Claims
- 1. A compound selected from those of formula I: ##STR45## wherein A-B is selected from the group consisting of: CH.sub.2 --CH and CH.dbd.C,
- n is selected from the group consisting of zero and 1 to 6 inclusive,
- D represents one of the following bicyclic systems: ##STR46## wherein: R.sub.1 and R.sub.2, which are identical or different, are each selected from the group consisting of hydrogen, halogen, straight-chain and branched alkyl and alkoxy each having 1 to 5 carbon atoms inclusive, and hydroxy; and
- E represents one of the following heterocycles: ##STR47## with the proviso that E does not represent: ##STR48## when D is ##STR49## its racemic mixtures or racemates and optical isomers or enantiomers and salts thereof with a pharmaceutically acceptable acid.
- 2. A new intermediate product selected from those compounds of formula V: ##STR50## wherein A-B, D, and E are as defined in claim 1 and n' is 1 to 6 inclusive.
- 3. A method for treating a living animal body afflicted with a condition associated with a dysfunction of the dopaminergic system, comprising the step of administering to the living animal body an amount of a compound of claim 1 which is effective for alleviation of said condition.
- 4. A pharmaceutical composition acting as D4 receptor ligand and useful in the alleviation of a dopaminergic system dysfunction, comprising as active ingredient at least one of the compounds according to claim 1, together with one or more pharmaceutical excipients.
- 5. A compound of claim 1 selected from the group consisting of 4-(2,3-dihydrobenzo-1,4-dioxin-6-yl)-1-(indan-2-ylmethyl)piperidine and its dihydrochloride.
- 6. A compound of claim 1 selected from the group consisting of 4-(2,3-dihydrobenzo-1,4-dioxin-6-yl)-1-�(indan-2-yl)methyl!-1,2,3,6-tetrahydropyridine and its fumarate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
95 06436 |
May 1995 |
FRX |
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Parent Case Info
The present application is a division of our prior-filed copending application Ser. No. 08/655,457, filed May 30, 1996, now pending.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3377347 |
Jenny et al. |
Apr 1968 |
|
5232931 |
Prucher et al. |
Aug 1993 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
655457 |
May 1996 |
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