasulam, fenoprop, fenoxaprop, fenoxaprop-P, fenoxasulfone, fenquinotrione, fenteracol, fenthiaprop, fentrazamide, fenuron, ferrous sulfate, flamprop, flamprop-M, flazasulfuron, florasulam, fluazifop, fluazifop-P, fluazolate, flucarbazone, flucetosulfuron, fluchloralin, flufenacet, flufenican, flufenpyr, flumetsulam, flumezin, flumiclorac, flumioxazin, flumipropyn, fluometuron, fluorodifen, fluoroglycofen, fluoromidine, fluoronitrofen, fluothiuron, flupoxam, flupropacil, flupropanate, flupyrsulfuron, fluridone, flurochloridone, fluroxypyr, flurtamone, fluthiacet, fomesafen, foramsulfuron, fosamine, furyloxyfen, glufosinate, glufosinate-P, glyphosate, halauxifen, halosafen, halosulfuron, haloxydine, haloxyfop, haloxyfop-P, hexachloroacetone, hexaflurate, hexazinone, imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron, indanofan, indaziflam, iodobonil, iodomethane, iodosulfuron, iofensulfuron, ioxynil, ipazine, ipfencarbazone, iprymidam, isocarbamid, isocil, isomethiozin, isonoruron, isopolinate, isopropalin, isoproturon, isouron, isoxaben, isoxachlortole, isoxaflutole, isoxapyrifop, karbutilate, ketospiradox, lactofen, lenacil, linuron, MAA, MAMA, MCPA, MCPA-thioethyl, MCPB, mecoprop, mecoprop-P, medinoterb, mefenacet, mefluidide, mesoprazine, mesosulfuron, mesotrione, metam, metamifop, metamitron, metazachlor, metazosulfuron, metflurazon, methabenzthiazuron, methalpropalin, methazole, methiobencarb, methiozolin, methiuron, methometon, methoprotryne, methyl bromide, methyl isothiocyanate, methyldymron, metobenzuron, metobromuron, metolachlor, metosulam, metoxuron, metribuzin, metsulfuron, molinate, monalide, monisouron, monochloroacetic acid, monolinuron, monuron, morfamquat, MSMA, naproanilide, napropamide, napropamide-M, naptalam, neburon, nicosulfuron, nipyraclofen, nitralin, nitrofen, nitrofluorfen, norflurazon, noruron, OCH, orbencarb, ortho-dichlorobenzene, orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxapyrazon, oxasulfuron, oxaziclomefone, oxyfluorfen, parafluron, paraquat, pebulate, pelargonic acid, pendimethalin, penoxsulam, pentachlorophenol, pentanochlor, pentoxazone, perfluidone, pethoxamid, phenisopham, phenmedipham, phenmedipham-ethyl, phenobenzuron, phenylmercury acetate, picloram, picolinafen, pinoxaden, piperophos, potassium arsenite, potassium azide, potassium cyanate, pretilachlor, primisulfuron, procyazine, prodiamine, profluazol, profluralin, profoxydim, proglinazine, prometon, prometryn, propachlor, propanil, propaquizafop, propazine, propham, propisochlor, propoxycarbazone, propyrisulfuron, propyzamide, prosulfalin, prosulfocarb, prosulfuron, proxan, prynachlor, pydanon, pyraclonil, pyraflufen, pyrasulfotole, pyrazolynate, pyrazosulfuron, pyrazoxyfen, pyribenzoxim, pyributicarb, pyriclor, pyridafol, pyridate, pyriftalid, pyriminobac, pyrimisulfan, pyrithiobac, pyroxasulfone, pyroxsulam, quinclorac, quinmerac, quinoclamine, quinonamid, quizalofop, quizalofop-P, rhodethanil, rimsulfuron, saflufenacil, S-metolachlor, sebuthylazine, secbumeton, sethoxydim, siduron, simazine, simeton, simetryn, SMA, sodium arsenite, sodium azide, sodium chlorate, sulcotrione, sulfallate, sulfentrazone, sulfometuron, sulfosulfuron, sulfuric acid, sulglycapin, swep, TCA, tebutam, tebuthiuron, tefuryltrione, tembotrione, tepraloxydim, terbacil, terbucarb, terbuchlor, terbumeton, terbuthylazine, terbutryn, tetrafluron, thenylchlor, thiazafluron, thiazopyr, thidiazimin, thidiazuron, thiencarbazone-methyl, thifensulfuron, thiobencarb, tiafenacil, tiocarbazil, tioclorim, tolpyralate, topramezone, tralkoxydim, triafamone, tri-allate, triasulfuron, triaziflam, tribenuron, tricamba, triclopyr, tridiphane, trietazine, trifloxysulfuron, trifludimoxazin, trifluralin, triflusulfuron, trifop, trifopsime, trihydroxytriazine, trimeturon, tripropindan, tritac, tritosulfuron, vernolate, and xylachlor.

Another embodiment of the present disclosure is a method for the control or prevention of fungal attack. This method comprises applying to the soil, plant, roots, foliage, or locus of the fungus, or to a locus in which the infestation is to be prevented (for example applying to cereal or grape plants), a fungicidally effective amount of one or more of the compounds of Formula I. The compounds are suitable for treatment of various plants at fungicidal levels, while exhibiting low phytotoxicity. The compounds may be useful both in a protectant and/or an eradicant fashion.

The compounds have been found to have significant fungicidal effect particularly for agricultural use. Many of the compounds are particularly effective for use with agricultural crops and horticultural plants.

It will be understood by those skilled in the art that the efficacy of the compound for the foregoing fungi establishes the general utility of the compounds as fungicides.

The compounds have broad ranges of activity against fungal pathogens. Exemplary pathogens may include, but are not limited to, causing agent of wheat leaf blotch (Mycosphaerella graminicola; anamorph: Septoria tritici), wheat brown rust (Puccinia triticina), wheat stripe rust (Puccinia striiformis), scab of apple (Venturia inaequalis), powdery mildew of grapevine (Uncinula necator), barley scald (Rhynchosporium secalis), blast of rice (Magnaporthe grisea), rust of soybean (Phakopsora pachyrhizi), glume blotch of wheat (Leptosphaeria nodorum), powdery mildew of wheat (Blumeria graminis f sp.tritici), powdery mildew of barley (Blumeria graminisf sp. hordei), powdery mildew of cucurbits (Erysiphe cichoracearum), anthracnose of cucurbits (Glomerella lagenarium), leaf spot of beet (Cercospora beticola), early blight of tomato (Alternaria solani), and spot blotch of barley (Cochliobolus sativus). The exact amount of the active material to be applied is dependent not only on the specific active material being applied, but also on the particular action desired, the fungal species to be controlled, and the stage of growth thereof, as well as the part of the plant or other product to be contacted with the compound. Thus, all the compounds, and formulations containing the same, may not be equally effective at similar concentrations or against the same fungal species.

The compounds are effective in use with plants in a disease-inhibiting and phytologically acceptable amount. The term “disease-inhibiting and phytologically acceptable amount” refers to an amount of a compound that kills or inhibits the plant disease for which control is desired, but is not significantly toxic to the plant. This amount will generally be from about 0.1 to about 1000 ppm (parts per million), with 1 to 500 ppm being preferred. The exact concentration of compound required varies with the fungal disease to be controlled, the type of formulation employed, the method of application, the particular plant species, climate conditions, and the like. A suitable application rate is typically in the range from about 0.10 to about 4 pounds/acre (about 0.01 to 0.45 grams per square meter, g/m²).

Any range or desired value given herein may be extended or altered without losing the effects sought, as is apparent to the skilled person for an understanding of the teachings herein.

The compounds of Formula I may be made using well-known chemical procedures. Intermediates not specifically mentioned in this disclosure are either commercially available, may be made by routes disclosed in the chemical literature, or may be readily synthesized from commercial starting materials utilizing standard procedures.

General Schemes

The following schemes illustrate approaches to generating picolinamide compounds of Formula I. The following descriptions and examples are provided for illustrative purposes and should not be construed as limiting in terms of substituents or substitution patterns.

Compounds of Formula 1.1, wherein R₃ and R₁₂ are as originally defined and are equivalent, can be prepared by the methods shown in Scheme 1, step a. The compound of Formula 1.0 can be treated with an organometallic nucleophile such as phenylmagnesium bromide (PhMgBr) in a polar aprotic solvent such as tetrahydrofuran (THF) at a temperature of about 0° C. to 23° C. to afford compounds of Formula 1.1, wherein R₃ and R₁₂ are as previously defined, as shown in a.

Compounds of Formula 2.2, wherein R₃ is as originally defined and may or may not be equal to R₁₂, can be prepared by the methods shown in Scheme 2, steps a-c. Compounds of Formula 2.2, wherein R₃ and R₁₂ are as previously defined but not an electron-deficient aryl or heteroaryl group and may or may not be equivalent, can be obtained by treating the compounds of Formula 2.0, wherein R₃ and R₁₂ are as previously defined but not an electron-deficient aryl or heteroaryl group and may or may not be equivalent, with a mixture of a hydride reagent, such as triethylsilane (Et₃SiH), and an acid, such as 2,2,2-trifluoroacetic acid (TFA) in a halogenated solvent such as dichloromethane (DCM) at a temperature of about 0° C. to 23° C., as depicted in a. Alternatively, compounds of Formula 2.1, wherein R₃ and R₁₂ are an electron-deficient aryl or heteroaryl group and may or may not be equivalent, can be obtained by treating the compounds of Formula 2.0, wherein R₃ and R₁₂ are an electron-deficient aryl or heteroaryl group and may or may not be equivalent, with a base, such as sodium hydride (NaH), and a catalyst, such as imidazole, in a polar aprotic solvent such as THF at a temperature of about 23° C., followed by sequential addition of carbon disulfide (CS₂) and an alkyl iodide, such as iodomethane (Mel), as depicted in b. Compounds of Formula 2.2, wherein R₃ and R₁₂ are an electron-deficient aryl or heteroaryl group and may or may not be equivalent, can be obtained by treating the compounds of Formula 2.1, wherein R₃ and R₁₂ are as previously defined and may or may not be equivalent, with a tin reagent, such as tributyltin hydride, and a radical initiator, such as azobisisobutyronitrile (AIBN), in a nonpolar solvent such as toluene at a temperature of about 115° C., as depicted in c.

Compounds of Formula 3.1, wherein R₃ and R₁₂ are as originally defined and may or may not be equivalent, can be prepared according to the method outlined in Scheme 3, step a. Compounds of Formula 3.1, wherein R₃ and R₁₂ are as originally defined and may or may not be equivalent, can be prepared from compounds of Formula 3.0, wherein R₃ and R₁₂ are as previously defined and may or may not be equivalent, by treating with a base, such as NaH and an alkyl halide, such as Mel, in a polar aprotic solvent like N,N-dimethylformamide (DMF) at a temperature of about 0° C. to 23° C., as depicted in a.

Compounds of Formula 4.1, wherein R₃ and R₁₂ are as originally defined and may or may not be equivalent, can be prepared according to the method outlined in Scheme 4, step a. Compounds of Formula 4.1, wherein R₃ and R₁₂ are as originally defined and may or may not be equivalent, can be prepared from compounds of Formula 4.0, wherein R₃ and R₁₂ are as previously defined and may or may not be equivalent, by treating with a fluorination reagent, such as (diethylamino)sulfur trifluoride (DAST), in a halogenated solvent such as DCM at a temperature of about 0° C. to 23° C., as depicted in a.

Compounds of Formula 5.3, wherein R₃, R₄, and R₁₂ are as originally defined and R₃ may or may not be equivalent to R₁₂, can be prepared according to the methods outlined in Scheme 5, steps a-c. Compounds of Formula 5.3, wherein R₃, R₄, and R₁₂ are as originally defined and R₃ may or may not be equivalent to R₁₂, can be prepared from compounds of Formula 5.0, wherein R₃, R₄, and R₁₂ are as originally defined and R₃ may or may not be equivalent to R₁₂, by treating with a catalyst such as palladium on carbon (Pd/C) in a mixture of an unsaturated hydrocarbon solvent, such as cyclohexene, and a polar protic solvent, such as ethanol (EtOH), at an elevated temperature of about 65° C., as shown in a. Alternatively, compounds of Formula 5.3, wherein R₃ and R₁₂ are an electron-deficient aryl or heteroaryl group and may or may not be equivalent and R₄ is hydroxyl (OH) or alkoxy, can be obtained by treating compounds of Formula 5.1, wherein R₃, R₄, and R₁₂ are as previously defined and R₃ may or may not be equivalent to R₁₂, with a mixture of a hydride reagent, such as Et₃SiH, and an acid, such as TFA in a halogenated solvent such as DCM at a temperature of about 0° C. to 23° C., as indicated in b. Additionally, compounds of Formula 5.3, wherein R₃ and R₁₂ are as originally defined but not an electron-deficient aryl or heteroaryl group and may or may not be equivalent, and R₄ is a proton (H), can be obtained by treating the compounds of Formula 5.2, wherein R₃, R₄, and R₁₂ are as previously defined and R₃ may or may not be equivalent to R₁₂, with a mixture of a hydride reagent, such as Et₃SiH, and an acid, such as TFA in a halogenated solvent such as DCM at a temperature of about 0° C. to 23° C., as depicted in c.

Compounds of Formula 6.1, wherein n is either 0 or 1, and W is either CH₂ or O, can be prepared according to the method outlined in Scheme 6, step a. Compounds of Formula 6.1, wherein n is either 0 or 1, and W is either CH₂ or O, can be prepared from compounds of Formula 6.0, wherein n is either 0 or 1, and W is either CH₂ or O, by treating with a base, such as n-butyllithium (n-BuLi), and an aldehyde, such as acetaldehyde, in a polar aprotic solvent such as THF at a temperature of about −78° C. to 23° C., as indicated in a.

Compounds of Formula 7.1, wherein R₂, R₃ and R₁₂ are as originally defined, can be prepared according to the method outlined in Scheme 7, step a. Compounds of Formula 7.1, wherein R₂, R₃ and R₁₂ are as originally defined, can be prepared from compounds of Formula 7.0, wherein R₂ and R₃ are as originally defined, by treating with a pre-mixed suspension of a copper(I) salt, such as copper iodide (CuI), and an organometallic nucleophile, such as 4-(trifluoromethyl)phenylmagnesium bromide in a polar aprotic solvent such as THF, at a temperature of about −78° C. to 23° C., as shown in a.

Compounds of Formula 8.2, wherein R₁, R₂, R₃, R₄ and R₁₂ are as originally defined, can be prepared according to the method outlined in Scheme 8, step a. Compounds of Formula 8.0, wherein R₁ is as originally defined, can be treated with alcohols of Formula 8.1, wherein R₂, R₃, R₄ and R₁₂ are as originally defined, and a coupling reagent such as 3-(ethyliminomethyleneamino)-N,N-dimethylpropan-1-amine hydrochloride (EDC), and a catalyst such as N,N-dimethylpyridin-4-amine (DMAP) in a halogenated solvent like DCM to afford compounds of Formula 8.2, wherein R₁, R₂, R₃, R₄ and R₁₂ are as previously defined, as shown in a.

Compounds of Formula 9.2, wherein R₁, R₂, R₃, R₄, R₆, R₁₂ and Z are as originally defined, can be prepared according to the methods outlined in Scheme 9, steps a-b. As depicted in a, compounds of Formula 8.2, wherein R₁, R₂, R₃, R₄ and R₁₂ are as originally defined, can be subjected to an acid, such as a 4 normal (N) solution of hydrogen chloride (HCl) in dioxane, in a halogenated solvent such as DCM to afford compounds of Formula 9.0, wherein R₁, R₂, R₃, R₄ and R₁₂ are as originally defined, as shown in a.

Compounds of Formula 9.0, wherein R₁, R₂, R₃, R₄ and R₁₂ are as originally defined, can be treated with compounds of Formula 9.1, wherein R₆ and Z are as originally defined, in the presence of a base, such as diisopropylethylamine (DIPEA), and a peptide coupling reagent, such as benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate (PyBOP), in an halogenated solvent like DCM, to afford compounds of Formula 9.2, wherein R₁, R₂, R₃, R₄, R₆, R₁₂ and Z are as originally defined, as shown in b.

Compounds of Formula 10.0, wherein R₁, R₂, R₃, R₄, R₆, R₇, R₁₂ and Z are as originally defined, can be prepared according to the method outlined in Scheme 10, step a. As shown in a, compounds of Formula 9.2, wherein R₁, R₂, R₃, R₄, R₆, R₁₂ and Z are as originally defined, can be treated with an appropriate alkyl halide with or without a reagent such as sodium iodide (NaI) and an alkali carbonate base, such as sodium carbonate (Na₂CO₃) or potassium carbonate (K₂CO₃), in a solvent like acetone at a temperature of about 55° C., or by treatment with an acyl halide in the presence of an amine base, such as pyridine, triethylamine (Et₃N), DMAP, or mixtures thereof, in an aprotic solvent such as DCM, at a temperature of about 23° C., to afford compounds of Formula 10.0 wherein R₁, R₂, R₃, R₄, R₆, R₇, R₁₂ and Z are as originally defined.

EXAMPLES

The chemistry in the following examples may be conducted using either enantiomer of 2-((tert-butoxycarbonyl)amino)propanoic acid (Boc-Ala-OH) or either protected (PMB or Bn) enantiomer of ethyl lactate.

Example 1: Preparation of (S)-2-(benzyloxy)-1,1-bis(4-fluorophenyl)propan-1-ol

To a solution of (S)-ethyl 2-(benzyloxy)propanoate (2.08 grams (g), 10.0 millimoles (mmol)) in tetrahydrofuran (THF; 20 milliliters (mL)) at 0° C. was slowly added (4-fluorophenyl)magnesium bromide (31.3 mL, 25.0 mmol, 0.8 molar (M) in THF) over a 10 minute (min) period. The reaction vessel was allowed to warm slowly to room temperature over 2 hours (h), and the reaction mixture was quenched by careful addition of saturated (sat.) aqueous (aq.) ammonium chloride (NH₄Cl; 50 mL). The mixture was diluted with diethyl ether (Et₂O; 50 mL), the phases were separated, and the aq. phase was extracted with Et₂O (2×50 mL). The combined organic phases were washed with sat. aq. sodium chloride (NaCl, brine; 100 mL), dried over sodium sulfate (Na₂SO₄), filtered, and concentrated. The resulting oil was purified by flash column chromatography (silica gel (SiO₂), 045% acetone in hexanes) to afford the title compound (3.28 g, 93%) as a colorless oil: ¹H NMR (300 MHz, CDCl₃) δ 7.47-7.38 (m, 2H), 7.38-7.27 (m, 5H), 7.17-7.09 (m, 2H), 7.04-6.89 (m, 4H), 4.64 (dd, J=11.4, 0.7 Hz, 1H), 4.51-4.38 (m, 2H), 3.12 (s, 1H), 1.11 (d, J=6.1 Hz, 3H); ¹⁹F NMR (376 MHz, CDCl₃) δ-116.19, −116.41; ESIMS m/z 377 ([M+Na]⁺).

Example 2A: Preparation of (S)-4,4′-(2-(benzyloxy)propane-1,1-diyl)bis(fluorobenzene)

To a solution of (S)-2-(benzyloxy)-1,1-bis(4-fluorophenyl)propan-1-ol (709 milligrams (mg), 2.00 mmol) in dichloromethane (DCM; 20 mL) at 0° C. was added triethylsilane (Et₃SiH; 3.19 mL, 20.0 mmol) followed by 2,2,2-trifluoroacetic acid (TFA; 1.53 mL, 20.0 mmol). The mixture was stirred at 0° C. for 1 h. The resulting solution was quenched by careful addition of sat. aq. sodium bicarbonate (NaHCO₃; 20 mL). The phases were separated, and the aq. phase was extracted with DCM (2×30 mL). The combined organic phases were washed with brine (50 mL), dried over Na₂SO₄, filtered, and concentrated. The resulting oil was purified by flash column chromatography (SiO₂, 0→10% acetone in hexanes) to afford the title compound (627 mg, 92%) as a white solid: ¹H NMR (400 MHz, CDCl₃) δ 7.31-7.22 (m, 5H), 7.21-7.16 (m, 2H), 7.10-7.03 (m, 2H), 7.00-6.91 (m, 4H), 4.54 (dd, J=11.5, 0.7 Hz, 1H), 4.31 (dd, J=11.6, 0.8 Hz, 1H), 4.14 (dq, J=8.1, 6.1 Hz, 1H), 3.93 (d, J=8.1 Hz, 1H), 1.18 (d, J=6.0 Hz, 3H); ¹⁹F NMR (376 MHz, CDCl₃) δ−116.60, −117.10; ESIMS m/z 361 ([M+Na]⁺).

Example 2B: Preparation of (S)-(2-(benzyloxy)-1-methoxypropane-1,1-diyl)dibenzene

To a suspension of sodium hydride (NaH; 52.0 mg, 1.30 mmol, 60% weight per weight (w/w) in mineral oil) in N,N-dimethylformamide (DMF; 3 mL) at 0° C. was added a solution of (S)-2-(benzyloxy)-1,1-diphenylpropan-1-ol (318 mg, 1 mmol) in DMF (1 mL). The reaction mixture was stirred at room temperature for 30 min and then cooled to 0° C. Iodomethane (Mel; 93.0 microliters (μL), 1.50 mmol) was added, and the reaction mixture was stirred at room temperature for 1 h. The resulting solution was quenched by careful addition of sat. aq. NaHCO₃ (10 mL). The mixture was diluted with diethyl ether (Et₂O; 10 mL), the phases were separated, and the aq. phase was extracted with Et₂O (2×10 mL). The combined organic phases were washed with brine (20 mL), dried over Na₂SO₄, filtered, and concentrated. The resulting oil was purified by flash column chromatography (SiO₂, 0→5% acetone in hexanes) to afford the title compound (295 mg, 89%) as a colorless oil: ¹H NMR (400 MHz, CDCl₃) δ 7.47-7.41 (m, 2H), 7.40-7.35 (m, 2H), 7.33-7.18 (m, 11H), 4.69 (d, J=11.9 Hz, 1H), 4.54 (d, J=12.3 Hz, 1H), 4.50 (q, J=6.1 Hz, 1H), 3.13 (s, 3H), 1.10 (d, J=6.1 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ 142.96, 141.31, 138.79, 129.13, 128.54, 128.14, 127.61, 127.16, 127.08, 126.95, 126.69, 99.99, 85.35, 78.13, 70.80, 52.46, 13.65; ESIMS m/z 333 ([M+H]⁺).

Example 2C: Preparation of (S)-(2-(benzyloxy)-1-fluoropropane-1,1-diyl)dibenzene

To a solution of (S)-2-(benzyloxy)-1,1-diphenylpropan-1-ol (300 mg, 0.942 mmol) in DCM (5 mL) at 0° C. was added (diethylamino)sulfur trifluoride (DAST; 1.88 mL, 1.88 mmol, 1 M in DCM). The reaction was slowly warmed to room temperature over 3 h. The resulting solution was quenched by careful addition of sat. aq. NaHCO₃ (5 mL). The phases were separated, and the aq. phase was extracted with DCM (2×10 mL). The combined organic phases were washed with brine (10 mL), dried over Na₂SO₄, filtered, and concentrated. The resulting oil was purified by flash column chromatography (SiO₂, 0→10% acetone in hexanes) to afford the title compound (300 mg, 98%) as a colorless oil: ¹H NMR (400 MHz, CDCl₃) δ 7.58-7.49 (m, 2H), 7.43-7.37 (m, 2H), 7.36-7.20 (m, 9H), 7.09-6.99 (m, 2H), 4.47 (d, J=11.7 Hz, 1H), 4.37-4.25 (m, 2H), 1.26 (dd, J=6.3, 1.3 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ 142.23 (d, J=22.7 Hz), 141.00 (d, J=23.5 Hz), 138.03, 128.21, 128.16, 127.90 (d, J=1.5 Hz), 127.80, 127.72 (d, J=1.7 Hz), 127.52, 127.42 (d, J=1.3 Hz), 126.23 (d, J=9.6 Hz), 125.93 (d, J=8.7 Hz), 99.96 (d, J=180.8 Hz), 78.91 (d, J=26.9 Hz), 71.68, 14.47 (d, J=3.6 Hz); ¹⁹F NMR (376 MHz, CDCl₃) δ−159.80.

Example 2D, Step 1: Preparation of (S)—O-(2-(benzyloxy)-1,1-bis(3,4,5-trifluorophenyl)propyl)S-methyl carbonodithioate

To a solution of (S)-2-(benzyloxy)-1,1-bis(3,4,5-trifluorophenyl)propan-1-ol (496 mg, 1.16 mmol) in anhydrous THF (5.8 mL) was added NaH (93.0 mg, 2.33 mmol), followed by imidazole (3.96 mg, 0.0580 mmol), and the reaction mixture was stirred at ambient temperature for 1 h. Carbon disulfide (562 μL, 9.30 mmol) was added via syringe in one portion, followed by Mel (579 μL, 9.30 mmol), and the reaction mixture was stirred at ambeint temperature for 2 h. The reaction mixture was diluted with Et₂O (5 mL) and quenched with sat. aq. NH₄Cl (10 mL). The layers were separated, and the aq. layer was extracted with Et₂O (3×10 mL). The combined organic layers were dried over magnesium sulfate (MgSO₄), filtered and concentrated to afford an orange/brown oil. The crude oil was purified by flash column chromatography (SiO₂, 0→50% ethyl acetate (EtOAc) in hexanes) to afford the title compound (627 mg, 94%) as a clear, bright yellow colored oil: ¹H NMR (400 MHz, CDCl₃) δ 7.40-7.27 (m, 3H), 7.24-7.16 (m, 2H), 7.02 (dd, J=9.1, 6.6 Hz, 2H), 6.96 (dd, J=8.8, 6.5 Hz, 2H), 5.44 (q, J=6.1 Hz, 1H), 4.66 (d, J=11.6 Hz, 1H), 4.51 (d, J=11.6 Hz, 1H), 2.49 (s, 3H), 1.16 (d, J=6.1 Hz, 3H); ¹⁹F NMR (376 MHz, CDCl₃) δ −133.89 (d, J=20.7 Hz), −134.73 (d, J=20.6 Hz), −159.83 (t, J=20.6 Hz), −160.56 (t, J=20.7 Hz); IR (thin film) 2922, 1721, 1622, 1595, 1526, 1436, 1344, 1241, 1217, 1197, 1119, 1088, 1040, 965, 908, 861, 822, 730, 712, 697, 672 cm⁻¹.

Example 2D, Step 2: Preparation of (S)-5,5′-(2-(benzyloxy)propane-1,1-diyl)bis(1,2,3-trifluorobenzene)

A solution of (S)—O-(2-(benzyloxy)-1,1-bis(3,4,5-trifluorophenyl)propyl)S-methyl carbonodithioate (598 mg, 1.16 mmol) in toluene (200 mL) was degassed by a freeze-pump-thaw procedure (3 cycles using liquid nitrogen (N₂)) under an atmosphere of N₂. Tributyltin hydride (3.12 mL, 11.6 mmol) was then added, the reaction flask was fitted with a reflux condenser, and the reaction mixture was heated to a light reflux (115° C.). A solution of azobisisobutyronitrile (AIBN; 0.200 g, 1.22 mmol) in degassed toluene (3 cycles via liquid N₂; 32 mL) was added via syringe down the reflux condenser over 3 h. Once slow addition of the AIBN was complete, the reaction mixture was stirred at reflux overnight. The solvent was removed in vacuo to provide a pale yellow oil. The crude oil was purified by flash column chromatography (SiO₂, 0→30% EtOAc in hexanes) to afford the title compound (358 mg, 72%) as a clear, colorless oil: ¹H NMR (400 MHz, CDCl₃) δ 7.28 (d, J=6.6 Hz, 3H), 7.17-7.06 (m, 2H), 6.92 (dd, J=8.5, 6.5 Hz, 2H), 6.79 (dd, J=8.3, 6.4 Hz, 2H), 4.59 (d, J=11.7 Hz, 1H), 4.31 (d, J=11.7 Hz, 1H), 4.02 (p, J=6.2 Hz, 1H), 3.76 (d, J=6.8 Hz, 1H), 1.19 (d, J=6.1 Hz, 3H); ¹⁹F NMR (376 MHz, CDCl₃) δ−133.80 (d, J=20.5 Hz), −134.34 (d, J=20.5 Hz), −162.54 (t, J=20.5 Hz), −162.84 (t, J=20.5 Hz); IR (thin film) 2871, 1621, 1526, 1445, 1345, 1262, 1235, 1116, 1096, 1043, 859, 802, 728, 698, 679 cm⁻¹.

Example 3A: Preparation of (S)-1,1-bis(4-fluorophenyl)propan-2-ol

To a solution of (S)-4,4′-(2-(benzyloxy)propane-1,1-diyl)bis(fluorobenzene) (575 mg, 1.70 mmol) in ethanol (EtOH; 11 mL) and cyclohexene (5.5 mL) at room temperature was added palladium on carbon (Pd/C; 362 mg, 0.0850 mmol, 2.5% w/w of Pd). The reaction mixture was stirred at 65° C. for 2 h, cooled to room temperature, filtered through a plug of Celite®, and concentrated to afford the title compound (415 mg, 98%) as a colorless oil: ¹H NMR (400 MHz, CDCl₃) δ 7.36-7.29 (m, 2H), 7.25-7.18 (m, 2H), 7.09-6.93 (m, 4H), 4.47 (dqd, J=8.2, 6.1, 3.3 Hz, 1H), 3.80 (d, J=8.3 Hz, 1H), 1.55 (d, J=3.3 Hz, 1H), 1.19 (d, J=6.1 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ 162.90 (d, J=23.3 Hz), 160.46 (d, J=23.1 Hz), 138.15 (d, J=3.1 Hz), 136.94 (d, J=3.6 Hz), 130.14 (d, J=7.8 Hz), 129.55 (d, J=7.8 Hz), 115.70 (d, J=18.8 Hz), 115.49 (d, J=18.8 Hz), 70.07, 58.61, 21.63; ¹⁹F NMR (376 MHz, CDCl₃) δ−115.84, −116.19.

Example 3B: Preparation of (S)-1,1-bis(2-fluorophenyl)propane-1,2-diol

To a solution of (S)-1,1-bis(2-fluorophenyl)-2-((4-methoxybenzyl)oxy)propan-1-ol (790 mg, 2.06 mmol) in DCM (20 mL) at 0° C. was added Et₃SiH (3.28 mL, 20.6 mmol) followed by TFA (1.57 mL, 20.6 mmol). The mixture was stirred at 0° C. for 1 h. The resulting solution was quenched by careful addition of sat. aq. NaHCO₃ (20 mL). The phases were separated, and the aq. phase was extracted with DCM (2×30 mL). The combined organic phases were washed with brine (50 mL), dried over Na₂SO₄, filtered, and concentrated. The resulting oil was purified by flash column chromatography (SiO₂, 0→10% acetone in hexanes) to afford the title compound (388 mg, 71%) as a colorless oil: ¹H NMR (400 MHz, CDCl₃) δ 7.90-7.77 (m, 1H), 7.70 (tt, J=8.2, 1.5 Hz, 1H), 7.31-7.10 (m, 4H), 6.97 (ddd, J=12.7, 8.1, 1.3 Hz, 1H), 6.88 (ddd, J=11.8, 8.0, 1.4 Hz, 1H), 5.11 (qd, J=6.3, 2.3 Hz, 1H), 3.49 (s, 1H), 2.27 (s, 1H), 1.09 (d, J=6.3 Hz, 3H); ¹⁹F NMR (376 MHz, CDCl₃) δ−112.90 (d, J=8.3 Hz), −113.92 (d, J=8.4 Hz); ESIMS m/z 551 ([2M+Na]⁺).

Example 3C: Preparation of (S)-1,1-bis(4-bromophenyl)propan-2-ol

To a solution of (S)-1,1-bis(4-bromophenyl)-2-((4-methoxybenzyl)oxy)propan-1-ol (1.80 g, 3.56 mmol) in DCM (18 mL) at 0° C. was added Et₃SiH (5.68 mL, 35.6 mmol) followed by TFA (2.72 mL, 35.6 mmol). The mixture was warmed slowly to room temperature over 3 h. The resulting solution was quenched by careful addition of sat. aq. NaHCO₃ (20 mL). The phases were separated, and the aq. phase was extracted with DCM (2×30 mL). The combined organic phases were washed with brine (50 mL), dried over Na₂SO₄, filtered, and concentrated. The resulting oil was purified by flash column chromatography (SiO₂, 0→10% acetone in hexanes) to afford the title compound (742 mg, 56%) as a colorless oil: ¹H NMR (300 MHz, CDCl₃) δ 7.51-7.36 (m, 4H), 7.25-7.17 (m, 2H), 7.18-7.06 (m, 2H), 4.48 (dq, J=8.2, 6.1 Hz, 1H), 3.76 (d, J=8.2 Hz, 1H), 2.80 (s, 1H), 1.19 (d, J=6.2 Hz, 3H); ¹³C NMR (75 MHz, CDCl₃) δ 140.94, 139.85, 131.98, 131.85, 130.39, 129.84, 121.06, 120.72, 69.82, 58.91, 21.65; IR (thin film) 3390, 3024, 2969, 2900, 1486, 1072 cm⁻¹.

Example 3D, Step 1: Preparation of (S)-1,1-bis(4-((trimethylsilyl)ethynyl)-phenyl)propan-2-ol

To a solution of (S)-1,1-bis(4-bromophenyl)propan-2-ol (1.01 g, 2.72 mmol) in THF (9 mL) was added bis(triphenylphosphine)palladium dichloride (0.095 g, 0.136 mmol) and copper(I) iodide (CuI; 0.026 g, 0.136 mmol). The mixture was sparged with N₂ for 20 min, and triethylamine (Et₃N; 4.53 mL) was added dropwise. To the resulting mixture was added ethynyltrimethylsilane (1.15 mL, 8.15 mmol) dropwise, and the mixture was heated to reflux and stirred overnight. The mixture was cooled to room temperature, and the reaction was quenched with sat. aq. NaHCO₃. The products were extracted with EtOAc (2×), and the combined organic layers were washed with brine, dried over Na₂SO₄, filtered and concentrated. The crude residue was then purified by flash column chromatography (SiO₂, 0→20% acetone in hexanes) to provide the title compound (495 mg, 45%) as a brown foam: ¹H NMR (400 MHz, CDCl₃) δ 7.48-7.42 (m, 2H), 7.42-7.37 (m, 2H), 7.33-7.27 (m, 2H), 7.24-7.17 (m, 2H), 4.51 (dqd, J=12.2, 6.1, 3.5 Hz, 1H), 3.81 (d, J=8.3 Hz, 1H), 1.60 (d, J=3.8 Hz, 1H), 1.18 (d, J=6.1 Hz, 3H), 0.26 (s, 9H), 0.26 (s, 9H); ¹³C NMR (101 MHz, CDCl₃) δ 142.55, 141.48, 132.42, 132.29, 128.69, 128.15, 121.90, 121.57, 104.76, 104.71, 94.49, 94.33, 69.76, 59.96, 21.55, 0.00; IR (thin film) 3397, 2960, 2156, 1501, 1248, 861, 840 cm⁻¹; HRMS-ESI (m/z) [M+H]⁺ calcd for C₂₅H₃₃OSi₂, 405.2064; found, 405.2070.

Example 3D, Step 2: Preparation of (S)-1,1-bis(4-ethynylphenyl)propan-2-ol

To a solution of (S)-1,1-bis(4-((trimethylsilyl)ethynyl)phenyl)propan-2-ol (0.470 g, 1.16 mmol) in methanol (MeOH; 5.8 mL) was added potassium carbonate (K₂CO₃; 0.482 g, 3.48 mmol). The mixture was stirred for 1 h at room temperature and then filtered through Celite®. The filter cake was washed with MeOH, and the filtrate was concentrated. The crude material was purified by flash column chromatography (SiO₂, 0→20% acetone in hexanes) to provide the title compound (288 mg, 95%) as a yellow oil: ¹H NMR (300 MHz, CDCl₃) δ 7.48-7.43 (m, 2H), 7.43-7.39 (m, 2H), 7.35-7.29 (m, 2H), 7.24-7.19 (m, 2H), 4.51 (dqd, J=8.3, 6.1, 3.7 Hz, 1H), 3.82 (d, J=8.3 Hz, 1H), 3.05 (s, 1H), 3.04 (s, 1H), 1.63-1.55 (m, 1H), 1.18 (d, J=6.1 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ 142.84, 141.82, 132.60, 132.48, 128.74, 128.22, 120.87, 120.57, 83.31, 83.29, 77.39, 77.29, 69.73, 59.96, 21.66; IR (thin film) 3436, 3280, 2968, 2106, 1499, 1075, 825 cm⁻¹; HRMS-ESI (m/z) [M+H]⁺ calcd for C₁₉H₁₇O, 261.1274; found, 261.1272.

Example 3D, Step 3: Preparation of (S)-1,1-bis(4-ethylphenyl)propan-2-ol

To a solution of (S)-1,1-bis(4-ethynylphenyl)propan-2-ol (0.144 g, 0.553 mmol) in EtOAc (2.8 mL) was added palladium (5% weight (wt) on carbon, dry basis; 0.235 g, 0.055 mmol). The mixture was stirred under a balloon of hydrogen overnight. The mixture was filtered through Celite®, and the filter cake was washed with EtOAc. The combined filtrate was then concentrated, and the crude residue was purified by flash column chromatography (SiO₂, 0→25% acetone in hexanes) to provide the title compound (97.0 mg, 65%) as a clear oil: ¹H NMR (400 MHz, CDCl₃) δ 7.33-7.25 (m, 2H), 7.22-7.15 (m, 2H), 7.18-7.11 (m, 2H), 7.10 (d, J=8.1 Hz, 2H), 4.51 (dqd, J=8.7, 6.1, 2.5 Hz, 1H), 3.74 (d, J=8.9 Hz, 1H), 2.65-2.53 (m, 4H), 1.68 (d, J=2.8 Hz, 1H), 1.23-1.14 (m, 9H); ¹³C NMR (101 MHz, CDCl₃) δ 142.74, 142.33, 139.94, 138.91, 128.48, 128.40, 128.07, 128.02, 70.19, 60.02, 28.41, 28.39, 21.37, 15.47, 15.46; IR (thin film) 3421, 2963, 1510, 1110, 821 cm⁻¹; HRMS-ESI (m/z) [M+Na]⁺ calcd for C₁₉H₂₄NaO, 291.1719; found, 291.1725.

Example 3E: Preparation of 1-(9H-xanthen-9-yl)ethanol

To a solution of 9H-xanthene (364 mg, 2.00 mmol) in THF (10 mL) at −78° C. was added n-butyllithium (2.5 M in hexanes; 0.880 mL, 2.20 mmol). The mixture was stirred at −78° C. for 30 min. Acetaldehyde (0.226 mL, 4.00 mmol) was added, and the reaction mixture was warmed slowly to room temperature overnight. The resulting solution was quenched by careful addition of sat. aq. NH₄Cl (10 mL). The phases were separated, and the aq. phase was extracted with Et₂O (2×15 mL). The combined organic phases were washed with brine (20 mL), dried over Na₂SO₄, filtered, and concentrated. The resulting oil was purified by flash column chromatography (SiO₂, 0→10% acetone in hexanes) to afford the title compound (216 mg, 48%) as a colorless oil: ¹H NMR (400 MHz, CDCl₃) δ 7.33-7.22 (m, 4H), 7.17-7.04 (m, 4H), 3.99 (d, J=5.1 Hz, 1H), 3.96-3.82 (m, 1H), 1.54 (d, J=6.0 Hz, 1H), 1.00 (d, J=6.3 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ 152.94, 152.65, 129.54, 129.30, 128.19, 128.17, 123.18, 123.14, 122.48, 121.73, 116.59, 116.41, 73.07, 47.06, 18.81; ESIMS m/z 475 ([2M+Na]⁺).

Example 3F: Preparation of (1S,2S)-1-phenyl-1-(4-(trifluoromethyl)phenyl)propan-2-ol

To a mixture of magnesium turnings (102 mg, 4.20 mmol) in Et₂O (4 mL) was added 1-bromo-4-(trifluoromethyl)benzene (0.588 mL, 4.20 mmol) at room temperature, followed by Mel (5 μL). Upon warming to a gentle boil using a heat gun, the mixture turned a yellow/brown color. The reaction was then stirred in a water bath at room temperature for 30 min until almost all the magnesium was consumed. This was added to a suspension of copper(I) iodide (CuI; 400 mg, 2.10 mmol) in Et₂O (4 mL) at −78° C. The reaction was stirred at −20° C. for 30 min, then cooled to −78° C., and (2S,3S)-2-methyl-3-phenyloxirane (0.201 mL, 1.50 mmol) was added. The resulting mixture was warmed slowly to room temperature overnight. The resulting solution was quenched by careful addition of sat. aq. NH₄Cl (10 mL). The phases were separated, and the aq. phase was extracted with Et₂O (2×15 mL). The combined organic phases were washed with brine (20 mL), dried over Na₂SO₄, filtered, and concentrated. The resulting oil was purified by flash column chromatography (SiO₂, 0→10% acetone in hexanes) to afford the title compound (390 mg, 94%) as a light yellow oil: ¹H NMR (400 MHz, CDCl₃) δ 7.60-7.50 (m, 2H), 7.48-7.38 (m, 2H), 7.38-7.33 (m, 4H), 7.30-7.23 (m, 1H), 4.58 (dqd, J=8.4, 6.1, 3.5 Hz, 1H), 3.88 (d, J=8.5 Hz, 1H), 1.65 (d, J=3.6 Hz, 1H), 1.20 (d, J=6.1 Hz, 3H); ¹⁹F NMR (376 MHz, CDCl₃) δ −62.49; ESIMS m/z 263 ([M−OH]⁺).

Example 4A: Preparation of (S)-(S)-1,1-diphenylpropan-2-yl 2-((tert-butoxycarbonyl)amino)-propanoate (Cmpd 2)

To a solution of (S)-1,1-diphenylpropan-2-ol (317 mg, 1.493 mmol) in DCM (15 mL) at 0° C. were added (S)-2-((tert-butoxycarbonyl)amino)propanoic acid (Boc-Ala-OH; 311 mg, 1.64 mmol) and N,N-dimethylpyridin-4-amine (DMAP; 18.2 mg, 0.149 mmol) followed by N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride (EDC; 573 mg, 2.99 mmol), and the reaction mixture was stirred at room temperature overnight and concentrated to give a yellow oil. The crude material was purified by flash column chromatography (SiO₂, 1→10% acetone in hexanes) to afford the title compound (433 mg, 75%) as a colorless oil: ¹H NMR (400 MHz, CDCl₃) δ 7.42-7.07 (m, 10H), 5.80 (dq, J=10.1, 6.1 Hz, 1H), 4.97 (d, J=8.0 Hz, 1H), 4.19-4.06 (m, 1H), 4.03 (d, J=10.1 Hz, 1H), 1.41 (s, 9H), 1.23 (d, J=6.1 Hz, 3H), 0.76 (d, J=7.2 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ 172.83, 154.96, 141.52, 141.26, 128.79, 128.50, 128.10, 128.08, 126.91, 126.67, 79.62, 73.10, 57.98, 49.21, 28.33, 19.31, 17.98; ESIMS m/z 384 ([M+H]⁺).

Example 5, Step 1: Preparation of (S)-1-(((S)-1,1-diphenylpropan-2-yl)oxy)-1-oxopropan-2-aminium chloride (Cmpd 46)

To a solution of (S)-(S)-1,1-diphenylpropan-2-yl 2-((tert-butoxycarbonyl)amino)propanoate (Cmpd 2; 433 mg, 1.13 mmol) in DCM (6 mL) was added a 4 N solution of HCl in dioxane (2.8 mL, 11.3 mmol), and the mixture was stirred for 3 h at room temperature. The solvent was evaporated under a stream of N₂ to provide the title compound (360 mg, 100%) as a white solid: ESIMS m/z 284 ([M+H]⁺).

Example 5, Step 2: Preparation of (S)-(S)-1,1-diphenylpropan-2-yl 2-(3-hydroxy-4-methoxypicolinamido)propanoate (Cmpd 90)

To a solution of (S)-1-(((S)-1,1-diphenylpropan-2-yl)oxy)-1-oxopropan-2-aminium chloride (Cmpd 46; 361 mg, 1.13 mmol) and 3-hydroxy-4-methoxypicolinic acid (210 mg, 1.24 mmol) in DCM (11 mL) were added benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate (PyBOP; 646 mg, 1.24 mmol) and N-ethyl-N-isopropylpropan-2-amine (DIPEA; 0.651 mL, 3.72 mmol), and the reaction mixture was stirred for 2 h at room temperature. The solvent was evaporated and the crude oil was purified by flash column chromatography (SiO₂, 1→50% acetone in hexanes) to afford the title compound (340 mg, 70%) as a white foam: ¹H NMR (400 MHz, CDCl₃) δ 12.10 (s, 1H), 8.34 (d, J=8.0 Hz, 1H), 7.98 (d, J=5.2 Hz, 1H), 7.38-7.06 (m, 10H), 6.86 (d, J=5.3, 1H), 5.83 (dq, J=10.1, 6.1 Hz, 1H), 4.52 (dq, J=8.1, 7.2 Hz, 1H), 4.06 (d, J=10.2 Hz, 1H), 3.93 (s, 3H), 1.26 (d, J=6.1 Hz, 3H), 0.97 (d, J=7.2 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ 171.67, 168.53, 155.34, 148.72, 141.38, 141.13, 140.40, 130.48, 128.80, 128.50, 128.10, 128.03, 126.95, 126.70, 109.39, 73.57, 57.93, 56.07, 47.85, 19.24, 17.61; HRMS-ESI (m/z) [M+H]⁺ calcd for C₂₅H₂₇N₂O₅, 435.1920; found, 435.1925.

Example 6A: Preparation of (S)-(S)-1,1-diphenylpropan-2-yl 2-(3-acetoxy-4-methoxypicolinamido)propanoate (Cmpd 139)

To a solution of (S)-(S)-1,1-diphenylpropan-2-yl 2-(3-hydroxy-4-methoxypicolinamido)-propanoate (Cmpd 90; 70.0 mg, 0.161 mmol), Et₃N (44.9 μL, 0.332 mmol), and DMAP (3.94 mg, 0.032 mmol) in DCM (3.2 mL) was added acetyl chloride (17.2 μL, 0.242 mmol) at room temperature, and the reaction mixture was stirred for 2 h. The solvent was evaporated, and the resulting crude oil was purified by flash column chromatography (SiO₂, 1→40% acetone in hexanes) to afford the title compound (75.0 mg, 97%) as a colorless oil: ¹H NMR (400 MHz, CDCl₃) δ 8.41 (d, J=7.8 Hz, 1H), 8.30 (d, J=5.4 Hz, 1H), 7.38-7.10 (m, 10H), 6.97 (d, J=5.4 Hz, 1H), 5.82 (dq, J=10.0, 6.2 Hz, 1H), 4.52 (dt, J=8.2, 7.1 Hz, 1H), 4.05 (d, J=10.1 Hz, 1H), 3.87 (s, 3H), 2.37 (s, 3H), 1.24 (d, J=6.1 Hz, 3H), 0.89 (d, J=7.1 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ 172.23, 168.89, 162.28, 159.42, 146.66, 141.55, 141.44, 141.25, 137.45, 128.77, 128.50, 128.13, 128.11, 126.89, 126.67, 109.73, 73.32, 57.90, 56.27, 47.85, 20.75, 19.25, 17.92; HRMS-ESI (m/z) [M+H]⁺ calcd for C₂₇H₂₉N₂O₆, 477.2025; found, 477.2019.

Example 6B: Preparation of (S)-(S)-1,1-diphenylpropan-2-yl 2-(3-(acetoxymethoxy)-4-methoxypicolinamido)propanoate (Cmpd 141)

To a suspension of (S)-(S)-1,1-diphenylpropan-2-yl 2-(3-hydroxy-4-methoxypicolinamido)-propanoate (Cmpd 90; 100 mg, 0.230 mmol) and K₂CO₃ (63.6 mg, 0.460 mmol) in acetone (4.6 mL) was added bromomethyl acetate (33.9 μL, 0.345 mmol) at room temperature, and the mixture was heated to 55° C. for 3 h and then cooled to room temperature. The solvent was evaporated and the resulting crude material was purified by flash column chromatography (SiO₂, 1440% acetone in hexanes) to afford the title compound (94.0 mg, 80% yield) as a colorless oil: ¹H NMR (400 MHz, CDCl₃) δ 8.25 (d, J=5.4 Hz, 1H), 8.22 (d, J=7.9 Hz, 1H), 7.34-7.09 (m, 10H), 6.92 (d, J=5.4 Hz, 1H), 5.83 (dq, J=10.1, 6.2 Hz, 1H), 5.72 (d, J=0.7 Hz, 2H), 4.60-4.49 (m, 1H), 4.06 (d, J=10.1 Hz, 1H), 3.88 (s, 3H), 2.05 (s, 3H), 1.25 (d, J=6.1 Hz, 3H), 0.91 (d, J=7.2 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ 172.33, 170.25, 162.88, 160.24, 145.70, 143.91, 142.54, 141.48, 141.25, 128.76, 128.49, 128.12, 128.09, 126.89, 126.65, 109.56, 89.50, 73.27, 57.92, 56.17, 48.07, 20.86, 19.25, 17.73; HRMS-ESI (m/z) [M+H]⁺ calcd for C₂₈H₃₁N₂O₇, 507.2131; found, 507.2125.

Example 6C: Preparation of (S)-(S)-1,1-diphenylpropan-2-yl 2-(3-((isobutyryloxy)methoxy)-4-methoxypicolinamido)propanoate (Cmpd 142)

To a solution of (S)-(S)-1,1-diphenylpropan-2-yl 2-(3-hydroxy-4-methoxypicolinamido)-propanoate (Cmpd 90; 100 mg, 0.230 mmol) in acetone (4.6 mL) were added sodium carbonate (Na₂CO₃; 73.2 mg, 0.690 mmol), sodium iodide (NaI; 6.90 mg, 0.046 mmol) and chloromethyl 2-ethoxyacetate (62.9 mg, 0.460 mmol). The mixture was heated to 55° C. overnight and then cooled to room temperature, and the solvent was evaporated. The resulting residue was purified by flash column chromatography (SiO₂, 2→30% acetone in hexanes) to afford the title compound (79.0 mg, 64%) as a colorless oil: ¹H NMR (400 MHz, CDCl₃) δ 8.28 (d, J=7.9 Hz, 1H), 8.25 (d, J=5.3 Hz, 1H), 7.36-7.08 (m, 10H), 6.92 (d, J=5.4 Hz, 1H), 5.83 (dq, J=10.1, 6.2 Hz, 1H), 5.79-5.69 (m, 2H), 4.62-4.44 (m, 1H), 4.06 (d, J=10.1 Hz, 1H), 3.86 (s, 3H), 2.53 (hept, J=7.0 Hz, 1H), 1.25 (d, J=6.2 Hz, 3H), 1.13 (d, J=7.0 Hz, 6H), 0.91 (d, J=7.2 Hz, 3H); ¹³C NMR (101 MHz, CDCl₃) δ 176.22, 172.34, 162.85, 160.23, 145.55, 144.16, 142.18, 141.48, 141.26, 128.76, 128.49, 128.12, 128.09, 126.89, 126.65, 109.48, 89.90, 73.26, 57.93, 56.12, 48.07, 33.85, 19.26, 18.68, 17.74; HRMS-ESI (m/z) [M+H]⁺ calcd for C₃₀H₃₅N₂O₇, 535.2444; found, 535.2431.

Example A: Evaluation of Fungicidal Activity: Leaf Blotch of Wheat (Mycosphaerella graminicola; Anamorph: Septoria tritici; Bayer code SEPTTR):

Technical grades of materials were dissolved in acetone, which were then mixed with nine volumes of water (H₂O) containing 110 ppm Triton X-100. The fungicide solutions were applied onto wheat seedlings using an automated booth sprayer to run-off. All sprayed plants were allowed to air dry prior to further handling. All fungicides were evaluated using the aforementioned method for their activity vs. all target diseases, unless stated otherwise. Wheat leaf blotch and brown rust activity were also evaluated using track spray applications, in which case the fungicides were formulated as EC formulations, containing 0.1% Trycol 5941 in the spray solutions.

Wheat plants (variety Yuma) were grown from seed in a greenhouse in 50% mineral soil/50% soil-less Metro mix until the first leaf was fully emerged, with 7-10 seedlings per pot. These plants were inoculated with an aqueous spore suspension of Septoria tritici either prior to or after fungicide treatments. After inoculation the plants were kept in 100% relative humidity (one day in a dark dew chamber followed by two to three days in a lighted dew chamber at 20° C.) to permit spores to germinate and infect the leaf. The plants were then transferred to a greenhouse set at 20° C. for disease to develop. When disease symptoms were fully expressed on the 1^st leaves of untreated plants, infection levels were assessed on a scale of 0 to 100 percent disease severity. Percent disease control was calculated using the ratio of disease severity on treated plants relative to untreated plants.

Example B: Evaluation of Fungicidal Activity: Wheat Brown Rust (Puccinia triticina; Synonym: Puccinia recondita f sp. tritici; Bayer code PUCCRT):

Wheat plants (variety Yuma) were grown from seed in a greenhouse in 50% mineral soil/50% soil-less Metro mix until the first leaf was fully emerged, with 7-10 seedlings per pot. These plants were inoculated with an aqueous spore suspension of Puccinia triticina either prior to or after fungicide treatments. After inoculation the plants were kept in a dark dew room at 22° C. with 100% relative humidity overnight to permit spores to germinate and infect the leaf. The plants were then transferred to a greenhouse set at 24° C. for disease to develop. Fungicide formulation, application and disease assessment followed the procedures as described in the Example A.

Example C: Evaluation of Fungicidal Activity: Wheat Glume Blotch (Leptosphaeria nodorum; Bayer code LEPTNO)

Wheat plants (variety Yuma) were grown from seed in a greenhouse in 50% mineral soil/50% soil-less Metro mix until the first leaf was fully emerged, with 7-10 seedlings per pot. These plants were inoculated with an aqueous spore suspension of Leptosphaeria nodorum 24 h after fungicide treatments. After inoculation the plants were kept in 100% relative humidity (one day in a dark dew chamber followed by two days in a lighted dew chamber at 20° C.) to permit spores to germinate and infect the leaf. The plants were then transferred to a greenhouse set at 20° C. for disease to develop. Fungicide formulation, application and disease assessment followed the procedures as described in the Example A.

Example D: Evaluation of Fungicidal Activity: Apple Scab (Venturia inaequalis; Bayer code VENTIN)

Apple seedlings (variety McIntosh) were grown in soil-less Metro mix, with one plant per pot. Seedlings with two expanding young leaves at the top (older leaves at bottom of the plants were trimmed) were used in the test. Plants were inoculated with a spore suspension of Venturia inaequalis 24 h after fungicide treatment and kept in a 22° C. dew chamber with 100% relative humidity for 48 h, and then moved to a greenhouse set at 20° C. for disease to develop. Fungicide formulation, application and disease assessment on the sprayed leaves followed the procedures as described in the Example A.

Example E: Evaluation of Fungicidal Activity: Leaf Spot of Sugar Beets (Cercospora beticola; Bayer code CERCBE)

Sugar beet plants (variety HH88) were grown in soil-less Metro mix and trimmed regularly to maintain a uniform plant size prior to test. Plants were inoculated with a spore suspension 24 h after fungicide treatments. Inoculated plants were kept in a dew chamber at 22° C. for 48 h then incubated in a greenhouse set at 24° C. under a clear plastic hood with bottom ventilation until disease symptoms were fully expressed. Fungicide formulation, application and disease assessment on the sprayed leaves followed the procedures as described in the Example A.

Example F: Evaluation of Fungicidal Activity: Asian Soybean Rust (Phakopsora pachyrhizi; Bayer code PHAKPA)

Technical grades of materials were dissolved in acetone, which were then mixed with nine volumes of H₂O containing 0.011% Tween 20. The fungicide solutions were applied onto soybean seedlings using an automated booth sprayer to run-off. All sprayed plants were allowed to air dry prior to further handling.

Soybean plants (variety Williams 82) were grown in soil-less Metro mix, with one plant per pot. Two weeks old seedlings were used for testing. Plants were inoculated either 3 days prior to or 1 day after fungicide treatments. Plants were incubated for 24 h in a dark dew room at 22° C. and 100% relative humidity then transferred to a growth room at 23° C. for disease to develop. Disease severity was assessed on the sprayed leaves.

Example G: Evaluation of Fungicidal Activity: Barley Scald (Rhyncosporium secalis; Bayer code RHYNSE)

Barley seedlings (variety Harrington) were propagated in soil-less Metro mix, with each pot having 8 to 12 plants, and used in the test when the first leaf was fully emerged. Test plants were inoculated by an aqueous spore suspension of Rhyncosporium secalis 24 h after fungicide treatments. After inoculation the plants were kept in a dew room at 20° C. with 100% relative humidity for 48 h. The plants were then transferred to a greenhouse set at 20° C. for disease to develop. Fungicide formulation, application and disease assessment on the sprayed leaves followed the procedures as described in the Example A.

Example H: Evaluation of Fungicidal Activity: Rice Blast (Magnaporthe grisea; Anamorph: Pyricularia oryzae; Bayer code PYRIOR)

Rice seedlings (variety Japonica) were propagated in soil-less Metro mix, with each pot having 8 to 14 plants, and used in the test when 12 to 14 days old. Test plants were inoculated with an aqueous spore suspension of Pyricularia oryzae 24 h after fungicide treatments. After inoculation the plants were kept in a dew room at 22° C. with 100% relative humidity for 48 h to permit spores to germinate and infect the leaf. The plants were then transferred to a greenhouse set at 24° C. for disease to develop. Fungicide formulation, application and disease assessment on the sprayed leaves followed the procedures as described in the Example A.

Example I: Evaluation of Fungicidal Activity: Tomato Early Blight (Alternaria solani; Bayer code ALTESO)

Tomato plants (variety Outdoor Girl) were propagated in soil-less Metro mix, with each pot having one plant, and used when 12 to 14 days old. Test plants were inoculated with an aqueous spore suspension of Alternaria solani 24 h after fungicide treatments. After inoculation the plants were kept in 100% relative humidity (one day in a dark dew chamber followed by two to three days in a lighted dew chamber at 20° C.) to permit spores to germinate and infect the leaf. The plants were then transferred to a growth room at 22° C. for disease to develop. Fungicide formulation, application and disease assessment on the sprayed leaves followed the procedures as described in the Example A.

Example J: Evaluation of Fungicidal Activity: Cucumber Anthracnose (Glomerella lagenarium; Anamorph: Colletotrichum lagenarium; Bayer code COLLLA)

Cucumber seedlings (variety Bush Pickle) were propagated in soil-less Metro mix, with each pot having one plant, and used in the test when 12 to 14 days old. Test plants were inoculated with an aqueous spore suspension of Colletotrichum lagenarium 24 hr after fungicide treatments. After inoculation the plants were kept in a dew room at 22° C. with 100% relative humidity for 48 hr to permit spores to germinate and infect the leaf. The plants were then transferred to a growth room set at 22° C. for disease to develop. Fungicide formulation, application and disease assessment on the sprayed leaves followed the procedures as described in the Example A.

TABLE 1
Compound Structure, Preparation Method, and Appearance
		Prepared
		According
Compound		To
Number	Structure	Example	Appearance
1		Example 1; Example 3A; Example 4A	White Solid
2		Example 1; Example 2A; Example 3A; Example 4A	Colorless Oil
3		Example 1; Example 2A; Example 3A; Example 4A	Colorless Oil
4		Example 1; Example 2A; Example 3A; Example 4A	Clear, Colorless Oil
5		Example 1; Example 2B; Example 3A; Example 4A	Colorless Oil
6		Example 1; Example 2B; Example 3A; Example 4A	Colorless Oil
7		Example 1; Example 2A; Example 3A; Example 4A	Colorless Oil
8		Example 1; Example 2C; Example 3A Example 4A	Colorless Oil
9		Example 1; Example 2A; Example 3A; Example 4A	Colorless Oil
10		Example 1; Example 2A; Example 3A; Example 4A	Colorless Oil
11		Example 1; Example 2A; Example 3A; Example 4A	Colorless Oil
12		Example 3E; Example 4A	Colorless Oil
13		Example 3E; Example 4A	Colorless Oil
14		Example 1; Example 3C Example 4A	Colorless Oil
15		Example 1; Example 3C; Example 4A	Colorless Oil
16		Example 1; Example 2A; Example 3A; Example 4A	Colorless Oil
18		Example 3F; Example 4A	Colorless Oil
19		Example 1; Example 2A; Example 3A; Example 4A	Colorless Oil
20		Example 1; Example 2A; Example 3A; Example 4A	Clear Oil
21		Example 1; Example 2A; Example 3A; Example 4A	Clear Oil
22		Example 1; Example 2A; Example 3A; Example 4A	Clear Oil
23		Example 1; Example 2A; Example 3A; Example 4A	Clear Oil
24		Example 1; Example 3C; Example 4A	Sticky Wax
25		Example 1; Example 3C; Example 4A	Sticky Wax
26		Example 1; Example 3C; Example 4A	Sticky Wax
27		Example 1; Example 3C; Example 4A	Sticky Wax
28		Example 1; Example 3C; Example 3D, Steps 1-2; Example 4A	White Foam
29		Example 1; Example 3C; Example 3D, Steps 1-3; Example 4A	Sticky Wax
31		Example 3F; Example 4A	Clear Oil
33		Example 1; Example 3B; Example 4A	White Solid
34		Example 1; Example 3B; Example 4A	White Solid
35		Example 1; Example 2A; Example 3A; Example 4A	White Solid
36		Example 1; Example 3B; Example 4A	White Foam
37		Example 1; Example 2A; Example 3A; Example 4A	Clear, Colorless Oil
38		Example 1; Example 2A; Example 3A; Example 4A	Clear, Colorless Oil
39		Example 1; Example 2A; Example 3A; Example 4A	Clear, Colorless Oil
40		Example 1; Example 2A; Example 3A; Example 4A	White Foam
43		Example 1; Example 2A; Example 3A; Example 4A	White Solid
44		Example 1; Example 2A; Example 3A; Example 4A	White Solid
45		Example 5, Step 1	White Solid
46		Example 5, Step 1	Colorless Oil
47		Example 5, Step 1	Colorless Oil
48		Example 5, Step 1	Pale Yellow Oil
49		Example 5, Step 1	Colorless Oil
50		Example 5, Step 1	Colorless Oil
51		Example 5, Step 1	Colorless Oil
52		Example 5, Step 1	Colorless Oil
53		Example 5, Step 1	Colorless Oil
54		Example 5, Step 1	Colorless Oil
55		Example 5, Step 1	Colorless Oil
56		Example 5, Step 1	Colorless Oil
57		Example 5, Step 1	Colorless Oil
58		Example 5, Step 1	Colorless Oil
59		Example 5, Step 1	Colorless Oil
60		Example 5, Step 1	Colorless Oil
61		Example 5, Step 1	White Solid
63		Example 5, Step 1	Colorless Oil
64		Example 5, Step 1	Colorless Oil
65		Example 5, Step 1	Sticky Oil
66		Example 5, Step 1	Sticky Oil
67		Example 5, Step 1	Sticky Oil
68		Example 5, Step 1	Sticky Wax
69		Example 5, Step 1	Sticky Wax
70		Example 5, Step 1	Sticky Wax
71		Example 5, Step 1	White Solid
72		Example 5, Step 1	White Solid
73		Example 5, Step 1	White Solid
74		Example 5, Step 1	White Solid
75		Example 5, Step 1	White Solid
77		Example 5, Step 1	White Solid
78		Example 5, Step 1	White Solid
79		Example 5, Step 1	White Solid
80		Example 1; Example 3B; Example 4A; Example 5, Step 1	Sticky Oil
81		Example 5, Step 1	Sticky Oil
83		Example 5, Step 1	Colorless Oil
84		Example 5, Step 1	Clear, Colorless Oil
85		Example 5, Step 1	Clear, Colorless Oil
86		Example 5, Step 1	White Solid
87		Example 5, Step 1	White Solid
88		Example 5, Step 1	White Solid
89		Example 5, Step 2	White Solid
90		Example 5, Step 2	White Foam
91		Example 5, Step 2	Colorless Oil
92		Example 5, Step 2	White Foam
93		Example 5, Step 2	White Foam
95		Example 5, Step 2	Colorless Oil
96		Example 5, Step 2	White Foam
97		Example 5, Step 2	Colorless Oil
98		Example 5, Step 2	Colorless Oil
99		Example 5, Step 2	Colorless Oil
100		Example 5, Step 2	Colorless Oil
101		Example 5, Step 2	Colorless Oil
102		Example 5, Step 2	Colorless Oil
103		Example 5, Step 2	Colorless Oil
104		Example 5, Step 2	Colorless Oil
105		Example 5, Step 2	Colorless Oil
106		Example 5, Step 2	Colorless Gel
107		Example 5, Step 2	Colorless Gel
109		Example 5, Step 2	Colorless Oil
110		Example 5, Step 2	Clear, Colorless Oil
111		Example 5, Step 2	Clear, Colorless Oil
112		Example 5, Step 2	Clear, Colorless Oil
113		Example 5, Step 2	White Solid
114		Example 5, Step 2	White Solid
115		Example 5, Step 2	White Solid
116		Example 5, Step 2	White Solid
117		Example 5, Step 2	White Foam
118		Example 5, Step 2	White Foam
119		Example 5, Step 2	White Foam
120		Example 5, Step 2	White Foam
121		Example 5, Step 2	White Foam
122		Example 5, Step 2	White Foam
123		Example 5, Step 2	White Foam
124		Example 5, Step 2	White Foam
125		Example 5, Step 2	White Solid
127		Example 5, Step 2	White Solid
128		Example 5, Step 2	White Solid
129		Example 5, Step 2	White Solid
130		Example 5, Step 2	Clear, Colorless Oil
131		Example 5, Step 2	Clear, Colorless Oil
132		Example 5, Step 2	Colorless Foam
133		Example 5, Step 2	Colorless Foam
135		Example 5, Step 2	Colorless Tacky Semi- Solid
136		Example 5, Step 2	White Foam
137		Example 5, Step 2	White Foam
138		Example 6B	Colorless Semi-Solid
139		Example 6A	Colorless Oil
140		Example 6A	White Foam
141		Example 6B	White Foam
142		Example 6C	White Foam
143		Example 6A	Colorless Oil
144		Example 6B	Colorless Oil
145		Example 6A	Colorless Oil
146		Example 6B	Colorless Oil
147		Example 6B	Colorless Oil
148		Example 6B	Colorless Oil
149		Example 6B	Colorless Oil
150		Example 6B	Colorless Oil
152		Example 6B	Colorless Oil
153		Example 6A	Colorless Oil
155		Example 6A	Colorless Oil
156		Example 6A	Colorless Oil
157		Example 6A	Colorless Oil
158		Example 6B	Colorless Oil
159		Example 6B	Colorless Oil
160		Example 6B	Colorless Oil
161		Example 6A	Colorless Oil
162		Example 6A	Colorless Oil
163		Example 6B	Colorless Oil
164		Example 6B	Colorless Oil
165		Example 6A	Colorless Oil
166		Example 6A	Colorless Oil
167		Example 6A	Colorless Oil
168		Example 6A	Colorless Oil
169		Example 6B	Colorless Oil
170		Example 6B	Colorless Oil
171		Example 6B	Colorless Oil
173		Example 6A	Colorless Oil
174		Example 6A	Colorless Oil
175		Example 6B	Colorless Oil
176		Example 6B	Colorless Oil
178		Example 6B	Clear, Colorless Oil
179		Example 6B	Clear, Colorless Oil
180		Example 6B	Clear, Colorless Oil
181		Example 6B	White Foam
182		Example 6A	Colorless Oil
183		Example 6B	White Solid
184		Example 6B	White Solid
185		Example 6B	White Solid
186		Example 6B	White Solid
187		Example 6A	White Solid
188		Example 6A	White Solid
189		Example 6A	White Solid
190		Example 6A	White Solid
191		Example 6B	White Foam
192		Example 6B	White Foam
193		Example 6B	Sticky Wax
194		Example 6B	White Foam
195		Example 6B	White Foam
196		Example 6B	White Foam
197		Example 6B	White Foam
198		Example 6B	Sticky Wax
199		Example 6B	White Solid
201		Example 6B	White Solid
202		Example 6B	White Solid
203		Example 6B	White Solid
204		Example 6A	White Solid
206		Example 6A	White Solid
207		Example 6A	White Solid
208		Example 6A	Clear Colorless Oil
209		Example 6A	Slightly Cloudy Colorless Oil
210		Example 6A	Slightly Cloudy Colorless Oil
211		Example 6C	Clear Colorless Oil
212		Example 6C	Colorless Clear Film And Opaque Oil
213		Example 6A	Clear Colorless Viscous Oil And Semi- Solid
214		Example 6B	Clear, Colorless Oil
215		Example 6A	Pale Yellow Oil
216		Example 6A	Pale Yellow Oil
217		Example 6A	Pale Yellow Oil
218		Example 6B	Pale Yellow Oil
219		Example 6B	Pale Yellow Oil
220		Example 6B	Pale Yellow Oil
221		Example 6B	White Foam
222		Example 6B	White Foam
223		Example 6A	White Foam
224		Example 6A	White Foam
225		Example 6B	Slightly Opaque Colorless Oil
226		Example 1; Example 2D, Steps 1- 2; Example 3A; Example 4A	White Semi- Solid
227		Example 5, Step 1	White Glass
228		Example 5, Step 2	Colorless Foam
229		Example 6A	Clear, Colorless Oil
230		Example 6B	Clear, Colorless Oil
232		Example 5, Step 1	White Semi- Solid
233		Example 1; Example 2A; Example 3A; Example 4A	Clear, Colorless Viscous Oil

TABLE 2
Analytical Data
Cmpd.	MP	IR		NMR
No.	(° C.)	(cm−1)	MASS	(1H, 13C, 19F)
1	—	—	HRMS-ESI	1H NMR (500 MHz, CDCl3) δ 7.53-
			(m/z)	7.41 (m, 4H), 7.32-7.23 (m, 4H), 7.23-
			[M]+	7.13 (m, 2H), 6.01 (q, J = 6.3 Hz,
			calcd for	1H), 4.98 (d, J = 8.0 Hz, 1H), 4.13 (p, J =
			C23H29NO5,	7.1 Hz, 1H), 2.78 (s, 1H), 1.41 (s,
			399.2046;	9H), 1.21 (d, J = 6.3 Hz, 3H), 0.83 (d, J =
			found,	7.3 Hz, 3H)
			399.2048	13C NMR (126 MHz, CDCl3) δ 172.55,
				154.95, 145.04, 142.86, 128.32, 128.30,
				127.17, 127.11, 125.59, 125.52, 79.83,
				79.54, 75.16, 49.13, 28.29, 17.95, 14.38
2	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.42-
			m/z 384.5	7.07 (m, 10H), 5.80 (dq, J = 10.1, 6.1
			([M + H]+)	Hz, 1H), 4.97 (d, J = 8.0 Hz, 1H), 4.19-
				4.06 (m, 1H), 4.03 (d, J = 10.1 Hz,
				1H), 1.41 (s, 9H), 1.23 (d, J = 6.1 Hz,
				3H), 0.76 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.83,
				154.96, 141.52, 141.26, 128.79, 128.50,
				128.10, 128.08, 126.91, 126.67, 73.10,
				57.98, 28.33, 19.31, 17.98
3	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.22-
			m/z 396.5	7.15 (m, 2H), 7.00 (ddd, J = 3.5, 1.2,
			([M + H]+)	0.6 Hz, 1H), 6.97-6.89 (m, 3H), 5.52
				(dq, J = 7.3, 6.2 Hz, 1H), 4.99 (d, J =
				5.1 Hz, 1H), 4.63 (d, J = 7.3 Hz, 1H),
				4.29-4.18 (m, 1H), 1.43 (s, 9H), 1.28
				(d, J = 6.2 Hz, 3H), 1.04 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.64,
				143.87, 142.87, 126.75, 126.55, 125.98,
				125.39, 124.58, 124.56, 79.69, 74.40,
				49.31, 47.46, 28.32, 18.74, 18.22
4	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.31-
			m/z 420.6	7.16 (m, 4H), 6.97 (td, J = 8.7, 7.0 Hz,
			([M + H]+)	4H), 5.71 (dq, J = 9.8, 6.1 Hz, 1H), 4.95
				(d, J = 8.0 Hz, 1H), 4.22-4.07 (m,
				1H), 4.03 (d, J = 9.8 Hz, 1H), 1.42 (s,
				9H), 1.22 (d, J = 6.2 Hz, 3H), 0.84 (d,
				J = 7.2 Hz, 3H)
				19F NMR (376 MHz, CDCl3)
				δ −115.53, −115.94
5	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.37-
			m/z 450.6	7.19 (m, 10H), 6.01-5.89 (m, 1H),
			([M + Na]+)	5.02 (d, J = 7.9 Hz, 1H), 4.27-4.10 (m,
				1H), 3.38 (dq, J = 8.9, 6.9 Hz, 1H), 3.25-
				3.13 (m, 1H), 1.40 (d, J = 2.1 Hz,
				9H), 1.18 (t, J = 7.0 Hz, 3H), 1.15-
				1.06 (m, 6H)
6	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.38-
			m/z 436.6	7.21 (m, 10H), 6.01-5.82 (m, 1H),
			([M + Na]+)	5.01 (d, J = 8.0 Hz, 1H), 4.27-4.12 (m,
				1H), 3.15 (s, 3H), 1.40 (s, 9H), 1.15-
				1.07 (m, 6H)
7	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.36 (td,
			m/z 456.5	J = 8.5, 6.1 Hz, 1H), 7.26-7.15 (m,
			([M + H]+)	1H), 6.91-6.68 (m, 4H), 5.86-5.73
				(m, 1H), 4.92 (d, J = 8.0 Hz, 1H), 4.66
				(d, J = 10.1 Hz, 1H), 4.23-4.09 (m,
				1H), 1.42 (s, 9H), 1.27 (d, J = 6.1 Hz, 3H)
				19F NMR (376 MHz, CDCl3)
				δ −111.06 (d, J = 7.6 Hz), −111.55 (d, J =
				7.5 Hz), −111.91 (dd, J = 7.9, 2.7
				Hz), −112.72 (d, J = 5.9 Hz)
8	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.48-
			m/z 424.5	7.41 (m, 4H), 7.38-7.19 (m, 6H), 5.97
			([M + Na]+)	(dq, J = 25.6, 6.5 Hz, 1H), 4.90 (d, J =
				7.8 Hz, 1H), 4.23-4.05 (m, 1H), 1.41
				(s, 9H), 1.29 (dd, J = 6.5, 1.0 Hz, 3H),
				0.75 (d, J = 7.2 Hz, 3H)
				19F NMR (376 MHz, CDCl3) δ −169.03
9	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.22-
			m/z 444.6	7.09 (m, 4H), 6.91-6.65 (m, 4H), 5.70
			([M + H]+)	(dq, J = 9.8, 6.1 Hz, 1H), 4.94 (d, J =
				8.0 Hz, 1H), 4.19-4.05 (m, 1H), 3.93
				(d, J = 9.8 Hz, 1H), 3.76 (s, 3H), 3.74
				(s, 3H), 1.42 (s, 9H), 1.21 (d, J = 6.2
				Hz, 3H), 0.83 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.84,
				158.34, 158.22, 133.99, 133.81, 128.96,
				114.10, 113.84, 79.64, 73.33, 56.17,
				55.22, 49.22, 28.31, 19.28, 18.19
10	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.33-
			m/z 420.6	7.21 (m, 2H), 7.14-7.02 (m, 2H), 7.03-
			([M + H]+)	6.84 (m, 4H), 5.72 (dq, J = 9.9, 6.2
				Hz, 1H), 4.93 (d, J = 8.0 Hz, 1H), 4.22-
				4.07 (m, 1H), 4.03 (d, J = 9.8 Hz,
				1H), 1.42 (s, 9H), 1.24 (d, J = 6.2 Hz,
				3H), 0.84 (d, J = 7.1 Hz, 3H)
				19F NMR (376 MHz, CDCl3)
				δ −112.14, −112.59
11	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.33-
			m/z 452.5	7.11 (m, 8H), 5.71 (dq, J = 10.0, 5.9 Hz,
			([M + H]+)	1H), 4.94 (d, J = 8.0 Hz, 1H), 4.18-
				4.07 (m, 1H), 3.99 (d, J = 9.9 Hz, 1H),
				1.42 (d, J = 1.7 Hz, 9H), 1.24 (d, J = 6.2
				Hz, 3H), 0.87-0.81 (m, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.79,
				154.94, 142.68, 142.43, 134.73, 134.43,
				130.21, 129.93, 128.39, 128.32, 127.49,
				127.18, 126.28, 126.20, 79.79, 72.40,
				57.09, 49.15, 28.30, 19.21, 18.04
12	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.79-
			m/z 382.5	7.72 (m, 2H), 7.72-7.62 (m, 1H), 7.59-
			([M + H]+)	7.48 (m, 1H), 7.46-7.36 (m, 2H),
				7.36-7.25 (m, 2H), 5.81-5.64 (m,
				1H), 5.09 (s, 1H), 4.55-4.34 (m, 1H),
				4.33-4.18 (m, 1H), 1.46 (s, 9H), 1.45
				(d, J = 3.5 Hz, 3H), 0.70 (d, J = 6.3 Hz,
				3H)
13	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.33-
			m/z 398.6	7.21 (m, 4H), 7.15-7.04 (m, 4H), 5.15-
			([M + H]+)	5.03 (m, 1H), 5.01 (d, J = 8.0 Hz,
				1H), 4.35-4.24 (m, 1H), 4.27-4.15
				(m, 1H), 1.44 (s, 9H), 1.29 (d, J = 7.2
				Hz, 3H), 1.03 (d, J = 6.4 Hz, 3H)
14	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.46-
			m/z 542.5	7.36 (m, 4H), 7.17-7.07 (m, 4H), 5.71
			([M + H]+)	(dq, J = 9.7, 6.2 Hz, 1H), 4.91 (d, J =
				7.9 Hz, 1H), 4.13 (p, J = 7.2 Hz, 1H),
				3.97 (d, J = 9.8 Hz, 1H), 1.42 (s, 9H),
				1.22 (d, J = 6.1 Hz, 3H), 0.86 (d, J = 7.2
				Hz, 3H)
15	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 6.73 (d, J =
			m/z 424.5	3.4 Hz, 1H), 6.67 (d, J = 3.4 Hz, 1H),
			([M + H]+)	6.59-6.46 (m, 2H), 5.43 (dq, J = 7.4,
				6.2 Hz, 1H), 5.03 (d, J = 8.1 Hz, 1H),
				4.42 (d, J = 7.3 Hz, 1H), 4.24 (p, J =
				7.1, 6.7 Hz, 1H), 2.41 (d, J = 1.1 Hz,
				3H), 2.40 (d, J = 1.1 Hz, 3H), 1.43 (s,
				9H), 1.27 (d, J = 6.2 Hz, 3H), 1.09 (d,
				J = 7.1 Hz, 3H)
16	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.18-
			m/z 412.6	7.11 (m, 4H), 7.11-7.02 (m, 4H), 5.75
			([M + H]+)	(dq, J = 10.2, 6.2 Hz, 1H), 4.95 (d, J =
				8.0 Hz, 1H), 4.11 (p, J = 7.4, 6.5 Hz,
				1H), 3.95 (d, J = 10.0 Hz, 1H), 2.27 (s,
				3H), 2.25 (s, 3H), 1.41 (s, 9H), 1.22 (d,
				J = 6.1 Hz, 3H), 0.80 (d, J = 7.2 Hz, 3H)
18	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.55 (d,
			m/z 452.6	J = 8.1 Hz, 2H), 7.41 (d, J = 8.0 Hz, 2H),
			([M + H]+)	7.31-7.16 (m, 5H), 5.82 (dq, J = 9.9,
				6.2 Hz, 1H), 4.92 (d, J = 7.9 Hz, 1H),
				4.15-4.06 (m, 2H), 1.41 (s, 9H), 1.24
				(d, J = 6.2 Hz, 3H), 0.77 (d, J = 7.2 Hz,
				3H)
				19F NMR (376 MHz, CDCl3) δ −62.58
19	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.30-
			m/z 452.5	7.22 (m, 4H), 7.22-7.15 (m, 4H), 5.71
			([M + H]+)	(dq, J = 9.6, 6.2 Hz, 1H), 4.91 (d, J =
				8.0 Hz, 1H), 4.21-4.06 (m, 1H), 4.00
				(d, J = 9.8 Hz, 1H), 1.42 (s, 9H), 1.22
				(d, J = 6.2 Hz, 3H), 0.85 (d, J = 7.2 Hz,
				3H)
				13C NMR (101 MHz, CDCl3) δ 172.75,
				154.96, 139.41, 139.25, 133.03, 132.77,
				129.43, 129.35, 129.05, 128.74, 79.81,
				72.51, 56.45, 49.17, 28.30, 19.18, 18.09
20	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.25-
			m/z 406.5	7.14 (m, 4H), 7.06-6.87 (m, 4H), 5.68
			([M + H]+)	(dq, J = 9.3, 6.2 Hz, 1H), 4.83 (s, 1H),
				4.02 (d, J = 9.3 Hz, 1H), 3.82 (dd, J =
				18.2, 5.9 Hz, 1H), 3.56 (dd, J = 18.2,
				5.2 Hz, 1H), 1.43 (s, 9H), 1.22 (d, J =
				6.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 169.66,
				161.74 (d, J = 245.9 Hz), 161.63 (d, J =
				245.7 Hz), 155.45, 136.74, 129.65 (d,
				J = 7.9 Hz), 115.70 (d, J = 21.3 Hz),
				115.41 (d, J = 21.2 Hz), 79.97, 77.21,
				73.15, 55.84, 42.44, 28.29, 19.17
21	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.30-
			m/z 434.6	7.15 (m, 4H), 7.06-6.89 (m, 4H), 5.75-
			([M + H]+)	5.62 (m, 1H), 4.90 (d, J = 8.4 Hz,
				1H), 4.11 (q, J = 6.7 Hz, 1H), 4.03 (d,
				J = 9.8 Hz, 1H), 1.49-1.33 (m, 10H),
				1.30-1.08 (m, 4H), 0.54 (t, J = 7.4 Hz,
				3H)
				13C NMR (101 MHz, CDCl3) δ 172.10,
				161.70 (d, J = 245.6 Hz), 155.20,
				136.97, 129.52, 115.71 (d, J = 21.3 Hz),
				115.44 (d, J = 21.2 Hz), 79.73, 73.12,
				56.08, 54.46, 28.30, 25.40, 19.26, 8.95
22	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.30-
			m/z 448.6	7.15 (m, 4H), 7.04-6.91 (m, 4H), 5.69
			([M + H]+)	(dq, J = 9.7, 6.1 Hz, 1H), 4.86 (d, J =
				9.3 Hz, 1H), 4.09 (dd, J = 9.3, 4.2 Hz,
				1H), 4.03 (d, J = 9.8 Hz, 1H), 1.69-
				1.57 (m, 1H), 1.42 (s, 9H), 1.21 (d, J =
				6.2 Hz, 3H), 0.73 (d, J = 6.9 Hz, 3H),
				0.43 (d, J = 6.8 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.77,
				161.73 (d, J = 246.0 Hz), 155.60,
				137.05, 129.61, 129.52, 129.44, 115.71
				(d, J = 21.6 Hz), 115.49 (d, J = 21.4
				Hz), 79.69, 73.23, 58.49, 56.03, 30.92,
				28.28, 19.31, 18.96, 16.54
23	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.30-
			m/z 462.7	7.20 (m, 4H), 7.04-6.92 (m, 4H), 5.68
			([M + H]+)	(dq, J = 9.8, 6.2 Hz, 1H), 4.72 (d, J =
				8.9 Hz, 1H), 4.10 (td, J = 9.2, 5.1 Hz,
				1H), 4.02 (d, J = 10.0 Hz, 1H), 1.41 (s,
				9H), 1.22 (d, J = 6.1 Hz, 3H), 0.96
				(ddd, J = 13.7, 9.6, 5.5 Hz, 1H), 0.84
				(m, 1H), 0.75 (d, J = 6.5 Hz, 3H), 0.70
				(d, J = 6.6 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 173.06,
				161.72 (d, J = 245.8 Hz), 155.29,
				137.17, 136.83, 129.49, 115.73 (d, J =
				21.4 Hz), 115.46 (d, J = 21.3 Hz),
				79.74, 73.02, 56.27, 52.04, 41.48,
				28.28, 24.41, 22.76, 21.53, 19.23
24	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 7.50-
		3358, 2977,	(m/z)	7.37 (m, 1H), 7.29-7.19 (m, 1H), 7.20-
		1708, 1491,	[M + Na]+	7.06 (m, 2H), 6.92-6.75 (m, 4H),
		1243, 1162,	calcd for	5.91 (dq, J = 10.1, 6.4 Hz, 1H), 5.03-
		1051, 1027	C25H33NNaO6,	4.97 (m, 1H), 4.98 (d, J = 9.9 Hz, 1H),
			466.22;	4.22-4.04 (m, 1H), 3.84 (s, 3H), 3.76
			found,	(s, 3H), 1.41 (s, 9H), 1.23 (d, J = 6.2
			466.2191	Hz, 3H), 0.82 (d, J = 7.2 Hz, 3H)
25	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 7.18 (dt,
		3368, 2978,	(m/z)	J = 11.8, 7.9 Hz, 2H), 6.89 (dq, J = 7.6,
		1707, 1597,	[M + Na]+	1.5 Hz, 2H), 6.83 (dt, J = 4.0, 2.1 Hz,
		1488, 1156,	calcd for	2H), 6.71 (dddd, J = 10.7, 8.2, 2.6, 0.9
		1043	C25H33NNaO6,	Hz, 2H), 5.77 (dq, J = 10.2, 6.1 Hz,
			466.22;	1H), 4.96 (d, J = 8.0 Hz, 1H), 4.20-
			found,	4.01 (m, 1H), 3.96 (d, J = 10.3 Hz, 1H),
			466.2193	3.77 (s, 3H), 3.75 (s, 3H), 1.42 (s, 9H),
				1.24 (d, J = 6.2 Hz, 3H), 0.79 (d, J = 7.2
				Hz, 3H)
26	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 7.14-
		3368 2979,	(m/z)	7.02 (m, 2H), 6.99-6.84 (m, 4H), 5.67
		1706, 1504,	[M + H]+	(dq, J = 9.8, 6.2 Hz, 1H), 4.95 (d, J =
		1162, 1052	calcd for	7.9 Hz, 1H), 4.22-4.05 (m, 1H), 3.94
			C25H31F2NNaO4,	(d, J = 9.8 Hz, 1H), 2.20 (d, J = 2.1 Hz,
			470.2113;	3H), 2.19 (d, J = 2.2 Hz, 3H), 1.42 (s,
			found,	9H), 1.28-1.17 (m, 3H), 0.86 (d, J =
			470.2122	7.2 Hz, 3H)
27	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) 27 7.22 (dd,
		3366, 2978,	(m/z)	J = 4.6, 1.9 Hz, 2H), 7.13 (t, J = 7.9 Hz,
		1706, 1162,	[M + H]+	2H), 7.04 (ddd, J = 7.6, 5.1, 1.9 Hz,
		1051	calcd for	2H), 5.67 (dq, J = 10.0, 6.2 Hz, 1H),
			C25H31Cl2NNaO4,	4.96 (d, J = 7.9 Hz, 1H), 4.22-4.05 (m,
			502.1522;	1H), 3.91 (d, J = 9.9 Hz, 1H), 2.31 (s,
			found,	3H), 2.29 (s, 3H), 1.42 (s, 9H), 1.22 (d,
			502.1533	J = 6.0 Hz, 3H), 0.87 (d, J = 7.2 Hz,
				3H)
28	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 7.45-
		3285, 2979,	(m/z)	7.37 (m, 4H), 7.26-7.18 (m, 4H), 5.75
		2107, 1702,	[M + Na]+	(dq, J = 10.0, 6.1 Hz, 1H), 4.91 (d, J =
		1501, 1160	calcd for	7.9 Hz, 1H), 4.20-4.06 (m, 1H), 4.04
			C27H29NNaO4,	(d, J = 9.9 Hz, 1H), 3.05 (s, 1H), 3.04
			454.1989;	(s, 1H), 1.42 (s, 9H), 1.23 (d, J = 6.2
			found,	Hz, 3H), 0.82 (d, J = 7.2 Hz, 3H)
			454.1993
29	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 7.22-
		3362, 2964,	(m/z)	7.16 (m, 4H), 7.13-7.03 (m, 4H), 5.76
		1712, 1510,	[M + Na]+	(dq, J = 10.2, 6.1 Hz, 1H), 4.95 (d, J =
		1163, 1053	calcd for	7.8 Hz, 1H), 4.17-4.02 (m, 1H), 3.96
			C27H37NNaO4,	(d, J = 10.2 Hz, 1H), 2.67-2.45 (m,
			462.2615;	4H), 1.41 (s, 9H), 1.23 (d, J = 6.2 Hz,
			found,	3H), 1.21-1.10 (m, 6H), 0.73 (d, J =
			462.2622	7.2 Hz, 3H)
31	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.32-
			m/z 402.6	7.20 (m, 6H), 7.20-7.14 (m, 1H), 6.97
			([M + H]+)	(t, J = 8.7 Hz, 2H), 5.75 (dq, J = 10.0,
				6.2 Hz, 1H), 4.92 (d, J = 8.0 Hz, 1H),
				4.11 (t, J = 7.4 Hz, 1H), 4.02 (d, J =
				10.0 Hz, 1H), 1.41 (s, 9H), 1.23 (d, J =
				6.2 Hz, 3H), 0.77 (d, J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.81,
				161.71 (d, J = 245.7 Hz), 154.94,
				141.23, 137.03 (d, J = 3.5 Hz), 129.56
				(d, J = 7.9 Hz), 128.59, 127.99, 126.82,
				115.62 (d, J = 21.3 Hz), 79.70, 72.94,
				57.09, 49.16, 28.31, 14.13
33	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.58 (t, J =
			m/z 519.6	2.1 Hz, 2H), 7.38 (dd, J = 8.4, 3.9 Hz,
			([M − H2O]+)	2H), 7.29-7.25 (m, 1H), 7.20 (dd, J =
				8.5, 2.2 Hz, 1H), 5.84 (q, J = 6.2 Hz,
				1H), 4.94 (d, J = 7.8 Hz, 1H), 4.14 (t, J =
				7.4 Hz, 1H), 3.05 (s, 1H), 1.41 (s,
				9H), 1.18 (d, J = 6.3 Hz, 3H), 1.00 (d, J =
				7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.37,
				155.04, 144.43, 142.16, 132.90 (d, J =
				2.7 Hz), 131.93, 131.87, 130.51,
				130.46, 128.13, 127.70, 125.08, 124.99,
				80.20, 78.55, 74.10, 49.16, 34.67,
				28.25, 14.28
34	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.37-
			m/z 486.5	7.28 (m, 4H), 7.18 (ddd, J = 8.4, 2.2,
			([M − H2O]+)	0.8 Hz, 1H), 7.09 (ddd, J = 8.4, 2.2, 0.9
				Hz, 1H), 5.86 (q, J = 6.2 Hz, 1H), 4.93
				(d, J = 7.8 Hz, 1H), 4.14 (t, J = 7.4 Hz,
				1H), 3.06 (s, 1H), 1.41 (s, 9H), 1.18 (d,
				J = 6.3 Hz, 3H), 0.98 (d, J = 6.8 Hz,
				3H)
				13C NMR (126 MHz, CDCl3) δ 172.28,
				158.09 (d, J = 249.9 Hz), 158.06 (d, J =
				249.5 Hz), 155.05, 145.31 (d, J = 5.7
				Hz), 142.98, 130.64 (d, J = 10.0 Hz),
				121.90 (d, J = 8.8 Hz), 120.38 (d, J =
				12.3 Hz), 120.24 (d, J = 12.3 Hz),
				114.59 (d, J = 22.6 Hz), 114.20 (d, J =
				22.9 Hz), 80.19, 78.60, 74.13, 49.13,
				34.67, 28.25, 14.30
35	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.24 (dd,
			m/z 480.6	J = 10.4, 8.1 Hz, 2H), 7.09 (dd, J = 5.5,
			([M]+)	2.2 Hz, 2H), 7.02 (td, J = 8.6, 2.3 Hz,
				2H), 5.69 (dq, J = 10.1, 6.1 Hz, 1H),
				4.94 (d, J = 7.9 Hz, 1H), 4.13 (t, J = 7.5
				Hz, 1H), 3.92 (d, J = 10.0 Hz, 1H), 2.33
				(s, 3H), 2.31 (s, 3H), 1.42 (s, 9H), 1.21
				(d, J = 6.1 Hz, 3H), 0.84 (d, J = 7.2 Hz,
				3H)
				13C NMR (126 MHz, CDCl3) δ 172.81,
				154.92, 139.66, 139.44, 136.53, 136.10,
				133.08, 132.72, 130.69, 130.57, 129.43,
				129.12, 126.59, 126.46, 79.77, 72.61,
				56.49, 49.17, 28.29, 20.16, 20.09,
				19.23, 18.09
36	—	(Thin film)	—	1H NMR (300 MHz, CDCl3) δ 7.82
		3385, 2980,		(ddd, J = 8.6, 7.3, 1.8 Hz, 1H), 7.51 (tt,
		1669, 1486,		J = 7.9, 1.5 Hz, 1H), 7.33-7.12 (m,
		1452, 1160,		3H), 7.09 (td, J = 7.6, 1.4 Hz, 1H), 6.94
		757		(dd, J = 8.1, 1.4 Hz, 1H), 6.90 (dd, J =
				8.1, 1.4 Hz, 1H), 6.23 (qd, J = 6.3, 1.6
				Hz, 1H), 5.02 (d, J = 7.9 Hz, 1H), 4.30-
				4.13 (m, 1H), 3.21 (s, 1H), 1.42 (s,
				9H), 1.26 (d, J = 6.2 Hz, 3H), 1.07 (d,
				J = 7.2 Hz, 3H)
37	-—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 7.18-
		3375, 2981,	(m/z)	6.91 (m, 6H), 5.63 (dq, J = 9.4, 6.2 Hz,
		1703, 1609,	[M + Na]+	1H), 4.92 (d, J = 8.0 Hz, 1H), 4.24-
		1515, 1453,	calcd for	4.06 (m, 1H), 3.98 (d, J = 9.5 Hz, 1H),
		1433, 1380,	C23H25F4NNaO4,	1.42 (s, 9H), 1.23 (d, J = 6.1 Hz, 3H),
		1367, 1284,	478.1612;	0.91 (d, J = 7.2 Hz, 3H)
		1250, 1208,	found,	19F NMR (471 MHz, CDCl3) δ −136.25
		1162, 1113,	478.1624	(dt, J = 20.6, 9.7 Hz), −136.69
		1053, 1023,		(dt, J = 20.4, 9.9 Hz), −139.30
		967, 909,		(dd, J = 21.3, 10.5 Hz), −139.70
		873, 821,		(dd, J = 21.1, 10.1 Hz)
		754, 731
38	—	(Thin film)	HRMS-ESI
		3440, 2981,	(m/z)	1H NMR (300 MHz, CDCl3) δ 7.32-
		1704, 1600,	[M + Na]+	7.22 (m, 2H), 7.18-7.02 (m, 4H), 5.64
		1497, 1452,	calcd for	(dq, J = 9.6, 6.2 Hz, 1H), 4.93 (d, J =
		1379, 1367,	C23H25Cl2F2NNaO4,	8.0 Hz, 1H), 4.25-4.03 (m, 1H), 3.98
		1306, 1250,	510.1021;	(d, J = 9.6 Hz, 1H), 1.42 (s, 9H), 1.23
		1210, 1162,	found, 510.1033	(d, J = 6.2 Hz, 3H), 0.92 (d, J = 7.2 Hz,
		1095, 1054,		3H)
		1023, 907,		19F NMR (471 MHz, CDCl3) δ −116.98
		867, 822,		(q, J = 6.9 Hz), −117.44 (q, J =
		799, 780,		6.8 Hz)
		731, 719,
		689
39	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 7.13-
		3364, 2980,	(m/z)	6.98 (m, 4H), 6.90 (td, J = 9.1, 7.4 Hz,
		2931, 1707,	[M + Na]+	2H), 5.67 (dq, J = 10.1, 6.1 Hz, 1H),
		1597, 1501,	calcd for	4.93 (d, J = 8.0 Hz, 1H), 4.22-4.02 (m,
		1451, 1379,	C25H31F2NNaO4,	1H), 3.91 (d, J = 10.1 Hz, 1H), 2.23 (d,
		1366, 1307,	470.2113;	J = 2.0 Hz, 3H), 2.21 (d, J = 2.0 Hz,
		1248, 1207,	found,	3H), 1.42 (s, 9H), 1.21 (d, J = 6.1 Hz,
		1163, 1118,	470.2120	3H), 0.83 (d, J = 7.2 Hz, 3H)
		1052, 1023,		19F NMR (471 MHz, CDCl3) δ −119.99
		959, 908,		(q, J = 6.8 Hz), −120.57 (q, J =
		881, 821,		7.0 Hz)
		781, 731
40	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.53
			m/z 536	(ddd, J = 13.6, 6.7, 4.2 Hz, 8H), 7.45-
			([M + H]+)	7.37 (m, 8H), 7.35-7.29 (m, 2H), 5.87
				(dq, J = 12.3, 6.1 Hz, 1H), 4.94 (d, J =
				7.1 Hz, 1H), 4.18-4.09 (m, 2H), 1.41
				(s, 9H), 1.31 (d, J = 6.2 Hz, 3H), 0.80
				(d, J = 7.1 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.93,
				154.96, 140.72, 140.60, 140.56, 140.21,
				139.92, 139.68, 128.76, 128.75, 128.51,
				127.58, 127.30, 127.27, 127.23, 127.00,
				126.96, 79.70, 73.12, 57.33, 49.22,
				28.31, 19.39, 18.04
43	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 7.38 (t,
			(m/z)	J = 8.1 Hz, 2H), 7.32 (dd, J = 13.6, 2.1
			[M + Na]+	Hz, 2H), 7.10 (dd, J = 8.4, 2.1 Hz, 1H),
			calcd for	7.07 (dd, J = 8.4, 2.1 Hz, 1H), 5.65 (dq,
			C23H25Cl4NNaO4,	J = 9.5, 6.2 Hz, 1H), 4.93 (d, J = 7.9
			542.0430;	Hz, 1H), 4.22-4.09 (m, 1H), 3.97 (d, J =
			found,	9.5 Hz, 1H), 1.42 (d, J = 0.9 Hz, 9H),
			542.0442	1.24 (d, J = 6.1 Hz, 3H), 0.93 (d, J = 7.2
				Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.73,
				154.93, 140.37, 140.26, 133.10, 132.76,
				131.66, 131.34, 130.97, 130.67, 130.23,
				130.06, 127.34, 127.27, 79.92, 71.96,
				55.79, 49.16, 28.29, 19.14, 18.11
44	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 7.38-
			(m/z)	7.28 (m, 2H), 7.06 (dd, J = 10.0, 1.8 Hz,
			[M + Na]+	1H), 7.04-6.94 (m, 3H), 5.66 (ddt, J =
			calcd for	9.1, 6.9, 5.5 Hz, 1H), 4.92 (d, J = 8.0
			C23H25Cl2F2NNaO4,	Hz, 1H), 4.22-4.08 (m, 1H), 4.01 (d,
			510.1021;	J = 9.4 Hz, 1H), 1.42 (d, J = 1.3 Hz, 9H),
			found,	1.24 (dd, J = 6.2, 1.3 Hz, 3H), 0.92 (d,
			510.1030	J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.68,
				158.17 (d, J = 250.1 Hz), 158.03 (d, J =
				250.1 Hz), 154.93, 141.08 (d, J = 6.1
				Hz), 140.95 (d, J = 6.1 Hz), 131.11,
				130.80, 124.51 (d, J = 3.3 Hz), 124.36
				(d, J = 3.6 Hz), 120.08 (d, J = 17.6 Hz),
				119.78 (d, J = 17.6 Hz), 116.48 (d, J =
				16.8 Hz), 116.24, 79.92, 72.02, 56.07,
				49.15, 28.28, 19.10, 18.10
45	—	—	ESIMS	—
			m/z 300
			([M + H]+)
46	—	—	ESIMS	—
			m/z 284.3
			([M + H]+)
47	—	—	ESIMS	—
			m/z 296.3
			([M + H]+)
48	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.55 (s,
		3395, 2885,	(m/z)	3H), 7.22 (dt, J = 9.0, 4.8 Hz, 4H), 6.98
		1741, 1603,	[M + H]+	(q, J = 8.2 Hz, 4H), 5.71 (dq, J = 11.8,
		1508, 1459,	calcd for	6.1 Hz, 1H), 4.05 (d, J = 9.8 Hz, 2H),
		1381, 1324,	C18H20F2NO2,	1.23 (d, J = 5.9 Hz, 3H), 1.13 (d, J = 6.7
		1224, 1159,	320.1457;	Hz, 3H)
		1137, 1118,	found,	19F NMR (376 MHz, CDCl3)
		1049, 1015,	320.1457	δ −115.32, −115.70
		955, 881,
		826, 793,
		779, 755,
		746, 721,
		693, 666
49	—	—	ESIMS	—
			m/z 341.5
			([M + Na]+)
50	—	—	ESIMS	—
			m/z 314.6
			([M + H]+)
51	—	—	ESIMS	—
			m/z 356.4
			([M + H]+)
52	—	—	ESIMS	19F NMR (376 MHz, CDCl3) δ −169.31
			m/z 302.4
			([M + H]+)
53	—	—	ESIMS	—
			m/z 344.5
			([M + H]+)
54	—	—	ESIMS	—
			m/z 320.4
			([M + H]+)
55	—	—	ESIMS	—
			m/z 352.4
			([M + H]+)
56	—	—	ESIMS	—
			m/z 282.4
			([M + H]+)
57	—	—	ESIMS	—
			m/z 298.4
			([M + H]+)
58	—	—	ESIMS	—
			m/z 442.4
			([M + H]+)
59	—	—	ESIMS	—
			m/z 324.4
			([M + H]+)
60	—	—	ESIMS	—
			m/z 312.3
			([M + H]+)
61	—	—	ESIMS	—
			m/z 436
			([M + H]+)
63	—	—	ESIMS	—
			m/z 375.5
			([M + Na]+)
64	—	—	ESIMS	—
			m/z 375.5
			([M + Na]+)
65	—	—	ESIMS	—
			m/z 344.5
			([M + H]+)
66	—	—	ESIMS	—
			m/z 344.5
			([M + H]+)
67	—	—	ESIMS	—
			m/z 348.5
			([M + H]+)
68	—	—	ESIMS	—
			m/z 380.5
			([M + H]+)
69	—	—	ESIMS	—
			m/z 332.5
			([M + H]+)
70	—	—	ESIMS	—
			m/z 340.5
			([M + H]+)
71	—	(Thin film)	HRMS-ESI	—
		2959, 1749,	(m/z)
		1508, 1401,	[M + H]+
		1229, 1159,	calcd for
		1055, 830	C17H17F2NO2,
			306.1300;
			found,
			306.1298
72	—	(Thin film)	HRMS-ESI	—
		3452, 2855,	(m/z)
		1742, 1601,	[M + H]+
		1506, 1454,	calcd for
		1220, 1159,	C19H22F2NO2,
		1136, 1046,	335.1646;
		824	found,
			335.1646
73	—	(Thin film)	HRMS-ESI	—
		2966, 1736,	(m/z)
		1602, 1507,	[M + H]+
		1221, 1158,	calcd for
		1120, 1046,	C20H24F2NO2,
		825	349.1803;
			found,
			349.1804
74	—	(Thin film)	HRMS-ESI	—
		2959, 1739,	(m/z)
		1603, 1507,	[M + H]+
		1219, 1158,	calcd for
		1132, 1046,	C21H26F2NO2,
		825	363.1959;
			found,
			363.1959
75	—	(Thin film)	HRMS-ESI	—
		3411, 2986,	(m/z)
		1740, 1605,	[M + H]+
		1509, 1453,	calcd for
		1223, 1137,	C18H21FNO2,
		1116, 1049,	302.1551;
		700	found,
			302.1551
77	—	(Thin film)	ESIMS	—
		3363, 2941,	m/z 438.0
		1743, 1467,	([M + H]+)
		1385, 1236,
		1201, 1173,
		1136, 1117,
		1061, 1029,
		992, 824,
		755, 723,
		675
78	—	(Thin film)	ESIMS	—
		3361, 2942,	m/z 404.0
		1742, 1582,	([M]+)
		1486, 1419,
		1240, 1207,
		1141, 1116,
		1057,800
79	—	(Thin film)	HRMS-ESI	—
		3218, 2980,	(m/z)
		2945, 1742,	[M + H]+
		1522, 1481,	calcd for
		1245, 1216,	C20H24Cl2NO2,
		1136, 1118,	380.1179;
		1048, 758	found,
			380.1181
80	—	—	ESIMS	—
			m/z 404.4
			([M + H]+)
81	—	—	ESIMS	—
			m/z 336.5
			([M + H]+)
83	—	—	ESIMS	—
			m/z 408.5
			([M + H]+)
84	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, methanol-d4) δ
		2881, 2193,	(m/z)	7.46-7.30 (m, 2H), 7.28-7.14 (m,
		2130, 1742,	[M + H]+	4H), 5.84 (dq, J = 10.1, 6.2 Hz, 1H),
		1609, 1516,	calcd for	4.24 (d, J = 10.1 Hz, 1H), 3.96 (q, J =
		1457, 1434,	C18H18F4NO2,	7.3 Hz, 1H), 3.31 (pd, J = 1.6, 0.5 Hz,
		1383, 1325,	356.1268;	3H), 1.27 (d, J = 6.1 Hz, 3H), 1.02 (d,
		1285, 1208,	found,	J = 7.2 Hz, 3H)
		1118, 1049,	356.1273	19F NMR (471 MHz, methanol-d4)
		966, 906,		δ −139.39 (ddd, J = 19.8, 11.5,
		875, 821,		7.5 Hz), −139.57-−139.84
		754, 710,		(m), −142.33-−142.56
		692, 681,		(m), −142.66-−142.93
		656		(m)
85	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, methanol-d4) δ
		3409, 2928,	(m/z)	7.54 (dt, J = 7.0, 2.7 Hz, 2H), 7.37 (ddt,
		2026, 1957,	[M + H]+	J = 8.6, 4.3, 2.1 Hz, 2H), 7.21 (td, J =
		1743, 1597,	calcd for	8.8, 4.7 Hz, 2H), 5.93-5.75 (m, 1H),
		1499, 1458,	C18H18Cl2F2NO2,	4.24 (d, J = 10.1 Hz, 1H), 3.96 (q, J =
		1408, 1323,	388.0677;	7.3 Hz, 1H), 3.31 (t, J = 1.7 Hz, 3H),
		1249, 1208,	found, 388.0677	1.28 (d, J = 6.1 Hz, 3H), 1.03 (d, J = 7.3
		1118, 1061,		Hz, 3H)
		917, 866,		19F NMR (471 MHz, methanol-d4)
		822, 798,		δ −119.62-−119.72
		780, 753,		(m), −119.99-−120.08 (m)
		718, 690,
		663
86	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, methanol-d4) δ
		3374, 2928,	(m/z)	7.30-7.12 (m, 4H), 6.95 (td, J = 8.9,
		1742, 1596,	[M + H]+	6.6 Hz, 2H), 5.91-5.74 (m, 1H), 4.07
		1501, 1457,	calcd for	(d, J = 10.4 Hz, 1H), 3.99-3.83 (m,
		1379, 1323,	C20H24F2NO2,	1H), 3.30 (dtd, J = 3.3, 1.6, 0.6 Hz, 3H),
		1233, 1206,	348.1770;	2.23 (t, J = 2.6 Hz, 6H), 1.25 (d, J = 6.1
		1118, 1052,	found,	Hz, 3H), 0.94 (dd, J = 7.3, 0.7 Hz, 3H)
		1003, 956,	348.1771	19F NMR (471 MHz, methanol-d4)
		933, 886,		δ −122.00-−122.37 (m), −122.69 (tt,
		824, 780,		J = 6.1, 2.9 Hz)
		752, 721,
		711, 690,
		681, 671,
		664, 655
87	—	(Thin film)	HRMS-ESI	—
		2879, 1746,	(m/z)
		1587, 1561,	[M + H]+
		1517, 1468,	calcd for
		1395, 1227,	C18H18Cl4NO2,
		1194, 1116,	420.0086;
		1053, 1029,	found,
		871, 822,	420.0090
		747, 727,
		669
88	—	(Thin film)	HRMS-ESI	—
		2858, 1747,	(m/z)
		1580, 1486,	[M + H]+
		1458, 1383,	calcd for
		1368, 1278,	C18H18Cl2F2NO2,
		1236, 1206,	388.0677;
		1119, 1048,	found,
		970, 871,	388.0688
		824, 779,
		761, 682
89	—	—	HRMS-ESI	1H NMR (500 MHz, CDCl3) δ 11.97 (d,
			(m/z)	J = 0.5 Hz, 1H), 8.33 (d, J = 8.1 Hz,
			[M]+	1H), 7.96 (d, J = 5.2 Hz, 1H), 7.47 (ddt,
			calcd for	J = 8.5, 6.4, 1.3 Hz, 4H), 7.33-7.13
			C25H26N2O6,	(m, 5H), 6.89-6.81 (m, 1H), 6.03 (q,
			450.1791;	J = 6.3 Hz, 1H), 4.62-4.49 (m, 1H),
			found,	3.93 (s, 3H), 2.74 (s, 1H), 1.23 (d, J =
			450.1794	6.3 Hz, 3H), 1.07 (d, J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.30,
				168.61, 155.37, 148.71, 144.85, 142.71,
				140.44, 130.29, 128.33, 128.32, 127.22,
				127.16, 125.51, 125.45, 109.44, 79.57,
				75.54, 56.08, 47.85, 17.62, 14.32
90	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.10 (d,
			(m/z)	J = 0.6 Hz, 1H), 8.34 (d, J = 8.0 Hz,
			[M + H]+	1H), 7.98 (d, J = 5.2 Hz, 1H), 7.38-
			calcd for	7.06 (m, 10H), 6.86 (dd, J = 5.3, 0.7 Hz,
			C25H27N2O5,	1H), 5.83 (dq, J = 10.1, 6.1 Hz, 1H),
			435.1920;	4.52 (dq, J = 8.1, 7.2 Hz, 1H), 4.06 (d,
			found,	J = 10.2 Hz, 1H), 3.93 (s, 3H), 1.26 (d,
			435.1925	J = 6.1 Hz, 3H), 0.97 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.67,
				168.53, 155.34, 148.72, 141.38, 141.13,
				140.40, 130.48, 128.80, 128.50, 128.10,
				128.03, 126.95, 126.70, 109.39, 73.57,
				57.93, 56.07, 47.85, 19.24, 17.61
91	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.10 (d,
			(m/z)	J = 0.6 Hz, 1H), 8.41 (d, J = 8.0 Hz,
			[M + H]+	1H), 7.98 (d, J = 5.2 Hz, 1H), 7.18-
			calcd for	7.16 (m, 2H), 7.01 (ddd, J = 3.6, 1.3,
			C21H23N2O5S2,	0.6 Hz, 1H), 6.94-6.88 (m, 3H), 6.86
			447.1048;	(dd, J = 5.3, 0.7 Hz, 1H), 5.56 (dq, J =
			found,	7.4, 6.2 Hz, 1H), 4.70-4.58 (m, 2H),
			447.1047	3.94 (s, 3H), 1.30 (d, J = 6.2 Hz, 3H),
				1.24 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.48,
				168.62, 155.35, 148.74, 143.75, 142.69,
				140.43, 130.48, 126.77, 126.57, 126.05,
				125.43, 124.61, 124.58, 109.44, 74.83,
				56.08, 47.98, 47.42, 18.69, 17.80
92	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.06 (d,
			(m/z)	J = 0.7 Hz, 1H), 8.32 (d, J = 8.0 Hz,
			[M + H]+	1H), 7.98 (d, J = 5.3 Hz, 1H), 7.26-
			calcd for	7.18 (m, 4H), 7.01-6.89 (m, 4H), 6.87
			C25H25F2N2O5,	(d, J = 5.3 Hz, 1H), 5.73 (dq, J = 9.7,
			471.1731;	6.1 Hz, 1H), 4.59-4.49 (m, 1H), 4.05
			found,	(d, J = 9.8 Hz, 1H), 3.94 (s, 3H), 1.25
			471.1735	(d, J = 6.2 Hz, 3H), 1.07 (d, J = 7.2 Hz,
				3H)
				19F NMR (376 MHz, CDCl3)
				δ −115.46, −115.80
93	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.03 (d,
			(m/z)	J = 0.7 Hz, 1H), 8.40 (d, J = 8.1 Hz,
			[2M + Na]+	1H), 7.97 (d, J = 5.2 Hz, 1H), 7.41-
			calcd for	7.09 (m, 10H), 6.85 (d, J = 5.2 Hz, 1H),
			C54H60N4NaO12,	5.97 (q, J = 6.3 Hz, 1H), 4.61 (dq, J =
			979.4106;	8.2, 7.2 Hz, 1H), 3.94 (s, 3H), 3.39 (dq,
			found,	J = 9.1, 6.9 Hz, 1H), 3.18 (dq, J = 9.2,
			979.4119	6.9 Hz, 1H), 1.30 (d, J = 7.2 Hz, 3H),
				1.17 (t, J = 6.9 Hz, 3H), 1.13 (d, J = 6.3
				Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.45,
				168.56, 155.34, 148.71, 141.84, 140.56,
				140.38, 130.37, 128.25, 127.87, 127.81,
				127.69, 127.33, 127.21, 109.41, 84.05,
				74.30, 59.93, 56.08, 48.05, 18.02,
				15.67, 14.95
95	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 12.04 (d,
			(m/z)	J = 0.6 Hz, 1H), 8.41 (d, J = 8.0 Hz,
			[M − OCH3]+	1H), 7.97 (d, J = 5.2 Hz, 1H), 7.41-
			calcd for	7.18 (m, 10H), 6.85 (d, J = 5.4 Hz, 1H),
			C25H25N2O5,	5.97 (q, J = 6.3 Hz, 1H), 4.75-4.49 (m,
			433.1764;	1H), 3.94 (s, 3H), 3.15 (s, 3H), 1.29 (d,
			found,	J = 7.2 Hz, 3H), 1.13 (d, J = 6.3 Hz,
			433.1763	3H)
				13C NMR (101 MHz, CDCl3) δ 171.42,
				168.58, 155.35, 148.72, 141.11, 140.39,
				139.89, 130.37, 128.51, 128.11, 127.86,
				127.69, 127.52, 127.31, 109.42, 84.47,
				74.02, 56.08, 52.55, 48.05, 17.97, 14.97
96	—	—	—	1H NMR (400 MHz, CDCl3) & 12.03 (d,
				J = 0.6 Hz, 1H), 8.31 (d, J = 7.9 Hz,
				1H), 7.97 (d, J = 5.2 Hz, 1H), 7.35 (td,
				J = 8.5, 6.2 Hz, 1H), 7.23 (td, J = 8.4, 6.2
				Hz, 1H), 6.91-6.74 (m, 4H), 6.69
				(ddd, J = 10.4, 8.8, 2.6 Hz, 1H), 5.88-
				5.74 (m, 1H), 4.69 (d, J = 9.9 Hz, 1H),
				4.64-4.48 (m, 1H), 3.95 (s, 3H), 1.30
				(d, J = 6.1 Hz, 3H), 1.17 (d, J = 7.2 Hz,
				3H)
				19F NMR (376 MHz, CDCl3) δ −110.97
				(d, J = 7.7 Hz), −111.39 (d, J =
				7.6 Hz), −111.98 (dd, J = 7.7, 2.6
				Hz), −112.83 (dd, J = 7.6, 2.6 Hz)
97	—	—	—	1H NMR (400 MHz, CDCl3) δ 12.06 (s,
				1H), 8.31 (d, J = 7.9 Hz, 1H), 7.98 (d,
				J = 5.2 Hz, 1H), 7.49-7.40 (m, 4H),
				7.37-7.24 (m, 5H), 7.23-7.18 (m,
				1H), 6.86 (d, J = 5.2 Hz, 1H), 6.00 (dq,
				J = 25.4, 6.4 Hz, 1H), 4.63-4.51 (m,
				1H), 3.94 (s, 3H), 1.32 (dd, J = 6.5, 1.0
				Hz, 3H), 0.96 (d, J = 7.2 Hz, 3H)
				19F NMR (376 MHz, CDCl3) δ −169.17
98	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.11 (s,
			(m/z)	1H), 8.35 (d, J = 8.0 Hz, 1H), 7.97 (d,
			[M + H]+	J = 5.2 Hz, 1H), 7.22-7.12 (m, 4H),
			calcd for	6.90-6.73 (m, 5H), 5.73 (dq, J = 9.8,
			C27H31N2O7,	6.1 Hz, 1H), 4.64-4.44 (m, 1H), 3.96
			495.2131;	(d, J = 9.9 Hz, 1H), 3.93 (s, 3H), 3.75
			found,	(s, 3H), 3.73 (s, 3H), 1.24 (d, J = 6.2
			495.2124	Hz, 3H), 1.05 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.65,
				168.54, 158.36, 158.20, 155.34, 148.70,
				140.40, 133.83, 133.69, 130.45, 128.97,
				128.92, 114.11, 113.81, 109.39, 73.77,
				56.11, 56.04, 55.20, 55.19, 47.90,
				19.20, 17.75
99	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.05 (s,
			(m/z)	1H), 8.34 (d, J = 8.0 Hz, 1H), 7.98 (d,
			[M + H]+	J = 5.3 Hz, 1H), 7.32-7.19 (m, 2H),
			calcd for	7.11-7.03 (m, 2H), 7.02-6.83 (m,
			C25H25F2N2O5,	5H), 5.75 (dq, J = 9.8, 6.1 Hz, 1H), 4.65-
			471.1731;	4.46 (m, 1H), 4.06 (d, J = 9.9 Hz,
			found,	1H), 3.94 (s, 3H), 1.27 (d, J = 6.1 Hz,
			471.1724	3H), 1.07 (d, J = 7.2 Hz, 3H)
				19F NMR (376 MHz, CDCl3)
				δ −112.07, −112.48
100	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.04 (s,
			(m/z)	1H), 8.32 (d, J = 7.7 Hz, 1H), 7.98 (d,
			[M + H]+	J = 5.3 Hz, 1H), 7.31-7.10 (m, 8H),
			calcd for	6.86 (d, J = 5.2 Hz, 1H), 5.73 (dq, J =
			C25H25Cl2N2O5,	9.9, 6.2 Hz, 1H), 4.60-4.48 (m, 1H),
			503.1140;	4.01 (d, J = 10.0 Hz, 1H), 3.94 (s, 3H),
			found,	1.27 (d, J = 6.2 Hz, 3H), 1.08 (d, J = 7.1
			503.1137	Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.55,
				168.60, 155.36, 148.72, 142.54, 142.33,
				140.47, 134.73, 134.42, 130.33, 130.23,
				129.94, 128.42, 128.33, 127.52, 127.21,
				126.18, 125.98, 109.47, 72.83, 57.03,
				56.08, 47.85, 19.11, 17.66
101	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.23-
			(m/z)	11.94 (m, 1H), 8.64-8.39 (m, 1H),
			[M + H]+	8.11-7.92 (m, 1H), 7.78-7.60 (m,
			calcd for	3H), 7.59-7.48 (m, 1H), 7.46-7.35
			C25H25N2O5,	(m, 2H), 7.36-7.26 (m, 1H), 7.27-
			433.1763;	7.20 (m, 1H), 6.91-6.84 (m, 1H), 5.87-
			found,	5.69 (m, 1H), 4.94-4.76 (m, 1H),
			433.1749	4.35-4.22 (m, 1H), 4.00-3.93 (m,
				3H), 1.69-1.51 (m, 3H), 0.95-0.59
				(m, 3H)
102	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.16 (s,
			(m/z)	1H), 8.51-8.38 (m, 1H), 8.11-7.82
			[M + H]+	(m, 1H), 7.34-7.15 (m, 4H), 7.15-
			calcd for	6.94 (m, 4H), 6.91-6.77 (m, 1H), 5.20-
			C25H25N2O6,	5.09 (m, 1H), 4.78-4.64 (m, 1H),
			449.1712;	4.33-4.17 (m, 1H), 3.96-9.92 (m,
			found,	3H), 1.55-1.42 (m, 3H), 1.10-0.91
			449.1707	(m, 3H)
103	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.06 (s,
			(m/z)	1H), 8.33 (d, J = 7.9 Hz, 1H), 7.97 (d,
			[M + H]+	J = 5.2 Hz, 1H), 7.50-7.31 (m, 4H),
			calcd for	7.24-7.01 (m, 4H), 6.87 (d, J = 5.2 Hz,
			C25H25Br2N2O5,	1H), 5.73 (dq, J = 9.6, 6.1 Hz, 1H), 4.55
			591.0130;	(p, J = 7.3 Hz, 1H), 4.01 (d, J = 9.7 Hz,
			found,	1H), 3.93 (s, 3H), 1.25 (d, J = 6.1 Hz,
			591.0125	3H), 1.09 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.50,
				168.61, 155.39, 148.74, 140.47, 139.69,
				139.59, 132.00, 131.69, 130.31, 129.80,
				129.73, 121.12, 120.84, 109.52, 72.81,
				56.45, 56.08, 47.86, 19.09, 17.67
104	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.13 (s,
			(m/z)	1H), 8.44 (d, J = 8.0 Hz, 1H), 7.99 (d,
			[M + H]+	J = 5.2 Hz, 1H), 6.87 (d, J = 5.2 Hz, 1H),
			calcd for	6.73 (d, J = 3.4 Hz, 1H), 6.67 (d, J = 3.4
			C23H27N2O5S2,	Hz, 1H), 6.54-6.35 (m, 2H), 5.54-
			475.1361;	5.40 (m, 1H), 4.78-4.59 (m, 1H), 4.45
			found,	(d, J = 7.1 Hz, 1H), 3.94 (s, 3H), 2.39
			475.1368	(s, 6H), 1.30 (d, J = 2.8 Hz, 3H), 1.28
				(d, J = 3.7 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.50,
				168.60, 155.35, 148.74, 141.52, 140.47,
				140.41, 139.03, 139.00, 130.53, 125.76,
				125.08, 124.67, 124.42, 109.41, 74.68,
				56.07, 48.00, 47.84, 18.65, 17.88, 15.25
105	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.14 (s,
			(m/z)	1H), 8.38 (d, J = 8.0 Hz, 1H), 7.94 (d,
			[M + H]+	J = 5.2 Hz, 1H), 7.21-7.10 (m, 4H),
			calcd for	7.09-6.97 (m, 4H), 6.82 (d, J = 5.2 Hz,
			C27H31N2O5,	1H), 5.79 (dq, J = 10.1, 6.2 Hz, 1H),
			463.2233;	4.53 (p, J = 7.3 Hz, 1H), 3.98 (d, J =
			found,	10.0 Hz, 1H), 3.88 (s, 3H), 2.25 (s, 3H),
			463.2242	2.23 (s, 3H), 1.25 (d, J = 6.3 Hz, 3H),
				1.01 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.66,
				168.57, 155.32, 148.71, 140.43, 138.63,
				138.47, 136.37, 136.05, 130.45, 129.44,
				129.11, 127.91, 127.85, 109.45, 73.66,
				57.08, 56.02, 47.92, 20.97, 20.93,
				19.24, 17.64
106	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.09 (s,
			(m/z)	1H), 8.35 (d, J = 8.0 Hz, 1H), 7.97 (d,
			[M + H]+	J = 5.2 Hz, 1H), 7.54 (d, J = 8.1 Hz, 2H),
			calcd for	7.42 (d, J = 8.1 Hz, 2H), 7.34-7.21 (m,
			C26H26F3N2O5,	4H), 7.21-7.13 (m, 1H), 6.86 (d, J =
			503.1794;	5.2 Hz, 1H), 5.85 (dq, J = 9.8, 6.1 Hz,
			found,	1H), 4.61-4.46 (m, 1H), 4.15 (d, J =
			503.1794	9.9 Hz, 1H), 3.93 (s, 3H), 1.27 (d, J =
				6.2 Hz, 3H), 1.00 (d, J = 7.2 Hz, 3H)
				19F NMR (376 MHz, CDCl3) δ −62.53
107	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.05 (s,
			(m/z)	1H), 8.32 (d, J = 8.0 Hz, 1H), 7.97 (d,
			[M + H]+	J = 5.2 Hz, 1H), 7.38-7.10 (m, 8H),
			calcd for	6.87 (d, J = 5.2 Hz, 1H), 5.73 (dq, J =
			C25H25Cl2N2O5,	9.9, 6.2 Hz, 1H), 4.62-4.45 (m, 1H),
			503.1140;	4.03 (d, J = 9.6 Hz, 1H), 3.94 (s, 3H),
			found,	1.25 (d, J = 6.1 Hz, 3H), 1.09 (d, J = 7.2
			503.1139	Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.52,
				168.61, 155.41, 148.74, 140.45, 139.26,
				139.15, 133.04, 132.77, 130.32, 129.41,
				129.36, 129.05, 128.73, 109.49, 72.95,
				56.35, 56.08, 47.86, 19.08, 17.67
109	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 12.10 (s,
			m/z 587	1H), 8.36 (d, J = 7.9 Hz, 1H), 7.95 (d,
			([M + H]+)	J = 5.2 Hz, 1H), 7.57-7.46 (m, 8H),
				7.43-7.38 (m, 7H), 7.34-7.29 (m,
				2H), 6.81 (d, J = 5.2 Hz, 1H), 5.90 (dq,
				J = 12.2, 6.1 Hz, 1H), 4.56 (p, J = 7.2
				Hz, 1H), 4.16 (d, J = 10.0 Hz, 1H), 3.89
				(d, J = 1.9 Hz, 3H), 1.34 (d, J = 6.1 Hz,
				3H), 1.02 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.71,
				168.59, 155.33, 148.72, 140.65, 140.58,
				140.43, 140.11, 139.94, 139.66, 130.44,
				128.77, 128.73, 128.67, 128.53, 127.58,
				127.30, 127.26, 127.21, 127.00, 126.94,
				109.40, 73.58, 57.25, 56.04, 47.91,
				19.33, 17.66
110	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 11.80 (s,
		3374, 2984,	(m/z)	1H), 8.30 (d, J = 8.0 Hz, 1H), 8.07 (dd,
		1735, 1649,	[M + H]+	J = 4.3, 1.5 Hz, 1H), 7.40-7.15 (m,
		1602, 1577,	calcd for	6H), 7.05-6.85 (m, 4H), 5.73 (dq, J =
		1530, 1507,	C24H23F2N2O4,	9.8, 6.2 Hz, 1H), 4.65-4.45 (m, 1H),
		1449, 1380,	441.1620;	4.05 (d, J = 9.8 Hz, 1H), 1.25 (d, J = 6.1
		1329, 1296,	found,	Hz, 3H), 1.07 (d, J = 7.2 Hz, 3H)
		1222, 1188,	441.1620	13C NMR (101 MHz, CDCl3) δ 171.60,
		1159, 1130,		168.26, 161.76 (d, J = 246.1 Hz),
		1105, 1049,		161.64 (d, J = 245.7 Hz), 157.79,
		1015, 906,		139.65, 136.82 (d, J = 3.3 Hz), 136.71
		826, 809,		(d, J = 3.5 Hz), 131.04, 129.50 (d, J =
		792, 778,		7.9 Hz), 128.80, 126.08, 115.74 (d, J =
		731, 704,		21.3 Hz), 115.41 (d, J = 21.3 Hz),
		666		73.34, 56.14, 47.84, 19.12, 17.69
				19F NMR (376 MHz, CDCl3)
				δ −115.44, −115.76
111	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) § 12.06 (d,
		3370, 2984,	(m/z)	J = 0.6 Hz, 1H), 8.33 (d, J = 8.0 Hz,
		2936, 2256,	[M + H]+	1H), 7.95 (d, J = 5.2 Hz, 1H), 7.35-
		1735, 1647,	calcd for	7.14 (m, 4H), 7.04-6.87 (m, 4H), 6.84
		1604, 1574,	C26H27F2N2O5,	(d, J = 5.2 Hz, 1H), 5.73 (dq, J = 9.7,
		1529, 1507,	485.1883;	6.1 Hz, 1H), 4.60-4.48 (m, 1H), 4.16
		1483, 1469,	found,	(q, J = 7.0 Hz, 2H), 4.05 (d, J = 9.7 Hz,
		1452, 1381,	485.1880	1H), 1.51 (t, J = 7.0 Hz, 3H), 1.24 (d,
		1323, 1281,		J = 6.1 Hz, 3H), 1.06 (d, J = 7.2 Hz, 3H)
		1262, 1222,		13C NMR (101 MHz, CDCl3) δ 171.58,
		1158, 1109,		168.66, 161.75 (d, J = 246.1 Hz),
		1048, 1015,		161.64 (d, J = 245.7 Hz), 154.75,
		990, 904,		148.82, 140.38, 136.82 (d, J = 3.3 Hz),
		824, 800,		136.73 (d, J = 3.3 Hz), 130.41, 129.51
		730		(d, J = 7.6 Hz), 115.72 (d, J = 21.4 Hz),
				115.39 (d, J = 21.2 Hz), 110.13, 73.32,
				64.67, 56.12, 47.84, 19.11, 17.69, 14.37
				19F NMR (376 MHz, CDCl3)
				δ −115.47, −115.80
112	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.05 (s,
		3370, 2984,	(m/z)	1H), 7.43-7.33 (m, 2H), 7.30-7.17
		1729, 1641,	[M + H]+	(m, 4H), 7.05-6.90 (m, 5H), 6.88-
		1601, 1531,	calcd for	6.77 (m, 2H), 5.75 (dq, J = 9.9, 6.1 Hz,
		1507, 1491,	C25H24F2NO4,	1H), 4.57 (p, J = 7.1 Hz, 1H), 4.06 (d,
		1450, 1361,	440.1668;	J = 9.9 Hz, 1H), 1.25 (d, J = 6.1 Hz, 3H),
		1305, 1281,	found,	1.00 (d, J = 7.1 Hz, 3H)
		1254, 1222,	440.1676	13C NMR (101 MHz, CDCl3) δ 172.22,
		1177, 1158,		169.33, 161.79 (d, J = 246.2 Hz),
		1135, 1087,		161.70 (d, J = 245.9 Hz), 161.59,
		1048, 1015,		136.83 (d, J = 3.4 Hz), 136.61 (d, J =
		908, 824,		3.4 Hz), 134.49, 129.49 (d, J = 8.1 Hz),
		778, 752,		129.46 (d, J = 7.9 Hz), 125.62, 118.70,
		731, 666		118.58, 115.79 (d, J = 21.4 Hz), 115.50
				(d, J = 21.3 Hz), 113.72, 73.62, 56.17,
				48.29, 19.15, 17.79
				19F NMR (376 MHz, CDCl3)
				δ −115.30, −115.60
113	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 11.98 (d,
			m/z 457.6	J = 0.6 Hz, 1H), 8.30 (t, J = 5.7 Hz,
			([M + H]+)	1H), 7.99 (d, J = 5.2 Hz, 1H), 7.24-
				7.15 (m, 4H), 7.03-6.85 (m, 5H), 5.71
				(dq, J = 9.2, 6.2 Hz, 1H), 4.11 (dd, J =
				18.1, 6.0 Hz, 1H), 4.04 (d, J = 9.2 Hz,
				1H), 3.95 (s, 3H), 3.90 (dd, J = 18.1, 5.6
				Hz, 1H), 1.25 (d, J = 6.3 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 169.18 ,
				168.43, 161.74 (d, J = 246.1 Hz),
				161.63 (d, J = 245.5 Hz), 155.42,
				148.71, 140.55, 136.68, 130.30, 129.68,
				129.60, 115.67 (d, J = 29.2 Hz), 115.46
				(d, J = 29.1 Hz), 109.55, 73.65, 56.11,
				55.77, 40.91, 19.12
114	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 12.08 (s,
			m/z 485.6	1H), 8.32 (d, J = 8.5 Hz, 1H), 7.98 (d,
			([M + H]+)	J = 5.2 Hz, 1H), 7.46-7.04 (m, 4H),
				7.11-6.65 (m, 5H), 5.71 (dq, J = 9.8,
				6.2 Hz, 1H), 4.51 (ddd, J = 8.5, 7.0, 5.4
				Hz, 1H), 4.05 (d, J = 9.6 Hz, 1H), 3.95
				(s, 3H), 1.70-1.57 (m, 1H), 1.49-1.36
				(m, 1H), 1.24 (d, J = 6.2 Hz, 3H), 0.67
				(t, J = 7.5 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 170.87,
				168.79, 161.74 (d, J = 245.9 Hz),
				161.66 (d, J = 245.8 Hz), 155.43,
				148.73, 140.42, 136.80, 130.36, 129.55
				(d, J = 2.7 Hz), 129.47 (d, J = 2.7 Hz),
				115.67 (d, J = 32.4 Hz), 115.45 (d, J =
				32.4 Hz), 109.44, 73.48, 56.09, 56.03,
				53.16, 25.16, 19.18, 9.27
115	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 12.08 (d,
			m/z 499.6	J = 0.6 Hz, 1H), 8.32 (d, J = 9.4 Hz,
			([M + H]+)	1H), 7.98 (d, J = 5.2 Hz, 1H), 7.31-
				7.07 (m, 4H), 6.97 (t, J = 8.6 Hz, 2H),
				6.93-6.86 (m, 3H), 5.72 (dq, J = 9.7,
				6.2 Hz, 1H), 4.48 (dd, J = 9.4, 4.7 Hz,
				1H), 4.05 (d, J = 9.7 Hz, 1H), 3.95 (s,
				3H), 1.93-1.82 (m, 1H), 1.23 (d, J =
				6.1 Hz, 3H), 0.82 (d, J = 6.9 Hz, 3H),
				0.65 (d, J = 6.8 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 170.46,
				168.95, 161.73 (d, J = 246.4 Hz),
				161.65 (d, J = 245.6 Hz), 155.43,
				148.71, 140.42, 136.85, 130.40, 129.54
				(d, J = 4.7 Hz), 129.47 (d, J = 4.7 Hz),
				115.71 (d, J = 21.3 Hz), 115.40 (d, J =
				21.3 Hz), 109.43, 73.51, 57.09, 56.09,
				55.98, 30.96, 19.22, 19.10, 17.10
116	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 12.07 (d,
			m/z 513.7	J = 0.6 Hz, 1H), 8.15 (d, J = 8.9 Hz,
			([M + H]+)	1H), 7.97 (d, J = 5.2 Hz, 1H), 7.31-
				7.04 (m, 4H), 7.08-6.74 (m, 6H), 5.70
				(dq, J = 10.0, 6.1 Hz, 1H), 4.54 (ddd,
				J = 9.7, 8.8, 5.0 Hz, 1H), 4.04 (d, J = 9.8
				Hz, 1H), 3.94 (s, 3H), 1.46-1.36 (m,
				1H), 1.33-1.18 (m, 4H), 1.08 (ddd, J =
				13.9, 9.0, 5.0 Hz, 1H), 0.82 (d, J = 6.5
				Hz, 3H), 0.77 (d, J = 6.6 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 171.62,
				168.81, 161.75 (d, J = 246.2 Hz),
				161.66 (d, J = 245.6 Hz), 155.43,
				148.74, 140.39, 137.02, 136.76, 130.34,
				129.51 (d, J = 3.4 Hz), 129.44 (d, J =
				3.5 Hz), 115.73 (d, J = 21.4 Hz), 115.41
				(d, J = 21.3 Hz), 109.44, 73.37, 56.21,
				56.09, 50.52, 41.00, 24.57, 22.76,
				21.49, 19.14
117	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 12.15 (d,
		3368, 2937,	(m/z)	J = 0.6 Hz, 1H), 8.38 (d, J = 8.0 Hz,
		1732, 1648,	[M + H]+	1H), 7.97 (d, J = 5.2 Hz, 1H), 7.45 (dd,
		1527, 1241,	calcd for	J = 7.6, 1.7 Hz, 1H), 7.30-7.20 (m,
		1144	C27H31N2O7,	1H), 7.12 (dddd, J = 13.5, 8.1, 7.5, 1.7
			495.2126;	Hz, 2H), 6.92-6.80 (m, 4H), 6.76 (dd,
			found,	J = 8.2, 1.1 Hz, 1H), 5.97 (dq, J = 9.0,
			495.2104	5.7, 5.2 Hz, 1H), 5.01 (d, J = 10.1 Hz,
				1H), 4.70-4.39 (m, 1H), 3.93 (s, 3H),
				3.85 (s, 3H), 3.75 (s, 3H), 1.25 (d, J =
				6.2 Hz, 3H), 1.01 (d, J = 7.2 Hz, 3H)
118	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 12.10 (d,
		3368, 2937,	(m/z)	J = 0.6 Hz, 1H), 8.35 (d, J = 8.0 Hz,
		1734, 1648,	[M + H]+	1H), 7.98 (d, J = 5.2 Hz, 1H), 7.21 (t,
		1527, 1261,	calcd for	J = 8.0 Hz, 1H), 7.15 (t, J = 7.9 Hz, 1H),
		1148, 1041	C27H31N2O7,	6.93-6.81 (m, 5H), 6.74 (ddd, J = 8.2,
			495.2126;	2.6, 0.9 Hz, 1H), 6.68 (ddd, J = 8.2, 2.6,
			found,	0.9 Hz, 1H), 5.80 (dq, J = 10.3, 6.1 Hz,
			495.2106	1H), 4.60-4.43 (m, 1H), 3.99 (d, J =
				10.3 Hz, 1H), 3.94 (s, 3H), 3.77 (s, 3H),
				3.75 (s, 3H), 1.26 (d, J = 6.0 Hz, 3H),
				1.00 (d, J = 7.2 Hz, 3H)
119	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 11.92 (s,
		3367, 2985,	(m/z)	1H), 8.36 (d, J = 8.1 Hz, 1H), 7.95 (d,
		1738, 1647,	[M + H]+	J = 5.2 Hz, 1H), 7.77 (t, J = 8.5 Hz, 1H),
		1575, 1481,	calcd for	7.37 (t, J = 8.5 Hz, 1H), 7.15 (ddd, J =
		1263, 1153,	C25H23Cl2F2N2O6,	8.5, 2.1, 0.7 Hz, 1H), 7.08-6.89 (m,
		1058, 914	555.0896;	3H), 6.86 (d, J = 5.3 Hz, 1H), 6.10 (q,
			found,	J = 6.2 Hz, 1H), 4.66 (p, J = 7.3 Hz, 1H),
			555.0909	3.95 (s, 3H), 3.22 (s, 1H), 1.36 (d, J =
				7.2 Hz, 3H), 1.24 (d, J = 6.3 Hz, 3H)
120	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 12.06 (d,
		3369, 2934,	(m/z)	J = 0.6 Hz, 1H), 8.34 (d, J = 8.0 Hz,
		1735, 1648,	[M + H]+	1H), 7.98 (d, J = 5.2 Hz, 1H), 7.16-
		1576, 1527,	calcd for	7.01 (m, 2H), 7.01-6.79 (m, 5H), 5.70
		1451, 1261	C27H29F2N2O5,	(dq, J = 9.9, 6.1 Hz, 1H), 4.70-4.43
			499.2039;	(m, 1H), 3.97 (d, J = 9.3 Hz, 1H), 3.94
			found,	(s, 3H), 2.20 (d, J = 1.9 Hz, 3H), 2.17
			499.2050	(d, J = 1.9 Hz, 3H), 1.25 (d, J = 6.1 Hz,
				3H), 1.09 (d, J = 7.2 Hz, 3H)
121	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 12.14-
		3367, 2980,	(m/z)	11.95 (m, 1H), 8.33 (d, J = 8.0 Hz, 1H),
		1735, 1648,	[M + H]+	7.98 (d, J = 5.2 Hz, 1H), 7.21 (d, J = 1.5
		1527, 1450,	calcd for	Hz, 2H), 7.19-6.99 (m, 4H), 6.86 (d,
		1262, 1050	C27H29Cl2N2O5,	J = 5.2 Hz, 1H), 5.69 (dq, J = 9.8, 6.1 Hz,
			531.1448;	1H), 4.55 (p, J = 7.3 Hz, 1H), 3.94 (d,
			found,	J = 9.9 Hz, 1H), 3.94 (s, 3H), 2.31 (s,
			531.1458	3H), 2.27 (s, 3H), 1.25 (d, J = 6.0 Hz,
				3H), 1.10 (d, J = 7.2 Hz, 3H)
122	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 12.00 (d,
		3367, 2986,	(m/z)	J = 0.6 Hz, 1H), 8.41 (d, J = 8.1 Hz,
		1737, 1647,	[M + H]+	1H), 7.97 (d, J = 5.2 Hz, 1H), 7.87-
		1611, 1482,	calcd for	7.75 (m, 1H), 7.48 (tt, J = 8.0, 1.5 Hz,
		1452, 1215,	C25H25F2N2O6,	1H), 7.28-7.12 (m, 3H), 7.10-6.98
		1148, 1057	487.1675;	(m, 1H), 6.99-6.86 (m, 2H), 6.90-
			found,	6.82 (m, 1H), 6.26 (qd, J = 6.3, 1.5 Hz,
			487.1686	1H), 4.73-4.57 (m, 1H), 3.94 (s, 3H),
				3.19 (dd, J = 2.8, 1.9 Hz, 1H), 1.28 (d,
				J = 6.3 Hz, 3H), 1.27 (d, J = 7.2 Hz, 3H)
				19F NMR (471 MHz, CDCl3)
				δ −111.85-−112.11
				(m), −112.15-−112.47 (m)
123	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.06 (d,
		3285, 2981,	(m/z)	J = 0.6 Hz, 1H), 8.33 (d, J = 8.0 Hz,
		2107, 1736,	[M + H]+	1H), 7.98 (d, J = 5.2 Hz, 1H), 7.45-
		1648, 1528,	calcd for	7.40 (m, 2H), 7.40-7.35 (m, 2H), 7.28-
		1263, 1050	C29H27N2O5,	7.18 (m, 4H), 6.86 (d, J = 5.2 Hz,
			483.1914;	1H), 5.78 (dq, J = 9.8, 6.1 Hz, 1H), 4.61-
			found,	4.45 (m, 1H), 4.07 (d, J = 9.8 Hz,
			483.1919	1H), 3.94 (s, 3H), 3.05 (s, 1H), 3.03 (s,
				1H), 1.25 (d, J = 6.2 Hz, 3H), 1.04 (d,
				J = 7.2 Hz, 3H)
124	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.12 (s,
		3368, 2963,	(m/z)	1H), 8.37 (d, J = 8.0 Hz, 1H), 7.98 (d, J
		1735, 1648,	[M + H]+	= 5.2 Hz, 1H), 7.24-7.18 (m, 4H),
		1527, 1480,	calcd for	7.14-7.08 (m, 2H), 7.08-7.02 (m,
		1450, 1280,	C29H35N2O5,	2H), 6.85 (d, J = 5.2 Hz, 1H), 5.80 (dq,
		1263, 1142,	491.2540;	J = 10.1, 6.2 Hz, 1H), 4.63-4.40 (m,
		1053	found,	1H), 3.99 (d, J = 10.2 Hz, 1H), 3.93 (s,
			491.2551	3H), 2.65-2.50 (m, 4H), 1.25 (d, J =
				6.1 Hz, 3H), 1.18 (t, J = 7.6 Hz, 3H),
				1.14 (t, J = 7.6 Hz, 3H), 0.94 (d, J = 7.2
				Hz, 3H)
125	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.08 (d,
			(m/z)	J = 0.6 Hz, 1H), 8.33 (d, J = 8.0 Hz,
			[M + H]+	1H), 7.98 (d, J = 5.2 Hz, 1H), 7.32-
			calcd for	7.20 (m, 5H), 7.19-7.10 (m, 1H), 6.97
			C25H26FN2O5,	(t, J = 8.7 Hz, 2H), 6.86 (d, J = 5.2 Hz,
			453.1820;	1H), 5.78 (dq, J = 10.0, 6.2 Hz, 1H),
			found,	4.58-4.45 (m, 1H), 4.05 (d, J = 10.0
			453.1831	Hz, 1H), 3.94 (s, 3H), 1.26 (d, J = 6.2
				Hz, 3H), 0.98 (d, J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.63,
				168.54, 161.72 (d, J = 245.7 Hz),
				155.35, 148.71, 141.10, 140.41, 136.91
				(d, J = 3.5 Hz), 130.42, 129.58 (d, J =
				7.8 Hz), 128.59, 127.95, 126.84, 115.64
				(d, J = 21.3 Hz), 109.40, 73.39, 57.04,
				56.07, 47.83, 19.15, 17.59
127	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 11.77 (d,
			m/z 589.5	J = 0.6 Hz, 1H), 8.25 (d, J = 8.0 Hz,
			([M + H]+)	1H), 7.96 (d, J = 5.2 Hz, 1H), 7.53 (dd,
				J = 20.0, 2.2 Hz, 2H), 7.35 (dd, J = 8.5,
				1.8 Hz, 2H), 7.18 (ddd, J = 10.9, 8.5,
				2.3 Hz, 2H), 6.88 (d, J = 5.2 Hz, 1H),
				5.80 (q, J = 6.3 Hz, 1H), 4.68-4.47 (m,
				1H), 3.95 (s, 3H), 1.27 (d, J = 7.3 Hz,
				3H), 1.20 (d, J = 6.4 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 170.98,
				168.86, 155.52, 148.74, 144.18, 141.99,
				140.57, 132.92, 132.87, 132.02, 131.86,
				130.48, 130.37, 129.91, 128.15, 127.74,
				125.09, 124.82, 109.64, 78.58, 74.60,
				56.11, 48.05, 17.56, 14.13
128	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 11.78 (d,
			m/z 555.6	J = 0.6 Hz, 1H), 8.25 (d, J = 8.0 Hz,
			([M + H]+)	1H), 7.96 (d, J = 5.3 Hz, 1H), 7.33-
				7.27 (m, 2H), 7.22 (dd, J = 10.4, 2.2 Hz,
				1H), 7.08 (dddd, J = 19.0, 8.5, 2.1, 0.8
				Hz, 2H), 6.88 (d, J = 5.2 Hz, 1H), 5.82
				(q, J = 6.3 Hz, 1H), 4.65-4.51 (m,
				1H), 3.95 (s, 3H), 3.00 (s, 1H), 1.26 (d,
				J = 7.2 Hz, 3H), 1.20 (d, J = 6.3 Hz,
				3H)
				13C NMR (126 MHz, CDCl3) δ 170.92,
				168.87, 158.04 (d, J = 249.8 Hz),
				157.99 (d, J = 249.5 Hz), 155.54,
				148.76, 145.02 (d, J = 5.5 Hz), 142.77
				(d, J = 6.0 Hz), 140.55, 130.65, 130.55,
				129.94, 122.05 (d, J = 3.7 Hz), 121.65
				(d, J = 3.6 Hz), 120.45 (d, J = 17.8 Hz),
				120.25 (d, J = 17.7 Hz), 114.56 (d, J =
				22.7 Hz), 114.26 (d, J = 23.0 Hz),
				109.62, 78.63, 74.64, 56.12, 48.02,
				17.52, 14.30
129	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.06 (s,
			(m/z)	1H), 8.32 (d, J = 8.0 Hz, 1H), 7.98 (d,
			[M + H]+	J = 5.2 Hz, 1H), 7.25 (d, J = 9.7 Hz, 1H),
			calcd for	7.19 (d, J = 8.2 Hz, 1H), 7.09 (dd, J =
			C27H29Cl2N2O5,	4.0, 2.3 Hz, 2H), 7.02 (td, J = 8.5, 2.3
			531.1448;	Hz, 2H), 6.87 (d, J = 5.2 Hz, 1H), 5.71
			found,	(dq, J = 10.0, 6.1 Hz, 1H), 4.54 (p, J =
			531.1454	7.3 Hz, 1H), 3.99-3.92 (m, 4H), 2.33
				(s, 3H), 2.29 (s, 3H), 1.24 (d, J = 6.1
				Hz, 3H), 1.07 (d, J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.61,
				168.57, 155.39, 148.74, 140.44, 139.53,
				139.35, 136.56, 136.15, 133.12, 132.77,
				130.63, 130.59, 130.34, 129.45, 129.12,
				126.59, 126.41, 109.44, 73.05, 56.45,
				56.08, 47.85, 20.17, 20.08, 19.15, 17.69
130	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 12.63 (s,
		3376, 2986,	(m/z)	1H), 8.32 (d, J = 7.9 Hz, 1H), 7.88 (d,
		2360, 2107,	[M + H]+	J = 4.9 Hz, 1H), 7.62 (d, J = 4.9 Hz, 1H),
		1736, 1652,	calcd for	7.29-7.15 (m, 4H), 7.05-6.85 (m,
		1604, 1558,	C24H22BrF2N2O4,	4H), 5.74 (dq, J = 9.9, 6.2 Hz, 1H), 4.61-
		1530, 1508,	521.0709;	4.48 (m, 1H), 4.05 (d, J = 9.9 Hz,
		1452, 1427,	found,	1H), 1.25 (d, J = 6.1 Hz, 3H), 1.06 (d,
		1381, 1329,	521.0713	J = 7.2 Hz, 3H)
		1287, 1262,		13C NMR (101 MHz, CDCl3) δ 171.39,
		1247, 1223,		167.69, 161.76 (d, J = 246.1 Hz),
		1187, 1159,		161.65 (d, J = 246.0 Hz), 155.39,
		1137, 1116,		139.43, 136.82 (d, J = 3.4 Hz), 136.63
		1049, 1015,		(d, J = 3.1 Hz), 132.21, 131.44, 129.47
		911, 826,		(d, J = 8.0 Hz), 129.44 (d, J = 7.9 Hz),
		792, 779,		122.15, 115.76 (d, J = 21.3 Hz), 115.42
		729, 680,		(d, J = 21.3 Hz), 73.47, 56.15, 48.05,
		668		19.11, 17.61
				19F NMR (471 MHz, CDCl3) δ −115.26-−115.47
				(m), −115.64 (ddd, J = 13.7,
				8.9, 5.2 Hz)
131	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 12.01 (d,
		3373, 2940,	(m/z)	J = 0.6 Hz, 1H), 8.31 (d, J = 8.0 Hz,
		1739, 1651,	[M + H]+	1H), 7.98 (d, J = 5.2 Hz, 1H), 7.18-
		1609, 1577,	calcd for	6.91 (m, 5H), 6.88 (d, J = 5.2 Hz, 1H),
		1518, 1481,	C25H23F4N2O5,	5.66 (dq, J = 9.4, 6.2 Hz, 1H), 4.64-
		1454, 1436,	507.1538;	4.49 (m, 1H), 4.01 (d, J = 9.4 Hz, 1H),
		1382, 1324,	found,	3.95 (s, 3H), 1.32-1.21 (m, 4H), 1.16
		1283, 1243,	507.1543	(d, J = 7.2 Hz, 3H)
		1210, 1149,		19F NMR (471 MHz, CDCl3)
		1120, 1054,		δ −136.05-−136.27 (m), −136.61
		954, 924,		(ddd, J = 20.1, 11.4, 8.1
		872, 850,		Hz), −139.14-−139.32
		824, 801,		(m), −139.45-−139.68 (m)
		754, 733
132	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 12.02 (d,
		3372, 2983,	(m/z)	J = 0.6 Hz, 1H), 8.31 (d, J = 7.9 Hz,
		1737, 1649,	[M + H]+	1H), 7.97 (d, J = 5.2 Hz, 1H), 7.27 (td,
		1601, 1576,	calcd for	J = 7.3, 2.1 Hz, 2H), 7.19-6.98 (m, 4H),
		1529, 1498,	C25H23Cl2F2N2O5,	6.88 (d, J = 5.2 Hz, 1H), 5.66 (dq, J =
		1481, 1453,	539.0947;	9.5, 6.1 Hz, 1H), 4.66-4.48 (m, 1H),
		1439, 1381,	found,	4.01 (d, J = 9.6 Hz, 1H), 3.95 (s, 3H),
		1323, 1245,	539.0954	1.26 (d, J = 6.2 Hz, 3H), 1.17 (d, J = 7.2
		1184, 1145,		Hz, 3H)
		1096, 1060,		19F NMR (471 MHz, CDCl3)
		953, 909,		δ −116.83-−116.94
		864, 849,		(m), −117.22-−117.34 (m)
		824, 800,
		730, 689
133	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 12.08 (d,
		3372, 2935,	(m/z)	J = 0.5 Hz, 1H), 8.34 (d, J = 8.0 Hz,
		2257, 1735,	[M + H]+	1H), 7.97 (d, J = 5.2 Hz, 1H), 7.12-
		1649, 1576,	calcd for	6.98 (m, 5H), 6.97-6.79 (m, 3H), 5.70
		1528, 1501,	C27H29F2N2O5,	(dq, J = 10.1, 6.1 Hz, 1H), 4.65-4.46
		1481, 1452,	499.2039;	(m, 1H), 3.94 (s, 3H), 2.21 (dd, J = 9.8,
		1439, 1380,	found,	1.9 Hz, 6H), 1.24 (d, J = 6.1 Hz, 3H),
		1324, 1281,	499.2046	1.06 (d, J = 7.2 Hz, 3H)
		1262, 1241,		19F NMR (471 MHz, CDCl3)
		1206, 1149,		δ −119.78-−120.04
		1118, 1051,		(m), −120.30-−120.53 (m)
		952, 908,
		849, 821,
		800, 729
135	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 12.08 (d,
			(m/z)	J = 0.6 Hz, 1H), 8.20 (d, J = 8.0 Hz,
			[M + H]+	1H), 8.00 (d, J = 5.2 Hz, 1H), 7.26-
			calcd for	7.13 (m, 4H), 7.02-6.83 (m, 5H), 5.69
			C25H25F2N2O5,	(dq, J = 9.0, 6.2 Hz, 1H), 4.53 (dq, J =
			471.1726;	8.0, 7.2 Hz, 1H), 4.05 (d, J = 9.1 Hz,
			found,	1H), 3.96 (s, 3H), 1.34 (d, J = 7.2 Hz,
			471.1742	3H), 1.22 (d, J = 6.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.27,
				168.54, 162.68, 162.58, 160.73, 160.63,
				155.43, 148.77, 140.44, 136.81, 136.78,
				136.46, 136.43, 130.33, 129.72, 129.66,
				129.63, 129.57, 115.74, 115.57, 115.43,
				115.26, 109.49, 73.33, 56.11, 55.65,
				47.80, 18.95, 17.74
136	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 12.00 (s,
			(m/z)	1H), 8.30 (d, J = 7.8 Hz, 1H), 7.98 (d,
			[M + H]+	J = 5.1 Hz, 1H), 7.42-7.28 (m, 4H),
			calcd for	7.09 (ddd, J = 10.1, 8.3, 2.2 Hz, 2H),
			C25H23C14N2O5,	6.87 (d, J = 5.2 Hz, 1H), 5.65 (dt, J =
			571.0356;	12.2, 6.1 Hz, 1H), 4.57 (p, J = 7.3 Hz,
			found,	1H), 4.00 (d, J = 9.6 Hz, 1H), 3.95 (s,
			571.0367	3H), 1.27 (d, J = 5.9 Hz, 3H), 1.17 (d,
				J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.45,
				168.64, 155.42, 148.74, 140.51, 140.21,
				140.16, 133.11, 132.76, 131.70, 131.38,
				130.97, 130.67, 130.27, 130.20, 130.08,
				127.25, 127.17, 109.53, 72.38, 56.09,
				55.71, 47.87, 19.03, 17.71
137	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 11.99 (s,
			(m/z)	1H), 8.30 (d, J = 8.0 Hz, 1H), 7.98 (d,
			[M + H]+	J = 5.2 Hz, 1H), 7.42-7.19 (m, 2H),
			calcd for	7.08-6.94 (m, 4H), 6.90-6.84 (m,
			C25H23Cl2F2N2O5,	1H), 5.67 (dq, J = 9.4, 6.2 Hz, 1H), 4.65-
			539.0947;	4.48 (m, 1H), 4.03 (d, J = 9.4 Hz,
			found,	1H), 3.95 (s, 3H), 1.27 (d, J = 6.1 Hz,
			539.0953	3H), 1.16 (d, J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.41,
				168.64, 158.16 (d, J = 250.2 Hz),
				158.01 (d, J = 250.1 Hz), 155.42,
				148.75, 140.91 (d, J = 6.1 Hz), 140.83
				(d, J = 6.3 Hz), 140.51, 131.12, 130.81,
				130.20, 124.67-123.96 (m), 120.11 (d,
				J = 17.5 Hz), 119.82 (d, J = 17.7 Hz),
				116.78-116.06 (m), 109.52, 72.44,
				56.09, 47.85, 18.99, 17.71
138	—	—	HRMS-ESI	1H NMR (500 MHz, CDCl3) δ 8.27 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.13 (d, J = 8.0 Hz, 1H),
			[M]+	7.50-7.44 (m, 4H), 7.27 (ddd, J =
			calcd for	11.5, 8.5, 7.0 Hz, 4H), 7.20-7.14 (m,
			C28H30N2O8,	2H), 6.94 (d, J = 5.4 Hz, 1H), 6.01 (q,
			522.2002;	J = 6.3 Hz, 1H), 5.75-5.62 (m, 2H),
			found,	4.63-4.52 (m, 1H), 3.90 (s, 3H), 2.94
			522.2006	(s, 1H), 2.06 (s, 3H), 1.22 (d, J = 6.3
				Hz, 3H), 1.03 (d, J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.88,
				170.27, 163.03, 160.26, 145.73, 144.99,
				143.90, 142.88, 142.57, 128.31, 128.28,
				127.14, 127.07, 125.56, 125.54, 109.58,
				89.49, 79.55, 75.21, 56.19, 48.10,
				30.93, 20.87, 17.75, 14.36
139	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.41 (d,
			(m/z)	J = 7.8 Hz, 1H), 8.30 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.38-7.10 (m, 10H), 6.97 (d, J = 5.4
			calcd for	Hz, 1H), 5.82 (dq, J = 10.0, 6.2 Hz,
			C27H29N2O6,	1H), 4.52 (dt, J = 8.2, 7.1 Hz, 1H), 4.05
			477.2025;	(d, J = 10.1 Hz, 1H), 3.87 (s, 3H), 2.37
			found,	(s, 3H), 1.24 (d, J = 6.1 Hz, 3H), 0.89
			477.2019	(d, J = 7.1 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.23,
				168.89, 162.28, 159.42, 146.66, 141.55,
				141.44, 141.25, 137.45, 128.77, 128.50,
				128.13, 128.11, 126.89, 126.67, 109.73,
				73.32, 57.90, 56.27, 47.85, 20.75,
				19.25, 17.92
140	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.35 (d,
			(m/z)	J = 7.7 Hz, 1H), 8.30 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.34-7.09 (m, 10H), 6.95 (d, J = 5.5
			calcd for	Hz, 1H), 5.81 (dq, J = 10.0, 6.2 Hz,
			C29H33N2O6,	1H), 4.62-4.44 (m, 1H), 4.05 (d, J =
			505.2338;	10.0 Hz, 1H), 3.85 (s, 3H), 2.93 (hept,
			found,	J = 7.0 Hz, 1H), 1.34 (d, J = 7.0 Hz, 6H),
			505.2324	1.24 (d, J = 6.2 Hz, 3H), 0.88 (d, J = 7.2
				Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 174.69,
				172.33, 162.28, 159.39, 146.56, 141.95,
				141.45, 141.27, 137.61, 128.76, 128.50,
				128.14, 128.12, 126.89, 126.67, 109.58,
				73.28, 57.90, 56.27, 47.83, 33.94,
				19.24, 18.82, 17.96
141	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.25 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.22 (d, J = 7.9 Hz, 1H),
			[M + H]+	7.34-7.09 (m, 10H), 6.92 (d, J = 5.4
			calcd for	Hz, 1H), 5.83 (dq, J = 10.1, 6.2 Hz,
			C28H31N2O7,	1H), 5.72 (d, J = 0.7 Hz, 2H), 4.60-
			507.2131;	4.49 (m, 1H), 4.06 (d, J = 10.1 Hz, 1H),
			found,	3.88 (s, 3H), 2.05 (s, 3H), 1.25 (d, J =
			507.2125	6.1 Hz, 3H), 0.91 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) & 172.33,
				170.25, 162.88, 160.24, 145.70, 143.91,
				142.54, 141.48, 141.25, 128.76, 128.49,
				128.12, 128.09, 126.89, 126.65, 109.56,
				89.50, 73.27, 57.92, 56.17, 48.07,
				20.86, 19.25, 17.73
142	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.28 (d,
			(m/z)	J = 7.9 Hz, 1H), 8.25 (d, J = 5.3 Hz, 1H),
			[M + H]+	7.36-7.08 (m, 10H), 6.92 (d, J = 5.4
			calcd for	Hz, 1H), 5.83 (dq, J = 10.1, 6.2 Hz,
			C30H35N2O7,	1H), 5.79-5.69 (m, 2H), 4.62-4.44
			535.2444;	(m, 1H), 4.06 (d, J = 10.1 Hz, 1H), 3.86
			found,	(s, 3H), 2.53 (hept, J = 7.0 Hz, 1H),
			535.2431	1.25 (d, J = 6.2 Hz, 3H), 1.13 (d, J = 7.0
				Hz, 6H), 0.91 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 176.22,
				172.34, 162.85, 160.23, 145.55, 144.16,
				142.18, 141.48, 141.26, 128.76, 128.49,
				128.12, 128.09, 126.89, 126.65, 109.48,
				89.90, 73.26, 57.93, 56.12, 48.07,
				33.85, 19.26, 18.68, 17.74
143	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.49 (d,
			(m/z)	J = 8.1 Hz, 1H), 8.31 (d, J = 5.5 Hz, 1H),
			[M + H]+	7.21-7.13 (m, 2H), 7.03-6.97 (m,
			calcd for	2H), 6.95-6.86 (m, 3H), 5.54 (dq, J =
			C23H25N2O6S2,	7.3, 6.2 Hz, 1H), 4.70-4.61 (m, 2H),
			489.1154;	3.88 (s, 3H), 2.39 (s, 3H), 1.28 (d, J =
			found,	6.2 Hz, 3H), 1.17 (d, J = 7.2 Hz, 3H)
			489.1154	13C NMR (101 MHz, CDCl3) δ 172.03,
				168.89, 162.33, 159.44, 146.66, 143.85,
				142.75, 141.50, 137.48, 126.75, 126.56,
				126.06, 125.43, 124.60, 124.55, 109.78,
				74.58, 56.28, 47.96, 47.41, 20.76,
				18.68, 18.14
144	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.30 (d,
			(m/z)	J = 7.9 Hz, 1H), 8.26 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.21-7.13 (m, 2H), 7.02 (ddd, J = 3.5,
			calcd for	1.2, 0.6 Hz, 1H), 6.96-6.88 (m, 4H),
			C24H27N2O7S2,	5.73 (d, J = 0.7 Hz, 2H), 5.55 (dq, J =
			519.1259;	7.4, 6.2 Hz, 1H), 4.75-4.60 (m, 2H),
			found,	3.89 (s, 3H), 2.06 (s, 3H), 1.29 (d, J =
			519.1258	6.3 Hz, 3H), 1.19 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.13,
				170.25, 162.91, 160.26, 145.69, 143.96,
				143.86, 142.81, 142.46, 126.74, 126.55,
				126.03, 125.42, 124.58, 124.54, 109.59,
				89.52, 74.55, 56.19, 48.18, 47.42,
				20.87, 18.70, 17.95
145	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.48-
			(m/z)	8.37 (m, 1H), 8.30 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.29-7.18 (m, 4H), 7.05-6.90 (m,
			calcd for	5H), 5.72 (dq, J = 9.7, 6.2 Hz, 1H), 4.55
			C27H27F2N2O6,	(dq, J = 8.3, 7.2 Hz, 1H), 4.05 (d, J =
			513.1837;	9.6 Hz, 1H), 3.88 (s, 3H), 2.38 (s, 3H),
			found,	1.22 (d, J = 6.1 Hz, 3H), 1.00 (d, J = 7.2
			513.1835	Hz, 3H)
				19F NMR (376 MHz, CDCl3)
				δ −115.58, −115.93
146	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.26 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.22 (d, J = 7.8 Hz, 1H),
			[M + H]+	7.32-7.16 (m, 4H), 7.05-6.89 (m,
			calcd for	5H), 5.78-5.68 (m, 1H), 5.72 (s, 2H),
			C28H29F2N2O7,	4.64-4.50 (m, 1H), 4.06 (d, J = 9.7 Hz,
			543.1943;	1H), 3.90 (s, 3H), 2.06 (s, 3H), 1.24 (d,
			found,	J = 6.1 Hz, 3H), 1.00 (d, J = 7.2 Hz,
			543.1938	3H)
				19F NMR (376 MHz, CDCl3)
				δ −115.59, −115.97
147	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.34 (d,
			(m/z)	J = 7.9 Hz, 1H), 8.25 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.39-7.16 (m, 10H), 6.94 (d, J = 5.4
			calcd for	Hz, 1H), 5.97 (q, J = 6.2 Hz, 1H), 5.78-
			C30H35N2O8,	5.61 (m, 2H), 4.74-4.56 (m, 1H),
			551.2393;	3.90 (s, 3H), 3.42 (dq, J = 9.2, 7.0 Hz,
			found,	1H), 3.21 (dq, J = 9.2, 7.0 Hz, 1H), 2.05
			551.2396	(s, 3H), 1.25 (d, J = 7.2 Hz, 3H), 1.19
				(t, J = 6.9 Hz, 3H), 1.12 (d, J = 6.3 Hz,
				3H)
				13C NMR (101 MHz, CDCl3) δ 172.13,
				170.23, 162.87, 160.27, 145.64, 144.02,
				142.35, 142.09, 140.72, 128.24, 127.84,
				127.81, 127.70, 127.27, 127.18, 109.57,
				89.52, 84.04, 74.08, 59.96, 56.18,
				48.26, 20.86, 18.23, 15.70, 14.95
148	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.26 (d,
			(m/z)	J = 5.3 Hz, 1H), 8.22 (d, J = 7.8 Hz, 1H),
			[M + H]+	7.38 (td, J = 8.6, 6.2 Hz, 1H), 7.24 (td,
			calcd for	J = 8.4, 6.3 Hz, 1H), 6.96 (d, J = 5.5 Hz,
			C28H27F4N2O7,	1H), 6.88-6.69 (m, 4H), 5.88-5.75
			579.1754;	(m, 1H), 5.73 (s, 2H), 4.69 (d, J = 9.8
			found,	Hz, 1H), 4.65-4.55 (m, 1H), 3.91 (s,
			579.1756	3H), 2.07 (s, 3H), 1.29 (d, J = 6.2 Hz,
				3H), 1.10 (d, J = 7.2 Hz, 3H)
				19F NMR (376 MHz, CDCl3) δ −111.11
				(d, J = 7.6 Hz), −111.57 (d, J =
				7.5 Hz), −111.99 (dd, J = 7.7, 2.6
				Hz), −112.76 (dd, J = 7.6, 2.5 Hz)
149	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.33 (d,
			(m/z)	J = 7.9 Hz, 1H), 8.25 (d, J = 5.4 Hz, 1H),
			[M − OCH3]+	7.40-7.18 (m, 10H), 6.94 (d, J = 5.4
			calcd for	Hz, 1H), 5.97 (q, J = 6.2 Hz, 1H), 5.81-
			C28H29N2O7,	5.63 (m, 2H), 4.72-4.52 (m, 1H),
			505.1975;	3.90 (s, 3H), 3.17 (s, 3H), 2.05 (s, 3H),
			found,	1.24 (d, J = 7.2 Hz, 3H), 1.12 (d, J = 6.3
			505.1975	Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.09,
				170.24, 162.88, 160.27, 145.65, 144.02,
				142.35, 141.39, 140.04, 128.50, 128.08,
				127.87, 127.71, 127.45, 127.28, 109.57,
				89.53, 84.46, 73.81, 56.19, 52.59,
				48.25, 20.86, 18.18, 14.98
150	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.39 (d,
			(m/z)	J = 8.1 Hz, 1H), 8.31 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.37 (td, J = 8.5, 6.1 Hz, 1H), 7.23 (td,
			calcd for	J = 8.5, 6.2 Hz, 1H), 7.00 (d, J = 5.5 Hz,
			C27H25F4N2O6,	1H), 6.90-6.68 (m, 4H), 5.89-5.71
			549.1648;	(m, 1H), 4.69 (d, J = 9.8 Hz, 1H), 4.62-
			found,	4.51 (m, 1H), 3.90 (s, 3H), 2.39 (s,
			549.1645	3H), 1.28 (d, J = 6.2 Hz, 3H), 1.09 (d,
				J = 7.2 Hz, 3H)
				19F NMR (376 MHz, CDCl3) δ −111.11
				(d, J = 7.7 Hz), −111.55 (d, J =
				7.5 Hz), −112.01 (dd, J = 7.7, 2.6 Hz), −
				112.80 (dd, J = 7.6, 2.6 Hz)
152	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.38 (d,
			(m/z)	J = 8.2 Hz, 1H), 8.30 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.50-7.37 (m, 4H), 7.37-7.19 (m,
			calcd for	6H), 6.98 (d, J = 5.5 Hz, 1H), 5.98 (dq,
			C27H28FN2O6,	J = 25.1, 6.4 Hz, 1H), 4.63-4.54 (m,
			495.1931;	1H), 3.87 (s, 3H), 2.37 (s, 3H), 1.30 (d,
			found,	J = 6.5 Hz, 3H), 0.88 (d, J = 7.2 Hz,
			495.1926	3H)
				19F NMR (376 MHz, CDCl3) δ −168.48
153	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.26 (d,
			(m/z)	J = 5.3 Hz, 1H), 8.20 (d, J = 7.7 Hz, 1H),
			[M + H]+	7.49-7.40 (m, 4H), 7.36-7.21 (m,
			calcd for	6H), 6.93 (d, J = 5.5 Hz, 1H), 5.99 (dq,
			C28H30FN2O7,	J = 25.2, 6.4 Hz, 1H), 5.71 (s, 2H), 4.68-
			525.2037;	4.49 (m, 1H), 3.89 (s, 3H), 2.05 (s,
			found,	3H), 1.31 (d, J = 6.5 Hz, 3H), 0.90 (d,
			525.2033	J = 7.2 Hz, 3H)
				19F NMR (376 MHz, CDCl3) δ −168.67
155	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.42 (d,
			(m/z)	J = 8.1 Hz, 1H), 8.30 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.26-7.13 (m, 4H), 6.97 (d, J = 5.5 Hz,
			calcd for	1H), 6.85-6.71 (m, 4H), 5.71 (dq, J =
			C29H33N2O8,	9.9, 6.2 Hz, 1H), 4.64-4.47 (m, 1H),
			537.2237;	3.96 (d, J = 9.8 Hz, 1H), 3.87 (s, 3H),
			found,	3.74 (s, 3H), 3.72 (s, 3H), 2.38 (s, 3H),
			537.2226	1.22 (d, J = 6.1 Hz, 3H), 0.98 (d, J = 7.2
				Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.21,
				168.88, 162.28, 159.42, 158.33, 158.20,
				146.66, 141.53, 137.43, 133.90, 133.82,
				129.02, 129.00, 114.09, 113.83, 109.74,
				73.54, 56.26, 56.08, 55.19, 47.90,
				20.74, 19.22, 18.08
156	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.41 (d,
			(m/z)	J = 7.6 Hz, 1H), 8.31 (d, J = 5.5 Hz, 1H),
			[M + H]+	7.32-7.18 (m, 2H), 7.12-6.82 (m,
			calcd for	7H), 5.73 (dq, J = 9.7, 6.2 Hz, 1H), 4.64-
			C27H27F2N2O6,	4.43 (m, 1H), 4.06 (d, J = 9.8 Hz,
			513.1837;	1H), 3.89 (s, 3H), 2.38 (s, 3H), 1.25 (d,
			found,	J = 6.2 Hz, 3H), 0.99 (d, J = 7.2 Hz,
			513.1833	3H)
				19F NMR (376 MHz, CDCl3)
				δ −112.15, −112.56
157	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.41 (d,
			(m/z)	J = 7.7 Hz, 1H), 8.31 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.31-7.10 (m, 8H), 6.99 (d, J = 5.5 Hz,
			calcd for	1H), 5.72 (dq, J = 9.8, 6.0 Hz, 1H), 4.59-
			C27H27Cl2N2O6,	4.50 (m, 1H), 4.01 (d, J = 9.8 Hz,
			545.1246;	1H), 3.88 (s, 3H), 2.38 (s, 3H), 1.24 (d,
			found,	J = 6.1 Hz, 3H), 1.00 (d, J = 7.1 Hz,
			545.1239	3H)
				13C NMR (101 MHz, CDCl3) δ 172.10,
				168.87, 162.33, 159.43, 146.68, 142.60,
				142.44, 141.40, 137.46, 134.67, 134.38,
				130.21, 129.95, 128.46, 128.34, 128.10,
				127.45, 127.17, 126.23, 126.13, 109.80,
				72.61, 56.98, 56.28, 47.82, 20.75,
				19.12, 17.98
158	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.26 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.23 (d, J = 8.0 Hz, 1H),
			[M + H]+	7.24-7.14 (m, 4H), 6.93 (d, J = 5.4 Hz,
			calcd for	1H), 6.85-6.75 (m, 4H), 5.77-5.68
			C30H35N2O9,	(m, 1H), 5.72 (s, 2H), 4.63-4.50 (m,
			567.2342;	1H), 3.97 (d, J = 9.9 Hz, 1H), 3.89 (s,
			found,	3H), 3.75 (s, 3H), 3.73 (s, 3H), 2.05 (s,
			567.2338	3H), 1.23 (d, J = 6.2 Hz, 3H), 0.99 (d,
				J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.34,
				170.24, 162.88, 160.24, 158.33, 158.20,
				145.70, 143.91, 142.54, 133.95, 133.82,
				129.00, 114.09, 113.83, 109.55, 89.51,
				73.49, 56.17, 56.10, 55.20, 48.12,
				20.85, 19.23, 17.90
159	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.26 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.23 (d, J = 7.9 Hz, 1H),
			[M + H]+	7.32-7.18 (m, 2H), 7.14-7.03 (m,
			calcd for	2H), 7.04-6.80 (m, 5H), 5.82-5.67
			C28H29F2N2O7,	(m, 1H), 5.72 (s, 2H), 4.65-4.48 (m,
			543.1943;	1H), 4.07 (d, J = 9.9 Hz, 1H), 3.90 (s,
			found,	3H), 2.06 (s, 3H), 1.26 (d, J = 6.1 Hz,
			543.1941	3H), 1.00 (d, J = 7.2 Hz, 3H)
				19F NMR (376 MHz, CDCl3)
				δ −112.16, −112.59
160	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) & 8.26 (d,
			(m/z)	J = 5.3 Hz, 1H), 8.22 (d, J = 7.6 Hz, 1H),
			[M + H]+	7.33-7.10 (m, 8H), 6.94 (d, J = 5.4 Hz,
			calcd for	1H), 5.80-5.65 (m, 1H), 5.72 (s, 2H),
			C28H29Cl2N2O7,	4.60-4.52 (m, 1H), 4.03 (d, J = 9.8 Hz,
			575.1352;	1H), 3.90 (s, 3H), 2.06 (d, J = 1.8 Hz,
			found,	3H), 1.26 (d, J = 6.0 Hz, 3H), 1.02 (d,
			575.1349	J = 7.1 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.34,
				170.24, 162.88, 160.24, 158.33, 158.20,
				145.70, 143.91, 142.54, 133.95, 133.82,
				129.00, 114.09, 113.83, 109.55, 89.51,
				73.49, 56.17, 56.10, 55.20, 48.12,
				20.85, 19.23, 17.90
161	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.77-
			(m/z)	8.53 (m, 1H), 8.40-8.29 (m, 1H), 7.79-
			[M + H]+	7.62 (m, 3H), 7.61-7.47 (m, 1H),
			calcd for	7.47-7.34 (m, 2H), 7.34-7.20 (m,
			C27H27N2O6,	2H), 7.05-6.94 (m, 1H), 5.83-5.66
			475.1869;	(m, 1H), 4.93-4.77 (m, 1H), 4.37-
			found,	4.21 (m, 1H), 3.89 (s, 3H), 2.47-2.37
			475.1865	(m, 3H), 1.63-1.47 (m, 3H), 0.84-
				0.67 (m, 3H)
162	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.58-
			(m/z)	8.43 (m, 1H), 8.40-8.32 (m, 1H), 7.36-
			[M + H]+	7.19 (m, 4H), 7.13-7.03 (m, 4H),
			calcd for	7.02-6.97 (m, 1H), 5.17-5.05 (m,
			C27H27N2O7,	1H), 4.77-4.64 (m, 1H), 4.35-4.19
			491.1818;	(m, 1H), 3.96-3.85 (m, 3H), 2.40 (d,
			found,	J = 3.6 Hz, 3H), 1.50-1.41 (m, 3H),
			491.1813	1.07-0.93 (m, 3H)
163	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.52-
			(m/z)	8.37 (m, 1H), 8.32-8.24 (m, 1H), 7.80-
			[M + H]+	7.63 (m, 3H), 7.61-7.47 (m, 1H),
			calcd for	7.45-7.22 (m, 4H), 7.01-6.92 (m,
			C28H29N2O7,	1H), 5.83-5.68 (m, 3H), 4.97-4.73
			505.1975;	(m, 1H), 4.38-4.19 (m, 1H), 3.92 (s,
			found,	3H), 2.07 (s, 3H), 1.64-1.49 (m, 3H),
			505.1961	0.90-0.66 (m, 3H)
164	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.39-
			(m/z)	8.25 (m, 2H), 7.39-7.20 (m, 4H), 7.15-
			[M + H]+	7.00 (m, 4H), 6.99-6.92 (m, 1H),
			calcd for	5.81-5.72 (m, 2H), 5.16-5.09 (m,
			C28H29N2O8,	1H), 4.79-4.67 (m, 1H), 4.37-4.17
			521.1924;	(m, 1H), 3.91 (s, 3H), 2.08 (s, 3H), 1.51-
			found,	1.43 (m, 3H), 1.09-0.93 (m, 3H)
			521.1913
165	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.39 (d,
			(m/z)	J = 6.8 Hz, 1H), 8.31 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.45-7.31 (m, 4H), 7.18-7.06 (m,
			calcd for	4H), 7.00 (d, J = 5.5 Hz, 1H), 5.71 (dq,
			C27H27Br2N2O6,	J = 9.5, 6.2 Hz, 1H), 4.65-4.46 (m,
			633.0236;	1H), 4.00 (d, J = 9.5 Hz, 1H), 3.89 (s,
			found,	3H), 2.38 (s, 3H), 1.22 (d, J = 6.2 Hz,
			633.0230	3H), 1.02 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.05,
				168.89, 162.33, 159.47, 146.65, 141.39,
				139.74, 139.71, 137.49, 131.97, 131.68,
				129.89, 129.78, 121.06, 120.79, 109.84,
				72.56, 56.41, 56.30, 47.83, 20.76,
				19.09, 17.98
166	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.51 (d,
			(m/z)	J = 8.1 Hz, 1H), 8.32 (d, J = 5.4 Hz, 1H),
			[M + H]+	6.99 (d, J = 5.5 Hz, 1H), 6.74 (d, J = 3.4
			calcd for	Hz, 1H), 6.67 (d, J = 2.6 Hz, 1H), 6.60-
			C25H29N2O6S2,	6.42 (m, 2H), 5.53-5.39 (m, 1H),
			517.1467;	4.72-4.58 (m, 1H), 4.44 (d, J = 7.1 Hz,
			found,	1H), 3.88 (s, 3H), 2.41-2.38 (m, 9H),
			517.1465	1.27 (d, J = 6.2 Hz, 3H), 1.22 (d, J = 7.2
				Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.07,
				168.90, 162.33, 159.44, 146.66, 141.64,
				141.56, 140.54, 138.98, 138.92, 137.47,
				125.77, 125.08, 124.66, 124.42, 109.76,
				74.45, 56.28, 48.01, 47.83, 20.75,
				18.64, 18.21, 15.25
167	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.42 (d,
			(m/z)	J = 8.0 Hz, 1H), 8.29 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.20-7.10 (m, 4H), 7.10-6.99 (m,
			calcd for	4H), 6.96 (d, J = 5.5 Hz, 1H), 5.77 (dq,
			C29H33N2O6,	J = 10.0, 6.2 Hz, 1H), 4.65-4.45 (m,
			505.2338;	1H), 3.98 (d, J = 10.0 Hz, 1H), 3.85 (s,
			found,	3H), 2.37 (s, 3H), 2.26 (s, 3H), 2.23 (s,
			505.2345	3H), 1.23 (d, J = 6.1 Hz, 3H), 0.93 (d,
				J = 7.1 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.23,
				168.90, 162.28, 159.42, 146.67, 141.58,
				138.67, 138.57, 137.44, 136.33, 136.02,
				129.41, 129.11, 127.94, 127.91, 109.74,
				73.44, 57.06, 56.27, 47.91, 20.97,
				20.94, 20.76, 19.26, 17.99
168	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.36 (d,
			(m/z)	J = 8.8 Hz, 1H), 8.29 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.19-7.12 (m, 4H), 7.10-6.98 (m,
			calcd for	4H), 6.94 (d, J = 5.5 Hz, 1H), 5.76 (dq,
			C31H37N2O6,	J = 10.0, 6.2 Hz, 1H), 4.60-4.45 (m,
			533.2651;	1H), 3.97 (d, J = 9.9 Hz, 1H), 3.84 (s,
			found,	3H), 3.00-2.85 (m, 1H), 2.26 (s, 3H),
			533.2655	2.24 (s, 3H), 1.34 (d, J = 7.0 Hz, 6H),
				1.22 (d, J = 6.1 Hz, 3H), 0.93 (d, J = 7.2
				Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 174.69,
				172.32, 162.28, 159.39, 146.57, 141.98,
				138.67, 138.59, 137.60, 136.31, 136.01,
				129.40, 129.10, 127.95, 127.93, 109.58,
				73.40, 57.05, 56.27, 47.89, 33.95,
				20.97, 20.94, 19.25, 18.84, 18.04
169	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.26 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.21 (d, J = 7.8 Hz, 1H),
			[M + H]+	7.45-7.33 (m, 4H), 7.22-7.03 (m,
			calcd for	4H), 6.95 (d, J = 5.4 Hz, 1H), 5.83-
			C28H29Br2N2O7,	5.61 (m, 1H), 5.72 (s, 2H), 4.56 (p, J =
			663.0341;	7.3 Hz, 1H), 4.01 (d, J = 9.6 Hz, 1H),
			found,	3.90 (s, 3H), 2.06 (s, 3H), 1.24 (d, J =
			663.0336	6.2 Hz, 3H), 1.02 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.18,
				170.25, 162.91, 160.27, 145.69, 143.97,
				142.36, 139.81, 139.71, 131.97, 131.68,
				129.87, 129.76, 121.06, 120.77, 109.63,
				89.49, 72.51, 56.46, 56.20, 48.06,
				20.87, 19.12, 17.81
170	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.31 (d,
			(m/z)	J = 7.9 Hz, 1H), 8.27 (d, J = 5.3 Hz, 1H),
			[M + H]+	6.94 (d, J = 5.4 Hz, 1H), 6.75 (d, J = 3.4
			calcd for	Hz, 1H), 6.70-6.62 (m, 1H), 6.57-
			C26H31N2O7S2,	6.50 (m, 2H), 5.77-5.70 (m, 2H), 5.52-
			547.1572;	5.40 (m, 1H), 4.75-4.58 (m, 1H),
			found,	4.45 (d, J = 7.1 Hz, 1H), 3.90 (s, 3H),
			547.1585	2.40 (d, J = 1.2 Hz, 3H), 2.39 (d, J = 1.1
				Hz, 3H), 2.06 (s, 3H), 1.36-1.14 (m,
				6H)
				13C NMR (101 MHz, CDCl3) δ 172.17,
				170.25, 162.90, 160.26, 145.69, 143.95,
				142.56, 141.64, 140.61, 138.96, 138.93,
				125.73, 125.07, 124.65, 124.41, 109.55,
				89.54, 74.42, 56.18, 48.23, 47.85,
				20.87, 18.66, 18.03, 15.24
171	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.33-
			(m/z)	8.15 (m, 2H), 7.22-7.10 (m, 4H), 7.10-
			[M + H]+	6.99 (m, 4H), 6.92 (d, J = 5.4 Hz,
			calcd for	1H), 5.84-5.69 (m, 3H), 4.55 (p, J =
			C30H35N2O7,	7.3 Hz, 1H), 3.99 (d, J = 10.0 Hz, 1H),
			535.2444;	3.87 (s, 3H), 2.27 (s, 3H), 2.24 (s, 3H),
			found,	2.05 (s, 3H), 1.24 (d, J = 6.2 Hz, 3H),
			535.2449	0.95 (d, J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.34,
				170.24, 162.87, 160.24, 145.70, 143.90,
				142.59, 138.70, 138.58, 136.32, 135.99,
				129.40, 129.10, 127.93, 127.90, 109.55,
				89.51, 73.38, 57.07, 56.17, 48.12,
				20.96, 20.93, 20.86, 19.26, 17.81
173	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.42 (d,
			(m/z)	J = 7.7 Hz, 1H), 8.31 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.60-7.50 (m, 2H), 7.47-7.37 (m,
			calcd for	2H), 7.34-7.13 (m, 5H), 6.99 (d, J =
			C28H28F3N2O6,	5.4 Hz, 1H), 5.83 (dq, J = 9.6, 6.2 Hz,
			545.1899;	1H), 4.65-4.45 (m, 1H), 4.14 (d, J =
			found,	9.7 Hz, 1H), 3.88 (s, 3H), 2.38 (s, 3H),
			545.1902	1.25 (d, J = 6.2 Hz, 3H), 0.92 (d, J = 7.2
				Hz, 3H)
				19F NMR (376 MHz, CDCl3) δ −62.56
174	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.40 (d,
			(m/z)	J = 8.1 Hz, 1H), 8.30 (d, J = 5.5 Hz, 1H),
			[M + H]+	7.31-7.12 (m, 8H), 6.99 (d, J = 5.5 Hz,
			calcd for	1H), 5.72 (dq, J = 9.5, 6.1 Hz, 1H), 4.66-
			C27H27Cl2N2O6,	4.47 (m, 1H), 4.03 (d, J = 9.5 Hz,
			545.1246;	1H), 3.88 (s, 3H), 2.38 (s, 3H), 1.22 (d,
			found,	J = 6.1 Hz, 3H), 1.01 (d, J = 7.1 Hz,
			545.1244	3H)
				13C NMR (75 MHz, CDCl3) δ 172.06,
				168.91, 162.33, 159.45, 146.66, 141.36,
				139.32, 139.27, 137.47, 132.94, 132.69,
				129.51, 129.41, 129.01, 128.72, 109.85,
				72.70, 56.30, 56.27, 47.83, 20.75,
				19.09, 17.98
175	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.26 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.22 (d, J = 7.8 Hz, 1H),
			[M + H]+	7.58-7.49 (m, 2H), 7.42 (d, J = 8.2 Hz,
			calcd for	2H), 7.35-7.12 (m, 5H), 6.95 (d, J =
			C29H30F3N2O7,	5.4 Hz, 1H), 5.84 (dq, J = 9.8, 6.2 Hz,
			575.2005;	1H), 5.72 (s, 2H), 4.62-4.48 (m, 1H),
			found,	4.15 (d, J = 9.8 Hz, 1H), 3.90 (s, 3H),
			575.2011	2.06 (s, 3H), 1.26 (d, J = 6.1 Hz, 3H),
				0.93 (d, J = 7.2 Hz, 3H)
				19F NMR (376 MHz, CDCl3) 8-62.57
176	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.26 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.22 (d, J = 7.8 Hz, 1H),
			[M + H]+	7.34-7.09 (m, 8H), 6.95 (d, J = 5.4 Hz,
			calcd for	1H), 5.81-5.58 (m, 3H), 4.67-4.44
			C28H29Cl2N2O7,	(m, 1H), 4.04 (d, J = 9.5 Hz, 1H), 3.90
			575.1352;	(s, 3H), 2.06 (s, 3H), 1.24 (d, J = 6.2
			found,	Hz, 3H), 1.02 (d, J = 7.1 Hz, 3H)
			575.1352	13C NMR (75 MHz, CDCl3) δ 172.19,
				170.28, 162.91, 160.27, 145.71, 143.95,
				142.32, 139.38, 139.28, 132.94, 132.67,
				129.49, 129.40, 129.01, 128.71, 109.64,
				89.47, 72.65, 56.32, 56.22, 56.18,
				48.05, 20.89, 20.86, 19.12, 17.81
178	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.35 (dd,
		3387, 2984,	(m/z)	J = 4.5, 1.3 Hz, 1H), 8.15 (d, J = 7.8
		1737, 1673,	[M + H]+	Hz, 1H), 7.52 (dd, J = 8.4, 1.4 Hz, 1H),
		1603, 1579,	calcd for	7.42 (dd, J = 8.4, 4.5 Hz, 1H), 7.33-
		1506, 1451,	C27H27F2N2O6,	7.14 (m, 4H), 7.05-6.86 (m, 4H), 5.82
		1368, 1304,	513.1832;	(s, 2H), 5.72 (dq, J = 9.7, 6.1 Hz, 1H),
		1268, 1199,	found,	4.59 (p, J = 7.3 Hz, 1H), 4.06 (d, J = 9.7
		1159, 1136,	513.1833	Hz, 1H), 2.11 (s, 3H), 1.24 (d, J = 6.2
		1045, 1007,		Hz, 3H), 1.01 (d, J = 7.2 Hz, 3H)
		969, 825,		19F NMR (376 MHz, CDCl3)
		779, 730		δ −115.57, −115.97
179	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.23 (d,
		3380, 2985,	(m/z)	J = 5.3 Hz, 1H), 8.18 (d, J = 7.8 Hz, 1H),
		1737, 1674,	[M + H]+	7.23 (ddd, J = 13.9, 6.9, 2.6 Hz, 4H),
		1603, 1578,	calcd for	7.05-6.84 (m, 5H), 5.78-5.66 (m,
		1507, 1473,	C29H31F2N2O7,	3H), 4.56 (p, J = 7.3 Hz, 1H), 4.12 (q,
		1455, 1366,	557.2094;	J = 7.0 Hz, 2H), 4.05 (d, J = 9.7 Hz, 1H),
		1312, 1274,	found,	2.06 (s, 3H), 1.47 (t, J = 7.0 Hz, 3H),
		1222, 1200,	557.2089	1.24 (d, J = 6.2 Hz, 3H), 1.00 (d, J = 7.2
		1158, 1104,		Hz, 3H)
		1043, 1003,		19F NMR (376 MHz, CDCl3)
		968, 910,		δ −115.60, −115.98
		886, 824,
		792, 728
180	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.13 (dd,
		3404, 2983,	(m/z)	J = 7.9, 1.8 Hz, 1H), 8.06 (d, J = 6.9
		1737, 1652,	[M + H]+	Hz, 1H), 7.45 (ddd, J = 8.5, 7.4, 1.8 Hz,
		1602, 1508,	calcd for	1H), 7.29-7.05 (m, 6H), 7.04-6.90
		1482, 1453,	C28H28F2NO6,	(m, 4H), 5.92 (d, J = 6.4 Hz, 1H), 5.83
		1369, 1305,	512.1879;	(d, J = 6.4 Hz, 1H), 5.73 (dq, J = 9.9,
		1222, 1197,	found,	6.2 Hz, 1H), 4.57 (p, J = 7.1 Hz, 1H),
		1159, 1137,	512.1889	4.06 (d, J = 9.7 Hz, 1H), 2.14 (s, 3H),
		1106, 1088,		1.25 (d, J = 6.0 Hz, 3H), 1.00 (d, J = 7.2
		1049, 1010,		Hz, 3H)
		976, 911,		19F NMR (376 MHz, CDCl3)
		828, 792,		δ −115.62, −116.01
		759, 732
181	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.24 (t,
			(m/z)	J = 7.7 Hz, 2H), 7.57-7.49 (m, 8H),
			[M + H]	7.45-7.37 (m, 8H), 7.32 (dt, J = 9.3,
			calcd for	5.8 Hz, 2H), 6.90 (d, J = 5.4 Hz, 1H),
			C40H39N2O7,	5.89 (dq, J = 12.4, 6.1 Hz, 1H), 5.71 (s,
			659.2752;	2H), 4.58 (p, J = 7.3 Hz, 1H), 4.16 (d,
			found,	J = 10.0 Hz, 1H), 3.88 (s, 3H), 2.05 (s,
			659.2758	3H), 1.33 (d, J = 6.1 Hz, 3H), 0.96 (d,
				J = 7.2 Hz, 3H)
				13C NMR (101 MHz, CDCl3) δ 172.38,
				170.26, 162.88, 160.23, 145.68, 143.94,
				142.52, 140.73, 140.61, 140.52, 140.23,
				139.89, 139.63, 128.74, 128.71, 128.55,
				127.55, 127.26, 127.17, 126.99, 126.96,
				109.50, 89.54, 73.27, 57.25, 56.15,
				48.12, 20.87, 19.34, 17.79
182	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.41 (d,
			(m/z)	J = 5.1 Hz, 1H), 8.29 (d, J = 5.4 Hz, 1H),
			[M + H]+	7.57-7.47 (m, 8H), 7.41 (dd, J = 9.3,
			calcd for	6.0 Hz, 8H), 7.32 (dd, J = 12.1, 7.1 Hz,
			C39H37N2O6,	2H), 6.94 (d, J = 5.5 Hz, 1H), 5.88 (dq,
			629.2646;	J = 12.3, 6.1 Hz, 1H), 4.57 (p, J = 7.2
			found,	Hz, 1H), 4.15 (d, J = 10.0 Hz, 1H), 3.87
			629.2651	(s, 3H), 2.38 (s, 3H), 1.31 (d, J = 6.1
				Hz, 3H), 0.95 (d, J = 7.1 Hz, 3H)
				13C NMR (101 MHz, CDCl3) & 172.24,
				168.91, 162.29, 159.40, 146.63, 141.52,
				140.73, 140.62, 140.47, 140.23, 139.88,
				139.62, 137.45, 128.75, 128.71, 128.56,
				127.54, 127.25, 127.16, 127.00, 126.96,
				109.69, 73.30, 57.22, 56.25, 47.90,
				20.75, 19.31, 17.97
183	—	—	HRMS-ESI	1H NMR (500 MHz, CDCl3) δ 8.28 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.15 (t, J = 5.6 Hz, 1H),
			[M + H]+	7.25-7.15 (m, 4H), 7.03-6.89 (m,
			calcd for	5H), 5.75-5.66 (m, 3H), 4.11 (dd, J =
			C27H27F2N2O7,	18.3, 5.7 Hz, 1H), 4.04 (d, J = 9.1 Hz,
			530.1813;	1H), 3.92 (s, 3H), 3.89 (dd, J = 18.3, 5.4
			found,	Hz, 1H), 2.06 (s, 3H), 1.24 (d, J = 6.2
			530.1809	Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 170.32,
				169.11, 161.72 (d, J = 246.0 Hz),
				161.62 (d, J = 245.4 Hz), 160.31,
				145.73, 144.02, 142.27, 136.67 (d, J =
				26.2 Hz), 129.72, 129.66, 115.68 (d, J =
				21.5 Hz), 115.41 (d, J = 22.1 Hz),
				109.65, 89.48, 73.37, 56.16, 55.69,
				41.33, 20.87
				19F NMR (471 MHz, CDCl3)
				δ −115.60 (m), −115.94 (m)
184	—	—	HRMS-ESI	1H NMR (500 MHz, CDCl3) δ 8.26 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.22 (d, J = 8.4 Hz, 1H),
			[M + H]+	7.28-7.18 (m, 4H), 7.01-6.90 (m,
			calcd for	5H), 5.77-5.65 (m, 3H), 4.56 (ddd, J =
			C29H31F2N2O7,	8.4, 6.7, 5.3 Hz, 1H), 4.05 (d, J = 9.6
			558.2121;	Hz, 1H), 3.91 (s, 3H), 2.06 (s, 3H), 1.63-
			found,	1.52 (m, 1H), 1.40-1.29 (m, 1H),
			558.2133	1.23 (d, J = 6.2 Hz, 3H), 0.61 (t, J = 7.4
				Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.56,
				170.27, 163.06, 161.72 (d, J = 246.0
				Hz), 161.66 (d, J = 245.2 Hz), 160.32,
				145.66, 144.03, 142.38, 136.92, 129.60
				(d, J = 10.6 Hz), 129.54 (d, J = 10.4
				Hz), 115.63 (d, J = 35.4 Hz), 115.46 (d,
				J = 35.4 Hz), 109.55, 89.59, 73.22,
				56.19, 56.02, 53.26, 25.24, 20.87,
				19.22, 9.16
				19F NMR (471 MHz, CDCl3)
				δ −115.59-−115.70 (m), −116.06 (ddd,
				J = 14.0, 8.7, 5.3 Hz)
185	—	—	HRMS-ESI	1H NMR (500 MHz, CDCl3) δ 8.29-
			(m/z)	8.21 (m, 2H), 7.29-7.14 (m, 4H), 7.00-
			[M + H]+	6.88 (m, 5H), 5.85-5.51 (m, 3H),
			calcd for	4.55 (dd, J = 9.3, 4.6 Hz, 1H), 4.05 (d,
			C30H33F2N2O7,	J = 9.6 Hz, 1H), 3.91 (s, 3H), 2.06 (s,
			572.2283;	3H), 1.87-1.75 (m, 1H), 1.22 (d, J =
			found,	6.2 Hz, 3H), 0.78 (d, J = 6.9 Hz, 3H),
			572.2286	0.58 (d, J = 6.8 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.17,
				170.27, 163.21, 161.70 (d, J = 246.1
				Hz), 161.66 (d, J = 245.3 Hz), 160.38,
				145.62, 144.11, 142.32, 136.98, 129.54,
				129.54 (d, J = 14.9 Hz), 115.63 (d, J =
				32.3 Hz), 115.46 (d, J = 32.3 Hz),
				109.54, 89.63, 73.25, 57.14, 56.19,
				55.97, 31.09, 20.88, 19.27, 19.10, 17.06
				19F NMR (471 MHz, CDCl3) δ −115.69
				(ddd, J = 13.8, 8.8, 5.5 Hz), −116.12
				(ddd, J = 13.8, 8.7, 5.5 Hz)
186	—	—	HRMS-ESI	1H NMR (500 MHz, CDCl3) δ 8.25 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.07 (d, J = 8.8 Hz, 1H),
			[M + H]+	7.28-7.18 (m, 4H), 7.01-6.91 (m,
			calcd for	5H), 5.74-5.66 (m, 3H), 4.57 (ddd, J =
			C31H35F2N2O7,	9.6, 8.7, 5.1 Hz, 1H), 4.04 (d, J = 9.9
			585.2407;	Hz, 1H), 3.90 (s, 3H), 2.06 (s, 3H), 1.41-
			found,	1.31 (m, 1H), 1.23 (d, J = 6.1 Hz,
			585.2409	3H), 1.22-1.17 (m, 1H), 1.04-0.96
				(m, 1H), 0.79 (d, J = 6.5 Hz, 3H), 0.74
				(d, J = 6.6 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.38,
				170.29, 163.06, 161.73 (d, J = 245.7
				Hz), 161.67 (d, J = 245.4 Hz), 160.35,
				145.57, 144.14, 142.22, 137.17, 136.90,
				129.57 (d, J = 12.1 Hz), 129.50 (d, J =
				11.8 Hz), 115.64 (d, J = 35.1 Hz),
				115.47 (d, J = 35.0 Hz), 109.55, 89.60,
				73.08, 56.20, 56.19, 50.69, 41.20,
				24.56, 22.80, 21.63, 20.87, 19.19
				19F NMR (471 MHz, CDCl3) δ −115.66
				(td, J = 9.1, 4.7 Hz), −116.21
				(ddd, J = 13.9, 8.7, 5.3 Hz)
187	—	—	HRMS-ESI	1H NMR (500 MHz, CDCl3) δ 8.38-
			(m/z)	8.23 (m, 2H), 7.27-7.12 (m, 4H), 7.10-
			[M + H]+	6.83 (m, 5H), 5.69 (dq, J = 9.1, 6.2
			calcd for	Hz, 1H), 4.13-3.95 (m, 2H), 3.92 (s,
			C26H25F2N2O6,	4H), 2.39 (s, 3H), 1.23 (d, J = 6.2 Hz,
			499.1675;	3H)
			found,	13C NMR (126 MHz, CDCl3) δ 168.98,
			499.1664	168.92, 162.91, 161.71 (d, J = 245.8
				Hz), 161.62 (d, J = 245.4 Hz), 159.51,
				146.67, 141.23, 137.55, 136.79, 136.53
				(d, J = 3.4 Hz), 129.72 (d, J = 2.9 Hz),
				129.65 (d, J = 2.7 Hz), 115.67 (d, J =
				21.3 Hz), 115.40 (d, J = 21.3 Hz),
				109.89, 73.42, 56.31, 55.71, 41.17,
				20.73, 19.11
				19F NMR (471 MHz, CDCl3) δ −115.55-−115.66
				(m), −115.95 (tt, J = 8.3, 4.0 Hz)
188	—	—	HRMS-ESI	1H NMR (500 MHz, CDCl3) δ 8.39 (s,
			(m/z)	1H), 8.32 (d, J = 5.5 Hz, 1H), 7.33-
			[M + H]+	7.04 (m, 4H), 7.06-6.86 (m, 5H), 5.70
			calcd for	(dq, J = 9.4, 6.1 Hz, 1H), 4.54 (ddd, J =
			C28H29F2N2O6,	8.6, 6.5, 5.4 Hz, 1H), 4.04 (d, J = 9.4
			527.1988;	Hz, 1H), 3.91 (s, 3H), 2.38 (s, 3H), 1.62-
			found,	1.49 (m, 1H), 1.40-1.30 (m, 1H),
			527.1981	1.22 (d, J = 6.1 Hz, 3H), 0.59 (t, J = 7.4
				Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.41,
				168.90, 162.46, 161.71 (d, J = 245.9
				Hz), 161.66 (d, J = 245.4 Hz), 159.46,
				146.63, 141.46, 137.48, 136.88, 129.63
				(d, J = 7.8 Hz), 129.53 (d, J = 7.8 Hz),
				115.67 (d, J = 21.3 Hz), 115.40 (d, J =
				21.1 Hz), 109.74, 73.25, 56.30, 55.96,
				53.02, 25.34, 20.76, 19.20, 9.04
				19F NMR (471 MHz, CDCl3) δ −115.62-−115.72
				(m), −116.07 (td, J =
				9.3, 8.9, 4.1 Hz).
189	—	—	HRMS-ESI	1H NMR (500 MHz, CDCl3) δ 8.35 (s,
			(m/z)	1H), 8.31 (d, J = 5.4 Hz, 1H), 7.35-
			[M + H]+	7.16 (m, 4H), 7.08-6.80 (m, 5H), 5.70
			calcd for	(dq, J = 9.5, 6.1 Hz, 1H), 4.51 (dd, J =
			C29H31F2N2O6,	9.5, 4.7 Hz, 1H), 4.04 (d, J = 9.5 Hz,
			541.2145;	1H), 3.91 (s, 3H), 2.38 (s, 3H), 1.89-
			found,	1.68 (m, 1H), 1.21 (d, J = 6.3 Hz, 3H),
			541.2143	0.76 (d, J = 6.9 Hz, 3H), 0.58 (d, J = 6.9
				Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.01,
				168.88, 162.63, 161.69 (d, J = 245.9
				Hz), 161.65 (d, J = 244.8 Hz), 159.46,
				146.61, 141.54, 137.48, 136.97 (d, J =
				3.3 Hz), 136.88 (d, J = 3.4 Hz), 129.65
				(d, J = 7.9 Hz), 129.52 (d, J = 8.0 Hz),
				115.66 (d, J = 21.3 Hz), 115.41 (d, J =
				21.3 Hz), 109.71, 73.25, 56.95, 56.30,
				55.91, 20.77, 19.25, 18.99, 17.09
				19F NMR (471 MHz, CDCl3) δ −115.67-−115.78
				(m), −116.06-−116.17 (m)
190	—	—	HRMS-ESI	1H NMR (500 MHz, CDCl3) δ 8.30 (d,
			(m/z)	J = 5.5 Hz, 1H), 8.18 (d, J = 8.2 Hz, 1H),
			[M + H]+	7.35-7.13 (m, 4H), 7.04-6.80 (m,
			calcd for	5H), 5.68 (dq, J = 9.8, 6.2 Hz, 1H), 4.54
			C30H33F2N2O6,	(td, J = 9.2, 5.2 Hz, 1H), 4.03 (d, J = 9.7
			555.2301;	Hz, 1H), 3.90 (s, 3H), 2.38 (s, 3H), 1.20
			found,	(dd, J = 16.3, 6.1 Hz, 4H), 1.04 (ddd,
			555.2292	J = 13.9, 8.7, 5.2 Hz, 1H), 0.91-0.81 (m,
				1H), 0.78 (d, J = 6.4 Hz, 3H), 0.73 (d,
				J = 6.6 Hz, 3H)
				13C NMR (126 MHz, CDCl3) & 172.20,
				168.87, 162.46, 161.71 (d, J = 245.7
				Hz), 161.66 (d, J = 245.4 Hz), 159.46,
				146.57, 141.50, 137.48, 137.07 (d, J =
				3.3 Hz), 136.89 (d, J = 3.3 Hz), 129.60
				(d, J = 8.0 Hz), 129.50 (d, J = 8.0 Hz),
				115.68 (d, J = 21.3 Hz), 115.40 (d, J =
				21.3 Hz), 109.71, 73.08, 56.23, 50.54,
				24.54, 22.76, 21.71, 20.76, 19.16
				19F NMR (471 MHz, CDCl3) δ −115.59-−115.77
				(m), −116.14-−116.29 (m)
191	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.32-
		3381, 2937,	(m/z)	8.19 (m, 2H), 7.47 (dd, J = 7.7, 1.8 Hz,
		1735, 1676,	[M + H]+	1H), 7.23 (s, 1H), 7.24-7.04 (m, 2H),
		1492, 1245,	calcd for	6.93 (d, J = 5.5 Hz, 1H), 6.93-6.77 (m,
		1203, 1042	C30H35N2O9,	3H), 6.78 (dd, J = 8.3, 1.2 Hz, 1H), 5.95
			567.2335;	(dq, J = 9.9, 6.2 Hz, 1H), 5.78-5.66
			found,	(m, 2H), 5.01 (d, J = 9.8 Hz, 1H), 4.62-
			567.2337	4.48 (m, 1H), 3.90 (s, 3H), 3.85 (s,
				3H), 3.76 (s, 3H), 2.06 (s, 3H), 1.24 (d,
				J = 6.2 Hz, 3H), 0.95 (d, J = 7.2 Hz,
				3H)
192	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.27 (d,
		3378, 2938,	(m/z)	J = 5.4 Hz, 1H), 8.23 (d, J = 7.8 Hz, 1H),
		1737, 1675,	[M + H]+	7.26-7.14 (m, 1H), 7.16 (t, J = 7.9 Hz,
		1583, 1504,	calcd for	1H), 6.93 (d, J = 5.4 Hz, 1H), 6.92-
		1488, 1202,	C30H35N2O9,	6.87 (m, 2H), 6.87-6.80 (m, 2H), 6.73
		1041	567.2341;	(ddd, J = 8.2, 2.6, 0.9 Hz, 1H), 6.69
			found,	(ddd, J = 8.2, 2.6, 0.9 Hz, 1H), 5.79 (dq,
			567.2337	J = 9.7, 5.8 Hz, 1H), 5.73-5.69 (m,
				2H), 4.71-4.44 (m, 1H), 3.99 (d, J =
				10.2 Hz, 1H), 3.90 (s, 3H), 3.77 (s, 3H),
				3.76 (s, 3H), 2.06 (s, 3H), 1.25 (d, J =
				6.1 Hz, 3H), 0.94 (d, J = 7.2 Hz, 3H)
193	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.24 (dt,
		3378, 2983,	(m/z)	J = 5.4, 1.3 Hz, 1H), 7.99 (d, J = 8.1
		1741, 1672,	[M + H]+	Hz, 1H), 7.81 (t, J = 8.5 Hz, 1H), 7.36
		1575, 1483,	calcd for	(t, J = 8.5 Hz, 1H), 7.19-7.10 (m, 1H),
		1201, 1002	C28H27Cl2F2N2O8,	7.07-6.98 (m, 1H), 6.99-6.86 (m,
			627.1102;	3H), 6.14-6.04 (m, 1H), 5.70 (d, J =
			found,	6.4 Hz, 1H), 5.64 (d, J = 6.4 Hz, 1H),
			627.1107	4.66 (p, J = 7.2 Hz, 1H), 3.92 (s, 3H),
				3.82 (s, 1H), 2.07 (s, 3H), 1.35 (d, J =
				7.2 Hz, 3H), 1.22 (d, J = 6.9 Hz, 3H)
194	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.27 (d,
		3380, 2984,	(m/z)	J = 5.4 Hz, 1H), 8.23 (d, J = 7.8 Hz, 1H),
		1738, 1675,	[M + H]+	7.15-7.02 (m, 2H), 7.00-6.84 (m,
		1504, 1201,	calcd for	5H), 5.76-5.63 (m, 3H), 4.66-4.49
		1003	C30H32F2N2O7,	(m, 1H), 3.97 (d, J = 9.8 Hz, 1H), 3.91
			571.2257;	(s, 3H), 2.20 (d, J = 1.9 Hz, 3H), 2.18
			found,	(d, J = 1.8 Hz, 3H), 2.06 (s, 3H), 1.24
			571.225	(d, J = 6.2 Hz, 3H), 1.02 (d, J = 7.2 Hz,
				3H)
				19F NMR (471 MHz, CDCl3) δ −116.63
				(t, J = 9.5 Hz), −117.12 (t, J =
				9.5 Hz)
195	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.27 (d,
		3377, 2983,	(m/z)	J = 5.4 Hz, 1H), 8.23 (d, J = 7.9 Hz, 1H),
		1739, 1675,	[M + H]+	7.25-7.20 (m, 2H), 7.17-7.02 (m,
		1501, 1202,	calcd for	4H), 6.94 (d, J = 5.4 Hz, 1H), 5.75-
		1050	C30H33Cl2N2O7,	5.62 (m, 3H), 4.68-4.50 (m, 1H), 3.95
			603.1657;	(d, J = 9.9 Hz, 1H), 3.91 (s, 3H), 2.31
			found,	(s, 3H), 2.28 (s, 3H), 2.06 (s, 3H), 1.24
			603.1659	(d, J = 6.1 Hz, 3H), 1.03 (d, J = 7.2 Hz,
				3H)
196	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.26 (d,
		3379, 2987,	(m/z)	J = 5.4 Hz, 1H), 8.13 (d, J = 8.1 Hz, 1H),
		1741, 1673,	[M + H]+	7.85 (tt, J = 7.6, 1.9 Hz, 1H), 7.47 (tt,
		1507, 1486,	calcd for	J = 7.7, 1.8 Hz, 1H), 7.28-7.20 (m, 1H),
		1453, 1203,	C28H29F2N2O8,	7.22-7.11 (m, 2H), 7.09-6.99 (m,
		1002	559.1884;	1H), 7.01-6.79 (m, 3H), 6.29-6.20
			found,	(m, 1H), 5.71 (d, J = 6.4 Hz, 1H), 5.67
			559.1886	(d, J = 6.4 Hz, 1H), 4.75-4.57 (m,
				1H), 3.91 (s, 3H), 3.48 (d, J = 6.1 Hz,
				1H), 2.07 (s, 3H), 1.34-1.21 (m, 6H)
197	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.27 (d,
		3379, 3282,	(m/z)	J = 5.4 Hz, 1H), 8.21 (d, J = 7.8 Hz, 1H),
		2984, 2107,	[M + H]+	7.46-7.34 (m, 5H), 7.26-7.15 (m,
		1738, 1674,	calcd for	3H), 6.94 (d, J = 5.4 Hz, 1H), 5.87-
		1503, 1202,	C32H31N2O7,	5.68 (m, 3H), 4.62-4.48 (m, 1H), 4.07
		1043, 1004	555.2125;	(d, J = 9.8 Hz, 1H), 3.91 (s, 3H), 3.05
			found,	(s, 1H), 3.03 (s, 1H), 2.06 (s, 3H), 1.34-
			555.2126	1.22 (m, 3H), 0.98 (d, J = 7.2 Hz, 3H)
198	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.27 (d,
		3379, 2964,	(m/z)	J = 5.4 Hz, 1H), 8.23 (d, J = 7.8 Hz, 1H),
		1736, 1675,	[M + H]+	7.24-7.18 (m, 4H), 7.14-7.03 (m,
		1505, 1202,	calcd for	5H), 6.93 (d, J = 5.5 Hz, 1H), 5.87-
		1042, 1003	C32H39N2O7,	5.69 (m, 3H), 4.53 (p, J = 7.3 Hz, 1H),
			563.2753;	3.99 (d, J = 10.1 Hz, 1H), 3.90 (d, J =
			found,	1.0 Hz, 3H), 2.68-2.48 (m, 4H), 2.06
			563.2752	(d, J = 1.1 Hz, 3H), 1.24 (d, J = 7.1 Hz,
				3H), 1.22-1.10 (m, 6H), 0.88 (d, J =
				7.2 Hz, 2H)
199	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.27 (d,
			(m/z)	J = 5.3 Hz, 1H), 8.21 (d, J = 7.9 Hz, 1H),
			[M + H]+	7.31-7.22 (m, 5H), 7.21-7.12 (m,
			calcd for	1H), 7.00-6.81 (m, 3H), 5.81-5.74
			C28H30FN2O7,	(m, 1H), 5.72 (d, J = 0.8 Hz, 2H), 4.54
			525.2032;	(p, J = 7.2 Hz, 1H), 4.05 (d, J = 9.9 Hz,
			found,	1H), 3.90 (s, 3H), 2.06 (s, 3H), 1.24 (d,
			525.2045	J = 6.2 Hz, 3H), 0.92 (d, J = 7.2 Hz,
				3H)
				13C NMR (126 MHz, CDCl3) δ 172.31,
				170.28, 162.87, 161.70 (d, J = 245.6
				Hz), 160.25, 145.69, 143.97, 142.50,
				141.20, 137.03 (d, J = 3.3 Hz), 129.60
				(d, J = 7.8 Hz), 128.59, 128.02, 126.80,
				115.60 (d, J = 21.3 Hz), 109.52, 89.55,
				73.11, 57.04, 56.18, 48.05, 20.87,
				19.18, 17.74
201	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 8.26 (d,
			m/z 661.1	J = 5.4 Hz, 1H), 7.89 (d, J = 8.0 Hz, 1H),
			([M + H]+)	7.56 (d, J = 2.2 Hz, 1H), 7.48 (d, J = 2.2
				Hz, 1H), 7.34 (dd, J = 8.5, 4.2 Hz, 2H),
				7.18 (ddd, J = 10.5, 8.4, 2.2 Hz, 2H),
				6.97 (d, J = 5.4 Hz, 1H), 5.79 (q, J = 6.3
				Hz, 1H), 5.68 (d, J = 6.3 Hz, 1H), 5.61
				(d, J = 6.4 Hz, 1H), 4.63-4.52 (m,
				1H), 3.92 (s, 3H), 3.55 (s, 1H), 2.07 (s,
				3H), 1.27 (d, J = 7.2 Hz, 3H), 1.18 (d,
				J = 6.3 Hz, 3H)
				13C NMR (126 MHz, acetone-d6) δ
				166.30, 165.13, 158.33, 155.10, 140.60,
				139.16, 138.49, 137.43, 137.10, 127.58,
				126.60, 126.48, 125.21, 123.17, 122.62,
				119.99, 119.77, 104.55, 84.15, 73.35,
				69.04, 51.05, 43.24, 26.40, 15.69, 9.20
202	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 8.26 (d,
			m/z 627.1	J = 5.4 Hz, 1H), 7.91 (d, J = 8.0 Hz, 1H),
			([M]+)	7.33-7.27 (m, 3H), 7.21 (dd, J = 10.4,
				2.1 Hz, 1H), 7.11 (ddd, J = 8.5, 2.2, 0.8
				Hz, 1H), 7.06 (ddd, J = 8.6, 2.1, 0.9 Hz,
				1H), 6.97 (d, J = 5.4 Hz, 1H), 5.80 (q, J
				= 6.3 Hz, 1H), 5.68 (d, J = 6.3 Hz, 1H),
				5.61 (d, J = 6.3 Hz, 1H), 4.63-4.51 (m,
				1H), 3.92 (s, 3H), 3.54 (s, 1H), 2.07 (s,
				3H), 1.25 (d, J = 7.2 Hz, 3H), 1.18 (d,
				J = 6.4 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.43,
				170.32, 163.50, 160.30, 157.99 (d, J =
				249.5 Hz), 157.96 (d, J = 249.3 Hz),
				145.76, 145.20 (d, J = 5.8 Hz), 143.73,
				143.09 (d, J = 6.1 Hz), 142.58, 130.53
				(d, J = 3.2 Hz), 122.14 (d, J = 3.8 Hz),
				121.85 (d, J = 3.5 Hz), 120.23 (d, J =
				17.8 Hz), 120.05 (d, J = 17.8 Hz),
				114.70 (d, J = 22.5 Hz), 114.34 (d, J =
				23.0 Hz), 109.72, 89.34, 78.60, 74.30,
				56.24, 48.39, 30.94, 20.86, 17.51, 14.43
203	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.27 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.21 (d, J = 7.8 Hz, 1H),
			[M + H]+	7.26-7.19 (m, 2H), 7.10 (dd, J = 8.5,
			calcd for	2.2 Hz, 2H), 7.03 (ddd, J = 13.4, 8.2,
			C30H33Cl2N2O7,	2.3 Hz, 2H), 6.94 (d, J = 5.5 Hz, 1H),
			603.1659;	5.77-5.62 (m, 3H), 4.56 (p, J = 7.2 Hz,
			found,	1H), 3.95 (d, J = 10.0 Hz, 1H), 3.91 (s,
			603.1666	3H), 2.33 (s, 3H), 2.31 (s, 3H), 2.06 (s,
				3H), 1.23 (d, J = 6.1 Hz, 3H), 1.00 (d,
				J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.30,
				170.28, 162.90, 160.27, 145.70, 143.97,
				142.42, 139.64, 139.47, 136.51, 136.11,
				133.06, 132.71, 130.74, 130.63, 129.42,
				129.12, 126.63, 126.49, 109.57, 89.52,
				72.78, 56.44, 56.19, 48.06, 20.87,
				20.17, 20.09, 19.19 17.82
204	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.40 (d,
			(m/z)	J = 7.9 Hz, 1H), 8.32 (d, J = 5.5 Hz, 1H),
			[M + H]+	7.30-7.22 (m, 6H), 7.19-7.13 (m,
			calcd for	1H), 7.01-6.93 (m, 3H), 5.76 (dq, J =
			C27H27FN2O6,	9.8, 6.2 Hz, 1H), 4.58-4.49 (m, 1H),
			495.1926;	4.05 (d, J = 9.9 Hz, 1H), 3.90 (s, 3H),
			found,	2.38 (s, 3H), 1.23 (d, J = 6.1 Hz, 3H),
			495.1920	0.90 (d, J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.19,
				168.90, 162.27, 161.69 (d, J = 245.6
				Hz), 159.42, 146.64, 141.51, 141.14,
				137.46, 137.02 (d, J = 3.2 Hz), 129.60
				(d, J = 7.8 Hz), 128.59, 128.04, 126.81,
				115.59 (d, J = 21.2 Hz), 109.72, 73.14,
				56.99, 56.28, 47.81, 20.74, 19.15, 17.92
206	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.40 (s,
			(m/z)	1H), 8.32 (d, J = 5.4 Hz, 1H), 7.22 (dd,
			[M + H]+	J = 17.1, 8.2 Hz, 2H), 7.09 (dd, J = 7.2,
			calcd for	2.2 Hz, 2H), 7.06-6.96 (m, 3H), 5.69
			C29H31Cl2N2O6,	(dq, J = 9.9, 6.2 Hz, 1H), 4.61-4.47
			573.1554;	(m, 1H), 3.96-3.92 (m, 1H), 3.90 (s,
			found,	3H), 2.38 (s, 3H), 2.32 (s, 3H), 2.30 (s,
			573.1551	3H), 1.22 (d, J = 6.2 Hz, 3H), 0.99 (d,
				J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.16,
				168.91, 162.30, 159.45, 146.64, 141.45,
				139.58, 137.47, 136.50, 136.10, 133.05,
				132.71, 130.73, 130.63, 129.41, 129.12,
				126.64, 126.51, 109.76, 72.82, 56.34,
				47.83, 20.75, 20.16, 20.09, 19.16, 18.00
207	52-65	—	HRMS-FAB (m/z)	1H NMR (500 MHz, CDCl3) δ 8.30 (d,
			[M + H]+	J = 5.5 Hz, 1H), 8.29 (br s, 1H), 7.26-
			calcd for	7.18 (m, 4H), 7.01-6.88 (m, 5H), 5.70
			C30H33F2N2O6,	(dq, J = 9.5, 6.1 Hz, 1H), 4.64-4.48
			555.2301;	(m, 1H), 4.04 (d, J = 9.5 Hz, 1H), 3.88
			found,	(s, 3H), 1.39 (s, 9H), 1.22 (d, J = 6.1
			555.2311	Hz, 3H), 0.99 (d, J = 7.1 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 176.0,
				172.3, 162.2, 161.7 (d, J = 245.8 Hz),
				161.6 (d, J = 245.6 Hz), 159.4, 146.5,
				142.1, 137.8, 136.9, 136.8, 129.6 (d, J =
				8.0 Hz), 129.5 (d, J = 7.8 Hz), 115.7 (d,
				J = 21.3 Hz), 115.4 (d, J = 21.3 Hz),
				109.5, 73.0, 56.3, 56.1, 47.8, 39.1, 27.2,
				19.1, 18.1
				19F NMR (471 MHz, CDCl3)
				δ −115.7, −116.0
208	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.30 (d,
			(m/z)	J = 5.4 Hz, 2H), 7.28-7.14 (m, 4H),
			[M + H]+	7.02-6.89 (m, 5H), 5.70 (dq, J = 9.5,
			calcd for	6.2 Hz, 1H), 4.63-4.48 (m, 1H), 4.04
			C29H31F2N2O6,	(d, J = 9.5 Hz, 1H), 3.87 (s, 3H), 2.93
			541.2145;	(hept, J = 7.0 Hz, 1H), 1.34 (d, J = 7.0
			found,	Hz, 6H), 1.22 (d, J = 6.2 Hz, 3H), 0.98
			541.2159	(d, J = 7.1 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 174.69,
				172.21, 162.69, 162.61, 162.28, 160.74,
				160.66, 159.43, 146.54, 141.81, 137.65,
				136.86, 136.84, 129.64, 129.57, 129.51,
				115.76, 115.59, 115.46, 115.30, 109.61,
				73.03, 56.29, 56.07, 47.79, 33.94,
				19.12, 18.80, 18.04
209	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.45-
			(m/z)	8.25 (m, 2H), 7.30-7.15 (m, 4H), 7.05-
			[M + H]+	6.86 (m, 5H), 5.71 (dtd, J = 9.7, 7.3,
			calcd for	6.8, 5.5 Hz, 1H), 4.53 (tt, J = 8.3, 6.6
			C29H31F2N2O7,	Hz, 1H), 4.04 (d, J = 9.6 Hz, 1H), 3.88
			557.209;	(d, J = 1.2 Hz, 3H), 3.80 (td, J = 6.6, 1.2
			found,	Hz, 2H), 3.39 (d, J = 1.2 Hz, 3H), 2.97
			557.2094	(td, J = 6.7, 1.3 Hz, 2H), 1.22 (dd, J =
				6.3, 1.3 Hz, 3H), 0.98 (dd, J = 7.2, 1.3
				Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.13,
				169.42, 162.70, 162.61, 162.25, 160.74,
				160.66, 159.46, 146.69, 141.44, 137.34,
				136.87, 136.84, 136.81, 129.63, 129.56,
				129.50, 115.77, 115.60, 115.47, 115.30,
				109.78, 73.06, 67.57, 58.76, 56.31,
				56.08, 47.81, 34.62, 19.12, 17.99
210	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.33 (dd,
			(m/z)	J = 19.6, 5.4 Hz, 2H), 7.25-7.16 (m,
			[M + H]+	4H), 7.03-6.88 (m, 5H), 5.70 (dq, J =
			calcd for	9.5, 6.2 Hz, 1H), 4.65-4.52 (m, 1H),
			C29H29F2N2O6,	4.04 (d, J = 9.6 Hz, 1H), 3.90 (s, 3H),
			539.1985;	1.95 (tt, J = 8.0, 4.6 Hz, 1H), 1.25 (dd,
			found,	J = 4.6, 3.1 Hz, 2H), 1.22 (d, J = 6.2 Hz,
			539.1988	3H), 1.05 (dt, J = 8.1, 3.5 Hz, 2H), 0.98
				(d, J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.45,
				172.20, 162.70, 162.61, 162.26, 160.74,
				160.66, 159.50, 146.56, 141.80, 137.45,
				136.87, 136.85, 136.83, 129.64, 129.57,
				129.50, 115.76, 115.59, 115.47, 115.30,
				109.68, 73.03, 56.31, 56.08, 47.75,
				19.13, 18.09, 13.00, 9.27
211	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.25 (t,
			(m/z)	J = 6.2 Hz, 2H), 7.32-7.11 (m, 4H),
			[M + H]+	7.04-6.85 (m, 5H), 5.79-5.65 (m,
			calcd for	3H), 4.55 (p, J = 7.3 Hz, 1H), 4.04 (d,
			C30H33F2N2O7,	J = 9.7 Hz, 1H), 3.87 (s, 3H), 2.53 (hept,
			571.2242;	J = 7.0 Hz, 1H), 1.23 (d, J = 6.2 Hz,
			found,	3H), 1.12 (d, J = 7.0 Hz, 6H), 0.99 (d,
			571.225	J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 176.25,
				172.25, 162.88, 162.70, 162.60, 160.74,
				160.65, 160.26, 145.54, 144.21, 142.02,
				136.94, 136.92, 136.86, 136.83, 129.60,
				129.56, 129.54, 129.49, 115.77, 115.60,
				115.47, 115.30, 109.53, 89.88, 73.01,
				56.13, 48.05, 33.85, 19.15, 18.66, 17.81
212	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.23 (dd,
			(m/z)	J = 16.1, 6.6 Hz, 2H), 7.25-7.18 (m,
			[M + H]+	4H), 7.02-6.89 (m, 5H), 5.82-5.66
			calcd for	(m, 3H), 4.54 (p, J = 7.3 Hz, 1H), 4.08
			C30H33F2N2O8,	(s, 2H), 4.04 (d, J = 9.7 Hz, 1H), 3.89
			587.2199;	(s, 3H), 3.58 (q, J = 7.0 Hz, 2H), 1.25-
			found,	1.20 (m, 6H), 0.99 (d, J = 7.2 Hz, 3H)
			587.2217	13C NMR (126 MHz, CDCl3) δ 172.20,
				170.05, 162.84, 162.70, 162.61, 160.75,
				160.65, 160.21, 145.73, 143.95, 142.23,
				136.95, 136.92, 136.85, 136.83, 129.60,
				129.56, 129.54, 129.50, 115.78, 115.61,
				115.47, 115.30, 109.70, 89.55, 73.04,
				67.78, 67.17, 56.23, 56.14, 53.46,
				48.04, 19.15, 17.81, 15.00, 14.95
213	—	—	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.45-
			(m/z)	8.22 (m, 2H), 7.30-7.15 (m, 4H), 7.04-
			[M + H]+	6.89 (m, 5H), 5.71 (dq, J = 9.5, 6.2
			calcd for	Hz, 1H), 4.63-4.45 (m, 1H), 4.04 (d,
			C30H33F2N2O6,	J = 9.6 Hz, 1H), 3.89 (s, 3H), 2.68 (t, J =
			555.2301;	7.6 Hz, 2H), 1.76 (p, J = 7.6 Hz, 2H),
			found,	1.54-1.37 (m, 2H), 1.22 (d, J = 6.1 Hz,
			555.2315	3H), 1.06-0.88 (m, 6H)
				13C NMR (126 MHz, CDCl3) δ 172.17,
				171.61, 162.70, 162.61, 162.31, 160.74,
				160.66, 159.47, 146.56, 141.61, 137.57,
				136.87, 136.85, 136.82, 129.63, 129.57,
				129.50, 115.76, 115.60, 115.47, 115.30,
				109.69, 73.05, 56.26, 56.08, 47.80,
				33.64, 29.70, 26.61, 22.20, 19.12,
				18.02, 13.76
214	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.28 (d,
		3388, 2970,	(m/z)	J = 7.8 Hz, 1H), 8.17 (d, J = 4.9 Hz, 1H),
		2363, 2029,	[M + H]+	7.68 (d, J = 4.9 Hz, 1H), 7.30-7.16 (m,
		1738, 1677,	calcd for	4H), 7.05-6.90 (m, 3H), 5.81-5.69
		1604, 1508,	C27H26BrF2N206,	(m, 3H), 4.54 (p, J = 7.3 Hz, 1H), 4.05
		1449, 1414,	593.0921;	(d, J = 9.8 Hz, 1H), 2.09 (s, 3H), 1.59
		1366, 1307,	found,	(s, 1H), 1.31-1.21 (m, 3H), 1.00 (d,
		1218, 1203,	593.0925	J = 7.2 Hz, 3H)
		1159, 1139,
		1113, 1042,
		1000, 970,
		908, 831,
		806, 793,
		778, 731,
		711, 682,
		670, 663
215	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.38 (d,
		3380, 2985,	(m/z)	J = 8.0 Hz, 1H), 8.32 (d, J = 5.4 Hz, 1H),
		2362, 1769,	[M + H]+	7.18-6.88 (m, 7H), 5.64 (dq, J = 9.5,
		1738, 1674,	calcd for	6.3 Hz, 1H), 4.64-4.47 (m, 1H), 4.00
		1609, 1591,	C27H25F4N2O6,	(d, J = 9.3 Hz, 1H), 3.91 (s, 3H), 2.39
		1572, 1513,	549.1643;	(s, 3H), 1.23 (d, J = 6.1 Hz, 3H), 1.09
		1434, 1367,	found,	(d, J = 7.2 Hz, 3H)
		1310, 1277,	549.1655	19F NMR (471 MHz, CDCl3) 8-136.31
		1202, 1175,		(ddd, J = 20.1, 11.2, 8.2 Hz), −136.74
		1150, 1113,		(ddd, J = 20.3, 11.3, 7.8 Hz), −139.14-−139.50
		1051, 1009,		(m), −139.70 (dddd, J = 21.4,
		952, 907,		10.6, 7.7, 4.1 Hz)
		825, 805,
		731, 668,
		657
216	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.38 (d,
		3375, 2984,	(m/z)	J = 8.3 Hz, 1H), 8.31 (d, J = 5.4 Hz, 1H),
		2361, 2132,	[M + H]+	7.26 (ddd, J = 11.5, 7.2, 2.1 Hz, 2H),
		1770, 1738,	calcd for	7.18-6.95 (m, 5H), 5.63 (dq, J = 9.3,
		1676, 1590,	C27H25Cl2F2N2O6,	6.1 Hz, 1H), 4.65-4.49 (m, 1H), 4.00
		1572, 1499,	581.1052;	(d, J = 9.4 Hz, 1H), 3.91 (s, 3H), 2.39
		1452, 1437,	found,	(s, 3H), 1.24 (d, J = 6.2 Hz, 3H), 1.09
		1367, 1311,	581.1061	(d, J = 7.2 Hz, 3H)
		1251, 1199,		19F NMR (471 MHz, CDCl3) δ −116.85-−117.26
		1175, 1098,		(m), −117.29-−117.50 (m)
		1061, 1010,
		952, 907,
		828, 805,
		782, 764,
		733, 687,
		668, 657,
		651
217	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.40 (d,
		3383, 2983,	(m/z)	J = 8.2 Hz, 1H), 8.32 (d, J = 5.4 Hz, 1H),
		1771, 1736,	[M + H]+	7.14-6.96 (m, 5H), 6.96-6.81 (m,
		1676, 1591,	calcd for	2H), 5.68 (dq, J = 9.9, 6.1 Hz, 1H), 4.53
		1572, 1503,	C29H31F2N2O6,	(dt, J = 8.2, 7.1 Hz, 1H), 3.94 (d, J =
		1451, 1437,	541.2145;	10.0 Hz, 1H), 3.90 (s, 3H), 2.38 (s, 3H),
		1366, 1311,	found,	2.22 (dd, J = 6.7, 1.9 Hz, 6H), 1.21 (d, J
		1277, 1237,	541.2156	= 6.1 Hz, 3H), 0.98 (d, J = 7.1 Hz, 3H)
		1201, 1176,		19F NMR (471 MHz, CDCl3)
		1119, 1099,		δ −119.90-−120.14
		1051, 1009,		(m), −120.50-−120.65 (m)
		949, 907,
		825, 805,
		790, 733,
		668, 657
218	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.27 (d,
		3376, 2988,	(m/z)	J = 5.4 Hz, 1H), 8.21 (d, J = 7.8 Hz, 1H),
		2363, 1742,	[M + H]+	7.18-6.85 (m, 7H), 5.72 (s, 2H), 5.65
		1675, 1609,	calcd for	(dq, J = 10.5, 6.2 Hz, 1H), 4.58 (p, J =
		1580, 1515,	C28H27F4N2O7,	7.3 Hz, 1H), 4.01 (d, J = 9.4 Hz, 1H),
		1454, 1435,	579.1749;	3.91 (s, 3H), 2.07 (s, 3H), 1.25 (d, J =
		1368, 1310,	found,	5.9 Hz, 3H), 1.09 (d, J = 7.2 Hz, 3H)
		1284, 1236,	579.1762	19F NMR (471 MHz, CDCl3) δ −136.29
		1203, 1181,		(ddd, J = 20.1, 11.2, 8.0 Hz), −
		1149, 1120,		136.73 (ddd, J = 20.1, 11.3, 8.0
		1043, 1004,		Hz), −139.16-−139.43
		970, 910,		(m), −139.64-−139.84 (m)
		873, 829,
		754, 734
219	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) & 8.27 (dd,
		3393, 2986,	(m/z)	J = 5.4, 1.1 Hz, 1H), 8.21 (d, J = 7.8
		2364, 1742,	[M + H]+	Hz, 1H), 7.35-7.19 (m, 2H), 7.20-
		1676, 1580,	calcd for	7.01 (m, 4H), 6.96 (dd, J = 5.5, 1.1 Hz,
		1499, 1454,	C28H27Cl2F2N2O7,	1H), 5.72 (d, J = 1.1 Hz, 2H), 5.64
		1437, 1408,	611.1158;	(dddd, J = 11.6, 9.1, 5.3, 3.3 Hz, 1H),
		1367, 1310,	found,	4.65-4.51 (m, 1H), 4.01 (d, J = 9.5 Hz,
		1250, 1202,	611.1169	1H), 3.92 (d, J = 1.1 Hz, 3H), 2.07 (d,
		1180, 1148,		J = 1.1 Hz, 3H), 1.30-1.21 (m, 3H),
		1101, 1061,		1.09 (dd, J = 7.1, 1.1 Hz, 3H)
		1044, 1004,		19F NMR (471 MHz, CDCl3)
		972, 911,		δ −116.92-−117.10
		829, 732,		(m), −117.36-−117.53 (m)
		720, 687
220	—	(Thin film)	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.27 (d,
		3375, 2986,	(m/z)	J = 5.4 Hz, 1H), 8.21 (d, J = 7.8 Hz, 1H),
		1738, 1675,	[M + H]+	7.05 (td, J = 9.7, 8.2, 4.2 Hz, 4H), 6.98-
		1579, 1501,	calcd for	6.82 (m, 3H), 5.78-5.54 (m, 3H),
		1452, 1437,	C30H33F2N2O7,	4.63-4.48 (m, 1H), 3.95 (d, J = 10.1
		1366, 1310,	571.2250;	Hz, 1H), 3.91 (s, 3H), 2.22 (dd, J = 6.4,
		1275, 1237,	found,	2.0 Hz, 6H), 2.06 (s, 3H), 1.23 (d, J =
		1202, 1180,	571.2265	6.1 Hz, 3H), 0.99 (d, J = 7.2 Hz, 3H)
		1151, 1118,		19F NMR (471 MHz, CDCl3) δ −120.03
		1101, 1043,		(dt, J = 9.7, 5.9 Hz), −120.57
		1003, 970,		(dd, J = 8.8, 5.4 Hz)
		909, 828,
		785, 730
221	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.27 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.20 (d, J = 7.8 Hz, 1H),
			[M + H]+	7.42-7.29 (m, 4H), 7.12 (dd, J = 8.3,
			calcd for	2.2 Hz, 1H), 7.08 (dd, J = 8.3, 2.2 Hz,
			C28H27Cl4N2O7,	1H), 6.95 (d, J = 5.4 Hz, 1H), 5.72 (s,
			643.0567;	2H), 5.70-5.58 (m, 1H), 4.58 (p, J =
			found,	7.2 Hz, 1H), 4.00 (d, J = 9.5 Hz, 1H),
			643.0578	3.91 (s, 3H), 2.07 (s, 3H), 1.26 (d, J =
				6.2 Hz, 3H), 1.10 (d, J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.13,
				170.29, 162.96, 160.28, 145.71, 144.01,
				142.25, 140.34, 133.06, 132.72, 131.62,
				131.29, 130.94, 130.67, 130.34, 130.11,
				127.32, 109.64, 89.50, 72.10, 56.20,
				55.71, 48.07, 20.88, 19.07, 17.85
222	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.27 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.20 (d, J = 7.8 Hz, 1H),
			[M + H]+	7.32 (td, J = 8.3, 7.6 Hz, 2H), 7.11-
			calcd for	6.93 (m, 4H), 5.72 (d, J = 0.5 Hz, 3H),
			C28H27Cl2F2N2O7,	5.71-5.60 (m, 1H), 4.67-4.51 (m,
			611.1158;	1H), 4.03 (d, J = 9.3 Hz, 1H), 3.91 (s,
			found,	3H), 2.07 (s, 3H), 1.26 (d, J = 6.2 Hz,
			611.1175	3H), 1.09 (d, J = 7.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 172.10,
				170.29, 162.95, 160.29, 158.15 (d, J =
				250.2 Hz), 158.01 (d, J = 249.8 Hz),
				145.70, 144.03, 142.24, 141.03 (d, J =
				6.5 Hz), 131.08, 130.80, 124.51 (d, J =
				3.5 Hz), 124.40 (d, J = 3.6 Hz), 120.03
				(d, J = 17.6 Hz), 119.73 (d, J = 17.7
				Hz), 116.55 (d, J = 21.8 Hz), 109.64,
				89.51, 72.15, 56.20, 55.99, 48.05,
				20.87, 19.03, 17.84
223	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.80 (d,
			(m/z)	J = 6.6 Hz, 1H), 8.49 (d, J = 6.8 Hz, 1H),
			[M + H]+	7.58 (d, J = 6.6 Hz, 1H), 7.40-7.27 (m,
			calcd for	4H), 7.14-7.01 (m, 2H), 5.67-5.52
			C27H25Cl4N2O6,	(m, 1H), 4.61-4.46 (m, 1H), 4.18 (s,
			613.0461;	3H), 4.10 (d, J = 9.9 Hz, 1H), 2.44 (s,
			found,	3H), 1.27 (dd, J = 6.3, 3.1 Hz, 6H)
			613.0468	13C NMR (126 MHz, CDCl3) & 174.00,
				171.63, 170.13, 140.79, 140.20, 133.07,
				132.34, 131.62, 130.97, 130.85, 130.55,
				130.04, 127.30, 126.71, 108.57, 72.40,
				58.02, 55.48, 34.67, 18.65, 16.34
224	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.88 (d,
			(m/z)	J = 6.7 Hz, 1H), 8.49 (d, J = 6.7 Hz, 1H),
			[M + H]+	7.67 (d, J = 6.7 Hz, 1H), 7.38-7.28 (m,
			calcd for	2H), 7.09-6.95 (m, 4H), 5.68-5.49
			C27H25Cl2F2N2O6,	(m, 1H), 4.59-4.48 (m, 1H), 4.21 (s,
			581.1052;	3H), 4.12 (d, J = 9.8 Hz, 1H), 2.44 (s,
			found,	3H), 1.31-1.24 (m, 6H)
			581.1059	13C NMR (126 MHz, CDCl3) δ 174.30,
				171.60, 170.11, 157.88 (d, J = 307.7
				Hz), 141.43 (d, J = 6.1 Hz), 140.87 (d,
				J = 6.2 Hz), 131.11, 130.71, 124.43,
				123.96 (d, J = 3.6 Hz), 120.02 (d, J =
				17.7 Hz), 119.27 (d, J = 17.3 Hz),
				116.85 (d, J = 21.3 Hz), 116.32 (d, J =
				21.5 Hz), 108.58, 72.61, 58.04, 55.77,
				50.35, 31.59, 18.66, 16.35
				19F NMR (471 MHz, CDCl3)
				δ −113.83-−113.93 (m), −114.77 (t, J =
				8.7 Hz)
225	—	—	HRMS-ESI	1H NMR (300 MHz, CDCl3) δ 8.27 (d,
			(m/z)	J = 5.4 Hz, 1H), 8.13 (d, J = 7.8 Hz, 1H),
			[M + H]+	7.25-7.14 (m, 4H), 6.93 (dddd, J =
			calcd for	18.3, 8.7, 6.6, 2.1 Hz, 5H), 5.75-5.61
			C28H29F2N2O7,	(m, 3H), 4.64-4.42 (m, 1H), 4.05 (d,
			543.1937;	J = 8.9 Hz, 1H), 3.91 (s, 3H), 2.05 (s,
			found,	3H), 1.31 (d, J = 7.1 Hz, 3H), 1.21 (d,
			543.1949	J = 6.2 Hz, 3H)
				13C NMR (126 MHz, CDCl3) δ 171.93,
				170.30, 162.76, 162.66, 160.62, 160.36,
				145.64, 144.15, 142.26, 136.92, 136.54,
				129.80, 129.74, 129.69, 129.62, 115.71,
				115.54, 115.42, 115.25, 109.59, 89.62,
				73.10, 56.21, 55.59, 48.03, 20.86,
				18.95, 18.06
226	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 6.95-
		3375, 2982,	(m/z)	6.77 (m, 4H), 5.57 (dq, J = 9.0, 6.2 Hz,
		1704, 1623,	[M + Na]+	1H), 4.91 (d, J = 7.8 Hz, 1H), 4.27-
		1527, 1448,	calcd for	4.13 (m, 1H), 3.93 (d, J = 9.0 Hz, 1H),
		1367, 1346,	C23H23F6NNaO4,	1.42 (s, 9H), 1.24 (d, J = 6.2 Hz, 3H),
		1239, 1215,	514.1423;	1.00 (d, J = 7.2 Hz, 3H)
		1165, 1117,	found,	19F NMR (376 MHz, CDCl3) δ −132.38
		1094, 1043,	514.1428	(d, J = 20.6 Hz), −132.83 (d, J =
		863, 803,		20.6 Hz), −160.90 (t, J = 20.5
		786, 729,		Hz), −161.25 (t, J = 20.6 Hz)
		679
227	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, methanol-d4) δ
		2939, 2031,	(m/z)	7.36-7.17 (m, 4H), 5.83 (dq, J = 10.0,
		1744, 1620,	[M + H]+	6.1 Hz, 1H), 4.26 (d, J = 10.1 Hz, 1H),
		1526, 1447,	calcd for	4.00 (q, J = 7.2 Hz, 1H), 3.31 (p, J = 1.7
		1345, 1234,	C18H16F6NO2,	Hz, 3H), 1.28 (d, J = 6.2 Hz, 3H), 1.08
		1217, 1118,	392.1080;	(d, J = 7.2 Hz, 3H)
		1041, 1005,	found,	19F NMR (376 MHz, methanol-d4) δ −137.08
		872, 826,	392.1083	(d, J = 20.0 Hz), −137.39 (d, J =
		802, 752,		19.9 Hz), −166.29 (t, J = 19.9
		729, 707,		Hz), −166.61 (t, J = 19.9 Hz)
		680, 666,
		659
228	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 11.93 (s,
		3373, 2942,	(m/z)	1H), 8.29 (d, J = 7.9 Hz, 1H), 7.98 (d,
		1738, 1649,	[M + H]+	J = 5.2 Hz, 1H), 6.94-6.77 (m, 5H),
		1622, 1577,	calcd for	5.58 (dq, J = 9.0, 6.2 Hz, 1H), 4.65-
		1525, 1481,	C25H21F6N2O5,	4.49 (m, 1H), 3.94 (d, J = 5.5 Hz, 4H),
		1446, 1344,	543.1349;	1.25 (dd, J = 9.4, 6.7 Hz, 6H)
		1262, 1239,	found,	19F NMR (376 MHz, CDCl3) δ −132.34
		1214, 1148,	543.1362	(d, J = 20.7 Hz), −132.74 (d, J =
		1117, 1094,		20.5 Hz), −160.82 (t, J = 20.5
		1040, 984,		Hz), −161.08 (t, J = 20.5 Hz)
		954, 909,
		849, 801,
		727, 678
229	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.37 (d,
		3384, 2985,	(m/z)	J = 7.6 Hz, 1H), 8.32 (d, J = 5.4 Hz, 1H),
		1770, 1741,	[M + H]+	7.01 (d, J = 5.5 Hz, 1H), 6.88 (dd, J =
		1676, 1622,	calcd for	8.1, 6.3 Hz, 2H), 6.82 (dd, J = 8.1, 6.2
		1592, 1572,	C27H23F6N2O6,	Hz, 2H), 5.56 (dq, J = 8.7, 6.2 Hz, 1H),
		1527, 1447,	585.1455;	4.65-4.50 (m, 1H), 3.94 (d, J = 8.8 Hz,
		1368, 1345,	found,	1H), 3.91 (s, 3H), 2.38 (s, 3H), 1.24 (d,
		1312, 1237,	585.1464	J = 6.2 Hz, 3H), 1.18 (d, J = 7.2 Hz,
		1199, 1176,		3H)
		1117, 1095,		19F NMR (376 MHz, CDCl3) δ −132.51
		1042, 1010,		(d, J = 20.5 Hz), −132.94 (d, J =
		954, 909,		20.4 Hz), −161.06 (t, J = 20.5
		846, 828,		Hz), −161.30 (t, J = 20.6 Hz)
		803, 729,
		680
230	—	(Thin film)	HRMS-ESI	1H NMR (400 MHz, CDCl3) δ 8.27 (d,
		3384, 2987,	(m/z)	J = 5.4 Hz, 1H), 8.20 (d, J = 7.7 Hz, 1H),
		1743, 1675,	[M + H]+	6.96 (d, J = 5.4 Hz, 1H), 6.90 (dd, J =
		1622, 1579,	calcd for	8.2, 6.3 Hz, 2H), 6.84 (dd, J = 8.0, 6.2
		1526, 1506,	C28H25F6N2O7,	Hz, 2H), 5.72 (d, J = 1.0 Hz, 2H), 5.58
		1447, 1366,	615.1560;	(dq, J = 8.9, 6.2 Hz, 1H), 4.59 (p, J =
		1344, 1311,	found,	7.3 Hz, 1H), 3.96 (d, J = 8.8 Hz, 1H),
		1237, 1201,	615.1570	3.92 (s, 3H), 2.07 (s, 3H), 1.26 (d, J =
		1180, 1149,		6.2 Hz, 3H), 1.17 (d, J = 7.3 Hz, 3H)
		1117, 1101,		19F NMR (376 MHz, CDCl3) δ −132.49
		1040, 1003,		(d, J = 20.7 Hz), −132.92 (d, J =
		971, 911,		20.6 Hz), −161.02 (t, J = 20.6
		830, 803,		Hz), −161.33 (t, J = 20.6 Hz)
		728, 679
232	—	—	ESIMS	—
			m/z 320
			([M + H]+)
233	—	—	ESIMS	1H NMR (400 MHz, CDCl3) δ 7.21
			m/z 420	(ddd, J = 11.8, 8.4, 5.2 Hz, 4H), 6.98
			([M + H]+)	(td, J = 8.6, 5.6 Hz, 4H), 5.67 (dq, J =
				9.2, 6.2 Hz, 1H), 4.80 (d, J = 7.8 Hz,
				1H), 4.06 (dd, J = 21.8, 8.4 Hz, 2H),
				1.43 (s, 9H), 1.18 (dd, J = 12.5, 6.7 Hz,
				6H)
				13C NMR (126 MHz, CDCl3) δ 172.42,
				162.70, 162.62, 160.74, 160.67, 136.89,
				136.87, 129.74, 129.67, 129.61, 115.76,
				115.59, 115.47, 115.30, 79.79, 72.77,
				55.76, 49.40, 30.93, 28.30, 19.00, 18.30
*Cmpd. No.—Compound Number

TABLE 3
Biological Testing Rating Scale
Rating Table for Fungal Pathogens
% Control                   Rating
>80                         A
≤80                         B
Not Tested                  C
No Activity Observed in the D
Reported Assay

TABLE 4
Biological Activity - PUCCRT and SEPTTR Disease
Control in High and Low Volume Applications
	High Volume	Low Volume
	(100 ppm*)	(121.5 g/H*)
Cmpd.	PUCCRT*	SEPTTR *	PUCCRT*	SEPTTR*
No.	1DP*	3DC*	1DP*	3DC*	1DP*	3DC*	1DP*	3DC*
89	C	C	C	C	C	C	C	C
90	A	A	A	A	C	C	C	C
91	A	B	A	D	C	C	C	C
92	A	A	A	A	C	C	C	C
93	B	D	A	B	C	C	C	C
95	C	C	C	C	C	C	C	C
96	A	A	A	A	C	C	C	C
97	B	D	A	A	C	C	C	C
98	A	A	A	A	C	C	C	C
99	A	B	A	A	C	C	C	C
100	A	A	A	A	C	C	C	C
101	D	D	B	D	C	C	C	C
102	B	D	B	B	C	C	C	C
103	A	B	A	A	C	C	C	C
104	A	D	B	A	C	C	C	C
105	A	A	A	A	C	C	C	C
106	A	D	A	A	C	C	C	C
107	A	B	A	A	C	C	C	C
109	B	D	D	B	C	C	C	C
110	A	D	A	A	C	C	C	C
111	B	D	B	A	C	C	C	C
112	D	D	B	B	C	C	C	C
113	A	B	A	B	C	C	C	C
114	A	A	A	A	C	C	C	C
115	B	D	A	A	C	C	C	C
116	B	D	B	B	C	C	C	C
117	A	B	A	A	C	C	C	C
118	A	A	B	A	C	C	C	C
119	D	D	A	B	C	C	C	C
120	A	B	A	A	C	C	C	C
121	A	B	A	A	C	C	C	C
122	D	D	B	B	C	C	C	C
123	B	D	B	A	C	C	C	C
124	A	A	A	A	C	C	C	C
125	A	A	A	A	C	C	C	C
127	B	D	B	D	C	C	C	C
128	B	D	A	B	C	C	C	C
129	A	B	A	A	C	C	C	C
130	C	C	C	C	C	C	C	C
131	C	C	C	C	C	C	C	C
132	A	B	A	A	C	C	C	C
133	C	C	C	C	C	C	C	C
135	C	C	C	C	C	C	C	C
136	C	C	C	C	C	C	C	C
137	C	C	C	C	C	C	C	C
138	C	C	C	C	D	B	A	B
139	C	C	C	C	A	A	A	A
140	C	C	C	C	A	B	A	A
141	C	C	C	C	A	A	A	A
142	C	C	C	C	A	A	A	A
143	C	C	C	C	B	D	D	B
144	C	C	C	C	B	B	B	B
145	C	C	C	C	A	A	A	A
146	C	C	C	C	A	A	A	A
147	C	C	C	C	B	B	B	A
148	C	C	C	C	A	A	A	A
149	C	C	C	C	B	B	A	A
150	C	C	C	C	A	A	A	A
152	C	C	C	C	B	B	A	A
153	C	C	C	C	B	B	A	A
155	C	C	C	C	A	A	A	A
156	C	C	C	C	A	A	A	A
157	C	C	C	C	A	A	A	A
158	C	C	C	C	A	A	A	A
159	C	C	C	C	A	A	A	A
160	C	C	C	C	A	B	A	A
161	C	C	C	C	D	D	B	A
162	C	C	C	C	D	D	D	B
163	C	C	C	C	B	D	B	A
164	C	C	C	C	D	D	B	D
165	C	C	C	C	A	B	A	A
166	C	C	C	C	B	D	B	B
167	C	C	C	C	A	A	A	A
168	C	C	C	C	A	B	A	A
169	C	C	C	C	A	B	A	A
170	C	C	C	C	B	B	B	B
171	C	C	C	C	A	A	A	A
173	C	C	C	C	A	B	A	A
174	C	C	C	C	A	B	A	A
175	C	C	C	C	A	A	A	A
176	C	C	C	C	A	A	A	A
178	C	C	C	C	B	D	A	A
179	C	C	C	C	B	D	A	A
180	C	C	C	C	D	D	B	D
181	C	C	C	C	D	D	B	B
182	C	C	C	C	D	B	D	B
183	C	C	C	C	A	A	A	B
184	C	C	C	C	A	A	A	A
185	C	C	C	C	A	B	A	A
186	C	C	C	C	B	D	A	B
187	C	C	C	C	A	B	B	B
188	C	C	C	C	A	B	A	A
189	C	C	C	C	A	B	A	A
190	C	C	C	C	B	D	B	B
191	C	C	C	C	A	A	A	A
192	C	C	C	C	A	A	A	A
193	C	C	C	C	B	D	A	A
194	C	C	C	C	A	B	A	A
195	C	C	C	C	A	B	A	B
196	C	C	C	C	D	D	A	B
197	C	C	C	C	A	A	A	A
198	C	C	C	C	A	B	A	A
199	C	C	C	C	A	A	A	A
201	C	C	C	C	B	D	A	A
202	C	C	C	C	D	D	A	A
203	C	C	C	C	A	B	A	A
204	C	C	C	C	A	A	A	A
206	C	C	C	C	A	B	A	A
207	C	C	C	C	D	D	A	A
208	C	C	C	C	A	B	A	A
209	C	C	C	C	A	B	A	A
210	C	C	C	C	A	B	A	A
211	C	C	C	C	A	A	A	A
212	C	C	C	C	A	A	A	A
213	C	C	C	C	B	B	A	A
214	C	C	C	C	D	D	D	D
215	C	C	C	C	A	D	A	A
216	C	C	C	C	A	B	A	B
217	C	C	C	C	A	B	A	A
218	C	C	C	C	A	B	A	A
219	C	C	C	C	A	D	A	A
220	C	C	C	C	A	B	A	A
221	C	C	C	C	C	C	C	C
222	C	C	C	C	C	C	C	C
223	C	C	C	C	C	C	C	C
224	C	C	C	C	C	C	C	C
225	C	C	C	C	C	C	C	C
228	C	C	C	C	C	C	C	C
229	C	C	C	C	C	C	C	C
230	C	C	C	C	C	C	C	C
*Cmpd. No. - Compound Number
*PUCCRT - Wheat Brown Rust (Puccinia triticina)
*SEPTTR - Wheat Leaf Blotch (Septoria tritici)
*1DP - 1 Day Protectant
*3DC - 3 Day Curative
*g/H - Grams Per Hectare
*ppm - Parts Per Million

TABLE 5
Biological Activity - Disease Control at 100 ppm
Cmpd	ALTESO*	CERCBE*	COLLLA*	LEPTNO*
No.	1 DP*
139	B	A	A	A
140	A	A	A	A
141	B	A	A	A
142	A	A	A	A
145	A	A	A	A
146	A	A	A	A
148	B	A	A	A
150	A	A	A	A
174	B	A	A	A
176	B	A	A	A
*Cmpd. No.—Compound Number
*ALTESO—Tomato Early Blight (Alternaria solani)
*CERCBE—Leaf Spot of Sugar Beets (Cercospora beticola)
*COLLLA—Cucumber Anthracnose (Glomerella lagenarium; Anamorph: Colletotricum lagenarium)
*LEPTNO—Wheat Glume Blotch (Leptosphaeria nodorum)
*1 DP—1 Day Protectant

TABLE 6
Biological Activity - Disease Control at 100 ppm
	Cmpd	PYRIOR*	RHYNSE*	VENTIN*
	No.	1 DP*
	139	A	A	A
	140	A	C	A
	141	A	A	A
	142	A	A	A
	145	A	A	A
	146	A	A	A
	148	A	A	A
	150	A	A	A
	174	A	A	B
	176	A	A	A
	*Cmpd. No.—Compound Number
	*PYRIOR—Rice Blast (Magnaporthe grisea; Anamorph: Pyricularia oryzae)
	*RHYNSE—Barley Scald (Rhyncosporium secalis)
	*VENTIN—Apple Scab (Venturia inaequalis)
	*1 DP—1 Day Protectant

TABLE 7
Biological Activity - Disease Control at 25 ppm
Cmpd.	PHAKPA*
No.*	1 DP*	3 DC*
139	A	B
140	B	D
141	B	D
142	A	B
158	A	B
171	A	B
176	B	B
*Cmpd. No.—Compound Number
*PHAKPA—Asian Soybean Rust (Phakopsora pachyrhizi)
*1 DP—1 Day Protectant
*3 DC—3 Day Curative

Claims

1. A compound of Formula I

2. The compound according to claim 1, wherein X and Y are hydrogen.

3. The compound according to claim 2, wherein R1 and R11 are independently chosen from hydrogen or alkyl.

4. The compound according to claim 2, wherein R3 and R12 are independently aryl, each optionally substituted with 0, 1 or multiple R8.

5. The compound according to claim 2, wherein R4 is H.

6. The compound according to claim 2, wherein R1 and R11 are independently chosen from hydrogen or alkyl, R3 and R12 are independently aryl, each optionally substituted with 0, 1 or multiple R8, and R4 is H.

7. The compound according to claim 1, wherein X is C(O)R5 and Y is hydrogen.

8. The compound according to claim 7, wherein R1 and R11 are independently chosen from hydrogen or alkyl.

9. The compound according to claim 7, wherein R3 and R12 are independently aryl, each optionally substituted with 0, 1 or multiple R8.

10. The compound according to claim 7, wherein R4 is H.

11. The compound according to claim 7, wherein R1 and R11 are independently chosen from hydrogen or alkyl, R3 and R12 are independently aryl, each optionally substituted with 0, 1 or multiple R8, and R4 is H.

12. The compound according to claim 1, wherein X is hydrogen and Y is Q.

13. The compound according to claim 12, wherein Z is N.

14. The compound according to claim 13, wherein R6 is alkoxy.

15. The compound according to claim 14, wherein R7 is hydrogen.

16. The compound according to claim 15, wherein R1 and R11 are independently chosen from hydrogen or alkyl.

17. The compound according to claim 15, wherein R3 and R12 are independently aryl, each optionally substituted with 0, 1 or multiple R8.

18. The compound according to claim 15, wherein R4 is H.

19. The compound according to claim 15, wherein R1 and R11 are independently chosen from hydrogen or alkyl, R3 and R12 are independently aryl, each optionally substituted with 0, 1 or multiple R8, and R4 is H.

20. The compound according to claim 14, wherein R7 is chosen from —C(O)R9, or —CH2OC(O)R9.

21-30. (canceled)