Claims
- 1. A compound having the formula ##STR18## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen, lower alkyl, aryl of 6 to 12 carbon atoms or halo, or R.sup.1 and R.sup.2 taken together represent --CH.dbd.CH--S--, .dbd.CH--S--CH.dbd., --S--CH.dbd.CH--, ##STR19## where the dotted lines represent optional double bonds; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each, independently, hydrogen, lower alkyl, aryl of 6 to 12 carbon atoms or halo;
- R.sup.7 is 2-pyridinyl, 2-pyrimidinyl, 2-pyrazinyl, 3-pyridazinyl or phenyl or any of
- the foregoing R.sup.7 moieties substituted by lower alkyl, trifluoromethyl,
- cyano, nitro or halo, with the proviso that when R.sup.1 and R.sup.2 taken together represent ##STR20## then R.sup.7 is other than 2-pyridinyl, 2-pyrimidinyl, substituted pyrimidin-2-yl, phenyl or substituted phenyl;
- Z is--(CH.sub.2).sub.n -- or vinylene;
- X is lower alkylene, vinylene or O;
- m is 2-5;
- n is 1-4;
- o is 1-3;
- p is 1-4;
- and the pharmaceutically acceptable salts thereof.
- 2. The compound of claim 1, having the name 3a,4,7,7a-tetrahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 3. The compound of claim 1, having the name 3a,3,7,7a-tetrahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-ethano-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 4. The compound of claim 1, having the name 3a,4,7,7a-tetrahydro-5,6-dimethyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 5. The compound of claim 1, having the name 2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-3a,4,7,7a-tetrahydro-5,6-dimethyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 6. The compound of claim 1, having the name 2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-3a,4,7,7a-tetrahydro-4,7-ethano-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 7. The compound of claim 1, having the name 4,4a,5,5a,6,6a,-hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,6-etheno-2H-cyclopropa[f][1,2]benzisothiazol-3(3aH)-one 1,1 -dixiode.
- 8. The compound of claim 1, having the name 2-[b 4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-4,4a,5,5a,6,6a-hexahydro-4,6-etheno-2H-cyclopropa[f][1,2]-benzisothiazol-3(3aH)-one 1,1-dioxide.
- 9. The compound of claim 1, having the name 3a,.alpha.,4.beta.,7.beta.,7a .alpha.-hexahyro-2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-4,7-epoxy-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 10. The compound of claim 1, having the name 2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 11. The compound of claim 1, having the name 2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]thieno[3,4-d]isothiazol-3(2H)-one 1,1-dioxide.
- 12. The compound of claim 1, having the name 2-[4-[4-(3-chloro-2-pyrazinyl)-piperazinyl]butyl]1,2-benzisothiazol-3(2H)-one 1,1-dixiode.
- 13. The compound of claim 1, having the name 2-[4-[4-(3-chloro-2-pyrazinyl)-1-piperazinyl]butyl]thieno[3,4-d]isothiazol-3(2H)-one 1,1-dioxide.
- 14. The compound of claim 1, having the name 2-[4-[4-(3-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-3a,4,7,7a-tetrahydro-5,6-dimethyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 15. The compound of claim 1, having the name 2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-3a,4,7,7a-tetrahydro-4,7-methano-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 16. The compound of claim 1, having the name 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-3a,4,5,6,7,7a-hexahydro-4,7-methano-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 17. The compound of claim 1, having the name 2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-3a,4,5,6,7,7a-hexahydro-4,7-methano-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 18. The compound of claim 1, having the name hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,6-ethano-2H-cycloprop[f]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 19. The compound of claim 1, having the name 2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]-4,4a,5,5a,6,6a-hexahydro-4,6-etheno-2H-cycloprop[f]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 20. The compound of claim 1, having the name (3a .alpha., 4.beta.,7.beta.,7a .alpha.)-hexahydro-2-[4-[4-(2-pyrazinyl)-1-piperazinyl]butyl]-4,7-epoxy-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 21. The compound of claim 1, having the name (3a.alpha.,4.alpha.,7.alpha.,7a.alpha.)-2-[4-[4-(6-chloro-2-pyrazinyl)-1-piperazinyl]butyl]hexahydro-4,7-epoxy-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
- 22. The compound of claim 1, having the name 3a,4,4a,6a,7,7a-hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-ethenocyclobut[f]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide.
Parent Case Info
This application is a continuation-in-part of U.S. Ser. No. 788,315, filed Oct. 17, 1985, now abandoned.
US Referenced Citations (3)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0109562 |
May 1984 |
EPX |
Non-Patent Literature Citations (2)
Entry |
Traber, et al., "Chemical Abstracts", vol. 101, 1984, Col. 101:204160r. |
Dumpert, et al., "Chemical Abstracts", vol. 102, 1985, Col. 102:197866x, Col. 102:220896m. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
788315 |
Oct 1985 |
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