Claims
- 1. A compound of formula I ##STR6## wherein R.sup.3 is 3,4-methylenedioxyphenyl, phenyl or naphthyl, each of which may be optionally substituted with halogen, amino, amino which is substituted with one or two C.sub.1-6 -alkyl groups, C.sub.1-6 -alkoxy, cyano, trifluoromethyl, C.sub.2-6 alkenyl, C.sub.1-6 -alkyl, C.sub.3-5 -alkylene, trifluoromethoxy, hydroxy or C.sub.1-4 -alkyl substituted with hydroxy;
- n is 0, 1, 2, 3 or 4;
- R.sup.1 is hydrogen, straight or branched C.sub.1-8 -alkyl, C.sub.1-8 -alkoxy-C.sub.1-8 -alkyl, C.sub.3-8 -cycloalkyl, C.sub.2-6 -alkenyl, C.sub.4-8 -cycloalkylalkyl, acetyl or C.sub.2-6 -alkynyl; and
- Y is NR wherein R is hydrogen or C.sub.1-5 -alkyl;
- X is halogen, C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl, C.sub.3-8 -cycloalkyl, C.sub.4-8 -cycloalkylalkyl, C.sub.1-6 -alkoxy, cyano, mono- or poly- halogenated C.sub.1-6 -alkyl, hydroxy or hydrogen; or a pharmaceutically acceptable salt thereof.
- 2. The compound according to claim 1, wherein n is 0.
- 3. The compound according to claim 1, wherein n is 1.
- 4. The compound according to claim 1, wherein R.sup.1 is butyl.
- 5. The compound according to claim 1, wherein X is hydrogen.
- 6. A compound according to claim 1 which is:
- 1-butyl-3-(4-methoxybenzylaminomethyl)-4-phenylpiperidine;
- 1-butyl-3-(4-trifluoromethylphenylaminomethyl)-4-phenylpiperidine;
- (-) trans-1-butyl-3-(2-phenylethylaminomethyl)-4-phenylpiperidine; or
- a pharmaceutically acceptable salt thereof.
- 7. A pharmaceutical composition for treating anoxia, cerebral ischemia, migraine or epilepsy comprising an effective amount of a compound according to claim 1 together with a pharmaceutically acceptable carrier or diluent.
- 8. The pharmaceutical composition according to claim 7 in the form of an oral dosage unit containing 1-100 mg of the active compound.
- 9. A method of treating anoxia, cerebral ischemia, migraine or epilepsy, comprising administering to a subject in need thereof an effective amount of a compound according to claim 1.
- 10. A method of treating anoxia, cerebral ischemia, migraine or epilepsy, comprising administering to a subject in need thereof a pharmaceutical composition according to claim 7.
Priority Claims (2)
Number |
Date |
Country |
Kind |
DK1724/90 |
Jul 1990 |
DKX |
|
DK0117/91 |
Jan 1991 |
DKX |
|
Parent Case Info
This application is a continuation application of co-pending application Ser. No. 07/728,930, filed Jul. 12, 1991, the contents of which are incorporated herein by reference.
US Referenced Citations (5)
Foreign Referenced Citations (2)
Number |
Date |
Country |
0190496 |
Aug 1986 |
EPX |
0339579 |
Feb 1989 |
EPX |
Non-Patent Literature Citations (3)
Entry |
Greenberg "Current Neurology" by Appel, pp. 93-109 (1987). |
Scarpelli "Cell Injury" pp. 44-45 Apr., 1986. |
Nachshen "The Effect of Some Organic Calcium Antagonist on Cainylux in Presynoptic Nerve Terminals" Mol. Pharm. 16 579-586 (1979). |
Continuations (1)
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Number |
Date |
Country |
Parent |
728930 |
Jul 1991 |
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