Claims
- 1. A method of treating confusional conditions in the elderly, myasthenia gravis, schizophrenia, mania or glaucoma in a subject in need of such treatment, which comprises administering a therapeutically effective amount of a compound of formula I: ##STR5## wherein R.sub.1 is (C.sub.1-4)alkyl,
- R.sub.2 and R.sub.3 independently are hydrogen or (C.sub.1-4)alkyl,
- R.sub.4 and R.sub.5 together are=0,=S or=NR, wherein R is mono- or di(C.sub.1-4)alkylcarbamoyloxy, or
- R.sub.4 is hydrogen and
- R.sub.5 is hydrogen, hydroxy or --OR', wherein R' is (C.sub.1-4)alkyl or mono- or di(C.sub.1-4)alkylcarbamoyl,
- in free base or acid addition salt form.
- 2. A method according to claim 1 of treating confusional conditions in the elderly.
- 3. A method according to claim 1 wherein
- R.sub.1 is (C.sub.1-4)alkyl,
- R.sub.2 is hydrogen,
- R.sub.3 is ethyl and
- R.sub.4 and R.sub.5 together are=0 or=S,
- in free base or acid addition salt form.
- 4. A method according to claim 1 wherein
- R.sub.1 is methyl,
- R.sub.2 is hydrogen,
- R.sub.3 is (C.sub.1-4)alkyl,
- R.sub.4 and R.sub.5 together are=0 or=S.
- 5. A method according to claim 1, in which 1 to 250 mg. of the compound is administered daily.
- 6. A method according to claim 1, in which 1 to 50 mg. of the compound is administered daily.
- 7. A method according to claim 1, in which 0.25 to 125 mg. of the compound is administered per unit dose.
- 8. The method according to claim 1, in which the compound is (+)-(3S-cis)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-thiophenone in free base or acid addition salt form.
- 9. The method according to claim 1, in which the compound is (+)-(3R-trans)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-thiophenone in free base or acid addition salt form.
- 10. The method according to claim 1, in which the compound is (-)-(3R-trans)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-thiophene-thione in free base or acid addition salt form.
- 11. The method according to claim 1, in which the compound is (-)-dihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-thiophenone in free base or acid addition salt form.
- 12. The method according to claim 1, in which the compound is (.+-.)-3-ethyldihydro-3-methyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-thiophenone in free base or acid addition salt form.
- 13. The method according to claim 1, in which the compound is (+)-(3R-trans)-3-ethyl-2-hydroxy-4-[(1-methyl-1H-imidazol-5-yl)methyl]-tetrahydrothiophene in free base or acid addition salt form.
- 14. The method according to claim 1, in which the compound is (+)-(3S-cis)-3-ethyl-2-hydroxy-4-[(1-methyl-1H-imidazol-5-yl)methyl]-tetrahydrothiophene in free base or acid addition salt form.
- 15. The method according to claim 1, in which the compound is (+)-(3S-cis)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2-methoxy-tetrahydrothiophene in free base or acid addition salt form.
- 16. The method according to claim 1, in which the compound is (+)-(3R-trans)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2-methoxy-tetrahydrothiophene in free base or acid addition salt form.
- 17. The method according to claim 1, in which the compound is (+)-(3R-trans)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2-(N,N-dimethylcarbamoyloxy)-tetrahydrothiophene in free base or acid addition salt form.
- 18. The method according to claim 1, in which the compound is (-)-(3R-trans)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2-(N,N-dimethylcarbamoyl-oximino)-3H-thiophene in free base or acid addition salt form.
Parent Case Info
This is a division of application Ser. No. 07/149,812, filed Jan. 29, 1988 which issued as U.S. Pat. No. 4,835,174 on May 30, 1989.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4581369 |
Tsuruda et al. |
Apr 1986 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
149812 |
Jan 1988 |
|