PIPERAZINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Abstract

The present application describes modulators of MIP-1α of formula (I):

Description

Claims

1. A compound of Formula (I):

2. The compound of claim 1, wherein the compound is a compound of formula (Ia) or (Ib):

3. The compound of claim 1, wherein: T is

4. The compound of claim 1, wherein: T is

5. The compound of claim 1, wherein: T is

6. The compound of claim 1, wherein R4, at each occurrence is alkyl; or any 2 alkyl R4's attached to the same carbon atom may form a 3-6 membered ring, which optionally may contain 0-4 heteroatoms selected from N, O, and S; and m is 1 or 2.

7. The compound of claim 6, wherein: T is

8. The compound of claim 6, wherein: T is

9. The compound of claim 1, wherein the compound is a compound of formula (Ic):

10. The compound of claim 9, wherein: T is

11. The compound of claim 9, wherein: T is

12. The compound of claim 1, wherein the compound is a compound of formula (Id):

13. The compound of claim 12, wherein: T is

14. The compound of claim 12, wherein: T is

15. The compound of claim 1, wherein the compound is a compound of formula (Ie):

16. The compound of claim 15, wherein: T is

17. The compound of claim 15, wherein: T is

18. A compound selected from the compounds exemplified in the examples.

19. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound of claim 1.

20. A method for treating a disorder comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of claim 1, wherein said disorder is selected from osteoarthritis, aneurysm, fever, cardiovascular effects, Crohn's disease, congestive heart failure, autoimmune diseases, HIV-infection, HIV-associated dementia, psoriasis, idiopathic pulmonary fibrosis, transplant arteriosclerosis, physically- or chemically-induced brain trauma, inflammatory bowel disease, alveolitis, colitis, systemic lupus erythematosus, nephrotoxic serum nephritis, glomerularnephritis, asthma, multiple sclerosis, artherosclerosis, rheumatoid arthritis, restinosis, organ transplantation, psoriatic arthritis, multiple myeloma, allergies, hepatocellular carcinoma, osteoporosis, renal fibrosis and cancer.

21. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound of claim 6.

22. A method for treating a disorder comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of claim 6, wherein said disorder is selected from osteoarthritis, aneurysm, fever, cardiovascular effects, Crohn's disease, congestive heart failure, autoimmune diseases, HIV-infection, HIV-associated dementia, psoriasis, idiopathic pulmonary fibrosis, transplant arteriosclerosis, physically- or chemically-induced brain trauma, inflammatory bowel disease, alveolitis, colitis, systemic lupus erythematosus, nephrotoxic serum nephritis, glomerularnephritis, asthma, multiple sclerosis, artherosclerosis, rheumatoid arthritis, restinosis, organ transplantation, psoriatic arthritis, multiple myeloma, allergies, hepatocellular carcinoma, osteoporosis, renal fibrosis and cancer.

23. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound of claim 9.

24. A method for treating a disorder comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of claim 9, wherein said disorder is selected from osteoarthritis, aneurysm, fever, cardiovascular effects, Crohn's disease, congestive heart failure, autoimmune diseases, HIV-infection, HIV-associated dementia, psoriasis, idiopathic pulmonary fibrosis, transplant arteriosclerosis, physically- or chemically-induced brain trauma, inflammatory bowel disease, alveolitis, colitis, systemic lupus erythematosus, nephrotoxic serum nephritis, glomerularnephritis, asthma, multiple sclerosis, artherosclerosis, rheumatoid arthritis, restinosis, organ transplantation, psoriatic arthritis, multiple myeloma, allergies, hepatocellular carcinoma, osteoporosis, renal fibrosis and cancer.

25. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound of claim 12.

26. A method for treating a disorder comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of claim 12, wherein said disorder is selected from osteoarthritis, aneurysm, fever, cardiovascular effects, Crohn's disease, congestive heart failure, autoimmune diseases, HIV-infection, HIV-associated dementia, psoriasis, idiopathic pulmonary fibrosis, transplant arteriosclerosis, physically- or chemically-induced brain trauma, inflammatory bowel disease, alveolitis, colitis, systemic lupus erythematosus, nephrotoxic serum nephritis, glomerularnephritis, asthma, multiple sclerosis, artherosclerosis, rheumatoid arthritis, restinosis, organ transplantation, psoriatic arthritis, multiple myeloma, allergies, hepatocellular carcinoma, osteoporosis, renal fibrosis and cancer.

27. A pharmaceutical composition comprised of a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound of claim 15.

28. A method for treating a disorder comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of claim 15, wherein said disorder is selected from osteoarthritis, aneurysm, fever, cardiovascular effects, Crohn's disease, congestive heart failure, autoimmune diseases, HIV-infection, HIV-associated dementia, psoriasis, idiopathic pulmonary fibrosis, transplant arteriosclerosis, physically- or chemically-induced brain trauma, inflammatory bowel disease, alveolitis, colitis, systemic lupus erythematosus, nephrotoxic serum nephritis, glomerularnephritis, asthma, multiple sclerosis, artherosclerosis, rheumatoid arthritis, restinosis, organ transplantation, psoriatic arthritis, multiple myeloma, allergies, hepatocellular carcinoma, osteoporosis, renal fibrosis and cancer.