Claims
- 1. A method for treating an angiogenesis-related disease, comprising administering to a subject in need thereof an effective amount of a compound having the formula:
- 2. The method of claim 1, wherein is a double bond.
- 3. The method of claim 2, wherein is a double bond.
- 4. The method of claim 3, wherein Rc is heteroaryl.
- 5. The method of claim 4, wherein Rc is 2-pyridyl substituted with arylalkoxy at position 5 and Rd is H.
- 6. The method of claim 5, wherein the compound is
- 7. The method of claim 2, wherein is a single bond.
- 8. The method of claim 1, wherein is a single bond.
- 9. The method of claim 8, wherein is a single bond.
- 10. The method of claim 9, wherein Rc is heteroaryl.
- 11. The method of claim 10, wherein Rc is 2-pyridyl substituted with arylalkoxy at position 5 and Rd is H.
- 12. The method of claim 11, wherein the compound is
- 13. The method of claim 8, wherein is a double bond.
- 14. A compound having the formula:
- 15. The compound of claim 14, wherein is a double bond.
- 16. The compound of claim 15, wherein is a double bond.
- 17. The compound of claim 16, wherein Ra′ is benzo[1,3]dioxol-5-yl, 4-benzyloxy-2-pyridyl, phenyl, or phenyl substituted with hydroxy or benzyloxy.
- 18. The compound of claim 17, wherein Rb′ is H.
- 19. The compound of claim 18, wherein Re is H.
- 20. The compound of claim 19, wherein R3 is benzyl.
- 21. The compound of claim 20, wherein the compound is
- 22. The compound of claim 15, wherein is a single bond.
- 23. The compound of claim 14, wherein is a single bond.
- 24. The compound of claim 23, wherein is a single bond.
- 25. The compound of claim 24, wherein Rc is 2-pyridyl substituted with arylalkoxy at position 5.
- 26. The compound of claim 25, wherein Rd is H.
- 27. The compound of claim 26, wherein Ra is aryl or heteroaryl.
- 28. The compound of claim 27, wherein Rb is H.
- 29. The compound of claim 28, wherein the compound is
- 30. The compound of claim 23, wherein is a double bond.
CROSS REFERENCE TO RELATED APPLICATION
[0001] This application is a continuation-in-part of U.S. application Ser. No. 09/851,077, filed on May 8, 2001, now U.S. Pat. No. 6,635,649, which claims priority to U.S. Provisional Application 60/304,191, filed on May 9, 2000, now abandoned, which was converted from U.S. Utility application Ser. No. 09/567,271.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60304191 |
May 2000 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09851077 |
May 2001 |
US |
Child |
10689865 |
Oct 2003 |
US |