Patent Application
20090263516
The invention pertains to the field of modulators of cellular activity, specifically within the field of inhibitors of extracellular proteases.
The cells of tissues are generally in contact with a network of large extracellular macromolecules that occupies the spaces in a tissue between the component cells and also occupies the space between adjacent tissues. This extracellular matrix functions as a scaffolding on which the cells and tissue are supported and is involved actively in regulating interaction of the cells that contact it. The principal macromolecules of the extracellular matrix include the collagens (the most abundant proteins in the body) and glycosaminoglycans (complex polysaccharides which are usually bonded also to protein and then termed proteoglycans). The macromolecules that comprise the extracellular matrix are produced typically by the cells in contact therewith, for example, epithelial cells in contact with a basement membrane and fibroblasts embedded in connective tissue.
The glycosaminoglycan (proteoglycan) molecules form a highly hydrated matrix (a gel) in which elastic or fibrous proteins (such as collagen fibres) are embedded. The aqueous nature of the gel permits diffusion of metabolically required substances between the cells of a tissue and between tissues. Additional proteins that may be found in extracellular matrix include elastin, fibronectin and laminin.
The term “connective tissue” refers to extracellular matrix plus specialised cells such as, for example, fibroblasts, chondrocytes, osteoblasts, macrophages and mast cells found therein. The term “interstitial tissue” is best reserved for an extracellular matrix that stabilises a tissue internally, filling the gaps between the cells thereof. There are also specialised forms of extracellular matrix (connective tissue) that have additional functional roles-cornea, cartilage and tendon, and when calcified, the bones and teeth.
A structural form of extracellular matrix is the basal lamina (basement membrane). Basal laminae are thin zones of extracellular matrix that are found under epithelium or surrounding, for example, muscle cells or the cells that electrically insulate nerve fibres. Generally speaking, basal laminae separate cell layers from underlying zones of connective tissue or serve as a boundary between two cell layers wherein a basal lamina can serve as a pathway for invading cells associated with pathologic processes, or for structural organisation associated with tissue repair (i.e. as a blueprint from which to regenerate original tissue architecture and morphology).
The regulated turnover of extracellular matrix macromolecules is critical to a variety of important biological processes. Localised degradation of matrix components is required when cells migrate through a basal lamina, as when white blood cells migrate across the vascular basal lamina into tissues in response to infection or injury, or when cancer cells migrate from their site of origin to distant organs via the bloodstream or lymphatic vessels, during metastasis. In normal tissues, the activity of extracellular proteases is tightly regulated and the breakdown/production of connective tissue is in dynamic equilibrium, such that there is a slow and continual turnover due to degradation and resynthesis in the extracellular matrix of adult animals.
In each of these cases, matrix components are degraded by extracellular proteolytic enzymes that are secreted locally by cells. These proteases belong to one of four general classes: many are metalloproteinases, which depend on bound Ca2+ or Zn2+ for activity, while the others are serine, aspartic and cysteine proteases, which have a highly reactive serine, aspartate or cysteine residue in their respective active site (Vincenti et al., (1994) Arthritis and Rheumatism, 37: 1115-1126). Together, metalloproteinases, serine, aspartate and cysteine proteases cooperate to degrade matrix proteins such as collagen, laminin, and fibronectin.
Several mechanisms operate to ensure that the degradation of matrix components is tightly controlled. First, many proteases are secreted as inactive precursors that can be activated locally. Second, the action of proteases is confined to specific areas by various secreted protease inhibitors, such as the tissue inhibitors of metalloproteases and the serine protease inhibitors known as serpins. These inhibitors are specific for particular proteases and bind tightly to the activated enzyme to block its activity. Third, many cells have receptors on their surface that bind proteases, thereby confining the enzyme to where it is needed.
Many pathogenic bacteria produce extracellular metalloproteases, of which many are zinc containing proteases that can be classified into two families, the thermolysin (neutral) proteases and the serralysin (alkaline) proteases.
A number of patents and publications report the inhibition of one or more extracellular proteases by compounds extracted from plants. For example, Sun et al., (1996) Phytotherapy Res., 10: 194-197, reports the inhibition in vitro of stromelysin (MMP-3) and collagenase by betulinic acid extracted from Doliocarpus verruculosis. Sazuka et al, (1997) Biosci. Biotechnol. Biochem., 61: 1504-1506, reports the inhibition of gelatinases (MMP-2 and MMP-9) and metastasis by compounds isolated from green and black teas. Kumagai et al, JP 08104628 A2, Apr. 1, 1996 (CA 125: 67741) reports the use of flavones and anthocyanines isolated from Scutellaris baicanlensis roots to inhibit collagenase. Gervasi et al., (1996) Biochem. Biophys. Res. Comm., 228: 530-538, reports the regulation of MMP-2 by some plant lectins and other saccharides. Dubois et al., (1998) FEBS Lett., 427: 275-278, reports the increased secretion of deleterious gelatinase-B (MMP-9) by some plant lectins. Nagase et al., (1998) Planta Med., 64: 216-219, reports the weak inhibition of collagenase (MMPs) by delphinidin, a flavonoid isolated from Solanum melongena. Other reports discuss the use of extracts to inhibit extracellular proteases. For example, Asano et al., (1998) Immunopharmacology, 39: 117-126, reports the inhibition of TNF-α production using Tripterygium wilfordii Hook F. extracts. Maheu et al., (1998) Arthritis Rheumatol., 41: 81-91, reports the use of avocado/soy bean non-saponifiable extracts in the treatment of arthritis. Makimura et al., (1993) J. Periodontol., 64: 630-636, also reports the use of green tea extracts to inhibit collagenases in vitro. Obayashi et al., (1998) Nippon Keshonin Gijutsusha Kaishi, 32: 272-279 (CA 130: 92196) reports the inhibition of collagenase-I (MMP-1) from human fibroblast and neutrophil elastase by plant extract from Eucalyptus and Elder.
When a plant is stressed, several biochemical processes are activated and many new chemicals, in addition to those constitutively expressed, are synthesised as a response. These chemicals include enzymes, enzyme inhibitors (especially protease inhibitors), lectins, alkaloids, terpenes, oligosaccharides, and antibiotics. The biosynthesis of these defense chemicals and secondary metabolites is not yet fully understood. The most studied system is the production of protease inhibitors following pest attack or mechanical wounding. On the other hand, several inducible chemicals are the products of complex biochemical pathways, which require several biosynthetic enzymes to be activated.
It has been shown that many chemicals can be used to “stress” plants and to artificially stimulate biosynthesis of several new and constitutive defense chemicals. Also, different types of stress can activate distinct metabolic defense pathways, thereby leading to production of a variety of chemicals. Although the various biosynthetic defense pathways share some similarities, these pathways are characteristic of specific plant species. Therefore, treating many plants with many types of stress can lead to a vast number of collections of diverse chemicals from plant origin.
In addition to pests, fungi, and other pathogenic attacks, stressors include drought, heat, water and mechanical wounding. Furthermore, many chemicals can act as stressors that activate gene expression; these include: hydrogen peroxide, ozone, sodium chloride, jasmonic acid and derivatives, α-linoleic acid, γ-linoleic acid, salicylic acid, abscesic acid, volicitin, small oligopeptides, among others.
The use of abiotic stressors on plants has been the focus of intense studies in plant science. Artificial stresses have been used to stimulate the production of natural plant protease inhibitors for insect digestive proteases, in order to enhance crop protection against certain pests and herbivores. They have proven useful in combination with plants genetically modified to express other protease inhibitor genes. Finally, in the area of molecular farming, stresses have been used to stimulate gene expression in plants genetically modified to include an inducible coding sequence for a protein of nutraceutical and/or medicinal interest (Ryan and Farmer, U.S. Pat. No. 5,935,809).
Likewise, the use of gene activators or elicitors have been described to enhance the production of volatile chemicals in plant cell cultures. These elicitors have been demonstrated to induce the activity of several enzymes such as for example phenylalanine ammonia lyase, therefore leading to an increase in the production of plant volatile components.
An object of the invention is to provide plant extract compositions and their use to modulate cellular activity. In accordance with one aspect of the present invention, there is provided a plant extract that inhibits the activity of at least one extracellular protease, said extract having at least one of the following properties: (i) is capable of slowing down or inhibiting migration of endothelial cells, and (ii) is capable of slowing down or inhibiting migration of neoplastic cells.
In accordance with another aspect of the present invention, there is provided a sub-library of plant extracts, said sub-library being prepared by a process comprising:
In accordance with another aspect of the present invention, there is provided a pharmaceutical composition comprising a plant extract of the invention and a pharmaceutically acceptable diluent, excipient or carrier.
In accordance with another aspect of the present invention, there is provided a use of a plant extract of the invention to slow down, inhibit or prevent angiogenesis in an animal in need thereof.
In accordance with another aspect of the present invention, there is provided a use of a plant extract of the invention to slow down, inhibit or prevent metastasis in an animal in need thereof.
In accordance with another aspect of the present invention, there is provided a use of a plant extract of the invention in the manufacture of a medicament.
In accordance with another aspect of the present invention, there is provided a use of a plant extract to slow down cell migration in an animal in need thereof, wherein said plant extract inhibits the activity of at least one extracellular protease and has at least one of the following properties: (i) is capable of slowing down or inhibiting migration of endothelial cells, and (ii) is capable of slowing down or inhibiting migration of neoplastic cells.
In accordance with another aspect of the present invention, there is provided a process for preparing a sub-library of plant extracts that are capable of slowing down or inhibiting cell migration, said process comprising:
In accordance with another aspect of the present invention, there is provided a process for identifying a plant extract capable of inhibiting cell migration, said process comprising:
In accordance with another aspect of the present invention, there is provided a plant extract produced by the above process.
The present invention provides for extracts from plant material, or semi-purified/purified molecules or compounds prepared from the extracts, that are capable of inhibiting one or more extracellular protease and that demonstrate the ability to modulate one or more cellular activities. In one embodiment of the invention the extracts are capable of slowing down, inhibiting or preventing cell migration, for example, the migration of endothelial cells or neoplastic cells. The present invention also provides for the use of the extracts to slow down, inhibit or prevent abnormal cell migration in an animal, and thus can be used, for example, in the alleviation of conditions where there is a need to slow down angiogenesis or neoplastic cell invasion.
The present invention further provides for methods of selecting and preparing the plant extracts and for methods of screening the extracts to determine their ability to modulate one or more cellular activity. The invention additionally provides for the purification or semi-purification of one or more molecules from the extract and for the use of the semi-purified/purified molecules, alone or in combination with an extract, to slow down, inhibit or prevent abnormal cell migration in an animal.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The term “potential plants,” as used herein, is intended to include all species of the Kingdom Plantae, including terrestrial, aquatic or other plants under the Division Chlorophyta, Division Rhodophora, Division Paeophyta, Division Bryophyta and Division Tracheophyta; Subdivision Lycopsida, Subdivision Sphenopsida, Subdivision Pteropsida and Subdivision Spermopsida; Class Gymnospermae, Class Angiospermae, Subclass Dicotyledonidae and Subclass Monocotyledonidae. In general terms, all plants, herbs, and lower plants such as fungi and algae are considered to be potential plants in accordance with the present invention.
The term “plant material,” as used herein, refers to any part or parts of a plant taken either individually or in a group. Examples include, but are not limited to, leaves, flowers, roots, seeds, stems, and other part of a plant, including those plants described herein as potential plants of the invention.
The term “extracellular protease,” as used herein, refers to an enzyme that is capable of degrading proteins (i.e. proteolysis) and which is secreted outside the cell. The cell can be prokaryotic or eukaryotic. Examples of extracellular proteases include, but are not limited to, matrix metalloproteases (MMPs), cathepsins, elastase, plasmin, TPA, uPA, kallikrein, ADAMS family members, neprilysin, gingipain, clostripain, thermolysin, serralysin, and other bacterial and viral proteases.
The term “panel of extracellular proteases,” refers to an array of distinct extracellular proteases that are used to perform routine assays to monitor the presence or absence of inhibitory activity throughout an extraction process of the invention. A panel typically comprises at least two proteases, but may for some purposes comprise as few as one protease. One skilled in the art would appreciate that as high throughput screening techniques develop, one could routinely assay for the presence or absence of inhibitory activity against as many extracellular proteases as the technology permits.
The term “potential pre-extract,” refers to refers to a composition prepared by contacting a solvent with plant material following the procedures described herein, which has not yet been determined to possess inhibitory activity against one or more extracellular protease.
The term “potential extract,” as used herein, refers to a potential pre-extract that has been subjected to one or more separation and/or purification step.
The term “extract of the invention,” as used herein, refers to a composition prepared by contacting a solvent with plant material following the procedures described herein, which demonstrates inhibitory activity against one or more extracellular protease and demonstrates an ability to modulate one or more cellular activity.
The term “protease inhibitor,” as used herein, refers to a molecule or compound that attenuates the proteolytic activity of proteases. A protease inhibitor may or may not be proteinaceous.
The term “stressor,” as used herein, refers to a factor, such as a physical stress, a chemical compound, or a biological agent that is used to elicit production of extracellular protease inhibitors as a result of activation of a defense response in a plant. Elicitors and inducers are also considered to be stressors.
The term “substantially purified” or “substantially pure” or “isolated,” when used in reference to a molecule or molecules having protease inhibitor activity, refers to a form of the molecule(s) that is relatively free of proteins, nucleic acids, lipids, carbohydrates or other materials with which it is naturally associated in a plant. As disclosed herein, a plant extract of the invention is considered to be substantially purified, in that it is removed from the plant tissue from which it is derived. In addition, molecules or compounds having protease inhibitor activity that are present within the extract can be further purified using routine and well-known methods such as those described herein. As such, a substantially pure protease inhibitor of the invention can constitute at least about one or a few percent of a sample, for example, at least about five percent of a sample. In one embodiment, the substantially pure protease inhibitor constitutes at least about twenty percent of a sample. In another embodiment, the protease inhibitor can be further purified to constitute at least about fifty percent of a sample. In a further embodiment, the protease inhibitor can be further purified to constitute at least about eighty percent of a sample. In other embodiments, the protease inhibitor can be further purified to constitute at least about ninety percent or at least about ninety-five percent or more of a sample. A determination that a protease inhibitor of the invention is substantially pure can be made using methods such as those disclosed herein or otherwise known in the art, for example, by performing electrophoresis and identifying the particular molecule as a relatively discrete band.
The term “cell migration,” as used herein, refers to the movement, typically abnormal, of a cell or cells from one locus to another. Examples of cell migration include the movement of cells through the extracellular matrix and/or basal lamina during angiogenesis or cell invasion.
Other chemistry terms herein are used according to conventional usage in the art, as exemplified by The McGraw-Hill Dictionary of Chemical Terms (ed. Parker, S., 1985), McGraw-Hill, San Francisco, incorporated herein by reference).
With reference to
Plant material suitable for use in preparing an extract of the invention is derived from a “potential plant.” Potential plants include all species of the Kingdom Plantae, including terrestrial, aquatic or other plants that can be subjected to the methodology described herein in order to generate an extract that can be tested against a panel of extracellular proteases. Those plants which yield an extract demonstrating inhibitory activity against an extracellular protease and an ability to modulate cellular activity are considered to be plants and extracts comprising the subject matter of the invention.
Examples of potential plants include, but are not limited to, those belonging to the following classifications: Superdivision Spermatophyta—Seed plants; Division Coniferophyta—Conifers; Class Pinopsida, Order Pinales; Family Araucariaceae—Araucaria family; Family Cephalotaxaceae—Plum Yew family; Family Cupressaceae—Cypress family; Family Pinaceae—Pine family; Family Podocarpaceae—Podocarpus family; Family Taxodiaceae—Redwood family; Order Taxales, Family Taxaceae—Yew family; Division Cycadophyta—Cycads, Class Cycadopsida, Order Cycadales, Family Cycadaceae—Cycad family; Family Zamiaceae—Sago-palm family; Division Ginkgophyta—Ginkgo, Class Ginkgoopsida, Order Ginkgoales, Family Ginkgoaceae—Ginkgo family; Division Gnetophyta—Mormon tea and other gnetophytes, Class Gnetopsida, Order Ephedrales, Family Ephedraceae—Mormon-tea family; Order Gnetales, Family Gnetaceae—Gnetum family; Division Magnoliophyta—Flowering plants, Class Liliopsida—Monocotyledons, Subclass Alismatidae, Order Alismatales, Family Alismataceae—Water-plantain family, Family Butomaceae—Flowering Rush family, Family Limnocharitaceae—Water-poppy family; Order Hydrocharitales, Family Hydrocharitaceae—Tape-grass family; Order Najadales, Family Aponogetonaceae—Cape-pondweed family, Family Cymodoceaceae—Manatee-grass family, Family Juncaginaceae—Arrow-grass family, Family Najadaceae—Water-nymph family, Family Posidoniaceae—Posidonia family, Family Potamogetonaceae—Pondweed family, Family Ruppiaceae—Ditch-grass family, Family Scheuchzeriaceae—Scheuchzeria family, Family Zannichelliaceae—Horned pondweed family, Family Zosteraceae—Eel-grass family; Subclass Arecidae, Order Arales, Family Acoraceae—Calamus family, Family Araceae—Arum family, Family Lemnaceae—Duckweed family; Order Arecales, Family Arecaceae—Palm family; Order Cyclanthales, Family Cyclanthaceae—Panama Hat family; Order Pandanales, Family Pandanaceae—Screw-pine family; Subclass Commelinidae, Order Commelinales, Family Commelinaceae—Spiderwort family, Family Mayacaceae—Mayaca family, Family Xyridaceae—Yellow-eyed Grass family; Order Cyperales, Family Cyperaceae—Sedge family, Family Poaceae—Grass family; Order Eriocaulales, Family Eriocaulaceae—Pipewort family; Order Juncales, Family Juncaceae—Rush family; Order Restionales, Family Joinvilleaceae—Joinvillea family; Order Typhales, Family Sparganiaceae—Bur-reed family, Family Typhaceae—Cat-tail family; Subclass Liliidae, Order Liliales, Family Agavaceae—Century-plant family, Family Aloeaceae—Aloe family, Family Dioscoreaceae—Yam family, Family Haemodoraceae—Bloodwort family, Family Hanguanaceae—Hanguana family, Family Iridaceae—Iris family, Family Liliaceae—Lily family, Family Philydraceae—Philydraceae family, Family Pontederiaceae—Water-Hyacinth family, Family Smilacaceae—Catbrier family, Family Stemonaceae—Stemona family, Family Taccaceae—Tacca family; Order Orchidales, Family Burmanniaceae—Burmannia family, Family Orchidaceae—Orchid family; Subclass Zingiberidae, Order Bromeliales, Family Bromeliaceae—Bromeliad family; Order Zingiberales, Family Cannaceae—Canna family, Family Costaceae—Costus family, Family Heliconiaceae—Heliconia family, Family Marantaceae—Prayer-Plant family, Family Musaceae—Banana family, Family Zingiberaceae—Ginger family; Class Magnoliopsida—Dicotyledons, Subclass Asteridae, Order Asterales, Family Asteraceae—Aster family; Order Callitrichales, Family Callitrichaceae—Water-starwort family, Family Hippuridaceae—Mare's-tail family; Order Calycerales, Family Calyceraceae—Calycera family; Order Campanulales, Family Campanulaceae—Bellflower family, Family Goodeniaceae—Goodenia family, Family Sphenocleaceae—Spenoclea family; Order Dipsacales, Family Adoxaceae—Moschatel family, Family Caprifoliaceae—Honeysuckle family, Family Dipsacaceae—Teasel family, Family Valerianaceae—Valerian family; Order Gentianales, Family Apocynaceae—Dogbane family, Family Asclepiadaceae—Milkweed family, Family Gentianaceae—Gentian family, Family Loganiaceae—Logania family; Order Lamiales, Family Boraginaceae—Borage family, Family Lamiaceae—Mint family, Family Lennoaceae—Lennoa family, Family Verbenaceae—Verbena family; Order Plantaginales, Family Plantaginaceae—Plantain family; Order Rubiales, Family Rubiaceae—Madder family; Order Scrophulariales, Family Acanthaceae—Acanthus family, Family Bignoniaceae—Trumpet-creeper family, Family Buddlejaceae—Butterfly-bush family, Family Gesneriaceae—Gesneriad family, Family Lentibulariaceae—Bladderwort family, Family Myoporaceae—Myoporum family, Family Oleaceae—Olive family, Family Orobanchaceae—Broom-rape family, Family Pedaliaceae—Sesame family, Family Scrophulariaceae—Figwort family; Order Solanales, Family Convolvulaceae—Morning-glory family, Family Cuscutaceae—Dodder family, Family Fouquieriaceae—Ocotillo family, Family Hydrophyllaceae—Waterleaf family, Family Menyanthaceae—Buckbean family, Family Polemoniaceae—Phlox family, Family Solanaceae—Potato family; Subclass Caryophyllidae, Order Caryophyllales, Family Achatocarpaceae—Achatocarpus family, Family Aizoaceae—Fig-marigold family, Family Amaranthaceae—Amaranth family, Family Basellaceae—Basella family, Family Cactaceae—Cactus family, Family Caryophyllaceae—Pink family, Family Chenopodiaceae—Goosefoot family, Family Molluginaceae—Carpet-weed family, Family Nyctaginaceae—Four o'clock family, Family Phytolaccaceae—Pokeweed family, Family Portulacaceae—Purslane family; Order Plumbaginales, Family Plumbaginaceae—Leadwort family; Order Polygonales, Family Polygonaceae—Buckwheat family; Subclass Dilleniidae, Order Batales, Family Bataceae—Saltwort family; Order Capparales, Family Brassicaceae—Mustard family, Family Capparaceae—Caper family, Family Moringaceae—Horse-radish tree family, Family Resedaceae—Mignonette family; Order Diapensiales, Family Diapensiaceae—Diapensia family; Order Dilleniales, Family Dilleniaceae—Dillenia family, Family Paeoniaceae—Peony family; Order Ebenales, Family Ebenaceae—Ebony family, Family Sapotaceae—Sapodilla family, Family Styracaceae—Storax family, Family Symplocaceae—Sweetleaf family; Order Ericales, Family Clethraceae—Clethra family, Family Cyrillaceae—Cyrilla family, Family Empetraceae—Crowberry family, Family Epacridaceae—Epacris family, Family Ericaceae—Heath family, Family Monotropaceae—Indian Pipe family, Family Pyrolaceae—Shinleaf family; Order Lecythidales, Family Lecythidaceae—Brazil-nut family; Order Malvales, Family Bombacaceae—Kapok-tree family, Family Elaeocarpaceae—Elaeocarpus family, Family Malvaceae—Mallow family, Family Sterculiaceae—Cacao family, Family Tiliaceae—Linden family; Order Nepenthales, Family Droseraceae—Sundew family, Family Nepenthaceae—East Indian Pitcher-plant family, Family Sarraceniaceae—Pitcher-plant family; Order Primulales, Family Myrsinaceae—Myrsine family, Family Primulaceae—Primrose family, Family Theophrastaceae—Theophrasta family; Order Salicales, Family Salicaceae—Willow family; Order Theales, Family Actinidiaceae—Chinese Gooseberry family, Family Caryocaraceae—Souari family, Family Clusiaceae—Mangosteen family, Family Dipterocarpaceae—Meranti family, Family Elatinaceae—Waterwort family, Family Marcgraviaceae—Shingle Plant family, Family Ochnaceae—Ochna family, Family Theaceae—Tea family; Order Violales, Family Begoniaceae—Begonia family, Family Bixaceae—Lipstick-tree family, Family Caricaceae—Papaya family, Family Cistaceae—Rock-rose family, Family Cucurbitaceae—Cucumber family, Family Datiscaceae—Datisca family, Family Flacourtiaceae—Flacourtia family, Family Frankeniaceae—Frankenia family, Family Loasaceae—Loasa family, Family Passifloraceae—Passion-flower family, Family Tamaricaceae—Tamarix family, Family Turneraceae—Turnera family, Family Violaceae—Violet family; Subclass Hamamelidae, Order Casuarinales, Family Casuarinaceae—She-oak family; Order Fagales, Family Betulaceae—Birch family, Family Fagaceae—Beech family; Order Hamamelidales, Family Cercidiphyllaceae—Katsura-tree family, Family Hamamelidaceae—Witch-hazel family, Family Platanaceae—Plane-tree family; Order Juglandales, Family Juglandaceae—Walnut family; Order Leitneriales, Family Leitneriaceae—Corkwood family; Order Myricales, Family Myricaceae—Bayberry family; Order Urticales, Family Cannabaceae—Hemp family, Family Cecropiaceae—Cecropia family, Family Moraceae—Mulberry family, Family Ulmaceae—Elm family, Family Urticaceae—Nettle family; Subclass Magnoliidae, Order Aristolochiales, Family Aristolochiaceae—Birthwort family; Order Illiciales, Family Illiciaceae—Star-anise family, Family Schisandraceae—Schisandra family; Order Laurales, Family Calycanthaceae—Strawberry-shrub family, Family Hernandiaceae—Hemandia family, Family Lauraceae—Laurel family, Family Monimiaceae—Monimia family; Order Magnoliales, Family Annonaceae—Custard-apple family, Family Canellaceae—Canella family, Family Magnoliaceae—Magnolia family, Family Myristicaceae—Nutmeg family, Family Sonneratiaceae—Sonneratia family, Family Winteraceae—Wintera family; Order Nymphaeales, Family Cabombaceae—Water-shield family, Family Ceratophyllaceae—Hornwort family, Family Nelumbonaceae—Lotus-lily family, Family Nymphaeaceae—Water-lily family; Order Papaverales, Family Fumariaceae—Fumitory family, Family Papaveraceae—Poppy family; Order Piperales, Family Chloranthaceae—Chloranthus family, Family Piperaceae—Pepper family, Family Saururaceae—Lizard's-tail family; Order Ranunculales, Family Berberidaceae—Barberry family, Family Lardizabalaceae—Lardizabala family, Family Menispermaceae—Moonseed family, Family Ranunculaceae—Buttercup family, Family Sabiaceae—Sabia family; Subclass Rosidae, Order Apiales, Family Apiaceae—Carrot family, Family Araliaceae—Ginseng family; Order Celastrales, Family Aquifoliaceae—Holly family, Family Celastraceae—Bittersweet family, Family Corynocarpaceae—Karaka family, Family Hippocrateaceae—Hippocratea family, Family Icacinaceae—Icacina family, Family Stackhousiaceae—Stackhousia family; Order Cornales, Family Cornaceae—Dogwood family, Family Garryaceae—Silk Tassel family, Family Nyssaceae—Sour Gum family; Order Euphorbiales, Family Buxaceae—Boxwood family, Family Euphorbiaceae—Spurge family, Family Simmondsiaceae—Jojoba family; Order Fabales, Family Fabaceae—Pea family; Order Geraniales, Family Balsaminaceae—Touch-me-not family, Family Geraniaceae—Geranium family, Family Limnanthaceae—Meadow-Foam family, Family Oxalidaceae—Wood-Sorrel family, Family Tropaeolaceae—Nasturtium family; Order Haloragales, Family Gunneraceae—Gunnera family, Family Haloragaceae—Water Milfoil family; Order Linales Family Erythroxylaceae—Coca family, Family Linaceae—Flax family; Order Myrtales, Family Combretaceae—Indian Almond family, Family Lythraceae—Loosestrife family, Family Melastomataceae—Melastome family, Family Myrtaceae—Myrtle family, Family Onagraceae—Evening Primrose family, Family Punicaceae—Pomegranate family, Family Thymelaeaceae—Mezereum family, Family Trapaceae—Water Chestnut family; Order Podostemales, Family Podostemaceae—River-weed family; Order Polygalales, Family Krameriaceae—Krameria family, Family Malpighiaceae—Barbados Chemy family, Family Polygalaceae—Milkwort family; Order Proteales, Family Proteaceae—Protea family; Order Rafflesiales, Family Rafflesiaceae—Rafflesia family; Order Rhamnales, Family Elaeagnaceae—Oleaster family, Family Rhamnaceae—Buckthorn family, Family Vitaceae—Grape family; Order Rhizophorales, Family Rhizophoraceae—Red Mangrove family; Order Rosales, Family Brunelliaceae—Brunellia family, Family Chrysobalanaceae—Cocoa-plum family, Family Connaraceae—Cannarus family, Family Crassulaceae—Stonecrop family, Family Crossosomataceae—Crossosoma family, Family Cunoniaceae—Cunonia family, Family Grossulariaceae—Currant family, Family Hydrangeaceae—Hydrangea family, Family Pittosporaceae—Pittosporum family Family Rosaceae—Rose family, Family Saxifragaceae—Saxifrage family, Family Surianaceae—Suriana family; Order Santalales, Family Balanophoraceae—Balanophora family, Family Eremolepidaceae—Catkin-mistletoe family, Family Loranthaceae—Showy Mistletoe family, Family Olacaceae—Olax family, Family Santalaceae—Sandalwood family, Family Viscaceae—Christmas Mistletoe family; Order Sapindales, Family Aceraceae—Maple family, Family Anacardiaceae—Sumac family, Family Burseraceae—Frankincense family, Family Hippocastanaceae—Horse-chestnut family, Family Meliaceae—Mahogany family, Family Rutaceae—Rue family, Family Sapindaceae—Soapberry family, Family Simaroubaceae—Quassia family, Family Staphyleaceae—Bladdernut family, Family Zygophyllaceae—Creosote-bush family.
In one embodiment, potential plants comprise: Abelmoschus esculentus; Abies balsamea; Abies lasiocarpa; Achillea millefolium; Achillea tomentosa; Aconitum napellus; Aconitum spp.; Acorus calamus; Actaea racemosa; Actinidia arguta; Actinidia chinensis; Adiantum pedatum; Adiantum tenerum; Aesculus hippocastanum; Aframomum melegueta; Agaricus bisporus; Agastache foeniculum; Ageratum conyzoides; Agrimonia eupatoria; Agropyron cristatum; Agropyron repens; Agrostis alba; Agrostis stolonifera; Alcea rosea; Alchemilla mollis; Alkanna tinctoria; Allium ampeloprasum; Allium cepa; Allium fistulosum; Allium grande; Allium porrum; Allium sativum; Allium schoenoprasum; Allium tuberosum; Allium victorialis; Aloe vera; Alpinia officinarum; Althaea officinalis; Amaranthus caudatus; Amaranthus retroflexus; Amaranthus tricolor; Ambrosia artemisiifolia; Amelanchier alnifolia; Amelanchier canadensis; Amelanchier sanguinea; Amelanchier sanguinea×A. laevis; Amsonia tabernaemontana; Ananas comosus; Anaphalis margaritacea; Anethum graveolens; Angelica archangelica; Angelica dahurica; Angelica sinensis; Anthemis tinctoria; Anthoxanthum odoratum; Anthriscus cerefolium; Anthurium guildingii; Apium graveolens; Apocynum cannabinum; Arachis hypogaea; Aralia cordata; Aralia nudicaulis; Arctium lappa; Arctium minus; Arctostaphylos uva-ursi; Armoracia rusticana; Aronia melanocarpa; Aronia×prunifolia; Arrhenatherum elatius; Artemisia abrotanum; Artemisia absinthium; Artemisia dracunculus; Artemisia ludoviciana; Artemisia vulgaris; Asarum europaeum; Asclepias incamata; Asclepias tuberosa; Asparagus officinalis; Aster spp.; Astilbe×arendsii; Astilboides tabularis; Athyrium asperum; Atriplex hortensis; Atropa belladonna; Avena sativa; Averrhoa carambola; Baptisia tinctoria; Beckmannia eruciformis; Begonia convolvulacea; Begonia eminii; Begonia glabra; Begonia mannii; Begonia polygonoides; Bellis perennis; Berberis vulgaris; Beta vulgaris; Betula alleghaniensis; Betula glandulosa; Boesenbergia rotunda; Boletus edulis; Borago officinalis; Brassica cepticepa; Brassica juncea; Brassica napus; Brassica nigra; Brassica oleracea; Brassica rapa; Bromus inermis; Buddleja davidii; Bupleurum falcatum; Butomus umbellatus; Caladium spp.; Calamagrostis arundiflora; Calamintha nepeta; Calendula officinalis; Camellia sinensis; Campanula rapunculus; Canna indica; Cantharellus cibarius; Capsella bursa-pastoris; Capsicum annuum; Capsicum frutescens; Carex morrowii; Carica papaya; Carthamus tinctorius; Carum carvi; Carya cordiformis; Castanea spp.; Centaurea solstitialis; Cerastium tomentosum; Chaerophyllum bulbosum; Chamaemelum nobile; Chelidonium majus; Chenopodium album; Chenopodium bonus-henricus; Chenopodium quinoa; Chrysanthemum coronarium; Cicer arietinum; Cichorium endivia subsp. endivia; Cichorium intybus; Cinnamomum verum; Cirsium arvense; Cissus discolor; Citrullus colocynthis; Citrullus lanatus; Citrus limettoides; Citrus limon; Citrus reticulata; Citrus sinensis; Citrus×paradisi; Clematis armandii; Clematis chiisanensis; Coccoloba caracasana; Cocos nucifera; Coix lacryma-jobi; Colocasia spp.; Convallaria majalis; Conyza canadensis; Corchorus olitorius; Coriandrum sativum; Cornus canadensis; Cornus mas; Cosmos sulphureus; Cotinus coggygria; Crataegus sanguinea; Crataegus spp.; Crataegus submollis; Crithmum maritimum; Cryptotaenia canadensis; Cucumis anguria; Cucumis melo; Cucumis metuliferus; Cucumis sativus; Cucurbita maxima; Cucurbita moschata; Cucurbita pepo; Cullen corylifolium; Cuminum cyminum; Curcuma longa; Curcuma zedoaria; Cyclonia oblonga; Cymbopogon citratus; Cymbopogon martinii; Cynara cardunculus subsp. cardunculus; Cyperus esculentus; Dactylis glomerata; Datisca cannabina; Datura metel; Datura stramonium; Daucus carota; Digitalis purpurea; Dimocarpus longan; Dioscorea batatas; Diospyros kaki; Dipsacus sativus; Dirca palustris; Dolichos lablab; Dryopteris filix-mas; Echinacea purpurea; Echinochloa frumentacea; Eleusine coracana; Equisetum hyemale; Erigeron speciosus; Eriobotrya japonica; Eruca vesicaria; Erysimum perofskianum; Eschscholzia californica; Fagopyrum esculentum; Fagopyrum tataricum; Festuca rubra; Filipendula rubra; Filipendula ulmaria; Filipendula vulgaris; Foeniculum vulgare; Forsythia×intermedia; Fortunella spp.; Fragaria×ananassa; Frangula alnus; Fucus vesiculosus; Fumaria officinalis; Galinsoga quadriradiata; Galium odoratum; Gaultheria hispidula; Gaultheria procumbens; Genista multibracteata; Gentiana lutea; Gentiana macrophylla; Geum rivale; Ginkgo biloba; Glechoma hederacea; Glyceria maxima; Glycine max; Glycyrrhiza glabra; Gossypium herbaceum; Guizotia abyssinica; Hamamelis virginiana; Hedeoma pulegioides; Hedychium spp.; Helianthus annuus; Helianthus strumosus; Helianthus tuberosus; Helichrysum angustifolium; Helichrysum thianschanicum; Heliotropium arborescens; Helleborus niger; Herba schizonepetae; Hibiscus cannabinus; Hordeum hexastichon; Hordeum vulgare; Hordeum vulgare subsp. vulgare; Houttuynia cordata; Humulus lupulus; Hydrastis canadensis; Hylotelephium spp.; Hymenoxys hoopesii; Hyoscyamus niger; Hypericum henryi; Hypericum perforatum; Hypericum spp.; Hypomyces lactifluorum; Hyssopus officinalis; Iberis amara; Iberis sempervirens; Inula helenium; Ipomoea batatas; Iris versicolor; Isatis tinctoria; Jeffersonia diphylla; Juglans nigra; Juniperus communis; Kochia scoparia; Koeleria glauca; Kolkwitzia amabilis; Krameria lappacea; Lactuca sativa; Lactuca serriola; Laportea canadensis; Laserpitium latifolium; Lathyrus sativus; Lathyrus sylvestris; Laurus nobilis; Lavandula angustifolia; Lavandula latifolia; Ledum groenlandicum; Lens culinaris subsp. culinaris; Lentinus edodes; Leonurus cardiaca; Lepidium sativum; Leucanthemum vulgare; Levisticum officinale; Ligularia dentata; Ligustrum vulgare; Linaria vulgaris; Lindera benzoin; Linum usitatissimum; Litchi chinensis; Lolium multiflorum; Lolium perenne; Lonicera ramosissima; Lonicera syringantha; Lotus comiculatus; Lotus tetragonolobus; Lunaria annua; Lupinus polyphyllus; Luzula sylvatica; Lychnis chalcedonica; Lycopersicon esculentum; Lycopersicon pimpinellifolium; Lysimachia clethroides; Lythrum salicaria; Madia sativa; Magnolia stellata; Malus hupehensis; Malus prunifolia; Malus spp.; Malva moschata; Malva sylvestris; Mangifera indica; Manihot esculenta; Marrubium vulgare; Matricaria recutita; Matricaria spp.; Medicago sativa; Melaleuca alternifolia; Melilotus albus; Melilotus officinalis; Melissa officinalis; Mentha arvensis; Mentha pulegium; Mentha spicata; Mentha suaveolens; Mentha×piperita; Menyanthes trifoliata; Microlepia platyphylla; Miscanthus sacchariflorus; Miscanthus sinensis; Momordica charantia; Monarda didyma; Monarda fistulosa; Monarda spp.; Musa×paradisiaca; Myrica pensylvanica; Nasturtium officinale; Nepeta cataria; Nicotiana rustica; Nicotiana tabacum; Nigella sativa; Ocimum Basilicum; Oenothera biennis; Onobrychis viciifolia; Ophiopogon japonicus; Opuntia spp.; Origanum majorana; Origanum vulgare; Oryza sativa; Oxalis deppei; Oxyria digyna; Paeonia rubra; Paeonia spp.; Panax quinquefolius; Panicum miliaceum; Passiflora caerulea; Passiflora spp.; Pastinaca sativa; Pennisetum alopecuroides; Perilla frutescens; Persea americana; Petasites japonicus; Petroselinum crispum; Peucedanum cervaria; Peucedanum oreaselinum; Pfaffia paniculata; Phacelia tanacetifolia; Phalaris arundinacea; Phalaris canariensis; Phaseolus acutifolius; Phaseolus coccineus; Phaseolus vulgaris; Philadelphus coronarius; Phleum pratense; Phlox paniculata; Phoenix dactylifera; Physalis grisea; Physalis philadelphica; Physalis spp.; Physostegia virginiana; Phytolacca americana; Pimpinella anisum; Pisum sativum; Plantago coronopus; Plantago major; Plectranthus fruticosus; Plectranthus spp.; Pleurotus spp.; Plumbago zeylanica; Poa compressa; Poa pratensis; Podophyllum peltatum; Polygonatum odoratum; Polygonum aviculare; Polygonum chinense; Polygonum pensylvanicum; Polygonum persicaria; Pongamia pinnata; Pontederia cordata; Populus incrassata; Populus tremula; Populus×petrowskyana; Portulaca oleracea; Potentilla anserina; Poterium sanguisorba; Primula veris; Prunella vulgaris; Prunus armeniaca; Prunus cerasus; Prunus persica; Prunus spp.; Prunus tomentosa; Psathyrostachys juncea; Psidium guajava; Psidium spp.; Pteridium aquilinum; Pulmonaria officinalis; Pulmonaria saccharata; Punica granatum; Pyrus communis; Pyrus pyrifolia; Raphanus raphanistrum; Raphanus sativus; Rehmannia glutinosa; Reseda luteola; Reseda odorata; Rheum officinale; Rheum palmatum; Rheum×hybridum; Rhus aromatica; Rhus trilobata; Ribes grossularia; Ribes nigrum; Ribes rubrum; Ribes sylvestre; Ribes uva-crispa; Ribes×nidigrolaria; Ricinus communis; Rosa rugosa; Rosmarinus officinalis; Rubus allegheniensis; Rubus canadensis; Rubus idaeus; Rubus occidentalis; Rubus thibetanus; Rumex acetosa; Rumex acetosella; Rumex crispus; Rumex patientia; Rumex scutatus; Ruta graveolens; Saccharum officinarum; Salix purpurea; Salvia elegans; Salvia officinalis; Salvia sclarea; Salvia sylvestris; Sambucus canadensis; Sambucus ebulus; Sambucus nigra; Sanguisorba minor; Sanguisorba officinalis; Santolina chamaecyparissus; Saponaria officinalis; Satureja hortensis; Satureja montana; Satureja repandra; Scolymus hispanicus; Scorzonera hispanica; Scrophularia nodosa; Scutellaria lateriflora; Secale cereale; Sechium edule; Senecio vulgaris; Serenoa repens; Serratula tinctoria; Sesamum indicum; Setaria italica; Sidalcea spp.; Silene vulgaris; Silybum marianum; Sinapis alba subsp. alba; Sium sisarum; Solanum dulcamara; Solanum melongena; Solanum scabrum; Solanum tuberosum; Solidago canadensis; Solidago spp.; Solidago virgaurea; Solidago×hybrida; Sonchus oleraceus; Sorghum bicolor; Sorghum×drummondii; Spinacia oleracea; Stachys affinis; Stachys byzantina; Stachys macrantha; Stellaria graminea; Stellaria media; Stipa capillata; Symphytum officinale; Tamarindus indica; Tanacetum balsamita; Tanacetum balsamita subsp. balsamita; Tanacetum cinerariifolium; Tanacetum parthenium; Tanacetum vulgare; Taraxacum officinale; Tetradenia riparia; Teucrium chamaedrys; Thalictrum aquilegiifolium; Thlaspi arvense; Thuja occidentalis; Thymus fragantissimus; Thymus herba-barona; Thymus praecox subsp. arcticus; Thymus pseudolanuginosus; Thymus serpyllum; Thymus vulgaris; Thymus×citriodorus; Tiarella cordifolia; Tiarella spp.; Tragopogon porrifolius; Tragopogon spp.; Trichosanthes kirilowii; Trifolium hybridum; Trifolium incarnatum; Trifolium pannonicum; Trifolium pratense; Trifolium repens; Trigonella foenum-graecum; Triticum aestivum; Triticum aestivum subsp. spelta; Triticum turgidum; Trollius×cultorum; Tropaeolum majus; Tsuga canadensis; Tsuga diversifolia; Tsuga mertensiana; Tussilago farfara; Typha latifolia; Ulmus americana; Urtica dioica; Uvularia perfoliata; Vaccinium angustifolium; Vaccinium corymbosum; Vaccinium macrocarpon; Valeriana officinalis; Valerianella locusta; Veratrum viride; Verbascum thapsus; Verbena officinalis; Veronica officinalis; Viburnum opulus; Vicia faba; Vicia sativa; Vicia villosa; Vigna angularis; Vigna mungo; Vigna unguiculata; Vinca minor; Vitis spp.; Weigela coraeensis; Weigela hortensis; Withania somnifera; ×Triticosecale spp.; Xanthium sibiricum; Xanthium strumarium; Yucca filamentosa; Zea mays; Zingiber officinale; Achillea ptarmica; Ajuga reptans; Aster spp; Astilbe chinensis; Bergenia×schmidtii; Brassica chinensis; Butomus umbellatus; Buxus microphylla; Carpinus caroliniana; Centaurea dealbata; Chaenomeles×superba; Clematis alpina; Coreopsis verticillata; Cornus alba; Cornus sericea; Corylus maxima; Crambe cordifolia; Cyperus alternifolius; Dahlia spp.; Euphorbia amygdaloides; Fuchsia spp.; Fuchsia magellanica; Galium aparine; Geranium sanguineum; Geranium phaeum; Geranium pratense; Geranium sanguineum; Geranium×cantabrigiense; Glaux Maritima; Hamamelis mollis; Hedychium coronarium; Helenium spp.; Herba Schizonepetae; Hosta sieboldiana; Hydrangea quercifolia; Ipomoea aquatica; Lamiastrum galeobdolon; Magnolia×loebneri; Malva verticillata; Matteuccia pensylvanica; Microbiata decussata; Montia perfoliata; Ocimum tenuiflorum; Oenothera fruticosa subsp fruticosa; Onoclea sensibilis; paeonia suffruticosa; Penstemon digitalis; Petasites japonicus; Physalis alkekengi; Pinus cembra; Pinus mugo; Potentilla fruticosa; Rhododendron spp.; ribes americanum; Rodgersia spp.; Rodgersia podophylla; Rubus arcticus; Rubus phoenicolasius; Rubus pubescens; Rudbeckia maxima; Sempervivum tectorum; Soleirolia soleirolii; Solidago caesia; Staphylea trifolia; Stephanandra incisa; Stewartia pseudocamellia; Strelitzia reginae; Symphoricarpos orbiculatus; Symphoricarpos albus; Taxus×media; Vernonia gigantea; Veronica austriaca ssp teucrium; Veronica beccabunga and Viburnum plicatum.
In another embodiment, potential plants comprise: Abies cephalonica, Abies firma, Acer campestre, Acer mandshurica, Acer palmaturn “burgundy,” Acer tataricum, Acer truncatum, Acolypha hispida, Aconitum napellus, Actinidi colonicta, Actinidia chinensis, Actinidia colomicta, Adansonia digitata, Adianthum radiatum, Adianthum trapezieformis, Aechmea luddemoniana, Aesculus hippocastanum, Aesculus hypocastanum, Aesculus waertilensis, Aesculus woerlitzenis, Aessopteria crasifolia, Agastache mexuicana, Agatis robusta, Ageratum conizoides, Aglaonema commutatus, Agrimonia eupatora, Ailantus altissima, Alchemilla sp., Alium cernum (wild), Allium fistulosum, Allium nutans, Allium sp., Alum japonica, Amelanchier spicata, Amigdalus nana, Ananas comosus, Anemonajaponica, Antericum ramosum, Anthurium altersianum, Anthurium andreanum, Anthurium elegans, Anthurium hookeri, Anthurium magnificurn, Anthyrium filis-femina, Anthyrium nopponicum, Aralis mandshurica, Archirantus bidentata, Armoracea rusticana, Armoraica ristica, Artemisia dracunculus, Asimina triloba, Asorum canadensis, Asplenium australasicum, Aster-Nova anglicae, Astragulus sinicus, Atropa Belladonna, Austolachia australis, Bactisia australis, Barbaric sp., Berberis thungergi, Berberis vulgaris, Bergenia crassifolia, Betula alba, Betula daurica, Betula nigra, Betula nigra (flower), Betula nigra (leaf), Betula pendula, Betula pendula, Bocconia cordata, Boechimeria boloba, Boxus sempervirens, Brassica juncea, Brassica napa, Bromelia balansae, Brugmansi graveolens (ralf), Brugmansia suaveolens, Brugmansia suaveolens (old), Brugmansia suaveolens (young), Buxus microphilla “japonica,” Buxus microphylla “japonica,” Cachris alpina, Cactus officinalis, Calathea zebrina, Calicatus floridus, Campanula carpatica, Capparis spinosa inemis, Carica papaya, Carlina acaulis, carpinifolia, Carum capsicum, Caryota ureus, Casia hebecarpa, Castanea sativa, Celosia cristata, Celtis occidentalis, Celtis occidentalis, Centauria maculata, Cerasus japonica, Cerasus maghabab, Ceratoramia mexicana, Chaernomelis superba, Chamaechrista fasciculata, Charnaeciparis pisifera, Chelidonium majus, Cistus incanus, Citinis coggriaria, Clematis rectae, Clerodendrum speciossicum, Cobiaeum varilartum, Cocculus laurifolius, Comus mass, Convalaria majalis, Coronolla varia, Coryllus avelana, Corylus avelana, Cotoneaster fangianus, Cotoneaster horisontalis, Cotynus cogygria, Cramble cardifolia, Crataegus praegophyrum, Crategus macrophyllum, Crytomium fortunei, Cupress lusitanica, Cupressus sempervirens, Cupressus sempervirens, Cycas cirinalis, Cyclonia oblonga, Cynnamonum zeylonicum, Darura stramonium, Deutria scabra, Dieffenbachia leopoldii, Dieffenbachia segiunae, Digitalis lutea, Diopiros kaka, Dracaena fragrans, Dracaena sp., Dryopteris filis-max, Echinops sphae, Eleagnus angustifolia, Eleagnus cemutata, Encephalaris horridum, Epilobium augustifolium, Equisetum variegatum, Eriobotria japonica, Erungium campestre, Erythrinia caffra, Erythrinia crista, Erythrinia glabeliferus, Eucaliptus rudis, Eucomia ulurifolia, Euonimus elata, Euonomus europea, Euonomus verrucosa, Fagopyrum suffruticosum, Fagus silvatica, Fautenousus qualiqualia, Feucrium hamedris, Ficus benjamina, Ficus benjaminii, Ficus elastica, Ficus purnila, Ficus religiosa, Ficus sp., Ficus triangularis, Filipendula ulmaria, Filipendula vulgrais, Foenix zeulonica, Forsithsia suspensa, Forsitsia europea, Fraxinus exelsior, Gallium sporium, Gardenia jasminoides, Gaultheria procumbens, Gentiana cruciata, Gentiana littorala, Gentiana macrophilla, Gentiana tibetica, Geranium maculata, Geum fanieri, Geum macrophyllum, Gingko biloba, Gnetum guemon, Gratiola officinalis, Gravilea robusta, Gravilea robusta, Gravilia robusta, Haser trilobum, Helianthus annus, Heraclelum pubescens, Hernerocalis spp., Hhaemanthus katharina, Hissopus zeraucharicus, Hiuga reptans, Hosta fortuna, Hosta fortunaea, Hosta lancefolia, Hosta zibalda, Hydrocotile asiatica, Hydrocotile asiatica, Hyppoach rhamnoides, Ilex agnifolium, Ilex cornuta, Inula hilenium, Ipomea tricolor, Iris alida, Iris pseudocarpus, Jacobinia sp., Jasminum frutocarus, Juca sp., Juglands regia, Juniperus “blue pacific,” Keyleiteria paniculata, Kolkwitzia amabilis, Korria japonica, Lal lab purpurea, Lapia dulcis, Larix dedidua, Laurus nobilis, Laurus nobilis, Lavandula officinalis, Lavandula officinalis, Leontopodium alpinum, Liatris spinata, Liclum barbatum, Ligustum vulgare, Linium hirsutum, Lippa dulcis, Livistona fragrans, Lobelia siphitica, Luglands nigra, Lupinus luteaus, Lycodium japonicum, Magnolia cobus, Magnolia loebheril, Magnolia agrifolia, Matteucia strutioptoris, Mespilus germanica, Metasequoia glyptotrobioldes, Metrosideros excelsa, Microlepia platphylla, Microsorium punctatum, Minispermum dauricum, Mirica certifera, Monstera deliciosa, Monstera pertusa, Morus alba, Murraya exotica, Musa textilis (Leaf), Musa textilis (Stem), Myrthus communis, Myrthus comunis, Nepeta cataria, Nicodemia diversifolia, Nicotiana tabacum, Olea europaea, Olea olcaster, Oreopanax capitata, Origanurn vulgare, Osmanthus spp., Osmunda regalis, Osmundastrum claytonionum, Ostrea carpinifolia, Ostrea connote, Oxobachus nictogenea, Pachyra affinis, Paeonia daurica, Paeonia lactiflora, Paeonia suffructicisa, Parrotia persica, Parthenosicus tricuspidata, Pegamun hamalis, Pelagonium zonale, Pelargoniurn zonale, Pentaphylloides fruticosa, Phebodium aureum, Philodendron amurense, Phylidendron speciosus, Phyllanthus grandifolium, Phyllitis scolopendrium, Phymatosorus scolopendria, Physalis creticola, Picea schrenkiana, Pieras japonica, Pigelia pennata, Pinus bungiana, Pinus pinea, Pinus pumila, Pinus salinifolia, Pinus silvestris, Pinus sirtrobus, Pinus strobus, Piper chaba, Piper nigrum, Pithecelobium unguis, Pittisporum tibica, Plantago major, Plantago minor, Platanus acidentalis, Platicada grandiflora, Podocarpus spinulosus, Podophyllum amodii, Poligonum aviculare, Poligomun latifolia, Polygonium odoratum, Polygonum cuspidatum, Polymonium ceruleum, Polyschium braunii, Portulaca oleacea, Portulaca olleracea, Potentilla alba, Poterium sangiusorba, Princepia sp., Prunella vulgaris, Prunus cerasifera, Prunus serotica, Prunus xocane, Pseudotsuga menzisia, Psidium guajava, Psychotria metbacteriodomasica, Psychotria nigropunctata, Pterigota alata, Puansetia sp., Pulmonaria molissima, Quercus castanufolia, Quercus imbricaria, Quercus nigra, Quercus robur “fastigiata,” Quercus rubra, Quercus trojana, Ratibiunda columnus-Fera, Rauwolfia tetraphylla, Reseda luteola, Rhododendron spp., Rhus toxicodenta, Rimula japonica, Rosa cocanica, Rosa multiflora, Ruschia indurata, Ruta graveolens, Salis babilonics, Salix tamarisifolia, Sambucus niora, Sanchezia nobilis, Schisandra chinensis, Scotch pine, Scutellaria certicola, Scutellarian altissima, Sedum album, Sedum telchium, Senecio platifilla, Senseviera sp., Sering a josiceae, Seruginea suffruticisa, Sesbania exaltata, Sesbania speciosa, Sibirea altaiensis, Siring a vulgaris, Sluffera sp., Sorbocotoneaster sp., Sorbus aucuparia, Sorbus cominicta, Spartina potentiflora, Spathiphyllum cochlearispatum, Spathiphyllum grandiflorum, Stachis lanata, Stepochlaena tenuifolia, Sterulia elata, Stevartia coreana, Strelitzia reglinae, Sulda sanganea, Sundapsis spp., Symphitium officinalis, Syngonium aurutum, Syngoniurn podophyllum, Taccus bacata, Tagetes minuta, Talictrum minus, Talictrum sp., Tamarindus india, Tapeinochilos spectabilis, Taraxacum officinalis, Taxodium dixticum, Taxodium dixticum (Acetic acid), Taxodium dixticum (H2O), Taxus cuspidata, Taxus hiksii, Taxus media, Tetraclinis articulata hinensis, Thalictum flavum, Thuja occidentalis, Thuja occidentalis, Thymus camosus, Thymus carnosus, Thymus cretaceus, Thymus cytridorus “aureus,” Thymus lemabarona, Thymus portugalense, Thymus praecox, Thymus praecox “arcticus,” Thymus pseudolamginosus, Thymus puleglodes “lemons,” Thymus puliglodes, Thymus serphylum, Thymus serphylum (wild), Thymus speciosa, Thymus thrasicus, Thymus vulgaris, Thymus vulgaris “argenteus,” Thymus vulgaris “oregano,” Thymus wooly, Trambe pontica, Trevesia sungaica, Trifolium pratense, Tsuga canadensis “penola,” Tuja orientalis “eligantissima,” Tula ocidentalis “columbia,” Tulip tree, Turnera ulmifolia, Ulmus pumila, Uschusa sp., Valeriana officinalis, Veratrum nigrum, Verium oleander, Viburnum opulus, Vinca minor, Vincetocsicum officinalis, Vitis labrissa, Xanthosoma sagittifolium (leaf), Xanthosoma sagittifolium (stem), Xeupressocyparis deylandii, Yucca elephantipes, Zelcova and Zingiber officinalis.
Another group of potential plants comprise the plants that are indigenous to arid regions, for example, those located between 35° north latitude and 35° south latitude. In accordance with another embodiment of the present invention, therefore, potential plants comprise: the agave, Agavaceae, family including such members as: Yucca elata, Y. breviflora, Agave deserti, A. chrysantha, Dasylirion wheeleri; the buckwheat, Polygonaceae, family, such as Eriogonum fasciculatum; the crowfoot, Ranunculaceae, family, such as Delphinium scaposum, Anemone tuberosa and D. parishii; the poppy, Papaveraceae, family, including Platystemon californicus, Argemone pleiacantha, Corydalis aurea, Eschschoizia californica and Ar. corymbosa; members of the mustard, Cruciferae, family, such as Dithyrea californica, Streptanthus carinatus and Lesquerella gordoni; members of the legume, Leguminosae, family, such as Acacia greggii, Prosopis velutina, A. constrica, Senna covesii, Cercidium floridum, C. microphyllum, Lotus huminstratus, Krameria parvifolia, Parkinsonia aculeata, Calliendia eriophylla, Lupinus arizonicus, Olyneya tesota, Astragalus lentiginosus, Psorothamunus spinosus and Lupinus sparsiflorus; members of the loasa family, Loasaceae, including Mentzelia involucrata, M. pumila and Mohavea Confertiflora; members of the cactus, Cactaceae, family, such as Carnegiea gigantia, Opuntia leptocaulis, Ferocactus wislizenii, O. bigelovii, O. pheacantha, O. versicolor, O. fulgida, Echinocereus engelmannii, Mammillaria microcarpa, O. basilaris, Stenocereins thurberi, O. violacea, M. tetrancistra, O. ramosissima, O. acanthocarpa, E. pectinatins and O. arbuscula; members of the evening primrose, Onagraceae, family, such as Oenothera deltoides, Camissonia claviformis and Oe. primiveris; members of the milkweed, Asclepiadaceae, family, including Asclepias erosa, A. sublata and Sarcostemma cynanchoides; members of the borage, Boraginaceae, family, such as Cryptantha augustifolia and Amsinckia intermedia; members of the sunflower, Compositae, family, including Baccharis sarothroides, Monoptiilon belloides, Erieron divergens, Zinnia acerosa, Melampodium leucanthan, Chaenactis fremontii, Calycoseris wrightii, Malacothrix californica, Helianthus annus, H. niveus, Geraea canescens, Hymenothrix wislizenii, Encelia farinosa, Psilostrophe cooperi, Baileya multiradiata, Bebbia juncea, Senecio douglasii, Trixis californica, Machaeranthera tephrodes, Xylorhiza tortifolia, Cirsium neomexicanum, Antennaria parviflora and Ch. douglasii; members of the caltrop, Zygophyllaceae, family, including Larrea tridentata and Kallstroemia grandiflora; members of the mallow, Malvaceae, family, including Hibiscus coulteri, H. denudatus and Sphaeralcea ambigua; members of the phlox, Polemoniaceae, family, such as Luanthus aureus; members of the unicorn plant, Martyniaceae, family, such as Proboscidiea altheaefolia; members of the gourd, Cucurbitaceae, family, such as Cucurbita digitata; members of the lily, Lilaceae, family, including Calochortus kennedyi, Dichelostemma pulchellum, Allium macropetalum and Hesperocallis indulata; members of the ocotillo, Fouquieriaceae, family, including Fouquieria splendens; members of the figwort, Scrophulariaceae, family, such as Castilleja sp., Penstemon parryi and Orthocarpus purpurascens; members of the acanthus, Acanthaceae, family, including Anisacanthus thurberi, Justicia californica and Ruellia nudiflora; members of the four o'clock, Nyctaginaceae, family, such as Allionia incarnata, Abronia villosa and Mirabilis multiflora; members of the geranium, Geraniaceae, family, including Erodium cicutarium; members of the waterleaf, Hydrophyllaceae, family, such as Nama demissum, Phacelia bombycina and Ph. distans; members of the bignonia, Bignoniaceae, family, such as Chilopsis linearis; members of the vervain, Verbenaceae, family, including Glandularia gooddugii and Verbena neomexicana; members of the mint, Labiatae, family, such as Hyptis emoryi and Salvia columbariae; members of the broomrape, Orobanchaceae, family, such as Orobanche cooperi; members of the portulaca, Portulaceae, family, such as Talinum auriantiacum; members of the carpet-weed, Aizoaceae, family, such as Sesuvium verrucosum; members of the flax, Linaceae, family, such as Linum lewisii; members of the potato, Solanaceae, family, including Nicotiana trigonophylla and Physalis lobata; and members of the cochlospermum, Cochlospermaceae, family, such as Amoreuxia palmatifida.
In accordance with one embodiment of the present invention, the potential plant is selected from the group comprising: Allium tuberosum; Althacea officinalis; Amaranthus candathus; Ambrosia artemisiifolia; Angelica sinensis; Aronia×prunifolia; Asarum europaeum; Begonia Hannii; Begonia polygonoides; Brassica oleracea; Brassica napus; Brassica oleracea; Bromus inermis; Chenopodium quinoa; Citrullus lanatus; Conyza canadensis; Cynara cardunculus subsp. Cardunculus; Daucus carota; Dolichos lablab; Foeniculum vulgare; Hypomyces lactifluorum; Iberis sempervirens; Lotus corniculatus; Lunaria annua; Manihot esculenta; Matricaria recutita; Melilotus albus; Phaseolus vulgaris; Physostegia virginiana; Pisum sativum; Raphanus raphanistrum; Rheum rhabarbarum; Ribes sylvestre; Rubus occidentalis; Rumex crispus; Rumex scutatus; Salvia officinalis; Solidago canadensis; Solidago sp.; Solidago×hybrida; Tamarindus indica; Tanacetum cinerariifolium; Taraxacum officinale; Tropaeolum majus; Tsuga canadensis; Tsuga diversifolia; Vaccinium angustifolium; Zea mays; Zingiber officinale.
Once a potential plant has been chosen, a pre-harvest treatment is selected, wherein the treatment can be water or water in combination with one or more stressor, elicitor, or inducer. A pre-harvest treatment comprises contacting or treating a potential plant, or material from a potential plant, with one or more stressor, elicitor, or inducer. Examples of stressors, elicitors and inducers include, but are not limited to, chemical compounds, for example organic and inorganic acids, fatty acids, glycerides, phospholipids, glycolipids, organic solvents, amino acids and peptides, monosaccharides, oligosaccharides, polysaccharides and lipopolysaccharides, phenolics, alkaloids, terpenes and terpenoids, antibiotics, detergents, polyamines, peroxides, ionophores, etc.; subjection of the plant material to a physical treatment, such as ultraviolet radiation, low and high temperature stress, osmotic stress induced by salt or sugars, nutritional stress defined as depriving the plant of essential nutrients (e.g. nitrogen, phosphorus or potassium), in order to induce or elicit increased production of one or more chemicals. The one or more stressor (i.e. chemical compound or physical treatment) may be applied continuously or intermittently to the plant material. In one embodiment, such treatment may be accomplished by contacting the plant material with a solution containing the elicitor or by irradiating the plant material or exposing the plant material to other environmental stresses such as temperature stresses.
One skilled in the art would understand that a potential plant can be subjected to a variety of pre-harvest treatments and an extract prepared after each treatment. For example, the treatment can be with water and then with one or a series of stressors. The extracts are then tested to determine whether they become an extract of the invention. Thus, it is possible that, of several extracts prepared from the same potential plant subjected to different pre-harvest treatment, only some may become extracts of the invention.
In one embodiment, the potential plant is subjected to a pre-harvest treatment comprising stressing the plant through the use of chemical elicitors, which act as stressor agent, and/or mechanical wounding, drought, heat, or cold, which activate plant defense pathways, before tissue collection and extraction.
In another embodiment, the stressor employed involves exposing a potential plant to a solution of one or more chemical elicitors to induce defense metabolic pathways and secondary metabolites prior to collection of plant tissues. Known chemical elicitors reported in the literature include ozone, hydrogen peroxide, jasmonic acid and its derivatives, arachidonic acid, salicylic acid and ester derivatives, alpha- and gamma-linolenic acids, volicitin, peptides, oligopeptides, saccharides, oligosaccharides such as chitosan, and synthetic chemicals such as benzo-1,2,3-thiadiazole-7-carbathioic acid S-methyl ester (BTH).
A stressor may be one or more organic compound. Some exemplary compounds that may be used as stressors include jasmonic acid, jasmonic acid lower alkyl esters, αlinolenic acid, α-linolenic acid lower alkyl esters, γ-linolenic acid, γ-linolenic acid lower alkyl esters, arachidonic acid, arachidonic acid lower alkyl esters, salicylic acid.
In one embodiment of the present invention, the stressor is γ-linolenic acid, γ-linolenic acid lower alkyl esters, arachidonic acid, arachidonic acid lower alkyl esters, or a combination thereof.
A stressor may be able to induce abiotic stresses in plants. Thus, for example, plants can be treated with one or more mechanical or chemical stress prior to tissue collection.
Mechanical stress can be performed, for example, between about twelve hours to about ten days prior to tissue collection. In one embodiment of the present invention, a potential plant can be subjected to one or more mechanical stress between about one day to about three days prior to tissue collection. In another embodiment, a potential plant can be subjected to one or more mechanical stress between about three to about six days prior to tissue collection. In a further embodiment, a potential plant can be subjected to one or more mechanical stress between about four to about eight days prior to tissue collection. In another embodiment a potential plant can be subjected to one or more mechanical stress between about six to about ten days prior to tissue collection.
Chemical stress can be induced in a potential plant by spraying plant material once, or more than once, with an aqueous or alcoholic solution of one or more chemical elicitor. Chemical stress can also be induced by feeding a potential plant with an aqueous or alcoholic solution of one or more chemical elicitor. Similarly, a potential plant can be subjected to a chemical stress by means of contact with an airborne transport of one or more chemical elicitor. Chemical stress can be performed, for example, between about one hour to about 10 days prior to tissue collection. In one embodiment of the present invention, a potential plant can be subjected to one or more chemical stress between about ten hours and about one day prior to harvesting the plant tissue. In another embodiment, a potential plant can be treated with one or more chemical by spray one day before harvesting. In a further embodiment, a potential plant can be subjected to one or more chemical stress between about one day to about three days prior to harvesting the plant tissue. In other embodiments, a potential plant can be subjected to one or more chemical stress between about two to about four days and between about five to about ten days prior to harvesting the plant tissue.
Various combinations of the above-mentioned stressors and treatment regimes can be employed to induce or enhance the production of one or more extracellular proteases in the plant material. One skilled in the art would be able to determine from the results of the assay against the panel of extracellular proteases whether it is desirable to follow one or more than one of the stressor regimes.
The plant material may be used immediately after pre-harvest treatment, or it may be desirable to store the plant material for a period of time prior to performing the extraction procedure(s). If desired, the plant material can be treated prior to storage, for example, by drying, freezing, lyophilising, or some combination thereof.
Following treatment to prepare the plant material for storage, the plant material may be stored for a period of time prior to being contacted with a first solvent. The storage time may be of various durations, for example, the storage period may be between a few days and a few years. In one embodiment of the invention, the plant material is stored for a period of less than one week. In another embodiment, the plant material is stored for a period between one week to one month. In a further embodiment, the plant material is stored for a period of between one month to six months. In other embodiments, the plant material is stored for periods of between four months to one year and for a period over one year in duration.
In accordance with the embodiment depicted in
The liquid fraction is then separated from the solid (insoluble) matter resulting in the generation of two fractions: a liquid fraction, which is a potential pre-extract, and a solid fraction. In accordance with the embodiment depicted in
Separation of the liquid and solid fractions can be achieved by one or more standard processes known to those skilled in the art. For example, the solid material can be separated from the solvent by centrifugation, filtration (regular or suction), or other means known in the art to separate solids from a solution. In addition, when an alcoholic or organic solvent is used, the potential pre-extract can be dried to remove the solvent and then re-suspended or dissolved in an aqueous solvent prior to testing against a panel of extracellular proteases. The alcoholic or organic solvent can be removed by standard methods including, for example, by distillation or by the use of a lyophilizer, a speedvac, a rotary evaporator, or a vacuum pump and then further dried under vacuum, if necessary in order to remove any remaining solvent.
The dried extract can be dissolved can be dissolved in an aqueous buffer, or in a mixture of an aqueous buffer and a suitable solvent (such as dimethylsulfoxide) prior to analysing its activity against a panel of extracellular proteases. An example of an aqueous buffer is Tris-HCl buffer at a suitable pH, such as between pH 6 and pH 8. In one embodiment, Tris-HCl buffer at pH 7 is used.
Solvents A, B and C in
The term “liquid” is used to denote matter that is distinct from the solid, insoluble matter. Thus, a liquid, which may be converted to a gas or function in a gaseous form (as in the case with steam, for example), can serve as a solvent. Likewise, other non-solid solvents may be used such as highly viscous liquids or other gaseous solvents, some of which can then be converted into a liquid phase. A liquid solvent may also indicate a composition or a mixture of solvents. Common examples include a buffered aqueous solution, such as a TRIS-HCl buffer, an ethanol/methanol combination and combinations of an alcoholic solvent and a co-solvent, such as methanol or water.
The plant material employed in the extraction process can be the entire potential plant, or it can be one or more distinct tissues from a plant, for example, leaves, seeds, roots, stems, flowers, or various combinations thereof. The plant material can be fresh, dried or frozen. If desired, the plant material can be treated prior to the extraction process in order to facilitate the extraction of the inhibitory activity. Typically such treatment results in the plant material being fragmented by some means such that a greater surface area is presented to the solvent. For example, the plant material can be crushed or sliced mechanically, using a grinder or other device to fragment the plant parts into small pieces or particles, or the plant material can be frozen liquid nitrogen and then crushed or fragmented into smaller pieces.
In one embodiment of the present invention, plant material is first fragmented and then extracted with a first solvent comprising an aqueous TRIS-HCl buffer at pH 6-8 for a period of between 30 minutes to 8 hours at a temperature between about 4 to about 50° C. In an alternative embodiment, aqueous buffer has a pH of about 7. In another embodiment, extraction takes place over about 30 min to 2 hours. In a further embodiment, the extraction takes place at a temperature between about 4 to about 25° C. In another embodiment, the extraction takes place at a temperature between about 4 to about 10° C. In another embodiment, the extraction is performed at a temperature of about 4° C. for about 30 minutes.
In one embodiment of the invention, ethanol is used as an alcoholic solvent either alone or in combination with a co-solvent. In another embodiment, a combination of ethanol and methanol is used as the alcoholic solvent, wherein the range of ethanol:methanol is between about 50:50 and about 85:15. In a further embodiment, the plant material is contacted with an alcoholic solvent for a time period between about 10 minutes to one hour at a temperature between about 4 to about 25° C. In another embodiment, the plant material is contacted with an alcoholic solvent for a time period between about 15 and about 30 minutes. In other embodiments, the plant material is contacted with an alcoholic solvent at a temperature between about 4 to about 10° C. and at about 4° C.
In one embodiment of the present invention, diethylether, hexane, dichloromethane, or ethylacetate extract is used as the organic solvent. In another embodiment, the residual solid plant material is shaken for one to twenty-four hours with the organic solvent. In a further embodiment, the residual solid plant material is shaken for one to fifteen hours. In other embodiments, the residual solid plant material is shaken for one to eight hours and for one to four hours with the organic solvent. In another embodiment, dichloromethane is used as the organic solvent and the extraction is performed at room temperature for about 2 hours.
The present invention contemplates that the extraction process may be carried out on various scales including known large, medium and small-scale methods of preparing extracts.
Once the potential pre-extracts have been isolated, they can be tested directly for their ability to inhibit extracellular protease activity, or they may be subjected to further separation procedures to generate a potential extract as described below and outlined in
In accordance with the present invention, the plant extracts are capable of inhibiting the activity of at least one extracellular protease. In the context of the present invention, a plant extract that decreases the activity of an extracellular protease by at least 20% when measured according to one of the assays described herein is considered to be capable of inhibiting the activity of that protease.
Extracellular proteases that may be used to test the ability of the extract to inhibit extracellular protease activity include, but are not limited to, matrix metalloproteases (MMPs), cathepsins, elastase, plasmin, TPA, uPA, kallikrein, ADAMS family members, neprilysin, gingipain, clostripain, thermolysin, serralysin, and other bacterial and viral proteases.
It is contemplated that for some purposes, it may be desirable to determine the ability of the potential pre-extract/extract to inhibit a certain set or group of extracellular proteases. For example, it may be useful to determine which potential pre-extracts/extracts are capable of inhibiting at least one human extracellular protease. In this case a panel of extracellular proteases may be designed that comprises those proteases of particular interest. In one embodiment of the present invention, the ability of a potential pre-extract/extract to inhibit at least one extracellular protease is determined using a panel of proteases comprising: MMP-1, MMP-2, MMP-3, MMP-9, cathepsin B, cathepsin D, cathepsin G, cathepsin L, cathepsin K, human leukocyte elastase (HLE), clostripain and subtilisin. In another embodiment, the ability of a potential pre-extract/extract to inhibit at least one extracellular protease is determined using a panel of proteases comprising: MMP-1, MMP-2, MMP-3, MMP-9 and cathepsin B.
One skilled in the art would appreciate that there are numerous methods and techniques for measuring qualitatively and/or quantitatively the ability of the potential pre-extracts and/or potential extracts to inhibit the activity of extracellular protease(s).
For example, there are currently several assays to measure the activity of MMPs, elastase and cathepsins (for a review of these methods, see Murphy and Crabbe, In Barrett (ed.) Methods in Enzymology. Proteolytic Enzymes: Aspartic Acid and Metallopeptidases, New York: Academic Press, 1995, 248: 470), including the gelatinolytic assay (which is based on the degradation of radio-labelled type I collagen), the zymography assay (which is based on the presence of negatively-stained bands following electrophoresis through substrate-impregnated SDS polyacrylamide gels) and a microtitre plate assay developed by Pacmen et al., (Biochem. Pharm. (1996) 52:105-111).
Other methods include those that employ auto-quenched fluorogenic substrates, which do not have some of the drawbacks associated with the above methods, such as the use of radioisotopes, labour-intensiveness, long incubation times and/or low sensitivity. Many fluorogenic substrates have been designed for quantification of the activity of MMPs, elastase, and cathepsins through fluorescent level variation measuring (reviewed by Nagase and Fields (1996) Biopolymers 40: 399-416).
Fluorescence polarization assays are based on the principle that when fluorescent molecules are excited with plane polarized light, they will emit light in the same polarized plane provided that the molecule remains stationary throughout the excited state. However, if the excited molecule rotates or tumbles during the excited state, then light is emitted in a plane different from the excitation plane. If vertically polarized light is used to excite the fluorophore, the emission light intensity can be monitored in both the original vertical plane and also the horizontal plane. The degree to which the emission intensity moves from the vertical to horizontal plane is related to the mobility of the fluorescently labelled molecule. If fluorescently labelled molecules are very large, they move very little during the excited state interval, and the emitted light remains highly polarized with respect to the excitation plane. If fluorescently labelled molecules are small, they rotate or tumble faster, and the resulting emitted light is depolarized relative to the excitation plane. Therefore, FP can be used to follow any biochemical reaction that results in a change in molecular size of a fluorescently labelled molecule (e.g. protein-DNA interactions; immunoassays; receptor-ligand interactions; degradation reactions). (Adapted from Bolger R. Checovich W. (1994) Biotechniques 17(3):585-9.).
Another method of measuring extracellular protease activity makes use of the fluorescent activated substrate conversion (FASC) assay described in Canadian Patent No. 2,189,486 (1996) and in St-Pierre et al., (1996) Cytometry 25: 374-380.
Various formats known in the art may be employed to test the ability of the potential pre-extracts and potential extracts to inhibit the activity of extracellular proteases. For example, the potential pre-extract/extract may be tested against one or more proteases in a sequential fashion or it may be tested against a plurality of proteases, such as an array of extracellular proteases, simultaneously. The assays may be adapted to high throughput in order to facilitate the simultaneous testing of a potential pre-extract/extract against a plurality of proteases. High throughput techniques are constantly being developed and the use of such techniques to adapt the assays in the future is also considered to be within the scope of the present invention.
In one embodiment of the present invention, a potential pre-extract or potential extract is selected for further testing when it demonstrates inhibitory activity against one extracellular protease. In another embodiment, a potential pre-extract or potential extract is selected for further testing when it demonstrates inhibitory activity against two or more extracellular proteases. In a further embodiment, a potential pre-extract or potential extract is selected for further testing when it demonstrates inhibitory activity against three or more extracellular proteases. In another embodiment, a potential pre-extract or potential extract is selected for further testing when it demonstrates inhibitory activity against four or more extracellular proteases.
In accordance with the present invention, extracts are selected by their ability to inhibit one or more extracellular protease and to modulate one or more cellular activity. In one embodiment, extracts are selected by their ability to slow down, inhibit or prevent cell migration.
There are a number of assays known to one skilled in the art, which can be used to test an extract for the ability to modulate cellular activity. For example, various cell migration assays can be used to test the extracts, such as those described herein in Example IV.
In general, the ability of an extract to inhibit migration of endothelial and/or neoplastic cells can be assessed in vitro using standard cell migration assays. Typically, such assays are conducted in multi-well plates, the wells of the plate being separated by a suitable membrane into top and bottom sections. The membrane is coated with an appropriate compound, the selection of which is dependent on the type of cell being assessed and can be readily determined by one skilled in the art. Examples include collagen or gelatine for endothelial cells and Matrigel for neoplastic cell lines. An appropriate chemo-attractant, such as EGM-2, IL-8, aFGF, bFGF and the like, is added to the bottom chamber as a chemo-attractant. An aliquot of the test cells together with the potential pre-extract/extract are added to the upper chamber, typically various dilutions of the potential pre-extract/extract are tested. After a suitable incubation time, the membrane is rinsed, fixed and stained. The cells on the upper side of the membrane are wiped off, and then randomly selected fields on the bottom side are counted.
Various cell lines can be used in cell migration assays. Examples of suitable endothelial cell lines include, but are not limited to, human umbilical vein endothelial cells (HUVECs), bovine aortic endothelial cells (BAECs), human coronary artery endothelial cells (HCAECs), bovine adrenal gland capillary endothelial cells (BCE) and vascular smooth muscle cells. HUVECs can be isolated from umbilical cords using standard methods (see, for example, Jaffe et al. (1973) J. Clin. Invest. 52: 2745), or they can be obtained from the ATCC or various commercial sources, as can other suitable endothelial cell lines. Examples of suitable neoplastic cell lines include those that are available from the American Type Culture Collection (ATCC), which currently provides 950 cancer cell lines, and other commercial sources.
In accordance with one embodiment of the present invention, a potential pre-extract/extract that demonstrates the ability to decrease cell migration by about 10% when used at a concentration of about 10 mg/ml in at least one of the above-described assays is selected as an extract of the invention.
In accordance with another embodiment, a potential pre-extract/extract that demonstrates the ability to decrease cell migration by about 10% when used at a concentration of about 2.5× in at least one of the above-described assays is selected as an extract of the invention, wherein 1× corresponds to the concentration of the potential pre-extract/extract required to inhibit the activity of a selected extracellular protease by at least 50% (i.e. the IC>50).
As an alternative, or in addition, to the above-described in vitro tests, the ability of the potential pre-extracts/extracts or extracts of the invention to inhibit cell migration in vivo can be assessed using various standard techniques. For example, the ability of the potential pre-extracts/extracts to inhibit endothelial cell migration can be determined using the chick chorioallantoic membrane (CAM) assay, Matrigel plug assay and/or corneal micropocket assay.
The CAM assay can be used to evaluate the ability of an extract to inhibit growth of blood vessels into various tissues, i.e. both angiogenesis and neovascularization (see Brooks et al., in Methods in Molecular Biology, Vol. 129, pp. 257-269 (2000), ed. A. R. Howlett, Humana Press Inc., Totowa, N.J.; Ausprunk et al., (1975) Am. J. Pathol., 79:597-618; Ossonski et al., (1980) Cancer Res., 40:2300-2309). The CAM assay measures neovascularization of whole tissue, wherein chick embryo blood vessels grow into the CAM or into the tissue transplanted on the CAM, and is, therefore, a well-recognised assay model for in vivo angiogenesis. In addition, the assay provides an internal toxicity control in that the chick embryo is exposed to the potential pre-extract/extract over the course of the assay. The health of the embryo can, therefore, provide an indication of the cytotoxicity of the extract.
The Matrigel plug assay is also a standard method for evaluating the anti-angiogenic properties of compounds in vivo (see, for example, Passaniti, et al., (1992) Lab. Invest. 67:519-528). In this assay, an extract is introduced into cold liquid Matrigel which, after subcutaneous injection into a suitable animal model, solidifies and permits penetration by host cells and the formation of new blood vessels. After a suitable period of time, the animal is sacrificed and the Matrigel plug is recovered, usually together with the adjacent subcutaneous tissues. Assessment of angiogenesis in the Matrigel plug is achieved either by measuring haemoglobin or by scoring selected regions of histological sections for vascular density, for example by immunohistochemistry techniques identifying specific factors such as hemagglutinin (HA), CD31 (platelet endothelial cell adhesion molecule-1) or Factor VIII. Modifications of this assay have also been described (see, for example, Akhtar et al., (2002) Angiogenesis 5:75-80; Kragh et al., (2003) Int J Oncol. 22:305-11).
The corneal micropocket assay is usually conducted in mice, rats or rabbits and has been described in detail by others (see D'Amato, et al., (1994) Proc. Natl, Acad. Sci. USA, 91:4082-4085; Koch et al., (1991) Agents Actions, 34:350-7; Kenyon, et al., (1996) Invest. Opthalmol. Vis. Sci. 37:1625-1632). Briefly, pellets for implantation are prepared from sterile hydron polymer containing a suitable amount of the extract. The pellets are surgically implanted into corneal stromal micropockets created at an appropriate distance medial to the lateral corneal limbus of the animal. Angiogenesis can be quantitated at various times after pellet implantation through the use of stereomicroscopy. Typically, the length of neovessels generated from the limbal vessel ring toward the centre of the cornea and the width of the neovessels are measured.
Similarly to the CAM assay both the Matrigel plug assay and the corneal micropocket assay provide some indication of the toxicity of the extract as the test animal is exposed to the extract. The overall health of the animal, therefore, can provide an indication of toxicity.
The ability of the extract to inhibit the migration of neoplastic cells in vivo can be determined using various models of experimental metastasis known in the art. Typically, this involves the treatment of neoplastic cells with the extract ex vivo and subsequent injection or implantation of the cells into a suitable test animal. The spread of the neoplastic cells from the site of injection, for example spread to the lungs and/or lymphoid nodes, is then monitored over a suitable period of time by standard techniques.
In addition to the above tests, potential pre-extracts/extracts or extracts of the invention may be submitted to other standard tests, such as those for the assessment of cytotoxicity, stability, bioavailability and the like. Such tests may be conducted prior to testing potential pre-extracts/extracts for their ability to modulate cellular activity or they may be conducted once an extract of the invention has been selected. As will be readily apparent to one skilled in the art, a selected extract will need to meet certain criteria in order to be suitable for in vivo use and to meet regulatory requirements. Conducting such tests, therefore, allows the suitability of an extract for in vivo use to be assessed. Similarly, once an extract has been found to be suitable for animal administration, its efficacy may be determined by standard in vivo tests and clinical trials.
The present invention contemplates the large-scale preparation of selected extracts of the invention. Such extracts can be prepared on a commercial scale by repeating the extraction process that lead to the isolation of the extract of interest. One embodiment of this aspect of the invention is presented in
Also contemplated by the present invention are modifications to the small-scale procedure that may be required during scale-up for industrial level production of the extract. Such modifications include, for example, alterations to the solvent being used or to the extraction procedure employed in order to compensate for variations that occur during scale-up and render the overall procedure more amenable to industrial scale production, or more cost effective. Modifications of this type are standard in the industry and would be readily apparent to those skilled in the art.
Purification/Fractionation of Extracts and Active Ingredients from Extracts of the Invention
The present invention also provides for active ingredients from the extracts of the inventions, and for purified or concentrated extracts. The present invention further provides for methods of purifying one or more active ingredient from the extracts of the invention. In the context of the present invention an “active ingredient” is a compound or molecule that is capable of inhibiting one or more extracellular protease and that demonstrates the ability to modulate one or more cellular activity. The active ingredient may be either proteinaceous or non-proteinaceous. “Purifying” an active ingredient or extract indicates that the active ingredient or purified extract can be obtained by purification, partial purification, and/or fractionation of an extract of the invention.
There are a number of techniques well known in the art for isolating active components from mixtures. For example, purification, partial purification, and/or fractionation can be performed using solid-liquid extraction, liquid-liquid extraction, solid-phase extraction (SPE), membrane filtration, ultrafiltration, dialysis, electrophoresis, solvent concentration, centrifugation, ultracentrifugation, liquid or gas phase chromatography (including size exclusion, affinity, etc.) with or without high pressure, lyophilisation, evaporation, precipitation with various “carriers” (including PVPP, carbon, antibodies, etc.), or various combinations thereof. One skilled in the art, would appreciate how to use such options, in a sequential fashion, in order to enrich each successive fraction in the activity of interest by following its activity throughout the purification procedure. Typically, the activity is the inhibitory activity against an extracellular protease of interest and can be measured using assays such as those described above.
Solid-liquid extraction means include the use of various solvents in the art, and includes the use of supercritical solvents, soxhlet extractors, vortex shakers, ultrasounds and other means to enhance extraction, as well as recovery by filtration, centrifugation and related methods as described in the literature (see, for example, R. J. P. Cannell, Natural Products Isolation, Humana Press, 1998). Examples of solvents that may be used include, but are not limited to, hydrocarbon solvents, chlorinated solvents, organic esters, organic ethers, alcohols, water, and mixtures thereof. In the case of supercritical fluid extraction, the invention also covers the use of modifiers such as those described in V. H. Bright (Supercritical Fluid Technology, ACS Symp. Ser. Vol. 488, ch. 22, 1999). Liquid-liquid extraction means include the use of various mixtures of solvents known in the art, including solvents under supercritical conditions. Typical solvents include, but are not limited to, hydrocarbon solvents, chlorinated solvents, organic esters, organic ethers, alcohols, water, various aqueous solutions, and mixtures thereof. The liquid-liquid extraction can be effected manually, or it can be semi-automated or completely automated, and the solvent can be removed or concentrated by standard techniques in the art (see, for example, S. Ahuja, Handbook of Bioseparations, Academic Press, 2000).
Solid-phase extraction (SPE) techniques include the use of cartridges, columns or other devices known in the art. The sorbents that may be used with such techniques include, but are not limited to, silica gel (normal phase), reverse-phase silica gel (modified silica gel), ion-exchange resins, and fluorisil. The invention also includes the use of scavenger resins or other trapping reagents attached to solid supports derived from organic or inorganic macromolecular materials to remove selectively active ingredients or other constituents from the extracts.
Membrane, reverse osmosis and ultrafiltration means include the use of various types of membranes known in the art, as well as the use of pressure, vacuum, centrifugal force, and/or other means that can be utilised in membrane and ultrafiltration processes (see, for example, S. Ahuja, Handbook of Bioseparations, Academic Press, 2000).
Dialysis means include membranes having a molecular weight cut-off varying from less than about 0.5 KDa to larger than about 50 KDa. The invention also covers the recovery of purified and/or fractionated extracts from either the dialysate or the retentate by various means known in the art including, but not limited to, evaporation, reduced pressure evaporation, distillation, vacuum distillation, and lyophilization.
Chromatographic means include various means of carrying out chromatography known by those skilled in the art and described in the literature (see, for example, G. Sofer, L. Hagel, Handbook of Process Chromatography, Academic Press, 1997). Examples include, but are not limited to, regular column chromatography, flash chromatography, high performance liquid chromatography (HPLC), medium pressure liquid chromatography (MPLC), supercritical fluid chromatography (SFC), countercurrent chromatography (CCC), moving bed chromatography, simulated moving bed chromatography, expanded bed chromatography, and planar chromatography. With each chromatographic method, examples of sorbents that may be used include, but are not limited to, silica gel, alumina, fluorisil, cellulose and modified cellulose, various modified silica gels, ion-exchange resins, size exclusion gels and other sorbents known in the art (see, for example, T. Hanai, HPLC: A Practical Guide, RSC Press, UK 1999). The present invention also includes the use of two or more solvent gradients to effect the fractionation, partial purification, and/or purification of said active extracts by chromatographic methods. Examples of solvents that may be utilised include, but are not limited to, hexanes, pentane, petroleum ethers, cyclohexane, heptane, diethyl ether, methanol, ethanol, isopropanol, propanol, butanol, isobutanol, tert-butanol, water, dichloromethane, dichloroethane, ethyl acetate, tetrahydrofuran, dioxane, tert-butyl methyl ether, acetone, and 2-butanone. When water or an aqueous phase is used, it may contain varying amounts of inorganic or organic salts, and/or the pH may be adjusted to different values with an acid or a base such that fractionation and/or purification is enhanced.
In the case of planar chromatography, the present invention includes the use of various forms of this type of chromatography including, but not limited to, one- and two dimension thin-layer chromatography (1D- and 2D-TLC), high performance thin-layer chromatography (HPTLC), and centrifugal thin-layer chromatography (centrifugal TLC).
In the case of countercurrent chromatography (CCC), the present invention includes the use of manual, semi-automated, and automated systems, and the use of various solvents and solvent combinations necessary to effect fractionation and/or purification of active ingredients or extracts (see, for example, W. D. Conway, R. J. Petroski, Modern Countercurrent Chromatography, ACS Symp. Ser. Vol. 593, 1995). Solvent removal and/or concentration can be effected by various means known in the art including, but not limited to, reduced pressure evaporation, evaporation, reduced pressure distillation, distillation, and lyophilization.
The present invention includes the fractionation, partial purification, and purification of active ingredients or extracts by expanded bed chromatography, moving and simulated moving bed chromatography, and other related methods known in the art (see, for example, G. Sofer, L. Hagel, Handbook of Process Chromatography, Academic Press, 1997 and S. Ahuja, Handbook of Bioseparations, Academic Press, 2000).
Selective precipitation means includes the use of various solvents and solvent combinations, the use of temperature changes, the addition of precipitant and/or modifiers, and/or modification of the pH by addition of base or acid to effect a selective precipitation of active ingredients or other constituents.
The invention also includes the fractionation, partial purification, and/or purification of active ingredients and extracts by steam distillation, hydrodistillation, or other related methods of distillation known in the art (see, for example, L. M. Harwood, C. J. Moody, Experimental Organic Chemistry, Blackwell Scientific Publications, UK, 1989).
The process of purifying the active ingredients or extracts also includes the concentration of purified or partially purified active ingredients or extracts by solvent removal of the original extract and/or fractionated extract, and/or purified extract. The techniques of solvent removal are known to those skilled in the art and include, but are not limited to, rotary evaporation, distillation (normal and reduced pressure), centrifugal vacuum evaporation (speed-vac), and lyophilization.
Purified, partially purified and/or concentrated active ingredients and extracts can be tested for their ability to inhibit one or more extracellular protease and to modulate cellular activity according to the one or more of the procedures described above.
The present invention further provides for formulations and pharmaceutical compositions comprising one or more extract of the invention, one or more active ingredient, or a combination thereof.
The formulations and pharmaceutical compositions of the invention comprise extracts and/or active ingredients capable of inhibiting one or more extracellular protease and modulating one or more cellular activity. In one embodiment of the invention, the formulations and pharmaceutical compositions comprise extracts and/or active ingredients capable of slowing down, inhibiting or preventing endothelial or neoplastic cell migration. In general, the extract or active ingredient has the capacity to inhibit at least one of the active proteases involved in the physiological process being targeted, i.e. preventing endothelial or neoplastic cell migration, with a good inhibition constant (Ki). The formulations and pharmaceutical compositions must also have acceptable toxicity and stability. In addition, if the formulation is administered by different means other than topically (e.g. via oral, intraperitoneal, intravenous, subcutaneous, intramuscular etc. routes), then the extract and/or active ingredient must demonstrate acceptable hepatotoxicity and must be sufficiently resistant to degradation to allow the site of action to be reached. Finally, the formulation or pharmaceutical composition must be formulated in a manner to enable administration to the animal in need of treatment. Testing for the above parameters and formulation of appropriate compositions and formulations can be readily achieved by one skilled in the art.
The formulation or pharmaceutical composition may be in a solid or liquid form, for example, a cream, gel or ointment (for a topical application), or gel-cap, tablet or capsule (for oral administration), or other formulation suitable for administration to an animal.
Criteria which must be considered in the preparation of a formulation include, but are not limited to, the physicochemical and biochemical characteristics (bioavailability, toxicity, stability, etc.) of the extracts and/or active ingredients which make up the formulation. In particular, the formulation is prepared so as to preserve, as much as possible, the maximum inhibitory activity of the active components upon administration, without being harmful to the animal. In one embodiment, the overall capacity for inhibition of proteolytic activity in the formulation correlates with the proteolytic overactivity profile of the biological condition being targeted, i.e. cell migration.
Pharmaceutical compositions may be formulated by mixing the extracts and/or active ingredients together with a physiologically acceptable carrier, excipient, binder, diluent, etc. Alternatively, the extracts and/or active ingredients can be formulated independently and the respective formulations can then be extemporaneously admixed using a diluent or the like and administered, or can be administered independently of each other, either concurrently or at staggered times to the same subject.
One embodiment of the invention relates to the preparation of pharmaceutical compositions comprising a therapeutically effective amount of the above said active material or mix of active materials and a pharmaceutically acceptable carrier, diluent, vehicle, or excipient. The pharmaceutical compositions according to the invention may be adapted for oral (capsules tablets, phials, etc.), parenteral, rectal, inhalation, or topical administration, including creams, gels, etc. and may be in unit dosage form. Also, the composition may be adapted for slow release in vivo as known in the art.
The pharmaceutical compositions of the invention may be used in conventional formulations including, but not limited to, solutions, syrups, emulsions, injectables, tablets, capsules, suppositories, hydrophobic and hydrophilic creams and lotions.
In another embodiment, the invention relates to the preparation of herbal and nutraceutical formulations comprising extracts and/or active ingredients or solid parts of the plant(s) from with the extracts were obtained. For nutraceutical formulations comprising solid parts of plant(s), the plant(s) must be an edible plant. The extracts and/or active ingredients or plant parts can be used in these herbal remedies and nutraceutical compositions as solutions, purified solutions, or dry powders after treatments such as those described below.
The formulations and compositions of the present invention may be administered orally, topically, parenterally, by inhalation or spray or rectally in dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles. The term parenteral as used herein includes subcutaneous injections, intravenous, intramuscular, intrasternal injection or infusion techniques. One or more extract and/or active ingredient may be present in association with one or more non-toxic pharmaceutically acceptable carriers and/or diluents and/or adjuvants and, if desired, other active ingredients. The pharmaceutical compositions containing one or more extract and/or active ingredient may be in a form suitable for oral use, for example, as tablets, troches, lozenges, aqueous or oily suspensions, dispersible powders or granules, emulsion hard or soft capsules, or syrups or elixirs.
Formulations intended for oral use may be prepared according to methods known in the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents such as sweetening agents, flavouring agents, colouring agents and preserving agents in order to provide pharmaceutically elegant and palatable preparations. Tablets contain the extracts and/or active ingredients in admixture with non-toxic pharmaceutically acceptable excipients which are suitable for the manufacture of tablets. These excipients may be, for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate: granulating and disintegrating agents for example, corn starch, or alginic acid: binding agents, for example starch, gelatine or acacia, and lubricating agents, for example magnesium stearate, stearic acid or talc. The tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period. For example, a time delay material such as glyceryl monostearate or glyceryl distearate may be employed.
Formulations for oral use may also be presented as hard gelatine capsules wherein the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or as soft gelatine capsules wherein the active ingredient is mixed with water or an oil medium, for example peanut oil, liquid paraffin or olive oil.
Aqueous suspensions contain extracts and/or active ingredients in admixture with excipients suitable for the manufacture of aqueous suspensions. Such excipients are suspending agents, for example, sodium carboxymethylcellulose, methyl cellulose, hydropropylmethylcellulose, sodium alginate, polyvinylpyrrolidone, gum tragacanth and gum acacia: dispersing or wetting agents may be a naturally-occurring phosphatide, for example, lecithin, or condensation products of an alkylene oxide with fatty acids, for example polyoxyethyene stearate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example hepta-decaethyleneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides, for example polyethylene sorbitan monooleate. The aqueous suspensions may also contain one or more preservatives, for example ethyl, or n-propyl p-hydroxy-benzoate, one or more colouring agents, one or more flavouring agents or one or more sweetening agents, such as sucrose or saccharin.
Oily suspensions may be formulated by suspending the extracts and/or active ingredients in a vegetable oil, for example, arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin. The oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. Sweetening agents such as those set forth above, and flavouring agents may be added to provide palatable oral preparations. These compositions may be preserved by the addition of an anti-oxidant such as ascorbic acid.
Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the extracts and/or active ingredients in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those described above. Additional excipients, for example, sweetening, flavouring and colouring agents, may also be present.
Pharmaceutical compositions of the invention may also be in the form of oil-in-water emulsions. The oil phase may be a vegetable oil, for example, olive oil or arachis oil, or a mineral oil, for example liquid paraffin or mixtures of these. Suitable emulsifying agents may be naturally-occurring gums, for example, gum acacia or gum tragacanth, naturally-occurring phosphatides, for example soy bean, lecithin, and esters or partial esters derived from fatty acids and hexitol, anhydrides, for example sorbitan monoleate, and condensation products of the said partial esters with ethylene oxide, for example polyoxyethylene sorbitan monoleate. The emulsions may also contain sweetening and flavouring agents.
Syrups and elixirs may be formulated with sweetening agents, for example, glycerol, propylene glycol, sorbitol or sucrose. Such formulations may also contain a demulcent, a preservative and flavouring and colouring agents. The pharmaceutical compositions may be in the form of a sterile injectable aqueous or oleaginous suspension. This suspension may be formulation according to methods known in the art using suitable dispersing or wetting agents and suspending agents such as those mentioned above. The sterile injectable preparation may also be sterile injectable solution or suspension in a non-toxic parentally acceptable diluent or solvent, for example as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed including synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables.
The present invention further provides for the in vivo use of the extracts of the invention and/or active ingredients derived from the extracts, and formulations and pharmaceutical compositions comprising extracts and/or active ingredients. Thus, the extracts, active ingredients, formulations or pharmaceutical compositions can be administered to an animal in order to slow down, inhibit or prevent undesirable migration of endothelial and/or neoplastic cells and to ameliorate conditions associated therewith. For example, the extracts, active ingredients, formulations or pharmaceutical compositions can be administered to an animal in order to slow down angiogenesis, neovascularisation or tumour metastasis.
As is known in the art, a variety of tissues, or organs comprised of organised tissues, can support angiogenesis including skin, muscle, gut, connective tissue, joints, bones and the like in which blood vessels can invade upon angiogenic stimuli. In addition, a variety of tumour types are known to be capable of metastasizing. The extracts, active ingredients, formulations or pharmaceutical compositions are, therefore, useful in slowing down the migration or invasion of endothelial or neoplastic cells in a variety of animal tissues.
To gain a better understanding of the invention described herein, the following examples are set forth. It should be understood that these examples are for illustrative purposes only. Therefore, they should not limit the scope of this invention in any way.
Pre-Harvest Treatment: Aerial parts of a living plant are sprayed with an aqueous solution of gamma linolenic acid (6,9,12-Octadecatrienoic acid, Sigma L-2378) (stress G) or arachidonic acid (5,8,11,14-Eicosatetraenoic acid, Sigma A-3925) (stress A) (400 μM in water with 0.125% (v/v) Triton X-100) to completely cover the leaves. Twenty to twenty-four hours after the stress, plants are harvested.
Twenty to twenty-four hours after the stress, more than 4 grams of leaves, stems, fruit, flowers, seeds or other plant parts are harvested and frozen immediately in dry ice, then transferred as soon as possible to a −20° C. freezer until use. Plant materials may be stored at −20 C for a long period of time, more than a year, without losing inhibitory activity. Temperature is monitored to ensure a constant condition.
Stressed and non-stressed plant specimens are collected as wet samples and stored at −20° C. for various periods of time, and are submitted to a process which generates 3 subfractions: aqueous, ethanolic and organic fractions. The complete extraction process is performed in a continuous cycle using the following steps. An initial 5 g of plant specimen is homogenized in liquid nitrogen with a blender. The resulting powder is weighed.
To each 4.5 grams of plant powder, 12 ml of a cold solution of 100 mM Tris, pH 7.0 is added. The mixture is thoroughly vortexed for 2 minutes. The mixture is kept on ice for 30 minutes and vortexed after each 10 minute period of time. The sample is centrifuged in a Corex™ 30 ml tube for 5 minutes at 4500 rpm. The resulting supernatant is decanted in a 15 ml tube after filtration with a Miracloth™ filter. This extract is therefore referred as the Potential Pre-Extract A. The pellet, referred as Solid S2, is kept for ethanolic extraction.
The aqueous extract (Potential Pre-Extract A) is further purified in order to determine its extracellular protease inhibition capability. The Potential Pre-Extract A is purified by size-exclusion chromatography, wherein the aqueous extract is chromatographed on a calibrated Sephadex G-25 column (1×10 cm) using a 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 buffer as eluant. Fractions corresponding to compounds that seem to have a molecular weight (MW) less than 1500 daltons (D) are pooled to constitute the purified aqueous extract that is tested for inhibitory activity in an assay as described in Example II.
Prior to this analysis, the extract is treated with 10% gelatin-Sepharose (Pharmacia Biotech, Uppsala, Sw.) in order to remove unspecific enzyme ligands. To 1 mL of extract, 100 μL of gelatin-Sepharose resin is added in a microassay tube, the solution in the tube is mixed, kept on ice for 30 minutes, and then centrifuged 5 minutes at 5,000 rpm. The supernatant is removed and used directly for assays.
To the pellet, Solid S2, collected from the previous aqueous extraction, 12 ml of cold ethanol:methanol (85:15) is added and the mixture is thoroughly vortexed for 2 minutes. The mixture is kept on ice for 30 minutes and vortexed every 10 minutes. The sample is centrifuged in a Corex™ 30 ml tube for 5 minutes at 4,500 rpm. The resulting supernatant is decanted in a 15 ml tube after filtration with a Miracloth™ filter. The pellet, referred as Solid S3 is kept for the subsequent organic extraction. This extract is therefore referred as the Potential Pre-Extract B.
The ethanolic extract, Potential Pre-Extract B, is purified by liquid/liquid extraction prior to analysis by enzymatic assay. For this purpose, 1 ml of ethanolic extract is evaporated under vacuum, dissolved in 150 μl of dimethylsulfoxide (DMSO), and completed to a final volume of 1.5 ml with Tris buffer (final concentration: Tris-HCl 20 mM; pH 7.5). Four ml of hexane is added to the Tris phase in a glass tube and the tube is thoroughly vortexed, then allowed to form a biphasic liquid. The organic phase is removed and the extract is submitted to a second round of liquid/liquid extraction. The aqueous phase is removed and treated with 10% gelatin-Sepharose (Pharmacia Biotech, Uppsala, Sw) to remove unspecific enzyme ligands prior to conducting subsequent assays. To 1 ml of extract, 1001 L of gelatin-Sepharose resin is added in a microassay tube, the tube is mixed, kept on ice for 30 minutes, and then centrifuged 5 minutes at 5,000 rpm. Supernatant is removed and used directly for assays as described in Example II.
To the pellet, Solid S3, collected from previous ethanolic extraction, 12 ml of cold dichloromethane is added and the mixture is thoroughly vortexed for 2 minutes. The mixture is kept on ice for 30 minutes and vortexed after each 10 minutes period. The sample is centrifuged in a Corex™ 30 ml tube for 5 minutes at 4,500 rpm. The resulting supernatant is decanted in a 15 ml glass tube after filtration with a Miracloth™ filter. The final pellet is discarded. The organic solvent is evaporated under vacuum and the phase is dissolved with dimethylsulfoxide (DMSO). This extract is therefore referred as the Potential Pre-Extract C, which was further purified by solid phase extraction prior to analysis by enzymatic assay.
In order to assay the Potential Pre-Extract C, the organic extract is diluted 1:10 in a solution of DMSO:Methanol:Tris (20 mM, pH 7.5) (10 :50 :40) (Solution A), i.e., 220 μl of extract is added to 2.0 ml of solution A. After 10 seconds of vigorous vortex, the mix is sonicated for 10 seconds. Dissolved extracts are subsequently applied to a solid phase extraction plate (Discovery SPE-96, Sigma Chemical Co, St-Louis, Mo.). After initial conditioning of the columns with 1 ml of methanol, columns are equilibrated with solution A, and extract samples are deposited on the columns. Elution is completed with solution A (final volume of 2 ml) and this fraction is used directly in assays as described in Example II.
The inhibitory activity of sample compositions towards human MMP-1, human MMP-2, human MMP-3, human MMP-9, human cathepsin-B, human cathepsin-D, human cathepsin-G, human cathepsin-L, human cathepsin-K, human leukocyte elastase (HLE), bacteria clostripain and bacteria subtilisin can be determined using either fluorogenic substrates or the FASC assay.
Measurement of Human MMP-1, -2, -3 and -9 Activity with Fluorogenic Peptidic Substrates
MMP-1, -2, -9 are purified from natural sources (human immortalized cell lines: 8505C (Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH) for MMP-1, HT-1080 (ATCC, Manassas, Va.) for MMP-2 and THP-1 (ATCC, Manassas, Va.) for MMP-9) as described in literature and based on protocols found in I. M. Clark: <<Matrix metalloproteinases protocols>>, Humana Press (2001). Recombinant human MMP-3 is overexpressed in E. coli and purified according to Windsor L J, Steele D L (2001), Methods Mol Biol 151:191-205. Proteolytic activity of these proteases is evaluated with the assay based on the cleavage of auto-quenched peptide substrate: (MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.TFA [Dpa ═N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]) for MMP-1, -2, and -9; and, MCA-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(DNP)—NH2 (DNP=2,4-dinitrophenyl; Nva=L-norvaline) for MMP-3 (Calbiochem, San Diego, Calif.). In the intact peptide, Dpa or DNP quenches the MCA fluorescence. Cleavage of the peptide causes release of the fluorescent MCA group which is then quantitated on a fluorometer (Gemini XS, Molecular Devices, Sunnyvale, Calif.). The assay is performed in TNCZ assay buffer (20 mM Tris-HCl; NaCl 150 mM; CaCl2 5 mM; ZnCl2 0.5 mM; pH 7.5) with human purified proteases (I. M. Clark: Matrix metalloproteinases protocols, Humana Press (2001)). The substrate, primarily dissolved in DMSO is then redissolved in TNCZ buffer for the assay. In a typical assay, 10 μl of purified enzyme (1-50 ng) and 5 μl of dissolved substrate (final concentration of 10 μM) is mixed in a final volume of 75 μl (completed with TNCZ). All assays were performed in 96 well plate and the reaction is started by the addition of substrate. Assays are measured (excitation 325 nm, emission 392 nm) for 20, 40 and 60 minutes.
Measurement of Human Cathepsin L and K Activity with Fluorogenic Peptidic Substrate.
Human recombinant cathepsins L and K are overexpressed in P. pastoris according to the protocol described by Krupa and Mort (Anal Biochem (2000), 283(1):99-103). The assay is similar to that described above except for the auto-quenched peptidic substrate: Z-Arg-Phe-AMC, 2HCl (Bachem California, Torrance, Calif.) and reaction buffer. Assays for Cathepsin L are performed in 20 mM acetate pH 5.5, 1 mM EDTA buffer and assays for Cathepsin K in 20 mM acetate pH 4.2, 1 mM EDTA. Assays are monitored with fluorometer settled at excitation 380 nm/emission 460 nm wavelengths (Krupa J C, Mort J S. (2000), Anal Biochem 283(1):99-103).
Human Cathepsin B and G and human leukocyte elastase are obtained from Calbiochem (San Diego, Calif.). Human MMP-9 is purified as previously described. The assay is based on the method described in Canadian Patent No. 2,189,486 (1996) and by St-Pierre et al., (Cytometry (1996) 25:374-380. For the assay, 5 μl of the purified enzyme (1-100 ng), 5 μl of concentrated buffer solution (20 mM Tris-HCl; NaCl 150 mM; CaCl2 5 mM; ZnCl2 0.5 mM; pH 7.5), and 5 μl of gelatin-FITC beads are typically used in a final volume of 100 μl. The assay is performed by incubation of the reaction mixture for 90 minutes at 37° C. The reaction is stopped by the transfer of the mix in 0.5 ml of 20 mM Tris, 150 mM NaCl; pH 9.5 buffer. This tube is analyzed in a flow cytometer (Epics MCL, Beckman Coulter, Mississauga, Ontario) as described in Canadian Patent No. 2,189,486 (1996).
Measurement of Human Cathepsin D, Cathepsin B, Cathepsin G and HLE Activity with a Fluorogenic Proteic Substrate
Cathepsin D is purified from human MCF-7 cells according to the method described by Stewart et al., (Int J Cancer (1994) 57(5):715-8. Cathepsin B, Cathepsin G and HLE are obtained as previously described. The activities of Cathepsin D, Cathepsin B, Cathepsin G and HLE are measured by an assay based on the increase of fluorescence of a proteic substrate (Haemoglobin in the case of Cathepsin D and B and beta-casein in the case of Cathepsin G and HLE) heavily labelled with Alexa-488 dye (Molecular Probes, Eugene, Or). The substrate, when highly labelled with the dye, will almost quench the dye fluorescence. Cleavage of the substrate will result in an increase of the fluorescence which can be measured with a spectrofluorometer, and which is proportional to protease activity. Typically, 10 μl of purified human Cathepsin D, Cathepsin B, Cathepsin G or HLE (10-50 ng) and 10 μL of Hemoglobin-Alexa488 or beta-casein-Alexa488 (100 ng) are assayed in final volume of 75 μl adjusted with 20 mM citrate pH 3.3 buffer in the case of Cathepsins D and B or TNCZ buffer in the case of Cathepsin G and HLE. The reaction is performed as already described except that the fluorescence is read at excitation 488 nm/emission 525 nm wavelengths.
Subtilisin (isolated from B. subtilis) is purchased from Fluka. Assays are performed with a fluorogenic peptide (Z-Gly-Gly-Leu-AMC, Bachem California, Torrance, Calif.) as already described for MMPs with the following modification: the assay is buffered with 20 mM Tris, 150 mM NaCl; pH 7.5 and the results are read at excitation 380 nm/emission 460 nm wavelengths.
Clostripain from Clostridium histolyticum (Worthington Lakewood, N.J.) is prepared and activated as described by manufacturer's protocol. The activity is determined by using Z-Arg-Arg-AMC, 2HCl (Calbiochem, San Diego, Calif.) as a fluorogenic peptidic substrate and the incubation buffer is 75 mM phosphate, pH 7.6. The reaction is performed as already described except that the fluorescence is read at excitation 380 nm/emission 460 nm wavelengths.
Before a typical assay, aqueous extracts prepared as described in Example I are preincubated with 1:10 of gelatin-Sepharose 4B™ for 30 minutes to remove fluorescence quenching. For the ethanolic extract, an initial hexane extraction is performed and samples are treated with 1:10 of gelatin-Sepharose 4B™ to remove quenching.
In a typical fluorescent assay, 10 μl of purified enzyme at concentrations previously mentioned for the enzymatic assay, 5 μl of dissolved fluorogenic peptide or 10 μl of dissolved fluorescent proteic substrate (final concentration of 10 μM) and 40 μL of the aqueous, ethanolic or organic extract to be tested and prepared as described in Example I are mixed in a final volume of 75 μl (completed with TNCZ for fluorogenic peptide substrate assay or 20 mM citrate pH 3.3 buffer for fluorescent protein substrate assay). All assays are performed in 96 well plate and the reaction is started by the addition of substrate. Assays are measured (excitation 325 nm, emission 392 nm for peptide and excitation 488 nm/emission 525 nm wavelengths for protein) for 20, 40 and 60 minutes. Activity and inhibition values are determined from the increase in fluorescence
For the FASC assay, 35 μl of the treated extract prepared as described in Example 1, 5 μl of the purified enzyme prepared as described previously, 5 μl of concentrated buffer solution (TNCZ), and 5 μl of gelatin-FITC beads are typically used. The initial step of the assay is the incubation of the reaction without beads for a 30 minutes period on ice to allow the binding of inhibitors to enzyme. Fluorescent beads are added and the reaction mix is incubated for 90 minutes at 37° C. The reaction is stopped by transfer of the mix in 0.5 ml of 20 mM Tris, 150 mM NaCl; pH 9.5 buffer. This tube is analyzed in the flow cytometer (Epics MCL, Beckman Coulter, Mississauga, Ontario) as described in Canadian Patent Application No. 2,189,486 (1996).
Results of the inhibition studies are shown in Tables 1-12 for aqueous (A), ethanolic (R) and organic (S) extracts from exemplary stressed (A and G) and non-stressed (T) plant sources. The inhibition is reported as percentage (%) of inhibition of substrate degradation as compared with the degradation without extract.
Table 1: inhibition of human MMP-1.
Table 2: inhibition of human MMP-2.
Table 3: inhibition of human MMP-3.
Table 4: inhibition of human MMP-9.
Table 5: inhibition of human Cathepsin B.
Table 6: inhibition of human Cathepsin D.
Table 7: inhibition of human Cathepsin G.
Table 8: inhibition of human Cathepsin L.
Table 9: inhibition of human Cathepsin K.
Table 10: inhibition of HLE.
Table 11: inhibition of bacterial subtilisin.
Table 12: inhibition of bacterial clostripain.
Extracts were separated by HPLC on an Agilent 1100 system (San Fernando, Calif.). Briefly, 100 μL of a crude extract prepared as described in Example I was applied on a C18 reverse-phase column (Purospher RP-18 5 μm, 4.0×125 mm (HP), Agilent, San Fernando, Calif.). Elution of compounds was achieved with a linear gradient of 10-85% acetonitrile. Fractions were collected, evaporated, resuspended in aqueous buffer and then reanalysed for their inhibition activity on specific enzymes as already described. Fractions of interest (demonstrating a biological activity) where then reisolated at a larger scale for further analysis and characterisation.
Plant extracts were prepared as described in Example I and underwent further testing to ascertain that they contain stable, orally bioavailable, non-cytotoxic molecules that are appropriate for product development. Stability is ascertained by recovery of protease inhibition over time under various conditions, including physiological conditions. Potential for oral bioavailability is ascertained by an in vitro test using Caco-2 cells and cytotoxicity is ascertained by incubation of the extracts with various cell types, including those indicated below.
In order to test the effect of various plant extracts that are also validated protease inhibitors on cellular migration, the following cellular assays were used: a cellular migration assay coupled with a cord formation assay using endothelial cells; and a cellular migration assay using one of 2 neoplastic cell lines. The experimental details are provided below and the results of the tests are set forth in Tables 13 and 14. Concentrations of plant extracts are expressed as a function of the IC50 concentration determined for protease inhibition, which is termed 1×. The extracts are, therefore, capable of decreasing the activity of at least one extracellular protease by at least 50% when measured according to one of the assays described herein. The 1× concentration can vary depending on the plant and the solvent used in the preparation of the extract. The average concentration of a 1× aqueous extract is about 1.6 mg/ml, whereas the average concentration of a 1× alcoholic extract is about 4 mg/ml. For each extract tested in the assays described below, 4 different concentrations were used (0.31×, 0.62×, 1.25× and 2.5×) in duplicate.
Migration was assessed using a multi-well system (Falcon 1185, 24-well format), separated by a PET membrane (8 μm pore size) into top and bottom sections. Depending on the cells that are used in the assay, the membrane was coated with 10 μg/ml rat tail collagen (for HUVECs) or with 80 μg/cm2 of Matrigel growth factor (BD Biosciences) (for cancer cell lines) and allowed to dry. All solutions used in top sections were prepared in DMEM-0.1% BSA, whereas all solutions used in the bottom sections were DMEM, or other media, containing 10% fetal calf serum. For HUVECs (Clonetics), EGM-2 (700 μl) was added to the bottom chamber as a chemo-attractant. HUVEC (100 μl of 106 cells/ml) and buffer containing the plant extract at the appropriate dilution were added to the upper chamber (duplicate wells of each plant extract at each dilution). After 5 h incubation at 37° C. in a 5% CO2 atmosphere, the membrane was rinsed with PBS, fixed and stained. The cells on the upper side of the membrane were wiped off, three randomly selected fields were counted on the bottom side.
The percent inhibition of migration is calculated as follows:
[(A−B)/A]×100,
where A is the average number of cells per field in the control well and B is the average number of cells per field in the treated wells.
For cancer cell lines, prior to starting the experiment, the Matrigel impregnated filter was rehydrated with 200 μl of DMEM. A mixture of cells (100 μl of 2.5×105/ml HT1080 or MDA-MB-231 cells, both from ATCC) and plant extracts were pipetted into the upper wells and 700 μl of DMEM-5% SVF was added to the bottom wells. The cells were incubated for 48 hours (HT1080 cells) or 72 hours (MDA-MB-231 cells), after which the membrane was treated as described above and inhibition of migration was determined as described above (see also
Matrigel (60 μl of 10 mg/ml) was added to a 96-well plate flat bottom plate (Costar 3096) and incubated for 30 minutes at 37° C. in a 5% CO2 atmosphere. A mixture of HUVECs and plant extract, or positive controls (Fumagillin and GM6001) were added to each well. HUVECs were prepared as suspensions of 2.5×105 cells per ml in EGM-2, then 500 μl of HUVECs preparation was mixed with 500 μl of 2× of the desired dilution of plant extract or control drug and 200 μl were added to each well. Four dilutions of each extract were tested in duplicate. After 18-24 hours at 37° C. in 5% CO2, the cells had migrated and organized into cords (see
[(A−B)/A]×100,
where A is the average number of cell junctions per field in the control well and B is the average number of cell junctions per field in the treated wells.
The invention being thus described, it will be obvious that the same may be varied in many ways. Such variations are not to be regarded as a departure from the spirit and scope of the invention, and all such modifications as would be obvious to one skilled in the art are intended to be included within the scope of the following claims.
Achillea millefolium
Acorus calamus
Actinidia arguta
Agastache foeniculum
Alchemilla mollis
Allium cepa
Allium grande
Allium porrum
Allium porrum
Allium sativum
Allium sativum
Allium schoenoprasum
Allium Tuberosum
Allium Tuberosum
Althaea officinalis
Angelica archangelica
Anthemis nobilis
Aralia nudicaulis
Armoracia rusticana
Armoracia rusticana
Aronia melanocarpa
Aster sp
Beckmannia eruciformis
Beta vulgaris
Beta vulgaris spp. Maritima
Brassica napus
Brassica oleracea
Brassica oleracea
Brassica Oleracea
Brassica rapa
Calamintha nepeta
Camellia sinensis
Capsicum annuum
Capsicum annuum
Capsicum frutescens
Chenopodium bonus-henricus
Chenopodium bonus-henricus
Chenopodium quinoa
Chrysanthenum coronarium
Cichorium intybus
Cichorium intybus
Citrullus lanatus
Cornus canadensis
Crataegus sp
Cucumis Anguria
Cucurbita moschata
Cucurbita pepo
Cymbopogn citratus
Cymbopogon citratus
Cyperus esculentus
Cyperus esculentus
Dactylis glomerata
Daucus carota
Daucus carota
Dipsacus sativus
Dirca palustris
Eruca vesicaria
Eschscholzia californica
Eschscholzia californica
Filipendula rubra
Foeniculum vulgare
Fragaria x ananassa
Fragaria X ananassa
Fragaria x ananassa
Galinsoga ciliata
Gallium odoratum
Gaultheria hispidula
Glycine max
Glycine max
Glycine max
Guizotia abyssinica
Hamamelis virginiana
Helianthus Tuberosus
Heliotropium arborescens
Hordeum hexastichon
Hordeum vulgare
Hordeum vulgare
subsp. Vulgare
Inula helenium
Lathyrus sativus
Leonurus cardiaca
Levisticum officinale
Lolium multiflorum
Lotus corniculatus
Malva sylvestris
Matricaria recutita
Matteucia pensylvanica
Medicago sativa
Melissa officinalis
Mentha piperita
Mentha suaveolens
Nepeta cataria
Nicotiana rustica
Origanum vulgare
Origanum vulgare
Perilla frutescens
Perilla frutescens
Petroselinum crispum
Phacelia tanacetifolia
Phaseolus coccineus
Phaseolus coccineus
Phaseolus Vulgaris
Phaseolus vulgaris
Phaseolus Vulgaris
Phaseolus Vulgaris
Phlo x paniculata
Pimpinella anisum
Pimpinella anisum
Plantago coronopus
Plectranthus sp.
Poa compressa
Potentilla anserina
Pysalis ixocarpa
Raphanus raphanistrum
Raphanus sativus
Raphanus sativus
Rheum officinale
Rheum rhabarbarum
Rheum rhabarbarum
Ribes nigrum
Ribes nigrum
Ribes salivum
Ribes sylvestre
Ribes uva-crispa
Rubus canadensis
Rubus canadensis
Rubus idaeus
Salvia officianalis
Salvia sclarea
Satureja montana
Solanum dulcamara
Solanum melanocerasum
Solanum tuberosum
Sorghum dochna
Stachys byzantina
Stellaria media
Tanacetum parthenium
Tanacetum vulgare
Taraxacum officinale
Thymus praeco x subsp arcticus
Thymus praeco x subsp arcticus
Thymus vulgaris
Thymus x citriodorus
Trichosanthes kirilowii
Trifolium hybridum
Trifolium incarnatum
Trifolium pannonicum
Trifolium repens
Vaccinum augustifolium
Vaccinum macrocarpon
Vicia sativa
Vicia sativa
Vicia villosa
Vicia villosa
Vigna sesquipedalis
Vigna sesquipedalis
Vigna unguiculata
Vitia spp
Vitia spp
Zea Mays
Zea Mays
Abelmochus esculentus
Aconitum napellus
Allium ampeloprasum
Allium ascalonicum
Allium cepa
Allium cepa
Allium sativum
Allium tuberosum
Althaea officianalis
Althaea officinalis
Althaea officinalis
Althea officinalis
Anethum graveolens
Apium graveolens
Armoracia rusticana
Armoracia rusticana
Aronia melanocarpa
Artemisia dracunculus
Artemisia dracunculus
Asparagus officinalis
Bellis perennis
Beta vulgaris spp. Maritima
Beta vulgaris spp. Maritima
Betula glandulosa
Borago officinalis
Borago officinalis
Brassica cepticepa
Brassica oleracea
Brassica oleracea
Brassica rapa
Brassica rapa
Calamintha nepeta
Calendula officinalis L.
Camellia sinensis
Campanula rapunculus
Capsella bursa-pastoris
Capsicum annum
Chaerophyllum bulbosum
Chenopodium quinoa
Cichorium intybus
Circium arvense
Citrullus lanatus
Cucurbita pepo
Cucurbita Pepo
Cuminum cyminum
Cymbopogon citratus
Datura stramonium
Daucus carota
Daucus carota
Dryopteris filix-mas
Erysimum perofskianum
Fagopyrum esculentum
Foeniculum vulgare
Foeniculum vulgare
Gaultheria hispidula
Gaultheria procumbens
Glechoma hederacea
Glycine max
Glycyrrhiza glabra
Guizotia abyssinica
Helenium hoopesii
Helianthus annuus
Helianthus tuberosus
Hordeum vulgare
Hordeum vulgare subsp. Vulgare
Hypericum henryl
Iberis amara
Lactuca sativa
Lathyrus sylvestris
Lavandula angustifolia
Lepidium Sativum
Levisticum officinale
Lolium multiflorum
Lolium multiflorum
Lotus corniculatus
Lycopersicon esculentum
Lycopersicon pimpinellifolium
Malus hupehensis
Malva verticillata
Matricaria recutita
Matteucia pensylvanica
Melissa officinalis
Mentha piperita
Mentha spicata
Mentha spicata
Mentha suaveolens
Nepeta cataria
Nicotiana rustica
Nicotiana tabacum
Oenothera biennis
Oenothera biennis
Origanum vulgare
Origanum vulgare
Origanum vulgare
Oryza Sativa
Pana x quinquefolius
Panicum miliaceum
Passiflora caerula
Pastinaca sativa
Pastinaca sativa
Pennisetum alopecuroides
Petroselinum crispum
Phalaris canariensis
Phaseolus coccineus
Phaseolus coccineus
Phaseolus coccineus
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Phlo x paniculata
Physalis pruinosa
Plantago coronopus
Plantago major
Plectranthus sp.
Potentilla anserina
Prunella vulgaris
Raphanus Raphanistrum
Raphanus sativus
Reseda odorata
Rheum officinale
Rheum rhabarbarum
Ribes Nigrum
Ribes Sylvestre
Ricinus communis
Rubus Phoenicalasius
Ruta graveolens
Salvia officinalis
Santolina
Satureja hortensis
Satureja repandra
Scrophularia nodosa
Scutelaria lateriflora
Sium sisarum
Solanum dulcamara
Solanum melanocerasum
Solanum melorgena
Solanum tuberosum
Sorghum caffrorum
Sorghum dochna
Sorghum dochna
Sorghum sudanense
Stachys byzantina
Stellaria media
Symphytum officinale
Tanacetum parthenium
Tanacetum vulgare
Taraxacum officinale
Teucrium chamaedrys
Teucrium chamaedrys
Thymus praeco x subsp arcticus
Thymus x citriodorus
Trichosanthes kirilowii
Trifolium hybridum
Trifolium incarnatum
Trifolium pannonicum
Trifolium repens
Triticosecale spp.
Triticum spelta
Tropaeolum majus
Urtica dioica
Vaccinium corymbosum
Vaccinium corymbosum
Vaccinum angustifolium
Vicia sativa
Vicia sativa
Vicia villosa
Vicia villosa
Vigna sesquipedalis
Vitia spp
Withania somnifera
Xanthium strumarium
Zea mays
Aconitum napellus
Agaricus bisporus
Agaricus bisporus
Allium ampeloprasum
Allium ascalonicum
Allium cepa
Allium cepa
Allium grande
Allium schoenoprasum
Allium tuberosum
Allium tuberosum
Aloe vera
Althaea officinalis
Amelanchier alnitolia
Ananas comosus
Anthemis nobilis
Anthriscus cerefolium
Apium graveolens
Aralia nudicaulis
Armoracia rusticana
Artemisia dracunculus
Asparagus officinalis
Atriple x hortensis
Bellis perennis
Beta vulgaris
Betula glandulosa
Boletus edulis
Brassica juncea
Brassica napus
Brassica oleracea
Brassica oleracea
Camellia sinensis
Camellia sinensis
Canna edulis
Carum carvi
Chaerophyllum bulbosum
Chrysanthemun coronarium (Chp suey)
Chrysanthenum coronarium
Chrysanthenum coronarium
Cichorium endivia
Cichorium endivia
Cichorium intybus
Cichorium intybus
Cichorium intybus
Citrullus lanatus
Citrus paradisi
Cocos nucifera
Cornus canadensis
Crithmum maritimum
Cucumis anguria
Cucurbita moschata
Cucurbita moschata (Early Butternut)
Cucurbita pepo
Cuminum cyminum
Curcuma zedoaria
Cymbopogon citratus
Datura metel
Datura metel
Dioscorea batatas
Dipsacus sativus
Dryopteris filix-mas
Erigeron canadensis
Eruca vesicaria
Erysimum perofskianum
Eschscholzia californica
Eschscholzia californica
Fagopyrum esculentum
Fagopyrum tartaricum
Foeniculum vulgare
Foeniculum vulgare
Forsythia x intermedia
Fragaria x ananassa
Galinsoga ciliata
Gaultheria procumbens
Hedeoma pulegioides
Helianthus tuberosus
Hordeum vulgare
Humulus lupulus
Hypericum henryi
Hypericum perforatum
Iberis amara
Ipomea aquatica
Lathyrus Sativus
Laurus nobilis
Lavandula latifolia
Lens culinaris subsp. Culinaris
Lepidium sativum
Levisticum officinale
Lolium multiflorum
Lunaria annua
Lycopersicon pimpinellifolium
Malus hupehensis
Malus sp.
Malva sylvestris
Malva sylvestris
Manihot esculenta
Melissa officinalis
Melissa officinalis
Mentha suaveolens
Nigella sativa
Nigella sativa
Ocimum Basilicum
Origanum majorana
Origanum vulgare
Origanum vulgare
Pana x quinquefolius
Passiflora spp.
Pastinaca sativa
Perroselinum crispum
Petroselinum crispum
Petroselinum crispum
Peucedanum oreaselinum
Phacelia tanacetifolia
Phalaris canariensis
Phaseolus coccineus
Phaseolus mungo
Phaseolus vulgaris
Phaseolus vulgaris
Phoeni x dactylifera
Physalis ixocarpa goldie ou pourpre
Phytolacca americana
Plectranthus sp.
Pleurotus spp.
Poa compressa
Poa pratensis
Populus Tremula
Prunella vulgaris
Psoralea corylifolia
Pteridium aquilinum
Raphanus raphanistrum
Raphanus sativus
Raphanus sativus
Raphanus sativus
Reseda luteola
Reseda odorata
Rheum officinale
Rheum officinale
Ribes nigrum
Ribes Sativum
Ribes Sylvestre
Ricinus communis
Rosmarinus officinalis
Rubus canadensis
Sabal serrulata
Salvia officinalis
Sambucus canadensis
Satureja montana
Satureja repandra
Satureja repandra
Satureja repandra
Scrophularia nodosa
Secale cereale
Setaria italica
Silybum marianum
Solanum melongena
Solanum tuberosum
Solidago virgaurea
Sorghum dochna
Stachys byzantina
Stellaria media
Symphytum officinale
Tanacetum parthenium
Tanacetum vulgare
Taraxacum officinale
Teucrium chamaedrys
Teucrium chamaedrys
Thalpsi arvense
Thymus praeco x subsp arcticus
Tragopogon porrifolium
Trifolium incarnatum
Trifolium pannonicum
Trifolium repens
Triticosecale spp.
Tropaeolum majus
Tropaeolum majus
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium macrocarpon
Vicia villosa
Vigna sesquipedalis
Vigna unguiculata
Vinca minor
Withania somnifera
Xanthium strumarium
Zea mays
Zea mays
Achillea millefolium
Achillea millefolium
Achillea millefolium
Aconitum napellus
Alcea rosea
Alchemilla mollis
Allium ascalonicum
Allium cepa
Allium grande
Allium porrum
Allium porum
Allium porum
Allium sativum
Allium schoenoprasum
Allium Tuberosum
Allium Tuberosum
Allium Tuberosum
Aloe vera
Althaea officinalis
Althaea officinalis
Amaranthus gangeticus
Anethum graveolens
Apium graveolens
Apium graveolens
Aralia cordata
Aralia cordata
Aralia nudicaulis
Arctium minus
Armoracia rusticana
Armoracia rusticana
Arrhenatherum elatius
Artemisia dracunculus
Asparagus officinalis
Atriple x hortensis
Avena sativa
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Brassica chinensis
Brassica napus
Brassica Napus
Brassica Napus
Brassica nigra
Brassica oleracea
Brassica Oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica rapa
Brassica rapa
Brassica rapa
Brassica rapa
Brassica rapa
Calamintha nepeta
Camellia sinensis
Camellia sinensis
Camellia sinensis
Cana edulis
Canna edulis
Capsella bursa-pastoris
capsicum annuum
Capsicum annuum
Capsicum annuum
Capsicum frutescens
Capsicum frutescens
Carthamus tinctorius
Carthamus tinctorius
Chaerophyllum bulbosom
Chelidonium majus
Chenopodium bonus-henricus
Chenopodium bonus-henricus
Chenopodium bonus-henricus
Chenopodium quinoa
Chrysanthemum coronarium
Chrysanthemum coronarium
Chrysanthemum coronarium
Chrysanthemum coronarium
Cicer arietinum
Cicer arietinum
Cichorium intybus
Cichorium intybus
Citrullus lanatus
Citrullus lanatus
Citrullus lanatus
Coi x Lacryma-Jobi
Cornus canadensis
Cosmos sulphureus
Crataegus spp
Cryptotaenia canadensis
Cryptotaenia canadensis
Cucumis anguria
Cucumis Anguria
Cucumis melo
Cucurbita Maxima
Cucurbita Maxima
Cucurbita moschata
Cucurbita moschata
Cucurbita pepo
Cucurbita pepo
Curcuma zedoaria
Curcuma zedoaria
Curcurbita maxima
Cymbopogon citratus
Cymbopogon citratus
Cymbopogon martinii
Dactylis glomerata
Dactylis glomerata
Daucus carota
Daucus carota
Dipsacus sativus
Dirca palustris
Dolichos Lablab
Dryopteris filix-mas
Echinacea purpurea
Eleusine coracana
Eleusine coracana
Erigeron canadensis
Eruca vesicaria
Eschscholzia californica
Eschscholzia californica
Eschscholzia californica
Fagopyrum esculentum
Fagopyrum tartaricum
Fagopyrum tartaricum
Galinsoga ciliata
Galium odoratum
Galium odoratum
Gaultheria hispidula
Gaultheria hispidula
Glau x maritima
Glycine max
Glycine Max
Glycine max
Guizotia abyssinica
Guizotia abyssinica
Hamamelis virginiana
Helianthus annuus
Helianthus Tuberosus
Helianthus tuberosus
Helianthus Tuberosus
Hordeum hexastichon
Hordeum hexastichon
Hordeum hexastichon
Hordeum vulgare
Hordeum vulgare subsp. Vulgare
Hordeum vulgare subsp. Vulgare
Hyssopus officinalis
Inula helenium
Ipomoea Batatas
Lathyrus sativus
Lathyrus sativus
Lathyrus sylvestris
Lavandula latifolia
Lepidium sativum
Lepidium sativum
Levisticum officinale
Levisticum officinale
Linum usitatissimum
Lolium multiflorum
Lolium multiflorum
Lotus corniculatus
Lotus tetragonolobus
Lycopersicon esculentum
Lycopersicon esculentum
Lycopersicon esculentum
Lycopersicon pimpinollifolium
Malva moschata
Malva moschata
Malva verticillata
Matricaria recutita
Matricaria recutita
Melaleuca alternifolia
Melilotus albus
Melilotus albus
Melissa officinalis
Mentha pulegium
Mentha spicata
Mentha suaveolens
Nepeta cataria
Nicotiana rustica
Nicotiana rustica
Nicotiana tabacum
Nicotiana tabacum
Nigella sativa
Ocimum tenuiflorum
Oenothera biennis
Origanum majorana
Origanum majorana
Origanum vulgare
Pana x quinquefolius
Pastinaca sativa
Pastinaca sativa
Petasites japonicus
Petroselinum crispum
Phalaris canariensis
Phalaris canariensis
Phalaris canariensis
Phaseolus coccineus
Phaseolus coccineus
Phaseolus coccineus
Phaseolus mungo
Phaseolus vulgaris
Phaseolus Vulgaris
Phaseolus vulgaris
Phaseolus Vulgaris
Phlo x paniculata
Phlo x paniculata
Physalis alkekengi
Physalis ixocarpa
Physalis ixocarpa
Physalis Pruinosa
Physalis Pruinosa
Phytolacca decandra
Phytolacca decandra
Pimpinella anisum
Pimpinella anisum
Plantago coronopus
Plantago coronopus
Plantago coronopus
Plantago major
Plectranthus sp.
Poa compressa
Poa compressa
Poa compressa
Polygonum pensylvanicum
Polygonum pensylvanicum
Polygonum persicaria
Polygonum persicaria
Poterium sanguisorba
Poterium Sanguisorba
Pteridium aquilinum
Pteridium aquilinum
Pysalis ixocarpa
Raphanus raphanistrum
Raphanus sativus
Raphanus sativus
Raphanus sativus
Raphanus sativus
Raphanus Sativus
Rheum officinale
Ribes nigrum
Ribes nigrum
Ricinus communis
Rosa rugosa
Rosa rugosa
Rosa rugosa
Rosmarinus officinalis
Rubus idaeus
Rubus ideaus
Rume x Acetosa
Rume x Acetosa
Rume x Acetosa
Rume x crispus
Rume x crispus
Ruta graveolens
Saccharum officinarum
Sali x purpurea
Salvia officinalis
Salvia officinalis
Salvia sclarea
Santolina chamaecyparissus
Satureja hortensis
Satureja hortensis
Satureja montana
Satureja montana
Scorzonera hispanica
Secale cereale
Secale cereale
Senecio vulgaris
Senecio vulgaris
Sesamum indicum
Sesamum indicum
Solanum dulcamara
Solanum melanocerasum
Solanum melanocerasum
Solanum melanocerasum
Solanum melongena
Solanum melongena
Sonchus oleraceus
Sorghum caffrorum
Sorghum dochna
Sorghum dochna
Sorghum dochna
Sorghum durra
Sorghum durra
Sorghum sudanense
Spinacia oleracea
Stachys affinis
Stachys byzantina
Stachys byzantina
Stellaria graminea
Stellaria graminea
Stellaria media
Stellaria media
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
Thymus praeco x subsp arcticus
Thymus vulgaris
Thymus x citriodorus
Trichosanthes kirilowii
Trichosanthes kirilowii
Trigonella foenumgraecum
Triticosecal spp.
Triticum aestivum
Triticum durum
Triticum spelta
Triticum spelta
Triticum spelta
Tropaeolum majus
Urtica dioica
Urtica dioica
Vaccinium Corymbosum
Veratrum viride
Verbascum thapsus
Veronica beccabunga
Veronica officinalis
Vicia sativa
Vicia villosa
Vicia villosa
Vigna angularis
Vigna sesquipedalis
Vigna sesquipedalis
Vigna sesquipedalis
Vigna unguiculata
Vinca minor
Vinca minor
Vitis sp.
Vitis sp.
Xanthium sibiricum
Xanthium sibiricum
Xanthium sibiricum
Zea mays
Zea Mays
Abelmochus esculentus
Abelmochus esculentus
Achillea millefolium
Aconitum napellus
Acorus calamus
Ageratum conyzoides
Alcea rosea
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Allium ampeloprasum
Allium ampeloprasum
Allium ascalonicum
Allium cepa
Allium cepa
Allium cepa
Allium grande
Allium sativum
Allium sativum
Allium sativum
Allium schoenoprasum
Allium schoenoprasum
Allium tuberosum
Allium tuberosum
Allium tuberosum
Aloe vera
Althaea officinalis
Altheaa officinalis
Amaranthus caudathus
Amaranthus caudathus
Amaranthus gangeticus
Anethum graveolens
Angelica archangelica
Angelica archangelica
Apium graveolens
Apium graveolens
Apium graveolens
Apium graveolens
Aralia nudicaulis
Arctium minus
Armoracia rusticana
Aronia melanocarpa
Aronia melanocarpa
Artemisia dracunculus
Artemisia dracunculus
Artemisia dracunculus
Artemisia dracunculus
Asclepias incarnata
Asparagus officinalis
Asparagus officinalis
Asparagus officinalis
Aster spp
Beckmannia eruciformis
Bellis perennis
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Brassica cepticepa
Brassica chinensis
Brassica juncea
Brassica Napus
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica rapa
Brassica rapa
Brassica Rapa
Calamintha nepeta
Calamintha nepeta
Camellia sinensis
Campanula rapunculus
Canna edulis
Capsella bursa-pastoris
Capsella bursa-pastoris
Capsicum annuum
Capsicum annuum
Capsicum annuum
Capsicum frutescens
Capsicum frutescens
Carthamus tinctorius
Centaurea solstitialis
Cerastium tomentosum
Chenopodium bonus-henricus
Chenopodium quinoa
Chenopodium quinoa
Chrysanthemun coronarium
Chrysanthenum coronarium
Cicer arietinum
Cichorium endivia subsp endivia
Cichorium endivia subsp endivia
Cichorium intybus
Cichorium intybus
Circium arvense
Circium arvense
Citrullus lanatus
Citrullus lanatus
Citrullus lanatus
Cosmos sulphureus
Cosmos sulphureus
Cucumis sativus
Cucumis sativus
Cucurbita maxima
Cucurbita maxima
Cucurbita maxima
Cucurbita moschata
Cucurbita pepo
Cucurbita pepo
Cucurbita pepo
Cuminum cyminum
Curcuma zedoaria
Cymbopogon citratus
Cymbopogon martinii motia
Cymbopogon martinii motia
Dactylis glomerata
Dactylis glomerata
Datura stramonium
Daucus carota
Daucus carota
Daucus carota
Digitalis purpurea
Dipsacus sativus
Dirca palustris
Dolichos Lablab
Dryopteris filix-mas
Echinacea purpurea
Eleusine coracana
Erigeron speciosus
Errhenatherum elatius
Eruca vesicaria
Eschscholzia californica
Eschscholzia californica
Fagopyrum tartaricum
Filipendula rubra
Foeniculum vulgare
Foeniculum Vulgare
Galinsoga ciliata
Galinsoga ciliata
Gaultheria hispidula
Gaultheria hispidula
Gaultheria hispidula
Glau x maritima
Glycine max
Glycine max
Glycine max
Guizotia abyssinica
Guizotia abyssinica
Guizotia abyssinica
Hedeoma pulegioides
Helianthus annuus
Helianthus annuus
Helianthus annuus
Helianthus strumosus
Helianthus tuberosus
Helichrysum thianschanicum
Helleborus niger
Hordeum hexastichon
Hordeum vulgare
Hordeum vulgare subsp. Vulgare
Humulus lupulus
Hypericum henryi
Hypericum henryi
Hyssopus officinalis
Iberis amara
Inula helenium
Lactuca sativa
Lactuca serriola
Laportea canadensis
Lathyrus sylvestris
Lavandula angustifolia
Lavandula latifolia
Lepidium Sativum
Lepidium sativum
Levisticum officinale
Lolium multiflorum
Lotus corniculatus
Lotus corniculatus
Lotus tetragonolobus
Lycopersicon esculentum
Lycopersicon esculentum
Lycopersicon pimpinellifolium
Malus hupehensis
Malus hupehensis
Malva moschata
Malva sylvestris
Malva verticillata
Matricaria recutita
Matricaria recutita
Melaleuca alternifolia
Melilotus alba
Melilotus albus
Melilotus albus
Melissa officinalis
Mentha arvensis
Mentha arvensis
Mentha piperita
Mentha piperita
Mentha piperita
Mentha spicata
Mentha spicata
Mentha suaveolens
Mentha suaveolens
Momordica charantia
Monarda didyma
Monarda didyma
Monarda fistulosa
Nepeta cataria
Nicotiana tabacum
Nigella sativa
Ocimum basilicum
Ocimum basilicum
Ocimum tenuiflorum
Oerothera biennis
Origanum majorana
Origanum majorana
Origanum vulgare
Origanum vulgare
Origanum vulgare
Oxalis Deppei
Oxalis Deppei
Oxalis Deppei
Oxyria digyna
Panicum miliaceum
Panicum miliaceum
Panicum miliaceum
Passiflora caerula
Passiflora caerula
Pastinaca sativa
Pastinaca sativa
Petroselinum crispum
Petroselinum crispum
Phalaris canariensis
Phalaris canariensis
Phaseolus acutifolius
Phaseolus coccineus
Phaseolus coccineus
Phaseolus mungo
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Phlo x paniculata
Phlo x paniculata
Phlo x paniculata
Physalis ixocarpa
Physalis ixocarpa
Physalis ixocarpa
Physalis pruinosa
Phytolacca americana
Phytolacca americana
Pimpinella anisum
Pimpinella anisum
Pisum sativum
Plantago coronopus
Plantago coronopus
Plantago coronopus
Plantago major
Plantago major
Poa compressa
Poa compressa
Poa compressa
Poa pratensis
Polygonum aviculare
Polygonum pensylvanicum
Polygonum pensylvanicum
Polygonum persicaria
Polygonum persicaria
Polygonum persicaria
Portulaca oleracera
Poterium sanguisorba
Poterium sanguisorba
Poterium sanguisorba
Prunella vulgaris
Prunus cerasifera
Raphanus Raphanistrum
Raphanus Raphanistrum
Raphanus sativus
Raphanus sativus
Raphanus sativus
Raphanus sativus
Raphanus sativus
Reseda odorata
Rheum officinale
Ribes nigrum
Ribes nigrum
Ribes Sylvestre
Ricinus communis
Ricinus communis
Rosmarinus officinalis
Rubus idaeus
Rubus ideaus
Rubus occidentalis
Rume x crispus
Rume x crispus
Rume x patientia
Rume x patientia
Ruta graveolens
Ruta graveolens
Saccharum officinarum
Salvia elegens
Salvia officinalis
Salvia officinalis
Salvia officinalis
Sambucus ebulus
Santolina chamaecyparissus
Santolina chamaecyparissus
Santolina chamaecyparissus
Saponaria officinalis
Satureja hortensis
Satureja hortensis
Satureja montana
Satureja repandra
Satureja repandra
Scorzonera hispanica
Scrophularia nodosa
Scrophularia nodosa
Scrophularia nodosa
Scutellaria lateriflora
Scutellaria lateriflora
Secale cereale
Senecio vulgaris
Sesamum indicum
Sesamum indicum
Silene vulgaris
Sium sisarum
Solanum melanocerasum
Solanum melanocerasum
solanum melongena
solanum melongena
solanum melongena
Solanum tuberosum
Sonchus oleraceus
Sorghum dochna
Sorghum dochna
Sorghum dochna
sorghum durra
Sorghum durra
Sorghum sudanense
Spinacia oleracea
Spinacia oleracea
Stachys byzantina
Stellaria graminea
Stellaria media
Stellaria media
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
Thymus fragantissimus
Thymus fragantissimus
Thymus praeco x subsp arcticus
Thymus serpyllum
Thymus vulgaris
Thymus vulgaris
Thymus x citriodorus
Tragopogon porrifolius
Trichosanthes kirilowii
Trigonella foenumgraecum
Trigonella foenumgraecum
Triticosecale spp
Triticosecale spp
Triticum aestivum
Triticum durum
Triticum spelta
Triticum spelta
Triticum turgidum
Tropaeolum majus
Tropaeolum majus
Urtica dioica
Urtica dioica
Valerianella locusta
Veratrum viride
Verbascum thapsus
Veronica beccabunga
Veronica officinalis
Veronica officinalis
Viburnum trilobum
Vicia faba
Vicia sativa
Vicia sativa
Vicia villosa
Vigna angularis
Vigna sesquipedalis
Vigna sesquipedalis
Vigna sesquipedalis
Vigna unguiculata
Vigna unguiculata
Vinca minor
Vitis sp.
Vitis sp.
Withania somnifera
Withania somnifera
Xanthium sibiricum
Xanthium sibiricum
Xanthium strumarium
Xanthium strumarium
Xanthium strumarium
Zea mays
Zea mays
Zea mays
Abies lasiocarpa
Abies lasiocarpa
Achillea millefolium
Aconitum napellus
Aconitum napellus
Adiantum pedatum
Agaricus bisporus
Agaricus bisporus
Ageratum conyzoides
Agropyron repens
Agrostis Stolonifera
Alcea rosea
Alchemilla mollis
Allium ampeloprasum
Allium ampeloprasum
Allium ascalonicum
Allium ascalonicum
Allium cepa
Allium cepa
Allium cepa
Allium cepa
Allium grande
Allium schoenoprasum
Allium tuberosum
Allium tuberosum
Allium tuberosum
Aloe vera
Althaea officianalis
Althaea officinalis
Althaea officinalis
Amaranthus caudathus
Amaranthus gangeticus
Ananas comosus
Ananas comosus
angelica archangelica
Anthemis nobilis
Anthemis nobilis
Anthriscus cerefolium
Anthriscus cerefolium
Apium graveolens
Apium graveolens
Aralia cordata
Aralia nudicaulis
Arctium minus
Arctium minus
Armoracia rusticana
Arrhenatherum elatius
Artemisia dracunlus
Asclepias incarnata
Asparagus officinalis
Atriple x hortensis
Avena sativa
Avena sativa
Avena sativa
Averrhoa carambola
Bellis perennis
Beta vulgaris
Beta vulgaris
Betula glandulosa
Boletus edulis
Borago officinalis
Borago officinalis
Brassica hirta
Brassica hirta
Brassica Napus
Brassica Napus
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica rapa
Brassica rapa
Brassica rapa
Brassica rapa
Brassica rapa
Calamintha nepeta
Calendula officinalis
Camellia sinensis
Camellia sinensis
Camellia sinensis
Canna edulis
Cantharellus cibarias
Capsicum annuum
Capsicum annuum
Capsicum frutescens
Capsicum frutescens
Care x morrowii
Carica papaya
Carthamus tinctorius
Carya cordiformis
Cerastium tomentosum
Chaerophyllum bulbosum
Chaerophyllum bulbosum
Chelidonium majus
Chenopodium quinoa
Chrysanthemum coronarium
Chrysanthemum parthenium
chrysanthemun coronarium
Chrysanthenum coronarium
Cicer arietinum
Cichorium endivia subsp endivia
Cichorium endivia subsp. Endivia
Cichorium endivia subsp. Endivia
Cichorium intybus
Cichorium intybus
Cimicifuga racemosa
Cimicifuga racemosa
Circium arvense
Circium arvense
Citrullus lanatus
Citrullus lanatus
Citrullus lanatus
Citrus limettoides
Citrus limon
Citrus paradisi
Citrus paradisi
Citrus sinensis
Colocasia sp
Colocasia sp
Corchorus olitorius
Coriandrum sativum
Cornus canadensis
Cosmos sulphureus
Crataegus submollis
Crataegus submollis
Cucumis anguria
Cucumis anguria
Cucumis melo
Cucumis melo
Cucumis melo
Cucumis metuliferus
Cucumis sativus
Cucurbita maxima
Cucurbita maxima
Cucurbita maxima
Cucurbita moschata
Cucurbita moschata
Cucurbita moschata
Cucurbita moschata
Cucurbita moschata
Cucurbita pepo
Cucurbita pepo
Erysimum perofskianum
Erysimum perofskianum
Eschscholzia californica
Eschscholzia californica
Fagopyrum esculentum
Fagopyrum tartaricum
Fagopyrum tartaricum
Fagopyrum tartaricum
Festuca rubra
Festuca rubra
Festuca rubra
Foeniculum vulgare
Foeniculum vulgare
Foericulum vulgare
Fortunella spp
Fragaria x ananassa
Galinsoga ciliata
Galinsoga ciliata
Galium odoratum
Galium odoratum
Glau x Maritima
Glycine max
Glycine max
Glycine max
Glycine max
Gossypium herbaceum
Guizotia abyssinica
Guizotia abyssinica
Hedeoma pulegioides
Hedeoma pulegioides
Helianthus annuus
Helianthus strumosus
Helianthus tuberosus
Helianthus tuberosus
Helianthus tuberosus
Helianthus tuberosus
Helichrysum angustifolium
Helichrysum angustifolium
Helichrysum thianschanicum
Heliotropium arborescens
Helleborus niger
Hibiscus cannabinus
Hordeum vulgare
Hordeum vulgare supsp vulgare
Hordeum vulgare supsp vulgare
Humulus lupulus
Humulus lupulus
Hypericum henryi
Hypericum henryi
Hypericum perforatum
Hyssopus officinalis
Iberis amara
Juniperus communis
Kochia scoparia
Koeleria glauca
Lactuca sativa
Lactuca serriola
Laportea canadensis
Lathyrus sylvestris
Laurus nobilis
Lavandula angustifolia
Lavandula angustifolia
Lavandula latifolia
Lepidium sativum
Lepidium sativum
Lepidium sativum
Levisticum officinale
Levisticum officinale
Linum usitatissimum
Lolium multiflorum
Lolium multiflorum
Lonicera ramosissima
Lonicera ramosissima
Lonicera syringantha
Lotus corniculatus
Lotus corniculatus
Lotus tetragonolobus
Lunaria annua
Lycopersicon esculentum
Lycopersicon pimpinellifolium
Malus hupehensis
Malus hupehensis
Malus sp.
Malva moschata
Malva verticillata
Manihot esculenta
Melaleuca alternifolia
Melaleuca alternifolia
Melilotus albus
Melilotus officinalis
Melilotus officinalis
Melissa officinalis
Mentha piperita
Mentha pulegium
Mentha suaveolens
Miscanthus sinensis Andress
Momordica charantia
Monarda didyma
Monarda fistulosa
Monarda fistulosa
Montia perfoliata
Musa paradisiaca
nasturtium officinale
Nepeta cataria
Nepeta cataria
Nepeta cataria
Nicotiana rustica
Nicotiana rustica
Nicotiana tabacum
Nicotiana tabacum
Nigella sativa
Nigella sativa
Nigella sativa
Ocimum Basilicum
Ocimum Basilicum
Ocimum tenuiflorum
Oenothera biennis
Onobrychis viciifolia
Onobrychis viciifolia
Opuntia sp.
Origanum vulgare
Origanum vulgare
Origanum vulgare
Oryza sativa
Oxalis Deppei
Oxalis Deppei
Passiflora caerulea
Passiflora caerulea
Passiflora spp
Pastinaca sativa
Pastinaca sativa
Perilla frutescens
Perroselinum crispum
Perroselinum crispum
Persea americana
Petasites Japonicus
Petroselinum crispum
Peucedanum oreaselinum
Phalaris canariensis
Phalaris canariensis
Phaseolus acutifolius
Phaseolus coccineus
Phaseolus coccineus
Phaseolus coccineus
Phaseolus coccineus
Phaseolus mungo
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Phlo x paniculata
Phlo x paniculata
Physalis alkekengi
Physalis ixocarpa
Physalis ixocarpa
Physalis pruinosa
Physalis pruinosa
Physalis pruinosa
Physalis pruinosa
Phytolacca decandra
Phytolacca decandra
Pimpinella anisum
Pimpinella anisum
Pimpinella anisum
Pimpinella anisum
Pisum sativum
Plantago coronopus
Plantago coronopus
Plantago coronopus
Plantago major
Plectranthus sp.
Pleurotus spp
Poa compressa
Poa compressa
Poa compressa
Poa pratensis
Polygonum pensylvanicum
Polygonum pensylvanicum
Polygonum persicaria
Polygonum persicaria
Populus incrassata
Populus incrassata
Prunus armeniaca
Prunus cerasus
Prunus persica
Prunus persica
Psoralea corylifolia
Pteridium aquilinum
Pyrus communis
Raphanus raphanistrum
Raphanus raphanistrum
Raphanus raphanistrum
Raphanus raphanistrum
Raphanus sativus
Raphanus sativus
Raphanus sativus
Reseda odorata
Rhamnus frangula
Rhamnus frangula
Rheum officinale
Rheum officinale
Ricinus communis
Rosmarinus officinalis
Rosmarinus officinalis
Rubus ideaus
Rume x acetosella
Rume x crispus
Rume x patientia
Ruta graveolens
Ruta graveolens
Saccharum officinarum
Saccharum officinarum
Salvia elegans
Salvia elegans
Salvia officinalis
Salvia officinalis
Salvia sclarea
Sambucus canadensis
Sambucus canadensis
Sambucus canadensis
Sanguisorba minor
Sanguisorba minor
Santolina chamaecyparissus
Santolina chamaecyparissus
Saponaria officinalis
Satureja hortensis
Satureja hortensis
Satureja montana
Satureja montana
Satureja montana
Satureja repandra
Satureja repandra
Satureja repandra
Scolymus hispanicus
Scorzorera hipanica
Scrophularia nodosa
Scrophularia nodosa
Scrophularia nodosa
Scutellaria lateriflora
Scutellaria lateriflora
Secale cereale
Senecio vulgaris
Senecio vulgaris
Sesamum indicum
Silene vulgaris
Sium sisarum
Sium sisarum
Solanum melanocerasum
Solanum melanocerasum
Solanum melanocerasum
Solanum melongena
Sorghum caffrorum
Sorghum dochna
Sorghum dochna
Sorghum durra
Sorghum durra
Sorghum sudanense
Sorghum sudanense
Spinacia oleracea
Spinacia oleracea
Stachys byzantina
Stachys byzantina
Stellaria media
Stellaria media
Stipa capillata
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum cinerariifolium
Tanacetum parthenium
Tanacetum vulgare
Taraxacum officinale
Teucrium chamaedrys
Thalpsi arvense
Thymus fragantissimus
Thymus praeco x subsp arcticus
Thymus pseudolanuginosus
Thymus pseudolanuginosus
Thymus serpyllum
Thymus vulgaris
Thymus X citriodorus
Tragopogon porrifolium
Tragopogon porrifolius
Tragopogon porrifolius
Tragopogon sp.
Trifolium repens
Trigonella foenum graecum
Trigonella foenum graecum
Triticosecale spp
Triticosecale spp
Triticum aestivum
Triticum aestivum
Triticum durum
Triticum spelta
Triticum turgidumm
Tropaeolum majus
Tropaeolum majus
Tsuga diversifolia
Typha latifolia
Urtica dioica
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium macrocarpon
Vaccinium macrocarpon
Valerianella locusta
Valerianella locusta
Veronica beccabunga
Veronica officinalis
Veronica officinalis
Viburnum trilobum
Vicia faba
Vicia faba
Vicia sativa
Vicia villosa
Vigna angularis
Vigna sesquipedalis
Vigna sesquipedalis
Vigna unguiculata
Vigna unguiculata
Vinca minor
Vitis sp.
Vitis sp.
Vitis sp.
Weigela coraeensis
Weigela coraeensis
Withania somnifera
Withania somnifera
Xanthium sibiricum
Xanthium sibiricum
Xanthium sibiricum
Xanthium strumarium
Xanthium strumarium
Zea mays
Zea mays
Zingiber officinale
Achillea millefolium
Allium Tuberosum
Anethum graveolens
Anthemis nobilis
Anthemis tinctoria
Apium graveolens
Arctium minus
Arctium minus
Arctostaphylos uva-ursi
Aronia melanocarpa
Artemisia Absinthium
Artemisia dracunculus
Artemisia dracunculus
Aster sp
Atropa belladonna
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris var. condivata
Brassica napus
Brassica napus
Brassica oleracea
Canna edulis
Capsicum annuum
Capsicum frutescens
Cichorium intybus
Cichorium intybus
Cichorium intybus
Citrullus lanatus
Citrullus lanatus
Citrullus lanatus
Coix Lacryma-Jobi
Coix Lacryma-Jobi
Cosmos sulphureus
Crataegus submollis
Crataegus submollis
Cucumis anguria
Cucurbita Maxima
Cucurbita moschata
Cucurbita pepo
Datisca cannabina
Datisca cannabina
Digitalis purpurea
Dipsacus sativus
Dirca palustris
Dryopteris filix-mas
Dryopteris filix-mas
Echinacea purpurea
Fagopyrum tataricum
Fagopyrum tataricum
Filipendula rubra
Filipendula rubra
Fragaria x ananassa
Fragaria x ananassa
Fragaria x ananassa
Fragaria x ananassa
Gaultheria hispidula
Glycyrrhiza glabra
Hedeoma pulegioides
Helianthus tuberosus
Hordeum vulgare subsp vulgare
Hypericum henryi
Hypericum perforatum
Hyssopus officinalis
Iris versicolor
Isatis tinctoria
Levisticum officinale
Lotus tetragonolobus
Matricaria recutita
Matteucia pensylvanica
Melissa officinalis
Mentha suaveolens
Nepeta cataria
Nigella sativa
Ocinum tenuiflorum
Ocinum tenuiflorum
Perilla frutescens
Petasites japonicus
Phaseolus mungo
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus Vulgaris
Phlox paniculata
Physalis alkekengi
Plantago major
Polygonum aviculare linné
Polygonum persicaria
Potentilla anserina
Poterium sanguisorba
Prunus cerasitera
Ptaridium aquilinus
Raphanus raphanistrum
Raphanus sativus
Ribes nigrum
ribes uva-crispa
ribes uva-crispa
Rosa rugosa
Rosmarinus officinalis
Rubus allegheniensis
Rubus arcticus
Rubus canadensis
Rubus idaeus
Rubus idaeus
Rubus pubescens
Rubus thibetanus
Rumex patientia
Ruta graveolens
Salvia officinalis
Santolina chamaecyparissus
Scutellaria lateriflora
Solanum melongena
Solidago canadensis
Stachys affinis
Stellaria media
Tanacetum vulgare
Thymus praecox subsp arcticus
Thymus praecox subsp arcticus
Trichosanthes kirilowii
Vaccinium Corymbosum
Vaccinium macrocarpon
Vaccinium augustifolium
Vigna angularia
Vigna sesquipedalis
Vigna unguiculata
Vinca minor
Vitis sp.
Vitis sp.
Vitis sp.
Xanthium sibiricum
Aconitum napellus
Agropyron repens
Alchemilla mollis
Alchemilla mollis
Allium grande
Anethum graveolens
Aronia melanocarpa
Artemisia absinthium
Artemisia absinthium
Artemisia dracunculus
Atropa belladonna
Bellis perennis
Brassica oleracea
Brassica oleracea
Brassica rapa
Capsicum annuum
Capsicum annuum
Capsicum frutescens
Chelidonium majus
Cichorium intybus
Coix Lacryma-Jobi
Cosmos sulphureus
Crataegus submollis
Crataegus submollis
Cucumis anguria
Cucurbita maxima
Cucurbita moschata
Cucurbita pepo
Cymbopogon citratus
Cymbopogon martinii
Daucus carota
Dryopteris filix-mas
Dryopteris filix-mas
Echinacea purpurea
Echinochloa frumentacea
Fagopyrum esculentum
Fagopyrum tartaricum
Fagopyrum tartaricum
Filipendula rubra
Filipendula rubra
Forsythia intermedia
Fragaria x ananassa
Fragaria x ananassa
Gaultheria hispidula
Gaultheria hispidula
Gaultheria procumbens
Glycine max
Glycyrrhiza glabra
Guizotia abyssinica
Hamamelis virginiana
Hamamelis virginiana
Helenium hoopesii
Helianthus tuberosus
Hordeum hexastichon
Humulus lupulus
Humulus lupulus
Hypericum henryi
Hypericum perforatum
Hyssopus officinalis
Hyssopus officinalis
Iris versicolor
Isatis tinctoria
Lavandula angustifolia
Levisticum officinale
Malus hupehensis
Malus hupehensis
Malva sylvestris
Matricaria recutita
Melaleuca alternifolia
Melissa officinalis
Melissa officinalis
Melissa officinalis
Mentha piperita
Mentha pulegium
Monarda didyma
Nepeta cataria
Nepeta cataria
Nigella sativa
Ocinum tenuiflorum
Oenothera biennis
Origanum vulgare
Origanum vulgare
Pennisetum alopecuroides
Petroselinum crispum
Peucedanum oreaselinum
Phaseolus acutifolius
Phaseolus acutifolius
Phaseolus vulgaris
Phaseolus vulgaris
Phlox paniculata
Physalis alkekengi
Physalis alkekengi
Plantago major
Plectranthus sp.
Polygonum persicaria
Potentilla anserina
Poterium sanguisorba
Prunus cerasifera
Ptaridium aquilinus
Rhaphanus sativus
Rheum x cultorum
Ribes nidigrolaria
Ribes Silvestris
Rosmarinus officinalis
Rubus idaeus
Rubus ideaus
Rubus Phoenicalasius
Rubus pubescens
Rubus thibetanus
Rumex patientia
Salvia officinalis
Salvia officinalis
Sanguisorba officinalis
Santolina chamaecyparissus
Secale cereale
Senecio vulgaris
Solanum melongena
Solanum tuberosum
Sorghum dochna
Sorghum dochna
Symphytum officinale
Teucrium chamaedrys
Thymus praecox subsp arcticus
Thymus praecox subsp arcticus
Thymus x citriodorus
Triticum durum
Triticum turgidum
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium corymbosum
Vaccinium corymbosum
Vaccinium corymbosum
Vaccinium macrocarpon
Vaccinum angustifolium
Vaccinum angustifolium
Valeriana officinalis
Veronica officinalis
Vicia faba
Vicia faba
Vigna angularia
Vigna angularis
Vigna unguiculata
Vitis sp.
Vitis sp.
Vitis sp.
Withania somnifera
Xanthium strumarium
Zea mays
Zea mays
Abies lasiocarpa
Acorus calamus
Actinidia arguta
Agropyron repens
Alchemilla mollis
Alchemilla mollis
Allium cepa
Allium cepa
Allium tuberosum
Allium tuberosum
Alpinia officinarum
Amelanchier alnitolia
Amelanchier sanguinea x A. laevis
angelica archangelica
Apium graveolens
Aralia cordata
Aralia nudicaulis
Aralia nudicaulis
Aronia melanocarpa
Aronia melanocarpa
Aronia prunifolia
Artemisia absinthium
Artemisia dracunlus
Ayperus esculentus
Beta vulgaris
Beta vulgaris
Beta vulgaris
Borago officinalis
Brassica Napus
Brassica oleracea
Brassica oleracea
Brassica rapa
Bromus inermis
Calendula officinalis L.
Camellia sinensis syn. Thea sinensis
Capsicum annus
Capsicum annus
Capsicum frutescens (tabasco)
Carya cordiformis
Chaerophyllum bulbosum
Chaerophyllum bulbosum
Chelidonium majus
Chrysanthemum parthenium
Chrysanthenum coronarium
Cichorium inlybus
Citrullus lanatus
Citrullus lanatus (Garden baby)
Citrus limettoides
Citrus limon
Corchorus olitorius
Cornus canadensis L.
Cornus canadensis L.
Cosmos sulphureus
Cosmos sulphureus
Crataegus sp
Crataegus submollis
Crataegus submollis
Cucumis anguria
Cucumis sativus Fanfare
Cucurbita moschata
Cucurbita pepo
Cucurbita pepo
Cuminum cyminum
Curcuma zedoaria
Cymbopogon citratus
Dolichus lablab
Dryopteris filix-mas
Echinacea purpurea
Eriobotrya japonica
Eriobotrya japonica
Foericulum vulgare
Fragaria x ananassa
Fragaria x ananassa
Glycine max
Glycine max
Gossypium herbaceum
Guizotia abyssinica
Hamamelis virginiana
Hamamelis virginiana
Hamamelis virginiana
Hedeoma pulegiodes
Helenium hoopesii
Helianthus annus
Helianthus strumosus
Heliotropium arborescens
Helleborus niger
Hibiscus cannabinus
Hordeum vulgare subsp. Vulgare
Humulus lupulus
Humulus lupulus
Humulus lupulus
Humulus lupulus
Humulus lupulus
Humulus lupulus
Humulus lupulus
Hypericum henryl
Hypericum perforatum
Hypomyces lactiflorum
Iris versicolor
Juniperus communis
Lactuca serriola
Laportea canadensis
Lavendula angustifolia
Lepidium sativum
Levisticum officinale
Lolium perenne
Lonicera ramosissima
Lonicera syringantha
Malus
Malus hupehensis (Pamp.) Rehd.
Malus sp.
Malus sp.
Malva moschata
Malva sylvestris
Matteucia pensylvanica
Melissa officinalis
Mentha piperita
Mentha piperita
Mentha piperita
Mentha pulegium
Mentha pulegium
Mentha spicata
Mentha spicata
Nicotiana tabacum
Nigella sativa
Ocimum Basilicum
Ocnothera bienris
Origanum marjonara
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Panicum miliaceum
Panicum miliaceum
Pastinaca saliva
Pastinaca sativa
Peucedanum oreaselinum
Peucedanum oreaselinum
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Physalis alkekengi
Physalis pruinosa
Plantago major
Poa compressa
Polygonium chinense
Polygonium chinense
Polygonum persicaria
Populus incrassata
Populus incrassata
Populus x petrowskyana
Prunus cerasifera
Prunus cerasifera
Psidium guajaba
Ptaridium aquilinus
Pyrus pyrifolia
Rahmnus frangula
Raphanus sativus
Raphanus sativus
Rhamnus frangula
Rheum rhabarbarum
Rheum X cultorum
Rianus communis
Ribes nidigrolaria
Ribes nigrum
Rosa rugosa
Rosmarinum officinalis
Rubus arcticus
Rubus ideaus
Rubus pubescens
Rubus thibetanus
Rumex patientia
Ruta graveolens
Salvia (elegens)
Salvia (elegens)
Salvia officinalis
Sambucus canadensis
Sanguisorba minor
Sanguisorba minor
Sanguisorba minor
Sanguisorba minor
Santolina
Sarratula tinctoria
Satureja montana
Satureja repandra
Scorzorera hipanica
Scuttellaria lateriflora
Setaria italica
Solidago canadensis
Stachys affinis
Stachys byzantina
Stellaria media (linné) Cyrillo
Tanacetum vulgare
Tepary
Tepary
Thymus serpyllum
Thymus serpyllum
Thymus x citriodorus
Tiarella cordifolia
Tragopogon porrifolium
Tragopogon porrifolium
Tragopogon porrifolium
Triticale sp.
Tropaeolum majus
Tropaeolum majus
Tropaeolum majus
Tsuga can0adensis
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium angustifolium Ait.
Vaccinium macrocarpon
Vaccinium macrocarpon
Vaccinium macrocarpon
Vaccinium macrocarpon
Vaccinium macrocarpon
Valeriana officinalis
Veratrum viride
Verbascum thapsus
Vicia faba
Vicia faba
Vigna angularia
Vigna angularia
Vigna sesquipedalis
Vigna unguiculata
Vitia sp.
Vitis sp
Vitis sp.
Weigela coracensis
Weigela coracensis
Weigela hortensis
Zea mays
Abelmochus esculentus
Achillea millefolium
Aconitum napellus
Acorus calamus
Actinidia arguta
Adiantum pedatum
Agastache foeniculum
Agrimonia eupatoria
Agropyron cristatum
Agropyron repens
Agrostis alba
Agrostis Stofonifera
Alcea rosea
Alkanna tinctoria
Allium cepa
Allium grande
Allium porrum
Allium porrum
Allium sativum
Allium schoenoprasum
Allium tuberosum
Allium Tuberosum
Althaea officinalis
Amaranthus gangeticus
Amaranthus gangeticus
Amaranthus gangeticus
Amaranthus retroflexus
Ambrosia artemisiifolia
Amelanchier sanguinea
Anthemis nobilis
Anthemis nobilis
Anthemis tinctorium
Apium graveolens
Arachis hypogaea
Aralia cordata
Aralia cordata
Arctium minus
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Armoracia rusticana
Armoracia rusticana
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa
Arrhenatherum elatius
Artemisia dracunculus
Asparagus officinalis
Asparagus officinalis
Aster sp
Aster sp
Atropa belladonna
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Beta vulgaris var. condivata
Brassica napus
Brassica napus
Brassica napus
Brassica nigra
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica Oleracea
Brassica rapa
Brassica rapa
Brassica rapa
Brassica rapa
Brassica rapa
Brassica rapa
Bromus inermis
Campanula rapunculus
Canna edulis
Canna edulis
Canna edulis
Capsella bursa-pastoris
Capsicum annuum
Capsicum annuum
capsicum annuum
Capsicum frutescens
Capsicum frutescens
Carthamus tinctorius
Carum carvi
Chelidonium majus
Chenopodium bonus-henricus
Chenopodium bonus-henricus
Chenopodium bonus-henricus
chenopodium bonus-henricus
Chenopodium quinoa
Chenopodium quinoa
Chrysanthemum leucanthemum
Chrysanthemum leucanthemum
Chrysanthemun coronarium (Chp Suey)
Chrysanthenum coronarium
Cichorium intybus
Citrullus lanatus
Citrullus lanatus
Cornus canadensis
Cosmos sulphureus
Cosmos sulphureus
Crataegus sp
Crataegus sp
Crataegus sp
Crataegus submollis
Cryptotaenia canadensis
Cucumis Anguria
Cucumis anguria
Cucumis anguria
Cucumis melo
Cucumis sativus
Cucumis sativus
Cucumis sativus
Cucurbita Maxima
Cucurbita moschata
Cucurbita pepo
Curburbita pepo
Curburbita pepo
Curcuma zedoaria
Curcurbita maxima
Cymbopogon citratus
Dactylis glomerata
Datisca cannabina
Datisca cannabina
Daucus carota
Daucus carota
Dirca palustris
Dirca palustris
Dolicos Lablab
Dolicos Lablab
Dryopteris filix-mas
Dryopteris filix-mas
Eleusine coracana
Eleusine coracana
Eleusine coracana
Elymus junceus
Erigeron canadensis
Eruca vesicaria
Fagopyrum esculentum
Fagopyrum tartaricum
Fagopyrum tartaricum
Festuca rubra
Foeniculum Vulgare
Foeniculum vulgare
Forsythia intermedia
Fragaria x ananassa
Fragaria x ananassa
Galium odoratum
Gaultheria hispidula
Gaultheria hispidula
Gentiana lutea
Glechoma hederacea
Glycine max
Glycine Max
Glycine max
Glycyrrhiza glabra
Glycyrrhiza glabra
Guizotia abyssinica
Hamamelis virginiana
Hamamelis virginiana
Hedeoma pulegioides
Helianthus tuberosus
Helianthus tuberosus
Helichrysum angustifolium
Heliotropium arborescens
Helleborus niger
Hordeum hexastichon
Hyssopus officinalis
Inula helenium
Isatis tinctoria
Lactuca serrila
Lactuca serriola
Laportea canadensis
Lathyrus sativus
Lathyrus sativus
Lathyrus sylvestris
Lathyrus sylvestris
Laurus nobilis
Laurus nobilis
Lavandula latifolia
Leonurus cardiaca
Lepidium sativum
Levisticum officinale
Levisticum officinale
Linaria vulgaris miller
Linum usitatissimum
Lolium multiflorum
Lolium perenne
Lotus corniculatus
Lotus tetragonolobus
Lycopersicon esculentum
Lycopersicon esculentum
Malva moschata
Malva sylvestris
Malva verticillata
Matteucia pensylvanica
Medicago sativa
Melilotus albus
Melissa officinalis
Melissa officinalis
Melissa officinalis
Mentha piperita
Mentha pulegium
Mentha spicata
Mentha suaveolens
Momordica charantia
Momordica charantia
Nicotiana rustica
Nicotiana rustica
Nicotiana tabacum
Nicotiana tabacum
Nicotiana tabacum
Nigella sativa
Oenothera biennis
Oenothera biennis
Origanum vulgare
Origanum vulgare
Oryza sativa
Oxyria digyna
Oxyria digyna
Pastinaca sativa
Pastinaca sativa
Pastinaca sativa
Pastinaca sativa
Phalaris canariensis
Phalaris canariensis
Phaseolus mungo
Phaseolus mungo
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Phlox paniculata
Physalis alkekengi
Physalis ixocarpa
Physalis ixocarpa
Physalis Pruinosa
Phytolacca americana
Phytolacca americana
Pimpinella anisum
Plantago coronopus
Plantago coronopus
Plantago major
Poa compressa
Poa compressa
Poa pratensis
Polygonum pensylvanicum
Polygonum persicaria
Polygonum persicaria
Potentilla anserina
Potentilla anserina
Poterium Sanquisorba
Pteridium aquilinum
Raphanus sativus
Raphanus sativus
Raphanus sativus
Raphanus sativus
Raphanus sativus
Rheum rhabarbarum
Rheum rhabarbarum
Rheum rhabarbarum
Ribes nidigrolaria
Ribes nidigrolaria
Ribes nigrum
Ribes nigrum
Ribes nigrum
Ribes nigrum
Ribes Nigrum
Ribes Salivum
Ribes Sylvestre
Ribes Sylvestre
ribes uva-crispa
Ribes Uva-crispa
Ricinus communis
Rosa rugosa
Rosa rugosa
Rosa rugosa
Rosmarinus officinalis
Rosmarinus officinalis
Rubus allegheniensis
Rubus canadensis
Rubus canadensis
Rubus canadensis
Rubus canadensis
Rubus idaeus
Rubus idaeus
Rubus idaeus
Rubus ideaus
Rumex acetosella
Rumex acotosa
Rumex crispus
Rumex crispus
Rumex patientia
Rumex patientia
Rumex Scutatus
Rumex Scutatus
Rumex Scutatus
Ruta graveolens
Ruta graveolens
Salix purpurea
Salix purpurea
Salvia elegans
Salvia officinalis
Salvia officinalis
Salvia sclarea
Satureja montana
Scuttellaria lateriflora
Secale cereale
Secale cereale
Secale cereale
Sesamum indicum
Setaria italica
Sium Sisarum
Sium Sisarum
Solanum dulcamara
Solanum dulcamara
Solanum melanocerasum
Solanum melongena
Solanum melongena
Solanum melongena
Solanum melongena
Solidago sp
Spinacia oleracea
Stachys affinis
Stachys affinis
Stachys affinis
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum cinerariifolium
Tanacetum vulgare
Tanacetum vulgare
Teucrium chamaedrys
Teucrium chamaedrys
Thymus serpyllum
Thymus vulgaris
Thymus x citriodorus
Tragopogon porrifolius
Tragopogon porrifolius
Trifolium hybridum
Trifolium pannonicum
Trifolium repens
Trigonella foenum graecum
Triticum spelta
Triticum turgidum
Typha latifolia
Urtica dioica
Urtica dioica
Vaccinium Corymbosum
Vaccinium Corymbosum
Vaccinum augustifolium
Vaccinum macrocarpon
Veratrum viride
Veratrum viride
Verbascum thapsus
Verbascum thapsus
Viburnum trilobum
Vicia sativa
Vicia villosa
Vigna unguiculata
Vigna unguiculata
Vigna unguiculata
Vinca minor
Vitis sp.
Vitis sp.
Vitis sp.
Xanthium sibiricum
Zea mays
Zea mays
Zea Mays
Achillea millefolium
Aconitum napellus
Aconitum napellus
Acorus calamus
Acorus calamus
Actinidia arguta
Adiantum pedatum
Adiantum pedatum
Ageratum conyzoides
Agropyron cristatum
Agropyron repens
Agropyron repens
Agrostis Stolonifera
Alcea rosea
Alchemilla mollis
Alchemilla mollis
Allium ampeloprasum
Allium cepa
Allium cepa
Allium schoenoprasum
Allium schoenoprasum
Allium tuberosum
Allium tuberosum
Althaea officianalis
Amaranthus candathus
Amaranthus caudathus
Amaranthus gangeticus
Amaranthus gangeticus
Ambrosia artemisiifolia
Amelanchier sanguinea
Angelica archangelica
Anthemis nobilis
Apium graveolens
Apium graveolens
Apium graveolens
Arachis hypogaea
Aralia cordata
Arctium minus
Arctium minus
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Armoracia rusticana
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa (Michx.) Ell.
Artemisia dracunculus
Artemisia dracunculus
Asclepias incarnata
Asparagus officinalis
Asparagus officinalis
Asparagus officinalis
Aster sp
Aster sp
Atropa belladonna
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Brassica cepticepa
Brassica cepticepa
Brassica juncea
Brassica juncea
Brassica Napus
Brassica Napus
Brassica napus
Brassica nigra
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica rapa
Brassica rapa
Brassica rapa
Bromus inermis
Campanula rapunculus
Canna edulis
Canna edulis
Capsicum annuum
Capsicum annuum
Capsicum annuum
Capsicum annuum
Capsicum frutescens
Carthamus tinctorius
Carum carvi
Chelidonium majus
Chenopodium bonus-henricus
Chenopodium quinoa
Chenopodium quinoa
Chenopodium quinoa
Chichorium endivia subsp endivia
Chichorium endivia subsp endivia
Chrysanthemum coronarium
Chrysanthemum coronarium
Chrysanthemum leucanthemum
Cicer arietinum
Cichorium intybus
Cichorium intybus
Citrullus lanatus
Citrullus lanatus
Coix Lacryma-Jobi
Cornus canadensis
Crataegus sp
Crataegus submollis
Cryptotaenia canadensis
Cucumis anguria
Cucumis anguria
Cucumis sativus
Cucumis sativus
Cucurbita maxima
Cucurbita maxima
Cucurbita moschata
Cucurbita moschata
Cucurbita pepo
Cucurbita pepo
Curcuma zedoaria
Curcuma zedoaria
Cymbopogon citratus
Cynara scolymus
Cynara scolymus
Cynara scolymus
Cyperus esculentus
Datura metel
Datura stramonium
Daucus carota
Daucus carota
Dipsacus sativus
Dirca palustris
Dirca palustris
Dolichos Lablab
Dolichos Lablab
Dryopteris filix-mas
Dryopteris filix-mas
Echinochloa frumentacea
Eleusine coracana
Elymus junceus
Erigeron canadensis
Erigeron speciosus
Errhenatherum elatius
Fagopyrum tartaricum
Foeniculum vulgare
Foeniculum vulgare
Foeniculum vulgare
Foeniculum Vulgare
Forsythia intermedia
Forsythia x intermedia
Galium odoratum
Galium odoratum
Gaultheria hispidula
Gaultheria hispidula
Gaultheria hispidula
Gaultheria procumbens
Gaultheria procumbens
Glechoma hederacea
Glycine max
Glycine max
Glycine max
Glycyrrhiza glabra
Glycyrrhiza glabra
Glycyrrhiza glabra
Guizotia abyssinica
Hamamelis virginiana
Hamamelis virginiana
Hamamelis virginiana
Hedeoma pulegioides
Helenium hoopesii
Helenium hoopesii
Helianthus annuus
Helianthus annuus
Helianthus strumosus
Helianthus strumosus
Helianthus tuberosus
Helianthus tuberosus
Helianthus tuberosus L.
Heliotropium arborescens
Heliotropium arborescens
Helleborus niger
Hordeum vulgare
Humulus lupulus
Hypericum sp
Hyssopus officinalis
Iberis amara
Iberis amara
Inula helenium
Ipomoea batatas
Isatis tinctoria
Lachica serrola
Lactuca sativa
Laportea canadensis
Laportea canadensis
Lathyrus sativus
Lathyrus sylvestris
Lathyrus sylvestris
Laurus nobilis
Lavandula angustifolia
Lavandula latifolia
Ledum groenlandicum
Leonurus cardiaca
Lepidium sativum
Levisticum officinale
Levisticum officinale
Levisticum officinale
Linum usitatissimum
Lolium perenne
Lotus corniculatus
Malus hupehensis
Malva verticillata
Matricaria recutita
Medicago sativa
Melilotus albus
Melissa officinalis
Melissa officinalis
Melissa officinalis
Mentha piperita
Mentha suaveolens
Momordica charantia
Momordica charantia
Nepeta cataria
Nicotiana rustica
Nicotiana rustica
Nicotiana tabacum
Nicotiana tabacum
Nigella sativa
Ocimum basilicum
Oenothera biennis
Oenothera biennis
Origanum vulgare
Oryza Sativa
Oxyria digyna
Oxyria digyna
Panicum miliaceum
Pastinaca sativa
Pastinaca sativa
Pennisetum alopecuroides
Petasites japonicus
Peucedanum oreaselinum
Phacelia tanacetifolia
Phalaris arundinacea
Phalaris canariensis
Phalaris canariensis
Phaseolus coccineus
Phaseolus coccineus
Phaseolus mungo
Phaseolus mungo
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Phlox paniculata
Phlox paniculata
Physalis-ixocarpa
Physalis pruinosa
Phytolacca americana
Phytolacca americana
Pimpinella anisum
Pisum sativum
Pisum sativum
Plantago coronopus
Plantago coronopus
Plantago major
Plantago major
Plectranthus sp.
Poa compressa
Poa compressa
Poa pratensis
Polygonum pensylvanicum
Polygonum persicaria
Potentilla anserina
Poterium sanquisorba
Poterium sanquisorba
Prunus cerasifera
Pteridium aquilinum
Raphanus Raphanistrum
Raphanus Raphanistrum
Raphanus sativus
Raphanus sativus
Raphanus sativus
Rheum rhabarbarum
Ribes Grossularia
Ribes nidigrolaria
Ribes nidigrolaria
Ribes nigrum
Ribes nigrum
Ribes Silvestris
Ribes Silvestris
Ricinus communis
Rosmarinus officinalis
Rosmarinus officinalis
Rosmarinus officinalis
Rubus ideaus
Rubus ideaus
Rubus occidentalis
Rubus occidentalis
Rumex acetosa
Rumex acetosella
Rumex acetosella
Rumex crispus
Rumex crispus
Rumex patientia
Rumex patientia
Rumex scutatus
Rumex scutatus
Rumex scutatus
Ruta graveolens
Ruta graveolens
Salvia elagens
Salvia elegans
Sambucus canadensis
Sambucus ebulus
Sambucus ebulus
Sambucus ebulus
Sanguisorba officinalis
Santolina chamaecyparissus
Santolina chamaecyparissus
Satureja montana
Scutiellaria lateriflora
Secale cereale
Secale cereale
Serratula tinctoria
Serratula tinctoria
Sesamum indicum
Sesamum indicum
Silybum marianum
Sium sisarum
Solanum dulcamara
Solanum dulcamara
solanum melongena
solanum melongena
solanum melongena
solanum melongena
Solanum tuberosum
Solanum tuberosum
Solidago sp
Sorghum caffrorum
Sorghum dochna
Sorghum dochna
Sorghum dochna
Sorghum dochna
Sorghum durra
sorghum durra
sorghum durra
Sorghum sudanense
Sorghum sudanense
Sorghum sudanense
Spinacia oleracea
Stachys Affinis
Stachys Affinis
Stachys-Affinis
Symphytum officinale
Symphytum officinale
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum vulgare
Tanacetum vulgare
Teucrium chamaedrys
Teucrium chamaedrys
Thymus fragantissumus
Thymus vulgaris
Thymus x citriodorus
Tiarella cordifolia
Tiarella cordifolia
Tragopogon porrifolius
Trifolium hybridum
Trifolium pannonicum
Trifolium repens
Trigonella foenumgraecum
Triticum furgidum
Triticum spelta
Tropaeolum majus
Typha latifolia
Urtica dioica
Vaccinium angustifolium
Vaccinium corymbosum
Vaccinium macrocarpon
Vaccinium angustifolium
Veratrum viride
Verbascum thapsus
Verbascum thapsus
Veronica officinalis
Viburnum trilobum
Viburnum trilobum
Viburnum trilobum
Vicia faba
Vicia sativa
Vicia villosa
Vigna angularia
Vigna angularia
Vigna unguiculata
Vigna unguiculata
Vigna unguiculata
Vinca minor
Vinca minor
Vitis sp.
Vitis sp.
Vitis sp.
Vitis sp.
Vitis sp.
Withania somnifera
Xanthium sibiricum
Xanthium strumarium
Zea mays
Zea mays
Zea mays
Abelmochus esculentus
Abies lasiocarpa
Achillea millefolium
Achillea millefolium
Aconitum napellus
Aconitum napellus
Acorus calamus
Actinidia arguta
Adiantum pedatum
Adiantum pedatum
Adiantum pedatum
Agaricus bisporus
Agaricus bisporus
Agaricus bisporus
Agaricus bisporus
Agaricus bisporus
Agastache foeniculum
Ageratum conyzoides
Agropyron cristatum
Agropyron repens
Agrostis alba
Agrostis Stolonifera
Alcea rosea
Alchemilla mollis
Allium ampeloprasum
Allium ascalonicum
Allium ascalonicum
Allium cepa
Allium grande
Allium schoenoporasum
Allium schoenoprasum
Allium tuberosum
Allium tuberosum
Althaea officianalis
Althaea officinalis
Amaranthus candathus
Amaranthus gangeticus
Amaranthus gangeticus
Ambrosia artemisiifolia
Amelanchier alnitolia
Amelanchier sanguinea
Ananas comosus
Ananas comosus
Ananas comosus
angelica archangelica
angelica archangelica
Anthemis nobilis
Anthemis nobilis
Anthemis tinctorium
Anthriscus cerefolium
Apium graveolens
Apium graveolens
Apium graveolens
Aralia cordata
Aralia cordata
Arctium minus
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Armoracia rusticana
Armoracia rusticana
Aronia melanocarpa
Aronia melanocarpa
Aronia prunifolia
Arrhenatherum elatius
Artemisia draculus
Artemisia dracunculus
Asclepias incarnata
Asctinidia chinensis
Asctinidia chinensis
Asparagus officinalis
Asparagus officiralis
Asparagus officiralis
Aster Linné
Aster sp
Atriplex hortensis
Atropa belladonna
Atropa belladonna
Avena sativa
Avena sativa
Averrhoa carambola
Ayperus esculentus
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Betula glandulosa
Betula glandulosa
Betula glandulosa
Betula glandulosa
Boletus edulis
Boletus edulis
Borago officinalis
Borago officinalis
Brassica cepticepa
Brassica cepticepa
Brassica Chineusis
Brassica juncea
Brassica juncea
Brassica juncea
Brassica Napus
Brassica Napus
Brassica Napus
Brassica nigra
Brassica nigra
Brassica nigra
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica rapa
Brassica rapa
Brassica rapa
Brassica rapa
Brassica rapa
Bromus inermis
Campanula rapunculus
Canna edulis
Cantharellus ciparium
Capsella bursa-pastoris
Capsicum annus
Capsicum annuum
Capsicum frutescens
Carica papaya
Carthamus tinctorius
Carum carvi
Castanea spp.
Chaerophyllum bulbosum
Chamaemelum nobile
Chamaemelum nobile
Chelidonium majus
Chenapodium bonus-henricus
Chenopodium bonus-henricus
Chenopodium quinoa
Chenopodium quinoa
Chrysanthemum leucanthemum
Chrysanthemun coronarium (Chp suey)
Chrysanthenum coronarium
Chrysanthenum coronarium
Cicer arietinum
Cichorium endivia
Cichorium endivia crispa
Cichorium intybus
Cimicifuga racemosa
Citrullus colocynthus
Citrullus lanatus
Citrullus lanatus
Citrus limettoides
Citrus limettoides
Citrus limon
Citrus limon
Citrus paradisi
Citrus paradisi
Citrus reticulata
Citrus reticulata
Citrus reticulata
Citrus reticulata
Citrus reticulata
Citrus reticulata
Citrus sinensis
Citrus sinensis
Coix Lacryma-Jobi
Corchorus olitorius
Cornus canadensis
Cosmos sulphureus
Crataegus sp
Crataegus sp
Crataegus submollis
Crithmum maritima
Cryptotaenia canadensis
Cryptotaenia canadensis
Cryptotaenia canadensis
Cucumis anguria
Cucumis anguria
Cucumis melo
Cucumis melo
Cucumis meluliferus
Cucumis sativus Fanfare
Cucurbita maxima
Cucurbita maxima
Cucurbita maxima
Cucurbita moschata
Cucurbita moschata
Cucurbita moschata
Cucurbita pepo
Cucurbita pepo
Curcuma zedoaria
Cydonia oblonga
Cynara scolymus
Cynara scolymus
Dactilis Glomerata
Datura stramonium
Daucus carota
Dioscorea batatas
Dioscorea batatas
Diospiros Kaki
Dirca palustris
Dirca palustris
Dolichus lablab
Dolichus lablab
Dryopteris filix-mas
Dryopteris filix-mas
Echinacea purpurea
Eleusine coracana
Elymus junceus
Erigeron canadensis
Eriobotrya japonica
Eruca vesicaria
Fagopyrum escutentum
Fagopyrum tartaricum
Festuca rubra
Festuca rubra
Foeniculum vulgare
Foericulum vulgare
Foericulum vulgare
Forsythia intermedia
Forsythia x intermedia
Fortunella spp
Fortunella spp
Fortunella spp
Fragaria
Fragaria
Fragaria
Fragaria x ananassa
Galium odoratum
Gaultheria hispidula
Ginkgo biloba
Ginkgo biloba
Glechoma hederacea
Glechoma hederacea
Glycine max
Glycine max
Glycine max
Glycyrrhiza glabra
Glycyrrhiza glabra
Glycyrrhiza glabra
Gossypium herbaceum
Guizotia abyssinica
Guizotia abyssinica
Hamamelis virginiana
Hamamelis virginiana
Hamamelis virginiana
Hedeoma pulegiodes
Helenium hoopesii
Helenium hoopesii
Helianthus annus
Helianthus strumosus
Helianthus strumosus
Helianthus tuberosa
Helianthus tuberosus L.
Helianthus tuberosus L.
Helichrysum angustifolium
Heliotropium arborescens
Helleborus niger
Hibiscus cannabinus
Hordeum vulgare
Humulus lupulus
Humulus lupulus
Humulus lupulus
Humulus lupulus
Hydrastis canadensis
Hydrastis canadensis
Hyoscyamus niger
Hypericum henryi
Hypericum perforatum
Hypericum perforatum
Hypomyces lactiflorum
Hypomyces lactiflorum
Hyssops officinalis
Inula helenium
Juniperus communis
Juniperus communis
Lactuca sativa
Lactuca sativa
Laportea canadensis
Lathyrus Sativus
Lathyrus Sativus
Lathyrus sylvestris
Lathyrus sylvestris
Laurus nobilis
Lavendula angustifolia
Lavendula angustifolia
Lavendula latifolia
Ledum groenlandicum
Lentinus edodes
Lentinus edodes
Lepidium sativum
Levisticum officinale
Levisticum officinale
Linum usitatissimum
Litchi chinensis
Lolium multiflorum
Lolium perenne
Lonicera ramosissima
Lonicera ramosissima
Lonicera ramosissima
Lonicera syringantha
Lotus corniculatus
Lotus tetragonolubus
Lunaria annua
Lunaria annua
Lycopersicon esculentum
Malus
Malus
Malus hupehensis (Pamp.) Rehd.
Malus hupehensis (Pamp.) Rehd.
Malus sp.
Malva moschata
Malva sylvestris
Malva sylvestris
Malva verticillata
Mangifera indica
Manihot esculenta syn. M. utilissima
Manihot esculenta syn. M. utilissima
Manihot esculenta syn. M. utilissima
Melilotus alba
Melilotus officinalis
Melissa officinalis
Melissa officinalis
mentha arvensis
Mentha suaveolens
Menyanthes trifoliata
Miscanthus sinensis Andress
Momordica charantia
Monarda didyma
Monarda fistulosa
Montia perfoliata
Musa paradisiaca
nasturtium officinale
Nepeta cataria
Nepeta cataria
Nepeta cataria
Nephelium longana ou Euphoria longana
Nicotiana rustica
Nicotiana rustica
Nicotiana tabacum
Nicotiana tabacum
Nigella sativa
Nigella sativa
Ocimum Basilicum
Ocimum Basilicum
Ocimum Basilicum
Oenothera biennis linné
Onobrychis viciafolia
Optunia sp.
Origanum marjonara
Origanum vulgare
Origanum vulgare
Oryza sativa
oxyria digyna
oxyria digyna
Panax quinquefolius L.
Panicum miliaceum
Passiflora spp
Passiflora spp
Passiflora spp
Passiflora spp
Pastinaca sativa
Pastinaca sativa
Pastinaca sativa
Persea americana
Persea americana
Petasites Japonicus
Phalaris canariensis
Phaseolus coccineus
Phaseolus coccineus
Phaseolus mungo
Phaseolus mungo
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Phlox paniculata
Phlox paniculata
Phoenix dactylifera
Physalis alkekengi
Physalis ixocarpa
Physalis ixocarpa
Physalis pruinosa
Physalis pruinosa
Physalis pruinosa
Physalis sp
Physalis sp
Phytolacca americana
Phytolacca americana
Phytolacca decandra syn. P. americana
Pimpinella anisum
Pimpinella anisum
Pisum sativum
Pisum sativum
Pisum sativum
Pisum sativum
Plantago coronopus
Plantago coronopus
Plantago coronopus
Plantago major
Pleurotus spp
Pleurotus spp
Pleurotus spp
Poa compressa
Poa pratensis
Poa pratensis
Podophyllum peltatum
Podophyllum peltatum
Polygonum aviculare linné
Polygonum pennsylvanicum
Polygonum persicaria
Populus incrassata
Populus Tremula
Populus x petrowskyana
Potentilla anserina
Potentilla anserina
Prunus cerasus
Prunus persica
Prunus persica
Prunus spp
Prunus spp
Psidium guajaba
Psidium guajaba
Psidium guajaba
Psidium spp
Psidium spp
Psidium spp
Pteridium aquilinum
Punica granalum
Pyrus communis
Pyrus pyrifolia
Raphanus raphanistrum
Raphanus raphanistrum
Raphanus raphanistrum
Raphanus sativus
Raphanus sativus
Raphanus sativus
Raphanus sativus
Raphanus sativus
Reseda luteola
Rhamnus frangula
Rhamnus frangula
Rheum officinale
Rheum palmatum
Rheum rhabarbarum
Rianus communis
Ribes nidigrolaria
Ribes nidigrolaria
Ribes nigrum
Ribes nigrum L.
Ribes nigrum L.
Ribes sativam syme
Ribes Sativum
Ribes Silvestre
Ribes Silvestre
Ribes uva-crispa
Rosa rugosa
Rosa rugosa thunb.
Rosa rugosa thunb.
Rosmarinum officinalis
Rosmarinum officinalis
Rubus canadensis
Rubus idaeus
Rubus idaeus
Rubus ideaus
Rubus ideaus
Rubus occidentalis
Rubus occidentalis
Rubus occidentalis
Rumes scutatus
Rumex crispus linné
Rumex crispus linné
Rumex patientia
Rumex patientia
Ruta graveolens
Sabal serrulata syn. Serenoa repens
Sabal serrulata syn. Serenoa repens
Salix purpurea
Salvia (elegens)
Sambucus canadensis
Sambucus canadensis
Sambucus canadensis L.
Sambucus ebulus
Sanguisorba officinalis
Santolina
Satureja montana
Satureja montana
Satureja repandra
Scorzorera hipanica
Scorzorera hipanica
Scuttellaria lateriflora
Secale cereale
Secale cereale
Sechium edule
Sesamum indicum
Setaria italica
Silybum marianum
Sium sisarum
Sium sisarum
Sium sisarum
Solanum melogena
solanum melogena
Solanum melogena
Solanum melogena
Solanum Tuberosum
Solidago canadensis
Solidago sp
Solidago virgaurea
Sorghum caffrorum
Sorghum dochna bicolor gr technicum
Sorghum dochna Snowdrew
Sorghum dochna Snowdrew
Spinacia oleracea
Spinacia oleracea
Spinacia oleracea
Spinacia oleracea
Stachys affinis
Stachys affinis
Stachys byzantina
Stipa capillata L.
Symphytum officinale
Tanacetum cinerarifolium
Tanacetum cinerarifolium
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale (Red ribe)
Tepary
Teucrium chamaedrys L.
Thalpsi arvense
Thymus fragantissumus
Thymus herba-barona
Thymus pseudolanuginosus
Thymus pseudolanuginosus
Thymus serpyllum
Thymus serpyllum
Thymus x citriodorus
Tiarella cordifolia
Tragopogon porrifolius
Tragopogon porrifolius
Tragopogon porrifolius
Tragopogon sp.
Tragopogon sp.
Tragopogon sp.
Trichosanthes kirilowii
Trifolium incarnatum
Trifolium repens
Trigonella foenum graecum
Triticale sp.
Triticum aestivum
Triticum aestivum
Triticum furgidumm
Triticum spelta
Tropaeolum majus
Tropaeolum malus
Tsuga can0adensis
Tsuga can0adensis
Tsuga diversifolia
Tsuga diversifolia
Tsuga F. macrophylla
Typha latifolia L.
Urtica dioica
Urtica dioica
Urtica dioica
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium macrocarpon
Vaccinium macrocarpon
Vaccinium macrocarpon
Vaccinum macrocarpon
Vaccinum macrocarpon
Veratrum viride
Veratrum viride
Verbascum thapsus
Verbascum thapsus
Veronica officinalis
Viburnum trilobum Marsh.
Vicia taba
Vicia sativa
Vigna angularia
Vigna angularia
Vigna unguiculata
Vigna unguiculata
Vigna unguiculata
Vinca minor
Vitis sp.
Vitis sp.
Vitis sp.
Vitis sp.
Vitis sp.
Vitis sp.
Weigela coracensis
Withania somnifera
Xanthium sibiricum
Xanthium strumarium
Zea mays
Zea mays
Zingiber officinale
Zingiber officinale
Zingiber officinale
Achillea millefolium
Achillea tomentosa
Aconitum
Aconitum napellus
Alchemilla mollis
Allium
Allium cepa gr. Cepa
Allium cepa gr. Cepa
Allium cepa gr. Cepa
Allium sativum
Allium Tuberosum
Allium Tuberosum
Allium victorialis
Amaranthus gangeticus
Amaranthus gangeticus
Amelanchier canadensis
Anthemis tinctoria
Anthemis tinctoria
Anthoxanthum odoratum
Apium graveolens
Apium graveolens
Aralia cordata
Arctium lappa
Arctium lappa
Aronia melanocarpa (Michx.) Ell.
Aronia melanocarpa (Michx.) Ell.
Asarum europaeum
Athaea officinalis
Athyrium asperum
Atropa belladonna
Begonia convolvulacea
Begonia eminii
Begonia glabra
Begonia Hannii
Begonia polygonoides
Berberis vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Brassica juncea
Brassica Oleracea
Brassica Oleracea
Brassica rapa
Calendula officinalis
Camellia sinensis syn. Thea sinensis
Cana edulis
Capsicum annuum
Capsicum frutescens
Chrysanthemum balsamita
Chrysanthemun balsamina
Chrysanthemun coronarium (Chp Suey)
Chrysanthemun coronarium (Chp Suey)
Cichorium intybus
Citrullus lanatus
Convallaria maialis
Coriandrum sativum
Cryptotaenia canadensis
Cucumis Anguria
Cucumis sativus
Curburbita pepo
Daucus carota
Daucus carota
Daucus carota
Daucus carota
Daucus carota
Daucus carota
Daucus carota
Daucus carota
Dirca palustris
Eruca vesicaria
Filipendula rubra
Forsythia intermedia
Forsythia x intermedia
Geum rivale
Glycyrrhiza glabra
Heliotropium arborescens
Humulus Lupulus
Humulus Lupulus
Hylotelephium
Hypericum henryi
Iberis sempervirens
Jeffersonia diphylla
Ligularia dentata
Lonicera ramosissima
Miscanthus sacchariflorus
Nicotiana tabacum
Nicotiana tabacum
Nicotiana tabacum
Nigella sativa
Origanum majorana
Origanum vulgare
Origanum vulgare
Panax quinquefolius L.
Pastinaca sativa
Petroselinum crispum
Peucedanum cervaria
Phaseolus Vulgaris
Philadelphus coronarius
Physostegia virginiana
Phytolacca americana
Plantago major
Plectranthus fruticosus
Polygonum pennsylvanicum
Pulmonaria saccharata
Raphanus sativus
Raphanus sativus
Raphanus sativus
Ribes nigrum L.
Rubus Allegheniensis
Rubus ideaus
Rumex crispus linne
Salvia elegens
Salvia nemorosa
Salvia officianalis
Salvia sclarea
Salvia sclarea
Saponaria officinalis
Satureja montana
Scorzonera hispanica
Sesamum indicum
Solanum dulcamara
Solidago canadensis
Solidago hybrida
Solidago hybrida
Solidago sp ?
Stellaria graminea linne
Tamarindus indica
Taraxacum officinale
Thalictrum aquilegiifolium
Thalictrum Aquilegiifolium
Thuja occidentalis
Thymus praecox subsp arctitus
Tiarella
Vaccinum augustifolium
Vaccinum macrocarpon
Vitia sp.
Xanthium strumarium
Yucca filamentosa
Zea mays
Zea mays
Achillea tomentosa
Adiantum tenerum
Alcea rosea
Alchemilla mollis
Allium schoenoporasum
Allium tuberosum
Allium tuberosum
Allium victorialis
Althaea officinalis
amaranthus gangeticus
Anaphalis margaritacea
Angelica dahurica
Anthemis nobilis
Apium graveolens
Apium graveolens
Arotostaphylos uva-ursi
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa (Michx.) Ell.
Aronia melanocarpa (Michx.) Ell.
Asarum europaeum
Atropa belladonna
Begonia eminii
Begonia glabra
Begonia manii
Begonia polygonoides
Berberis vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Betula glandulosa
Calendula officinalis
Capsicum annus
Chrysanthemum balsamita
Chrysanthemun balsamina
Cynara scolymus
Daucus carota
Daucus carota
Dirca palustris
Echinacea purpurea
Equisetum hyemale
Erigeron canadensis
Erigeron speciosus (Lindl.) D.C.
Eruca vesicaria
Erysimum perofskianum Fish. S.
Fenouil bronze
Filipendula rubra
Filipendula rubra
Filipendula ulmaria
Filipendula vulgaris
Forsythia intermedia
Forsythia x intermedia
Galium odoratum
Gaultheria hispidula (L.) Muhl
Gaultheria procumbens
Geum rivale
Glycine max
Glycyrrhiza glabra
Hamamelis virginiana
Heliotropium arborescens
Humulus lupulus
Humulus lupulus
Hydrastis canadensis
Hylotelephium
Hypericum henryi
Iberis sempervirens
Lathyrus sativus
Ligularia dentata
Lunaria annua
Lythrum salicaire
Melissa officinalis
Miscanthus sacchariflorus
Nicotiana rustica
Nicotiana tabacum
Nigella sativa
Origan
Origanum majorana
Panax quinquefolius L.
Panicum miliaceum
Passiflora caerula
Petroselinum crispum
Phaseolus vulgaris
Physostegia virginiana
Phytolacca americana
Plantago major
Plectranthus fruticosus
Polygonum aviculare linne
Pongamia pinnata
Pulmonaria officinalis
Pulmonaria saccharata
Raphanus sativus
Raphanus sativus
Rhus aromatica
Ribes nigrum L.
Rubus ideaus
Rubus occidentalis
Saponaria officinalis
Sarriette vivace
Satureja repandra
Sesamum indicum
Sidalcea
Silene vulgaris
Solanum dulcamara
Solidago canadensis
Solidago canadensis
Solidago~sp ?
Sorghum caffrorum
Tamarindus indica
Taraxacum officinale
taraxacum officinale
Tetradenia riparia
Thalictrum aquilegiifolium
Thuja occidentalis
Thymus vulgaris “Argenteus”
Tiarella
Tropaeolum majus
Tussilago farfara
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinum macrocarpon
Vitia sp.
Vitia sp.
Vitis sp.
Achillea millefolium
Aconitum napelius
Aesculus hippocastanum
Aesculus hippocastanum
Alcea rosea “Nigra”
Alchemilla moliis
Allium ascalonicum
Allium cepa gr. Cepa
Allium cepa gr. Cepa
Allium cepa gr. Cepa
Allium fistulosum
Allium grande
Allium tuberosum
Allium tuberosum
Allium tuberosum
Allium tuberosum
Allium victorialis
Alpinia oficinarum
Alpinia oficinarum
Althacea officinalis
Althaea officianalis
Amelanchier canadensis
Amelanchier canadensis
Amsonia tabernaemontana
Ananas comosus
Anaphalis margaritacea
Angelica dahurica
Angelica sinensis syn, A. polymorpha
Anthriscus cerefolium
Anthriscus cerefolium
Aralia cordata
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa (Michx.) Ell.
Aronia prunifolia
Artemisia draculus
Asarum europaeum
Asclepias incarnata L.
Asclepias tuberosa
Asctinidia chinensis
Atriplex hortensis
Atropa belladonna
Aubepine, hawthorne
Begonia convolvulacea
Begonia eminii
Begonia glabra
Begonia manii
Berberus vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Betula glandulosa
Borago officinalis
Brassica Napus
Brassica oleracea
Brassica oleracea
Butomus umbellatus
Canna edulis
cannelle
Carica papaya
Chrysanthemum balsamita
Chrysanthemum parthenium
chrysanthemun coronarium (Chp Suey)
chrysanthemun coronarium (Chp Suey)
Citrus paradisi
Citrus sinensis
Cocos nucifera
Cocos nucifera
Convallaria majalis
Corchorus olitorius
Crataegus sanguinea
Cryptotaenia canadensis
Cucumis anguria
Cucumis sativus (Fanfare)
Cydonia oblonga
Datura stramonium
Daucus carota
Diospiros Kaki
Echinacea purpurea
Eriobotrya japonica
Eruca vesicaria
Erysimum perofskianum Fish. S.
Fragaria x ananassa
Fucus vesiculosis
Fumaria officinalis
Gaultheria procumbens
Gentiana macrophylla
Glyceria maxima
Glycine max Envy
Glycyrrhiza glabra
Hamamelis virginiana
Helichrysum angustifolium
Heliotropium arborescens
Humulus lupulus
Humulus lupulus
Humulus lupulus
Humulus lupulus
Hydrastis canadensis
Hypericum henryi
Hypericum perforatum
Hypomyces lactiflorum
Iberis sempervirens
Jeffersonia diphylla
Juglans nigra
Kochia scoparia (L.) Schrad.
Krameria Triandra
Lentinus edodes
Lentinus edodes
Ligularia dentata
Ligustrum vulgare
Lunaria annua
Lunaria annua
Lupinus polyphyllus lindl.
Lychnis chalcedonica
Lythrum salicaire
Mangifera indica
Mangifera indica
Nigella sativa
Optunia sp.
Panax quinquefolius L.
Passiflora caerula
Pastinaca sativa
Perroselinum crispum
Phaseolus vulgaris
Physostegia virginiana
Phytolacca americana
Phytolacca americana
Plectranthus fruticosus
Polygonatum odoratum
Polygonium chinense
Pontederia cordata
Portulacea oleracea
Primula veris
Prunus persica
Prunus persica (hybrids de la peche)
Pulmonaria officinalis
Punica granatum
Pyrus pyrifolia
Radix Paeonia rubra
Rahmnus frangula
Raphanus sativus
Rhus trilobata
Ribes uva-crispa
Rosa Rugosa “Alba”
Rubus idaeus
Rubus idaeus L.
Rubus ideaus
Rubus occidentalis
Rumex crispus linne
Salvia nemorosa
Sambucus canadensis
Sambucus nigra
Sanguisorba minor
Saponaria officinalis
Saponaria officinalis L.
Satureja hortensis
Sechium edule
Sesamum indicum
Sidalcea
Silene vulgaris
Solidago hybrida
Solidago Hybrida
Solidago Hybrida
Solidago sp ?
Tamarindus indica
Tanacetum balsamila
Tanacetum vulgare
Taraxacum officinale
Taraxacum officinale (Red ribe)
Thuja occidentalis
Thymus serpyllum
Tiarella
Tragopogon sp.
Trigonella foenum graecum
Tropaeolum majus
Tropaeolum majus
Tropaeolum majus
Tsuga diversifolia
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium macrocarpon
Vitia sp.
Vitia sp.
Vitis sp.
Weigela coracensis
Zea mays
Zea mays
Agastache foeniculum
Agropyron cristatum
Agropyron repens
Agrostis Stofonifera
Alchemilla mollis
Allium sativum
Allium schoenoprasum
Althaea officinalis
Amaranthus gangeticus
Amaranthus gangeticus
Amaranthus retroflexus
Ambrosia artemisiifolia
Anethum graveolens
Angelica archangelica
Anthemis nobilis
Anthemis tinctoria
Aralia cordata
Aralia nudicaulis
Arctium minus
Arctium minus
Aronia melanocarpa
Artemisia abrotanum
Artemisia abrotanum
Artemisia absinthium
Artemisia Absinthium
Artemisia dracunculus
Artemisis Ludoviciana
Artemisis Ludoviciana
Asparagus officinalis
Aster sp
Aster sp
Atropa belladonna
Beckmannia eruciformis
Beckmannia eruciformis
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Betta vulgaris
Brassica napus
Brassica oleracea
Brassica rapa
Brassica rapa
Bromus inermis
Calamintha nepeta
Campanula rapunculus
Canna edulis
Capsella bursa-pastoris
Capsicum annuum
Capsicum annuum
Capsicum annuum
Capsicum annuum
Capsicum frutescens
Carthamus tinctorius
Carum carvi
Chaerophyllum bulbosom
Chelidonium majus
chenopodium bonus-henricus
Chenopodium quinoa
Chrysanthemum coronarium
Cichorium endivia susp. Endivia
Cichorium endivia susp. Endivia
Cichorium intybus
Citrullus lanatus
Citrullus lanatus
Citrullus lanatus
Citrullus lanatus
Coix Lacryma-Jobi
Coix Lacryma-Jobi
Cornus canadensis
Cuburbita pepo
Cucumis melo
Cucumis sativus
Cucumis sativus
Cucurbita Maxima
Cucurbita moschata
Cucurbita pepo
Cucurbita pepo
Cucurbita pepo
Curcuma zedoaria
Cymbopogon martinii
Daucus carota
Daucus carota
Dipsacus sativus
Elymus junceus
Eschscholzia californica
Foeniculum vulgare
Forsythia intermedia
Forsythia intermedia
Fragaria x ananassa
Galinsoga ciliata
Galium odoratum
Galium odoratum
Gaultheria hispidula
Gaultheria hispidula
Gentiana lutea
Glechoma hederacea
Glycine max
Glycine max
Glycyrrhiza glabra
Guizotia abyssinica
Hedeoma pulegioides
Helianthus tuberosus
Hordeum hexastichon
Hordeum hexastichon
Hordeum vulgare
Hordeum vulgure subsp. Vulgare
Hypericum henryi
Hyssopus officinalis
Ipomoea Batatas
Iris versicolor
Iris versicolor
Lathyrus sativus
Laurus nobilis
Levisticum officinale
Linum usitatissimum
Linum usitatissimum
Lolium perenne
Lotus corniculatus
Lycopersicon esculentum
Matricaria recutita
Medicago sativa
Melissa officinalis
Mentha piperita
Mentha piperita
Mentha suaveolens
Nepeta cataria
Nicotiana tabacum
Nicotiana tabacum
Oenothera biennis
Oenothera biennis
Oenothera biennis
Origanum vulgare
Panax quinquefolius
Panax quinquefolius
Panax quinquefolius
Pastinaca sativa
Perilla frutescens
Perilla frutescens
Petasites japonicus
Petroselinum crispum
Phalaris arundinacea
Phalaris canariensis
Phaseolus coccineus
Phaseolus mungo
Phaseolus mungo
Phaseolus vulgaris
Phaseolus vulgaris
Phleum pratense
Physalis ixocarpa
Pimpinella anisum
Plantago major
Plectranthus sp.
Plectranthus sp.
Polygonum aviculare
Poterium sanguisorba
Poterium Sanquisorba
Prunus Tomentosa
Raphanus Sativus
Raphanus sativus
Rheun rhabarbarum
Ribes nigrum
Ribes nigrum
Ribes rubrum
Ribes Sylvestre
Ribes Sylvestre
Rosa rugosa
Rosa rugosa
Rosa rugosa
Rosmarinus officinalis
Rubus canadensis
Rubus canadensis
Rubus idaeus
Rubus ideaus
Rumex acetosella
Rumex crispus
Rumex Scutatus
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia sclarea
Sanguisorba officinalis
Sanguisorba officinalis
Santolina chamaecyparissus
Satureja montana
Scorzonera hispanica
Secale cereale
Senecio vulgaris
Sesamum indicum
Silybum marianum
Sium sisarum
Solanum dulcamara
Solanum melanocerasum
Solanum melanocerasum
Solanum tuberosum
Solidago sp
Spinacia oleracea
Spinacia oleracea
Stachys affinis
Stachys byzantina
Stellaria graminea
Stellaria media
Symphytum officinale
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum parthenium
Tanacetum parthenium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
Taraxacum officinale
Teucrium chamaedrys
Thymus praecox subsp arcticus
Thymus praecox subsp arcticus
Thymus serpyllum
Thymus vulgaris
Trichosanthes kirilowii
Trifolium incarnatum
Trifolium pannonicum
Trifolium pratense
Trifolium repens
Triticum durum
Triticum spelta
Triticum spelta
Typha latifolia
Vaccinium Corymbosum
Vaccinium macrocarpon
Valefiana officinalis
Verbascum thapsus
Vitis sp.
Vitis sp.
Zea mays
Zea mays
Achillea millefolium
Agropyron repens
Alchemilla mollis
Allium ascalonicum
Allium sativum
Allium schoenoprasum
Allium tuberosum
Althaea officinalis
Amaranthus caudathus
Amaranthus gangeticus
Amaranthus retroflexus
Ambrosia arternisiifolia
Amelanchier alnifolius
Anethum graveofens
Anthemis nobilis
Apium graveolens
Arctium minus
Arctium minus
Arctostaphylos uva-ursi
Aronia melanocarpa
Arrhenatherum elatius
Artemisia abrotanum
Artemisia absinthium
Artemisia absinthium
Artemisia Ludoviciana
Artemisia Ludoviciana
Artemisia vulgaris
Artemisia vulgaris
Asclepias incarnata
Asclepias incarnata
Asparagus officinalis
Aster sp
Atropa belladonna
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Borago officinalis
Brassica napus
Brassica oleracea
Bromus inermis
Calamintha nepeta
Campanula rapunculus
Campanula rapunculus
Campanula rapunculus
Canna edulis
Capsella bursa-pastoris
Capsicum annuum
Capsicum annuum
Capsicum annuum
Capsicum annuum
Capsicum annuum
Capsicum annuum
Capsicum frutescens
Carthamus tinctorius
Carum carvi
Chaerophyllum bulbosum
Chrysanthemum coronarium
Cicer arietinum
Cichorium endivia subsp endivia
Cichorium intybus
Circium arvense
Circium arvense
Citrullus lanatus
Citrullus lanatus
Coix Lacryma-Jobi
Cornus canadensis
Cornus canadensis
Cucumis anguria
Cucurbita maxima
Cucurbita maxima
Cucurbita moschata
Cucurbita moschata
Cucurbita moschata
Cucurbita pepo
Cucurbita pepo
Cymbopogon martinii
Cynara scolymus
Datura metel
Daucus carota
Daucus carota
Digitalis purpurea
Dirca palustris
Elymus junceus
Erigeron speciosus
Foeniculum vulgare
Forsythia intermedia
Forsythia x intermedia
Galium odoratum
Galium odoratum
Gaultheria hispidula
Gaultheria hispidula
Glechoma hederacea
Glechoma hederacea
Glycine max
Glycine max
Guizotia abyssinica
Guizotia abyssinica
Helianthus annuus
Helianthus strumosus
Helianthus strumosus
Helianthus tuberosus
Helianthus tuberosus
Helichrysum thianschanicum
Heliotropium arborescens
Hysopus officinalis
Ipomoea batatas
Lactuca sativa
Lathyrus sativus
Lathyrus sylvestris
Lathyrus sylvestris
Lavandula angustifolia
Lavandula angustifolia
Lavandula latifolia
Leonurus cardiaca
Levisticum officinale
Levisticum officinale
Linum usitatissimum
Lolium perenne
Lotus tetragonolobus
Lupinus polyphyllus
Lycopersicon esculentum
Lycopersicon esculentum
Lycopersicon pimpinellifolium
Malva moschata
Medicago sativa
Melissa officinalis
Mentha piperita
Mentha suaveolens
Monarda didyma
Nepeta cataria
Ocimum basilicum
Oenothera biennis
Oenothera biennis
Origanum majorana
Origanum vulgare
Oxalis Deppei
Oxalis Deppei
Oxyria digyna
Panax quinquefolius
Panax quinquefolius
Panicum miliaceum
Pennisetum alopecuroides
Petasites japonicus
Petroselinum crispum
Peucedanum cervaria
Phaseolus mungo
Phaseolus vulgaris
Phaseolus vulgaris
Plantago major
Plectranthus sp.
Plectranthus sp.
Poa compressa
Portulaca oleracera
Potentilla anserina
Poterium sanguisorba
Poterium sanguisorba
Prunella vulgaris
Raphanus Raphanistrum
Raphanus Raphanistrum
Raphanus sativus
Raphanus sativus
Ribes nigrum
Ribes Sylvestre
Ricinus communis
Rosa rugosa
Rosa rugosa
Rosmarinus officinalis
Rubus ideaus
Rubus occidentalis
Rubus occidentalis
Rumex crispus
Ruta graveolens
Salvia officinalis
Salvia officinalis
Sambucus canadensis
Sambucus ebulus
Sambucus ebulus
Sanguisorba officinalis
Santolina chamaecyparissus
Saponaria officinalis
Satureja hortensis
Satureja hortensis
Senecio vulgaris
Sesamum indicum
Sium sisarum
Sium sisarum
Solanum melanocerasum
Solanum melongens
solanum melongens
Solidago sp
Sonchus oleraceus
Stachys Affinis
Stachys byzantina
Stellaria graminea
Stellaria media
Symphytum officinale
Symphytum officinale
Symphytum officinale
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum parthenium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
taraxacum officinale
taraxacum officinale
Teucrium chamaedrys
Teucrium chamaedrys
Thymus fragantissimus
Thymus praecox subsp arcticus
Thymus praecox subsp arcticus
Thymus praecox subsp arcticus
Thymus serpyllum
Thymus vulgaris
Thymus x citriodorus
Tiarella cordifolia
Trifolium hybridum
Trifolium pannonicum
Trifolium pratense
Trifolium repens
Triticum spelta
Triticum turgidum
Typha latifolia
Vaccinium corymbosum
Vaccinum angustifolium
Vaccinum macrocarpon
Valeriana officinalis
Valeriana officinalis
Verbascum thapsus
Vinca minor
Vitis sp.
Vitis sp.
Zea mays
Zea mays
Abies lasiocarpa
Agastache foeniculum
Agropyron cristatum
Agrostis alba
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Allium ampeloprasum
Allium ascalonicum
Allium ascalonicum
Allium cepa
Allium tuberosum
Alpinia officinarum
Althaea officinalis
Amaranthus candathus
Amaranthus candatus
Amaranthus caudathus
Amaranthus gangeticus
Amaranthus retroflexus
Ambrosia artemisiifolia
Amelanchier alnifolia
Anthemis nobilis
Anthriscus cerefolium
Aralia cordata
Arctium minus
Aronia melanocarpa
Aronia prunifolia
Arrhenatherum elatius
Artemisia absinthium
Artemisia dracunculus
Artemisia dracunculus
Artemisia Ludoviciana
Artemisia vulgaris
Artemisia vulgaris
Asclepias incarnata
Asparagus officinalis
Aster sp
Avena sativa
Baptisia tinctoria
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Brassica nigra
Brassica oleracea
Brassica oleracea
Bromus inermis
Calamagrostis arundiflora
Calendula officinalis
Campanula rapunculus
Canna edulis
Capsella bursa-pastoris
Capsicum annum
Capsicum annuum
Capsicum annuum
Capsicum annuum
Capsicum frutescens
Carthamus tinctorius
Carum carvi
Chaerophyllum bulbosum
Chaerophyllum bulbosum
Chelidonium majus
Chelidonium majus
Chenopodium bonus-henricus
Chenopodium quinoa
Chenopodium quinoa
Chrysanthemum coronarium
Chrysanthemum coronarium
Cicer arietinum
Cichorium endivia subsp endivia
Cichorium endivia subsp endivia
Cichorium intybus
Cimicifuga racemosa
Circium arvense
Citrullus lanatus
Citrullus lanatus
Citrullus lanatus
Coix Lacryma-Jobi
Coriandrum sativum
Cornus canadensis
Cucumis anguria
Cucumis anguria
Cucumis melo
Cucumis melo
Cucumis sativus
Cucurbita maxima
Cucurbita moschata
Cucurbita pepo
Cucurbita pepo
Cucurbita pepo
Curcuma zedoaria
Cymbopogon citratus
Cynara scolymus
Dactilis Glomerata
Datura metel
Datura stramonium
Daucus carota
Daucus carota
Daucus carota
Daucus carota
Dipsacus sativus
Dirca palustris
Eleusine coracana
Elymus junceus
Erigeron speciosus
Fagopyrum esculentum
Foeniculum vulgare
Forsythia intermedia
Forsythia x intermedia
Fucus vesiculosus
Fucus vesiculosus
Galinsoga ciliata
Galium aparine
Galium odoratum
Gaultheria hispidula
Gaultheria procumbens
Gentiana lutea
Gentiana macrophylla
Glechoma hederacea
Glycine max
Glycyrrhiza glabra
Glycyrrhiza glabra
Guizotia abyssinica
Guizotia abyssinica
Hedeoma pulegioides
Helianthus annus
Helianthus strumosus
Helianthus tuberosus
Helichrysum angustifolium
Helichrysum thianschanicum
Heliotropium arborescens
Helleborus niger
Herba Schizonepetae
Hibiscus cannabinus
Hordeum vulgare
Hydrastis canadensis
Hypericum henryi
Hypericum perforatum
Hyssopus officinalis
Inula helenium
Ipomoea batalas
Iris versicolor
Juniperus communis
Krameria Triandra
Lactuca sativa
Lathyrus Sativus
Lathyrus Sativus
Lathyrus sylvestris
Lathyrus sylvestris
Laurus nobilis
Laurus nobilis
Lavandula latifolia
Lavandula latifolia
Lens culinaris subsp culinaris
Leonorus cardiaca
Lepidium sativum
Levisticum officinale
Levisticum officinale
Linum usitatissimum
Lonicera syringantha
Lotus couniculatus
Lupinus polyphyllus lindl.
Lycopersicon esculentum
Malus hupehensis
Malva sylvestris
Matricaria spp.
Medicago sativa
Melissa officinalis
Menyanthes trifoliata
Menyanthes trifoliata
Miscanthus sinensis
Miscanthus sinensis
Nepeta cataria
Ocimum Basilicum
Ocimum Basilicum
Oenothera biennis
Origanum vulgare
Origanum vulgare
Oxalis Deppei
oxyria digyna
Panax quinquefolius
Panicum miliaceum
Pastinaca sativa
Pastinaca sativa
Pastinaca sativa
Pastinaca sativa
Pastinaca sativa
Perilla frutescens
Perilla frutescens
Petasites Japonicus
Petroselinum crispum
Peucedanum oreaselinum
Pfaffia paniculata
Phaseolus mungo
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Physalis ixocarpa
Pimpinella anisum
Pimpinella anisum
Pisum sativum
Plantago major
Plectranthus sp.
Plectranthus sp.
Poa pratensis
Populus X petrowskyana
Prunella vulgaris
Prunella vulgaris
Raphanus raphanistrum
Raphanus raphanistrum
Raphanus sativus
Raphanus sativus
Reseda luteola
Rheum officinale
Ribes sativum
Ribes Sylvestre
Ricinus communis
Rosmarinus officinalis
Rosmarinus officinalis
Rubus canadensis
Rubus canadensis
Rubus idaeus
Rubus ideaus
Rubus occidentalis
Rubus occidentalis
Rubus occidentalis
Rumex acetosella
Rumex crispus
Rumex scutatus
Ruta graveolens
Saccharum officinarum
Salvia officinalis
Salvia officinalis
Sambucus canadensis
Sanguisorba officinalis
Santolina chamaecyparissus
Saponaria officinalis
Saponaria officinalis
Satureja montana
Satureja repandra
Senecio vulgaris
Setaria italica
Silybum marianum
Sium sisarum
Sium sisarum
Solanum dulcamara
Solanum melongena
Solanum melongena
Solanum tuberosum
Solidago canadensis
Solidago sp
Sonchus oleraceus
Sorghum durra
Spinacia oleracea
Stachys affinis
Stachys affinis
Stachys affinis
Stachys byzantina
Stellaria graminea
Stipa capillata
Symphytum officinale
Symphytum officinale
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
Thymus praecox subsp arcticus
Thymus praecox subsp arcticus
Thymus praecox subsp arcticus
Thymus-pseudolanuginosus
Thymus serpyllum
Tiarella cordifolia
Tragopogon porrifolius
Tragopogon porrifolius
Trichosanthes kirilowii
Trifolium pannonicum
Trifolium pratense
Trifolium repens
Triticum aestivum
Triticum durum
Triticum turgidum
Ulmus americana
Ulmus americana
Urtica dioica
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium corymbosum
Vaccinium macrocarpon
Valeriana officinalis
Vicia sativa
Vitiis sp.
Vitiis sp.
Zea mays
Zea mays
Achillea millefolium
Achillea millefolium
Acorus calamus
Adiantum pedatum
Agastache foeniculum
Agastache foeniculum
Agropyron rupens
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alkanna tinctoria
Alkanna tinctoria
Allium Tuberosum
Althaea officinalis
Althaea officinalis
Ambrosia artemisiifolia linné
Ambrosia artemisiifolia linné
Amelanchier sanguinea (Pursh) DC.
Angelica archangelica
Anthemis tinctoria
Anthemis tinctoria
Anthemis tinctorium
Arachis hypogaea
Aralia nudicaulis
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Aronia melanocarpa (Michx.) Ell.
Aronia melanocarpa (Michx.) Ell.
Aronia melanocarpa (Michx.) Ell.
Artemisia dracunculus sativa
Artemisis Ludoviciana
Aster sp ?
Aster sp ?
Beta vulgaris
Brassica napus
Brassica napus
Brassica nigra
Brassica rapa
Capsella bursa-pastoris (linné) médicus
Chaerophyllum bulbosom
Chaerophyllum bulbosom
chenopodium bonus-henricus
Chichorium endivia
Chrysanthemum leucanthemum linné
Cicer arietinum
Cichorium intybus
Cichorium intybus
Cichorium intybus
Crataegus sp ?
Crataegus sp ?
Cymbopogan citratus
Datisca cannabina
Daucus carota
Daucus carota
Dirca palustris
Dirca palustris
Dryopteris filix-mas
Dryopteris filix-mas
Echinacea purpurea
Echinacea purpurea
Filipendula rubra
Filipendula rubra
Foeniculum vulgare
Fragaria x ananassa
Fragaria x ananassa
Fragaria x ananassa
Fragaria x ananassa
Frangoria x ananassa
Frangoria x ananassa
Galinsoga ciliata (Rofiresque) Blake
Gaultheria hispidula (L.) Muhl.
Gaultheria hispidula (L.) Muhl.
Gaultheria procumbens
Glycine Max
Glycine max
Glycyrrhiza glabra
Glycyrrhiza glabra
Glycyrrhiza glabra
Hamamelis virginiana
Helianthus tuberosus
Helichrysum angustifolium
Heliotropium arborescens
Heliotropium arborescens
Hordeum vulgare
Hypericum henryi
Hypericum perforatum
Inula helenium
Isatis tinctoria
Laurus nobilis
Lavendula latifolia
Lavendula latifolia
Leonorus cardiaca
Levisecum officinale
Lolium multiflorum
Melissa officinalis
Melissa officinalis
Melissa officinalis
Melissa officinalis
Mentha pulegium
Mentha spicata
Nepeta cataria
Ocrothera biennis
Oenothera biennis linné
Oenothera biennis linné
Origanum majorana
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Oxyria digyna
Perilla frutescens
Perilla frutescens
Peucedanum cervaria
Peucedanum cervaria
Phaseolus Vulgaris
Phaseolus Vulgaris
Phytolacca americana
Plantago coronopus
Polygonum aviculare linné
Poterium sanguisorba
Poterium sanguisorba
Poterium sanguisorba
Poterium sanguisorba
Pteridium aquilinum
Pteridium aquilinum
Ribes nidigrolaria
Ribes Nigrum
Ribes nigrum
Ribes nigrum L.
Ribes nigrum L.
Ribes Salivum
Ricinus communis
Rosa rugosa thunb.
Rosa rugosa thunb.
Rosa rugosa thunb.
Rosmarinus officinalis
Rosmarinus officinalis
Rosmarinus officinalis
Rosmarinus officinalis
Rubus allegheniensis
Rubus canadensis
Rubus canadensis
Rubus idaeus
Rubus idaeus
Rubus idaeus
Rubus idaeus
Rubus idaeus
Rubus idaeus L.
Rubus idaeus L.
Rubus idaeus L.
Rubus ideaus
Rubus ideaus
Rubus occidentalis
Rumex crispus linné
Salvia elegens
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia sclarea
Santolina
Satureja montana
Satureja montana
Satureja montana
Satureja montana
Scuttellaria lateriflora
Sonchus oleraceus L.
Sorghum dochra bicolor
Sorghum durra (Stapif)
Symphytum officinale
Symphytum officinale
Tanacetum cinerarifolium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare “Goldsticks”
Taraxacum officinale
Taraxacum officinale
Thymus praecox subsp arctitus
Thymus pseudolanuginosus
Thymus serpyllum
Thymus serpyllum
Thymus serpyllum
Thymus vulgaris
Thymus vulgaris
Thymus vulgaris “Argenteus”
Triticum furgidum??
Vaccinum augustifolium
Vaccinum Corymbosum
Vaccinum macrocarpon
Valerianella locusta
Veronica officinalis
Viburnum trilobum Marsh.
Vicia sativa
Vicia villosa
Vitia sp.
Vitia sp.
Vitia sp.
Vitia sp.
Vitia sp.
Vitia sp.
Zea Mays
Zea Mays
Achillea millefolium
Achillea millefolium
Aconitum napellus
Acorus calamus
Adiantum pedatum
Agastache toeniculum “Snow Pike”
Agastache toeniculum “Snow Pike”
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
althaea officinalis
althaea officinalis
Ambrosia artemisiifolia linné
Ambrosia artemisiifolia linné
Amelanchier sanguinea (Pursh) DC.
Angelica archangelica
Arachis hypogaea
Aralia nudicaulis
Arctium minus (Hill) Bernhardi
Arctostaphylos uva-ursi
Aronia melanocarpa (Michx.) Ell.
Artemisia Ludoviciana
Aster sp ?
Aster sp ?
Beta vulgaris
Brassica napus
Brassica napus
Brassica oleracea
Calamintha nepeta
Calendula officinalis L.
Canna edulis
Chaerophyllum bulbosum
Chaerophyllum bulbosum
Chaerophyllum bulbosum
Chichorium endivia
Chrysanthemum leucanthemum linné
Cicer arietinum
Cichorium endivia
Cichorium intybus
Cichorium intybus
Cichorium intybus
Crataegus sp ?
Cynara scolymus
Dirca palustris
Dirca palustris
Dryopteris filix-mas
Echinacea purpurea
Echinacea purpurea
Erigeron speciosus (Lindl.) D.C.
Fagopyrum esculentum
Filipendula rubra
Galinsoga ciliata (Rofiresque) Blake
Galium odoratum
Gaultheria hispidula (L.) Muhl
Glycyrrhiza glabra
Hamamelis virginiana
Hamamelis virginiana
Helianthus annus
Helianthus strumosus
Helianthus tuberosus L.
Helichrysum angustifolium
Helichrysum angustifolium
Helichrysum thianschanicum Regel
Heliotropium arborescens
Heliotropium arborescens
Humulus lupulus
Humulus lupulus
Hypericum henryi
Hypericum perforatum
Inula helenium
Inula helenium
Inula helenium
Ipomea batatas
Isatis tinctoria
Laportea canadensis
Laurus nobilis
Laurus nobilis
Lavendula angustifolia
Lavendula latifolia
Ledum groenlandicum
Levistecum officinale
Matricaria recutita
Melissa officinalis
Melissa officinalis
Melissa officinalis
Melissa officinalis
Mentha arvensis
Mentha piperita
Mentha piperita vulgaris
Mentha pulegium
Mentha spicata
Mentha spicata
Mentha spicata
Monarda didyma
Nepeta cataria
Ocimum basilicum
Ocimum basilicum
Ocimum basilicum
Ocimum basilicum
Oenothera biennis linné
Oenothera biennis linné
Oenothera biennis linné
Oenothera biennis Linne
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Oxyria digyna
Perilla frutescens
Peucedanum cervaria
Peucedanum cervaria
Plantago major
Plectranthus sp.
Portulaca oleracera linné
Potentilla anserina
Poterium sanguisorba
Poterium sanguisorba
Poterium sanquisorba
Poterium sanquisorba
Prunella vulgaris
Pteridium aquilinum
Pteridium aquilinum
Raphanus Raphanistrum
Ribes nidigrolaria
Ribes nigrum
Ribes Silvestris
Ribes Uva-crispa
Ricinus communis
Ricinus communis
Rosa rugosa thunb.
Rosa rugosa thunb.
Rosmarinus officinalis
Rosmarinus officinalis
Rosmarinus officinalis
Rosmarinus officinalis
Rubus canadensis
Rubus idaeus L.
Rubus ideaus
Rubus ideaus
Rubus ideaus
Rubus occidentalis
Rubus occidentalis
Rubus occidentalis
Rumex crispus linné
Rumex crispus linné
Salvia elegens
Salvia elegens
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia sclarea
Sarriette commune
Sarriette vivace
Sarriette vivace
Satureja montana
Satureja montana
Solanum tuberosum
Sonchus oleraceus L.
Sorghum dochna
Sorghum sudanense
Sorghum sudanense
Symphytum officinale
Symphytum officinale
Tanacetum parthenium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare “Goldsticks”
Taraxacum officinale
Thymus fragantissumus
Thymus herba-barona
Thymus herba-barona
Thymus praecox subsp arctitus
Thymus serpyllum
Thymus serpyllum
Thymus serpyllum
Thymus serpyllum
Thymus vulgaris
Thymus vulgaris
Thymus vulgaris “Argenteus”
Thymus x citriodorus
Vaccinum angustifolium
Vaccinum macrocarpon
Viburnum trilobum Marsh.
Viburnum trilobum Marsh.
Vicia sativa
Vicia villosa
Vitia sp.
Vitia sp.
Vitia sp.
Vitia sp.
Zea mays
Achillea millefolium
Achillea millefolium
Acorus calamus
Acorus calamus
Adiantum pedatum
Agastache foeniculum
Agastache foeniculum “Snow Pike”
Agastache foeniculum “Snow Pike”
Agrimonia eupatoria
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Althaea officinalis
Althaea officinalis
Althaea officinalis
Ambrosia artemisiifolia linné
Ambrosia artemisiifolia linné
Amelanchier sanguinea x A. laevis
angelica archangelica
Anthemis tinctorium
Arachis hypogaea
Aralia nudicaulis
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Aronia prunifolia
Artemisia draculus
Artemisia dracunlus
Artemisia Ludoviciana
Aster sp ?
Aster sp ?
Ayperus esculentus
Beta vulgaris
Beta vulgaris
Betula glandulosa
Borago officinalis
Brassica juncea
Brassica napus
Brassica nigra
Brassica rapa
Calamintha nepeta
Calamintha nepeta
Canna edulis
Canneberge
Capsella bursa-pastoris (linné) médicus
Carya cordiformis
Chaerophyllum bulbosum
Chrysanthemum leucanthemum linné
Cichorium intybus
Cichorium intybus
Cichorium intybus
Cimicifuga racemosa
Citrullus colocynthus
Citrus limettoides
Citrus limettoides
Citrus limon
Citrus limon
Coix Lacryma-Jobi
Coriandrum sativum
Crataegus sp ?
Crataegus submollis
Crataegus submollis
Curcuma longa syn. C. domestica
Cynara scolymus
Dioscorea batatas
Dioscorea batatas
Diospiros Kaki
Dirca palustris
Dolichus lablab
Dryopteris filix-mas
Dryopteris filix-mas
Echinacea purpurea
Echinacea purpurea
Echinacea purpurea
Erigeron speciosus (Lindl.) D.C.
Fragaria
Fragaria x ananassa
Fragaria x ananassa
Fucus vesicutosis
Galinsoga ciliata (Rofiresque) Blake.
Galium odoratum
Gaultheria hispidula (L) Muhl
Gaultheria procumbens
Gaultheria procumbens
Glycyrrhiza glabra
Guizotia abyssinica
Guizotia abyssinica
Hamamelis virginiana
Hamamelis virginiana
Helenium hoopesii
Helenium hoopesii
Helianthus annus
Helianthus strumosus
Helianthus tuberosa
Helianthus tuberosa
Helichrysum angustifolium
Helichrysum angustifolium
Helichrysum angustifolium
Helichrysum angustifolium
Helichrysum thianschanicum Regel
Heliotropium arborescens
Hibiscus cannabinus
Humulus lupulus
Humulus lupulus
Humulus lupulus
Humulus lupulus
Hypericum perforatum
Inula helenium
Inula helenium
Inula helenium
Ipomea batalas
Iris versicolor
Juniperus communis
Krameria Triandra
Lathyrus sylvestris
Laurus nobilis
Lavendula angustifolia
Lavendula angustifolia
Lavendula latifolia
Lavendula latifolia
Lavendula latifolia
Ledum groenlandicum
Ledum groenlandicum
Lepidium sativum
Litchi chinensis
Lolium multiflorum
Lonicera ramosissima
Lotus corniculatus
Malus
Malva moschata
Melissa officinalis
Melissa officinalis
Melissa officinalis
Melissa officinalis
Melissa officinalis
Melissa officinalis
Melissa officinalis
mentha arvensis
Mentha piperita
Mentha piperita
Mentha piperita
Mentha piperita
Mentha piperita vulgaris
Mentha piperita vulgaris
Mentha pulegium
Mentha spicata
Mentha spicata
Mentha spicata
Mentha spicata
Mentha spicata
Nepeta cataria
Ocimum Basilicum
Ocimum Basilicum
Ocimum Basilicum
Oenothera biennis linné
Oenothera biennis linné
Onobrychis viciafolia
Origanum marjonara
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum Vulgare
Origanum Vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
Origanum vulgare
oxyria digyna
Pastinaca sativa
Pastinaca sativa
Perilla frutescens
Perilla frutescens
Perilla frutescens
Petroselinum crispum Nyman ex. A. W. Hill
Peucedanum cervaria
Peucedanum cervaria
Plaffia paniculala
Phaseolus vulgaris
Phytolacca americana
Phytolacca decandra syn. P. americana
Plectranthus sp.
Polygonium chinense
Polygonum aviculare linné
Populus x petrowskyana
Potentilla anserina
Poterium sanguisorba
Poterium sanguisorba
Prunella vulgaris
Psoralea corylifolia
Psoralea corylifolia
Psoralea corylifolia
Pteridium aquilinum
Punica granatum
Punica granatum
Punica granatum
Radix Rehmannia
Raphanus raphanistrum
Raphanus raphanistrum
Rhamnus frangula
Rheum palmatum
Rianus communis
Rianus communis
Rianus communis
Ribes Grossularia L.
Ribes nidigrolaria
Ribes nigrum
Ribes nigrum
Ribes nigrum L.
Ribes nigrum L.
Ribes sativam syme
Ribes uva-crispa
Rosa rugosa
Rosa rugosa thumb.
Rosmarinum officinalis
Rosmarinum officinalis
Rosmarinum officinalis
Rubus canadensis
Rubus canadensis
Rubus canadensis
Rubus idaeus
Rubus idaeus L.
Rubus ideaus
Rubus ideaus
Rubus ideaus
Rubus occidentalis
Rubus occidentalis
Rumes scutatus
Rumex acetosella linné
Rumex crispus linné
Rumex crispus linné
Salvia (elegens)
Salvia elegens
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia sclarea
Sambucus canadensis
Sambucus canadensis L.
Sambucus caradensis
Sanguisorba minor
Sanguisorba minor
Sanguisorba minor
Sanguisorba minor
Satureja hortensis
Satureja hortensis
Satureja montana
Satureja montana
Satureja montana
Satureja montana
Satureja montana
Satureja montana
Satureja montana
Satureja repandra
Satureja repandra
Satureja repandra
Solanum Tuberosum
Solidago canadensis
Sonchus oleraceus L.
Sorghum dochna Snowdrew
Sorghum sudanense
Stipa capillata L.
Symphytum officinale
Symphytum officinale
Tanacetum parthenium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare “Goldsticks”
Taraxacum officinale
Thymus fragantissumus
Thymus fragantissumus
Thymus fragantissumus
Thymus praecox subsp arctitus
Thymus pseudolanuginosus
Thymus pseudolanuginosus
Thymus serpyllum
Thymus serpyllum
Thymus vulgaris
Thymus vulgaris “Argenteus”
Thymus X citriodorus
Tiarella cordifolia
Trichosanthes kirilowii
Triticale sp.
Tropaeolum majus
Ulmus americana
Urtica dioica
Vaccinium angustifolium
Vaccinium angustifolium
Vaccinium macrocarpon
Vaccinium macrocarpon
Vaccinium macrocarpon
Vaccinum macrocarpon
Veronica officinalis
Viburnum trilobum Marsh.
Vicia villosa
Vitia sp.
Vitis sp
Vitis sp.
Vitis sp.
Zea mays
Actinidia arguta
Actinidia arguta
Achillea millefolium
Achillea millefolium
Aconitum napellus
Acorus calamus
Adiantum pedatum
Adiantum pedatum
Agropyron repens
Agropyron repens
Alchemilla mollis
Alchemilla mollis
Allium porrum
Allium porrum
Allium cepa
Allium sativum
Allium schoenoprasum
Allium Tuberosum
Aloe vera
Aloe vera
Althaea officinalis
Althaea officinalis
Amaranthus retroflexus
Amaranthus retroflexus
Anethum graveolens
Anethum graveolens
Angelica archangelica
Apium graveolens
Apium graveolens
Aralia nudicaulis
Aralia nudicaulis
Arctium lappa
Arctium minus
Arctium minus
Armoracia rusticana
Aronia melanocarpa
Aronia melanocarpa
Artemisia Absinthium
Artemisia Absinthium
Artemisia dracunculus
Aster sp
Aster sp
Atropa belladonna
Atropa belladonna
Beckmannia eruciformis
Beckmannia eruciformis
Beta vulgaris
Beta vulgaris
Beta vulgaris spp. Maritima
Beta vulgaris spp. Maritima
Borago officinalis
Brassica napus
Brassica napus
Brassica oleracea
Brassica oleracea
Brassica rapa
Brassica rapa
Campanula rapunculus
Campanula rapunculus
Canna edulis
Capsella bursa-pastoris
Capsella bursa-pastoris
Capsicum annuum
Carum carvi
Chaerophyllum bulbosum
Chaerophyllum bulbosum
Chelidonium majus
Chelidonium majus
Chenopodium bonus-henricus
Chenopodium quinoa
Chenopodium quinoa
Cicer arietinum
Cichorium intybus
Cichorium intybus
Coix Lacryma-Jobi
Coix Lacryma-Jobi
Coriandrum sativum
Coriandrum sativum
Cornus canadensis
Cornus canadensis
Crataegus sp
Crataegus sp
Cryptotaenia canadensis
Cryptotaenia canadensis
Cymbopogon citratus
Cyperus esculentus
Cyperus esculentus
Daucus carota
Daucus carota
Dirca palustris
Dirca palustris
Echinacea purpurea
Eleusine coracana
Fagopyrum esculentum
Fagopyrum esculentum
Fagopyrum tataricum
Fagopyrum tataricum
Foeniculum vulgare
Fragaria x ananassa
Fragaria x ananassa
Galinsoga ciliata
Galium odoratum
Galium odoratum
Gaultheria hispidula
Gaultheria hispidula
Glechoma hederacea
Glechoma hederacea
Glycyrrhiza glabra
Glycyrrhiza glabra
Guizotia abyssinica
Guizotia abyssinica
Hamamelis virginiana
Hedeoma pulegioides
Helleborus niger
Helleborus niger
Hordeum hexastichon
Hyssopus officinalis
Hyssopus officinalis
Inula helenium
Inula helenium
Ipomoea Batatas
Lathyrus sativus
Lathyrus sativus
Lathyrus sylvestris
Lathyrus sylvestris
Laurus nobilis
Laurus nobilis
Leonurus cardiaca
Leonurus cardiaca
Levisticum officinale
Levisticum officinale
Lotus corniculatus
Lotus corniculatus
Lycopersicon esculentum
Malva sylvestris
Medicago sativa
Medicago sativa
Melilotus albus
Melilotus albus
Melissa officinalis
Melissa officinalis
Mentha piperita
Mentha piperita
Mentha pulegium
Mentha spicata
Mentha suaveolens
Nepeta cataria
Nepeta cataria
Nicotiana tabacum
Oenothera biennis
Oenothera biennis
Origanum majorana
Origanum vulgare
Origanum vulgare
Panax quinquefolius
Panax quinquefolius
Pastinaca sativa
Pastinaca sativa
Perilla frutescens
Petasites japonicus
Petasites japonicus
Petroselinum crispum
Petroselinum crispum
Phalaris canariensis
Phaseolus vulgaris
Phaseolus Vulgaris
Pimpinella anisum
Plantago major
Plectranthus sp.
Plectranthus sp.
Polygonum aviculare
Polygonum aviculare
Potentilla anserina
Poterium Sanquisorba
Pteridium aquilinum
Raphanus raphanistrum
Raphanus raphanistrum
Raphanus salivus
Raphanus sativus
Rheum rhabarbarum
Rheum rhabarbarum
Ribes nigrum
Ribes Sylvestre
Ribes Sylvestre
Ricinus communis
Ricinus communis
Rosa rugosa
Rosa rugosa
Rosmarinus officinalis
Rubus allegheniensis
Rubus canadensis
Rubus canadensis
Rubus idaeus
Rubus idaeus
Rumex Acetosa
Rumex acetosella
Rumex acetosella
Rumex crispus
Rumex crispus
Rumex Scutatus
Rumex Scutatus
Ruta graveolens
Salix purpurea
Salix purpurea
Salvia elegans
Salvia officinalis
Salvia officinalis
Salvia sclarea
Santolina chamaecyparissus
Santolina chamaecyparissus
Satureja montana
Scorzonera hispanica
Secale cereale
Senecio vulgaris
Senecio vulgaris
Setaria italica
Setaria italica
Sium Sisarum
Sium Sisarum
Solanum tuberosum
Solidago sp
Solidago sp
Sonchus oleraceus
Sonchus oleraceus
Sorghum dochna
Sorghum dochna
Sorghum durra
Sorghum durra
Stachys byzantina
Stachys byzantina
Stellaria graminea
Stellaria graminea
Stellaria media
Stellaria media
Tanacetum cinerariifolium
Tanacetum parthenium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
Taraxacum officinale
Teucrium chamaedrys
Thymus praecox subsp arcticus
Thymus praecox subsp arcticus
Thymus serpyllum
Thymus serpyllum
Thymus vulgaris
Thymus vulgaris
Thymus x citriodorus
Thymus x citriodorus
Tragopogon porrifolius
Tragopogon porrifolius
Tropaeolum malus
Typha latifolia
Typha latifolia
Vaccinium Corymbosum
Vaccinium Corymbosum
Vaccinium macrocarpon
Vaccinum macrocarpon
Verbascum thapsus
Verbascum thapsus
Vicia sativa
Vicia sativa
Vicia villosa
Vicia villosa
Vinca minor
Vinca minor
Vitiis sp.
Vitiis sp.
Zea mays
Zea mays
Achillea millefolium
Achillea millefolium
Aconitum napellus
Acorus calamus
Acorus calamus
Actinidia arguta
Actinidia arguta
Adiantum pedatum
Adiantum pedatum
Agropyron repens
Agropyron repens
Alchemilla mollis
Allium ampeloprasum
Allium ampeloprasum
Allium cepa
Allium cepa
Allium sativum
Allium schoenoporasum
Allium tuberosum
Aloe vera
Althaca officianalis
althaea officinalis
Amaranthus retroflexus
Amaranthus retroflexus
Anethum graveolens
Anethum graveolens
Angelica archangelica
Angelica archangelica
Apium graveolens
Apium graveolens
Aralia nudicaulis
Aralia nudicaulis
Arctium minus
Arctium minus
Armoracia rusticana
Aronia melanocarpa
Aronia melanocarpa
Artemisia absinthium
Artemisia absinthium
Asclepias incarnata
Asclepias incarnata
Asparagus officinalis
Asparagus officinalis
Aster Linne
Aster sp
Aster sp
Atropa belladonna
Beckmannia eruciformis
Beta vulgaris
Beta vulgaris
Borago officinalis
Brassica Napus
Brassica napus
Brassica oleracea
Brassica oleracea
Brassica rapa
Calamagrostis arundiflora
Campanula rapunculus
Campanula rapunculus
Canna edulis
Capsella bursa-pastoris
Capsella bursa-pastoris
Carum carvi
Cerastium tomentosum
Chaerophyllum bulbosum
Chaerophyllum bulbosum
Chelidonium majus
Chelidonium majus
Chichorium endivia
Chichorium endivia subsp endivia
Chichorium endivia subsp endivia
Cichorium intybus
Cichorium intybus
Circium arvense
Circium arvense
Coix Lacryma-Jobi
Coix Lacryma-Jobi
Cornus canadensis
Cornus canadensis
Crataegus submollis
Crataegus submollis
Cymbopogon citratus
Cyperus esculentus
Cyperus esculentus
Daucus carota
Daucus carota
Dirca palustris
Dirca palustris
Echinacea purpurea
Eleusine coracana
Eleusine coracana
Erigeron speciosus
Erysimum perofskianum
Erysimum perofskianum
Fagopyrum esculentum
Fagopyrum esculentum
Fagopyrum tataricum
Fagopyrum tataricum
Galinsoga ciliata
Galinsoga ciliata
Galium odoratum
Galium odoratum
Gaultheria hispidula
Gaultheria hispidula
Gaultheria procumbens
Gaultheria procumbens
Glechoma hederacea
Glechoma hederacea
Glycyrrhiza glabra
Glycyrrhiza glabra
Guizotia abyssinica
Guizotia abyssinica
Hamamelis virginiana
Helianthus strumosus
Helianthus strumosus
Helianthus tuberosus
Helianthus tuberosus
Helichrysum thianschanicum
Helichrysum thianschanicum
Helleborus niger
Helleborus niger
Hordeum hexastichon
Hordeum hexastichon
Hyssopus officinalis
Hyssopus officinalis
Inula helenium
Inula helenium
Ipomoea batatas
Lactuca sativa
Lactuca sativa
Lathyrus sativus
Lathyrus sativus
Lathyrus sylvestris
Lathyrus sylvestris
Laurus nobilis
Laurus nobilis
Lavandula angustifolia
Lavandula angustifolia
Ledum groenlandicum
Ledum groenlandicum
Leonurus cardiaca
Leonurus cardiaca
Levistecum officinale
Levistecum officinale
Lotus corniculatus
Lotus corniculatus
Lupinus polyphyllus
Lupinus polyphyllus
Malus hupehensis
Malus hupehensis
Malva sylvestris
Medicago sativa
Medicago sativa
Melilotus albus
Melilotus albus
Melissa officinalis
Mentha piperita
Mentha pulegium
Mentha spicata
Mentha spicata
Mentha suaveolens
Nepeta cataria
Ocimum basilicum
Oenothera biennis
Oenothera biennis
Origanum majorana
Origanum vulgare
Origanum vulgare
Oryza Sativa
Oryza Sativa
Oxalis Deppei
Oxalis Deppei
Oxyria digyna
Oxyria digyna
Panax quinquefolius
Panax quinquefolius
Panicum miliaceum
Passiflora caerula
Passiflora caerula
Pastinaca sativa
Pennisetum alopecuroides
Petasites japonicus
Petroselinum crispum
Petroselinum crispum
Phalaris canariensis
Phaseolus vulgaris
Pimpinella anisum
Pisum sativum
Pisum sativum
Plantago major
Plectranthus sp.
Plectranthus sp.
Polygonum aviculare
Polygonum aviculare
Portulaca oleracea
Portulaca oleracea
Potentilla anserina
Poterium sanquisorba
Prunella vulgaris
Prunella vulgaris
Raphanus Raphanistrum
Raphanus Raphanistrum
Rhaphanus sativus
Rhaphanus sativus
Rheum rhabarbarum
Rheum rhabarbarum
Ribes nidigrolaria
Ribes nigrum
Ribes nigrum
Ribes Sylvestris
Ribes Sylvestris
Ricinus communis
Ricinus communis
Rosmarinus officinalis
Rubus idaeus
Rumex crispus
Rumex crispus
Rumex scutatus
Ruta graveolens
Salix purpurea
Salix purpurea
Salvia elegans
Salvia officinalis
Salvia officinalis
Salvia sclarea
Sambucus ebulus
Sambucus ebulus
Santolina chamaecyparissus
Santolina chamaecyparissus
Saponaria officinalis
Saponaria officinalis
Satureja hortensis
Satureja montana
Scorzonera hispanica
Scuttellaria lateriflora
Scuttellaria lateriflora
Secale cereale
Senecio vulgaris
Senecio vulgaris
Setaria italica
Setaria italica
Silene vulgaris
Silene vulgaris
Sium sisarum
Sium sisarum
solanum melongena
Solanum tuberosum
Solidago sp
Solidago sp
Sonchus oleraceus
Sonchus oleraceus
Sorghum dochna
Sorghum dochna
sorghum durra
sorghum durra
Sorghum sudanense
Sorghum sudanense
Stachys byzantina
Stachys byzantina
Stellaria graminea
Stellaria graminea
Stellaria media
Stellaria media
Symphytum officinale
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum parthenium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
Taraxacum officinale
Teucrium chamaedrys
Teucrium chamaedrys
Thymus fragantissimus
Thymus fragantissimus
Thymus praecox subsp arcticus
Thymus praecox subsp arcticus
Thymus serpyllum
Thymus serpyllum
Thymus vulgaris
Thymus x citriodorus
Tiarella cordifolia
Tropaeolum majus
Tropaeolum majus
Typha latifolia
Typha latifolia
Vaccinium macrocarpon
Vaccinium corymbosum
Vaccinium corymbosum
Vaccinium angusutifolium
Vaccinium angusutifolium
Vaccinium macrocarpon
Veratrum viride
Verbascum thapsus
Verbascum thapsus
Viburnum trilobum
Vicia sativa
Vicia sativa
Vicia villosa
Vicia villosa
Vinca minor
Vinca minor
Vitis sp.
Vitis sp.
Zea mays
Zea mays
Achillea millefolium
Achillea millefolium
Aconitum napellus
Aconitum napellus
Acorus calamus
Acorus calamus
Actinidia arguta
Actinidia arguta
Adiantum pedatum
Agrimonia eupatoria
Agropyron repens
Agropyron repens
Alchemilla mollis
Alchemilla mollis
Allium ampeloprasum
Allium cepa
Allium cepa
Allium sativum
Allium schoenoprasum
Allium tuberosum
Allium tuberosum
Aloe vera
Aloe vera
Althaea officinalis
Althaea officinalis
Amaranthus candatus
Amaranthus candatus
Amaranthus retroflexus
Amaranthus retroflexus
angelica archangelica
angelica archangelica
Anthriscus cerefolium
Anthriscus cerefolium
Apium graveolens
Aralia nudicaulis
Aralia nudicaulis
Arctium minus
Arctium minus
Armoracia rusticana
Aronia melanocarpa
Aronia melanocarpa
Artemisia absinthium
Artemisia absinthium
Artemisia dracunculus
Artium lappa
Asclepias incarnata
Asclepias incarnata
Aster spp
Aster spp
Atropa belladonna
Atropa belladonna
Avena sativa
Cyperus esculentus
Cyperus esculentus
Beta vulgaris
Borago officinalis
Brassica Napus
Brassica nigra
Brassica oleracea
Brassica oleracea
Brassica oleracea
Bromus inermis
Bromus inermis
Calamagrostis arundiflora m
Calendula officinalis
Canna edulis
Capsella bursa-pastoris
Capsella bursa-pastoris
Carex morrowii
Carex morrowii
Carum carvi
Cerastium tomentosum
Chaerophyllum bulbosum
Chaerophyllum bulbosum
Chelidonium majus
Chelidonium majus
Chenopodium quinoa
Chenopodium quinoa
Cicer arietinum
Cicer arietinum
Cichorium endivia
Cichorium intybus
Cichorium intybus
Circium arvense
Circium arvense
Citrullus colocynthus
Citrullus colocynthis
Coix Lacryma-Jobi
Coriandrum sativum
Coriandrum sativum
Cornus canadensis
Cornus canadensis
Crataegus sp
Crataegus submollis
Cryptotaenia canadensis
Cryptotaenia canadensis
Cymbopogon citratus
Cymbopogon citratus
Daucus carota
Dioscorea batatas
Dirca palustris
Dirca palustris
Echinacea purpurea
Eleusine coracana
Erysimum perofskianum
Erysimum perofskianum
Fagopyrum esculentum
Fagopyrum esculentum
Fagopyrum tataricum
Fagopyrum tataricum
Foeniculum vulgare
Fragaria x ananassa
Frangula alnus
Frangula alnus
Galinsoga ciliata
Galinsoga ciliata
Galium odoratum
Galium odoratum
Gaultheria hispidula
Gaultheria procumbens
Glechoma hederacea
Glechoma hederacea
Glycyrrhiza glabra
Glycyrrhiza glabra
Guizotia abyssinica
Guizotia abyssinica
Hamamelis virginiana
Hedeoma pulegioides
Helianthus strumosus
Helianthus strumosus
Helianthus tuberosus
Helianthus tuberosus
Helichrysum angustifolium
Helichrysum angustifolium
Helichrysum thianschanicum
Helichrysum thianschanicum
Humulus lupulus
Humulus lupulus
Hyoscyamus niger
Hyssopus officinalis
Hyssopus officinalis
Inula helenium
Inula helenium
Ipomoea batalas
Juniperus communis
Kochia scoparia.
Koeleria glauca
Koeleria glauca
Lactuca sativa
Lactuca sativa
Lathyrus Sativus
Lathyrus Sativus
Lathyrus sylvestris
Lathyrus sylvestris
Laurus nobilis
Laurus nobilis
Lavandula angustifolia
Lavandula angustifolia
Lavandula latifolia
Lavandula latifolia
Ledum groenlandicum
Ledum groenlandicum
Lens culinaris subsp culinaris
Lens culinaris subsp culinaris
Levisticum officinale
Levisticum officinale
Lotus corniculatus
Lotus corniculatus
Lupinus polyphyllus
Lupinus polyphyllus
Luzula sylvatica
Malus
Malus hupehensis
Malus hupehensis
Medicago sativa
Medicago sativa
Melilotus officinalis
Melilotus officinalis
Mentha piperita
Menyanthes trifoliata
Miscanthus sinensis
Miscanthus sinensis
Nepeta cataria
Ocimum Basilicum
Oenothera biennis
Oenothera biennis
Onobrychis viciiafolia
Onobrychis viciiafolia
Origanum vulgare
Origanum vulgare
Oryza sativa
Oryza sativa
Oxalis Deppei
Oxalis Deppei
oxyria digyna
oxyria digyna
Panax quinquefolius
Panicum miliaceum
Passiflora caerulea
Pastinaca sativa
Pastinaca sativa
Pennisetum alopecuroides
Perilla frutescens
Perilla frutescens
Pertoselinum crispum
Petasites Japonicus
Petasites Japonicus
Pertoselinum crispum
Phalaris canariensis
Phalaris canariensis
Phaseolus vulgaris
Physalis pruinosa
Pimpinella anisum
Pimpinella anisum
Pisum sativum
Pisum sativum
Plantago major
Plantago major
Plectranthus sp.
Plectranthus sp.
Polygonum aviculare
Polygonum aviculare
Potentilla anserina
Prunella vulgaris
Prunella vulgaris
Pteridium aquilinum
Raphanus raphanistrum
Raphanus raphanistrum
Raphanus sativus
Raphanus sativus
Ribes Sylvestre
Ribes Siylvestre
Ribes Siylvestre
Ricinus communis
Ricinus communis
Ribes nigrum
Ribes nigrum
Rosmarinus officinalis
Rubus canadensis
Rubus canadensis
Rubus idaeus
Rubus idaeus
Rumes scutatus
Rumes scutatus
Rumex acetosella
Rumex acetosella
Rumex crispus
Rumex crispus
Ruta graveolens
Salix purpurea
Salix purpurea
Salvia officinalis
Salvia officinalis
Sambucus canadensis
Sambucus canadensis
Sanguisorba minor
Santolina chamaecyparissus
Santolina chamaecyparissus
Saponaria officinalis
Saponaria officinalis
Satureja hortensis
Satureja hortensis
Satureja montana
Satureja montana
Satureja repandra
Satureja repandra
Scuttellaria lateriflora
Scuttellaria lateriflora
Secale cereale
Senecio vulgaris
Setaria italica
Silene vulgaris
Silene vulgaris
Sium sisarum
Sium sisarum
Solidago sp
Solidago sp
Sonchus oleraceus
Sonchus oleraceus
Sorghum caffrorum
Sorghum caffrorum
Sorghum dochna
Sorghum dochna
Sorghum dochna
Sorghum dochna
Sorghum durra
Sorghum durra
Sorghum sudanense
Stachys affinis
Stachys affinis
Stachys byzantina
Stachys byzantina
Stellaria graminea
Stellaria graminea
Stellaria media
Stellaria media
Stipa capillata
Symphytum officinale
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum parthenium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
Taraxacum officinale
Teucrium chamaedrys
Teucrium chamaedrys L.
Thymus fragantissimus
Thymus fragantissimus
Thymus praecox subsp arcticus
Thymus praecox subsp arcticus
Thymus pseudolanuginosus
Thymus pseudolanuginosus
Thymus serpyllum
Thymus serpyllum
Thymus x citriodorus
Thymus x citriodorus
Tiarella cordifolia
Tragopogon porrifolius
Tragopogon porrifolius
Triticosecala spp.
Triticum aestivum
Triticum aestivum
Tropaeolum majus
Tropaeolum majus
Typha latifolia
Typha latifolia
Urtica dioica
Urtica dioica
Vaccinium angustifolium
Vaccinium macrocarpon
Vaccinium macrocarpon
Veratrum viride
Veratrum viride
Verbascum thapsus
Verbascum thapsus
Vibumum trilobum
Vibumum trilobum
Vicia sativa
Vicia villosa
Vicia villosa
Vinca minor
Vitis sp.
Vitis sp.
Zea mays
Zea mays
Achillea millefolium
Aconitum napellus
Acorus calamus
Actinidia arguta
Actinidia arguta
Agropyron repens
Alchemilla mollis
Alchemilla mollis
Allium cepa
Allium porrum
Allium porrum
Allium sativum
Allium schoenoprasum
Allium Tuberosum
Aloe vera
Aloe vera
Althaea officinalis
Amaranthus retroflexus
Amaranthus retroflexus
Anethum graveolens
Angelica archangelica
Angelica archangelica
Apium graveolens
Apium graveolens
Aralia nudicaulis
Aralia nudicaulis
Arctium minus
Arctium minus
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Armoracia rusticana
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa
Artemisia Absinthium
Artemisia dracunculus
Aster sp
Atropa belladonna
Beckmannia eruciformis
Beckmannia eruciformis
Beta vulgaris
Beta vulgaris
Beta vulgaris ssp. Maritima
Beta vulgaris ssp. Maritima
Borago officinalis
Brassica napus
Brassica napus
Brassica oleracea
Brassica rapa
Brassica rapa
Campanula rapunculus
Canna edulis
Capsella bursa-pastoris
Capsella bursa-pastoris
Capsicum annuum
Chaerophyllum bulbosum
Chelidonium majus
Chenopodium bonus-henricus
Chenopodium quinoa
Chenopodium quinoa
Cicer arietinum
Cichorium intybus
Cichorium intybus
Coix Lacryma-Jobi
Coriandrum sativum
Coriandrum sativum
Cornus canadensis
Cornus canadensis
Crataegus sp
Crataegus submollis
Cryptotaenia canadensis
Cryptotaenia canadensis
Cymbopogon citratus
Cyperus esculentus
Daucus carota
Dirca palustris
Dirca palustris
Dryopteris filix-mas
Echinacea purpurea
Eleusine coracana
Eleusine coracana
Fagopyrum esculentum
Fagopyrum tataricum
Fagopyrum tataricum
Foeniculum vulgare
Fragaria x ananassa
Fragaria x ananassa
Galinsoga ciliata
Galium odoratum
Gaultheria hispidula
Gaultheria hispidula
Glechoma hederacea
Glycine max
Glycine max
Glycyrrhiza glabra
Glycyrrhiza glabra
Guizotia abyssinica
Guizotia abyssinica
Hamamelis virginiana
Hedeoma pulegioides
Helleborus niger
Hordeum hexastichon
Hyssopus officinalis
Inula helenium
Ipomoea Batatas
Lathyrus sativus
Lathyrus sativus
Lathyrus sylvestris
Lathyrus sylvestris
Laurus nobilis
Laurus nobilis
Leonurus cardiaca
Levisticum officinale
Levisticum officinale
Lotus corniculatus
Lotus corniculatus
Lycopersicon esculentum
Malva sylvestris
Medicago sativa
Medicago sativa
Melilotus albus
Melilotus albus
Melissa officinalis
Melissa officinalis
Mentha piperita
Mentha piperita
Mentha pulegium
Mentha spicata
Mentha suaveolens
Nepeta cataria
Nepeta cataria
Nicotiana tabacum
Oenothera biennis
Oenothera biennis
Origanum majorana
Origanum vulgare
Origanum vulgare
Panax quinquefolius
Panax quinquefolius
Panicum miliaceum
Panicum miliaceum
Pastinaca sativa
Petasites japonicus
Petroselinum crispum
Petroselinum crispum
Petroselinum crispum
Phalaris canariensis
Phaseolus vulgaris
Phaseolus Vulgaris
Pimpinella anisum
Plantago major
Plantago major
Plectranthus sp.
Potentilla anserina
Pteridium aquilinum
Raphanus raphanistrum
Raphanus sativus
Raphanus sativus
Rheum rhabarbarum
Rheum rhabarbarum
Ribes nigrum
Ribes nigrum
Ribes Sylvestre
Ricinus communis
Ricinus communis
Rosa rugosa
Rubus allegheniensis
Rubus canadensis
Rubus idaeus
Rubus idaeus
Rumex Acetosa
Rumex acetosella
Rumex acetosella
Rumex crispus
Rumex crispus
Rumex Scutatus
Ruta graveolens
Salix purpurea
Salix purpurea
Salvia elegans
Salvia officinalis
Salvia officinalis
Salvia sclarea
Santolina chamaecyparissus
Santolina chamaecyparissus
Satureja montana
Scorzonera hispanica
Scutellaria lateriflora
Senecio vulgaris L.
Setaria italica
Setaria italica
Sium Sisarum
Sium Sisarum
Solanum tuberosum
Solanum tuberosum
Solidago sp
Solidago sp
Sonchus oleraceus
Sonchus oleraceus
Sorghum dochna
Sorghum durra
Stachys affinis
Stachys byzantina
Stellaria graminea
Stellaria graminea
Stellaria media
Stellaria media
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
Taraxacum officinale
Teucrium chamaedrys
Thymus praecox subsp arcticus
Thymus serpyllum
Thymus serpyllum
Thymus vulgaris
Thymus vulgaris
Thymus x citriodorus
Tragopogon porrifolius
Tragopogon porrifolius
Tropaeolum majus
Tropaeolum majus
Typha latifolia
Typha latifolia
Vaccinium Corymbosum
Vaccinium macrocarpon
Veratrum viride
Verbascum thapsus
Vicia sativa
Vicia villosa
Vicia villosa
Vinca minor
Vitis sp.
Vitis sp.
Zea mays
Zea mays
Achillea millefolium
Aconitum napellus
Acorus calamus
Actinidia arguta
Actinidia arguta
Adiantum pedatum
Agropyron repens
Alchemilla mollis
Alchemilla mollis
Allium ampeloprasum
Allium ampeloprasum
Allium cepa
Allium cepa
Allium sativum
Allium schoenoporasum
Allium tuberosum
Aloe vera
althaea officinalis
Amaranthus retroflexus
Amaranthus retroflexus
Anethum graveolens
Angelica archangelica
Angelica archangelica
Apium graveolens
Apium graveolens
Aralia nudicaulis
Aralia nudicaulis
Arctium minus
Arctium minus
Arctostaphylos uva-ursi
Armoracia rusticana
Aronia melanocarpa
Aronia melanocarpa
Artemisia absinthium
Artemisia dracunculus
Artemisia dracunculus
Asclepias incarnata
Asclepias incarnata
Asparagus officinalis
Aster
Aster sp
Aster sp
Beckmannia eruciformis
Beta vulgaris
Beta vulgaris
Borago officinalis
Brassica napus
Brassica napus
Brassica oleracea
Brassica rapa
Brassica rapa
Calamagrostis arundiflora
Campanula rapunculus
Canna edulis
Canna edulis
Capsella bursa-pastoris
Capsella bursa-pastoris
Carum carvi
Chaerophyllum bulbosum
Chaerophyllum bulbosum
Chelidonium majus
Cicer arietinum
Cicer arietinum
Cichorium endivia subsp. Endivia
Cichorium intybus
Cichorium intybus
Circium arvense
Circium arvense
Coix Lacryma-Jobi
Cornus canadensis
Cornus canadensis
Crataegus submollis
Crataegus submollis
Cymbopogon citratus
Cymbopogon citratus
Cyperus esculentus
Daucus carota
Daucus carota
Dirca palustris
Dirca palustris
Dryopteris filix-mas
Echinacea purpurea
Eleusine coracana
Eleusine coracana
Erigeron speciosus
Erysimum perofskianum
Erysimum perofskianum
Fagopyrum esculentum
Fagopyrum tartaricum
Fagopyrum tartaricum
Galinsoga ciliata
Galinsoga ciliata
Galium odoratum
Gaultheria hispidula
Gaultheria hispidula
Gaultheria procumbens
Glechoma hederacea
Glycine max
Glycine max
Glycyrrhiza glabra
Glycyrrhiza glabra
Guizotia abyssinica
Guizotia abyssinica
Hamamelis virginiana
Hamamelis virginiana
Helianthus strumosus
Helianthus strumosus
Helianthus tuberosus
Helianthus tuberosus
Helichrysum thianschanicum
Helichrysum thianschanicum
Helleborus niger
Helleborus niger
Hordeum hexastichon
Hordeum hexastichon
Hyssopus officinalis
Inula helenium
Lactuca sativa
Lactuca sativa
Lathyrus sylvestris
Lathyrus sylvestris
Laurus nobilis
Laurus nobilis
Lavandula angustifolia
Lavandula angustifolia
Ledum groenlandicum
Ledum groenlandicum
Leonurus cardiaca
Levisticum officinale
Levisticum officinale
Lotus corniculatus
Lotus corniculatus
Lupinus polyphyllus
Lupinus polyphyllus
Lycopersicon esculentum
Lycopersicon esculentum
Malus hupehensis
Malus hupehensis
Medicago sativa
Medicago sativa
Melilotus alba
Melilotus alba
Melissa officinalis
Melissa officinalis
Mentha piperita
Mentha pulegium
Mentha spicata
Mentha spicata
Mentha suaveolens
Nepeta cataria
Ocimum basilicum
Oenothera biennis
Oenothera biennis
Origanum majorana
Origanum vulgare
Origanum vulgare
Oryza Sativa
Oxalis Deppei
Oxalis Deppei
Oxyria digyna
Oxyria digyna
Panax quinquefolius
Panicum miliaceum
Panicum miliaceum
Passiflora caerulae
Passiflora caerulae
Pastinaca sativa
Pennisetum alopecuroides
Petasites japonicus
Petroselinum crispum
Petroselinum crispum
Phalaris canariensis
Phalaris canariensis
Phaseolus vulgaris
Phaseolus vulgaris
Pimpinella anisum
Pisum sativum
Plantago major
Plantago major
Plectranthus sp.
Polygonum aviculare
Portulaca oleracera
Potentilla anserina
Poterium sanquisorba
Prunella vulgaris
Prunella vulgaris
Pteridium aquilinum
Rhaphanus sativus
Rhaphanus sativus
Rheum rhabarbarum
Rheum rhabarbarum
Ribes nidigrolaria
Ribes nigrum
Ribes nigrum
Ribes Sylvestre
Ricinus communis
Ricinus communis
Rosmarinus officinalis
Rubus idaeus
Rubus idaeus
Rumex crispus
Rumex crispus
Rumex scutatus
Ruta graveolens
Ruta graveolens
Salix purpurea
Salix purpurea
Salvia elegans
Salvia officinalis
Salvia officinalis
Salvia sclarea
Sambucus ebulus
Sambucus ebulus
Santolina chamaecyparissus
Saponaria officinalis
Saponaria officinalis
Satureja hortensis
Satureja montana
Scorzonera hispanica
Scorzonera hispanica
Scutellaria lateriflora
Secale cereale
Senecio vulgaris
Setaria italica
Setaria italica
Silene vulgaris
Sium sisarum
Sium sisarum
solanum melongena
Solanum tuberosum
Solanum tuberosum
Solidago sp
Solidago sp
Sonchus oleraceus
Sonchus oleraceus
Sorghum dochna
Sorghum dochna
sorghum durra
sorghum durra
Sorghum sudanense
Sorghum sudanense
Stachys Affinis
Stachys byzantina
Stachys byzantina
Stellaria graminea
Stellaria media
Stellaria media
Symphytum officinale
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
taraxacum officinale
Teucrium chamaedrys
Teucrium chamaedrys
Thymus fragantissimus
Thymus fragantissimus
Thymus praecox subsp arcticus
Thymus praecox subsp arcticus
Thymus serpyllum
Thymus serpyllum
Thymus vulgaris
Thymus vulgaris
Thymus x citriodorus
Tiarella cordifolia
Tropaelum majus
Typha latifolia
Typha latifolia
Vaccinium corymbosum
Vaccinium corymbosum
Vaccinium macrocarpon
Veratrum viride
Verbascum thapsus
Verbascum thapsus
Viburnum trilobum
Viburnum trilobum
Vicia sativa
Vicia sativa
Vicia villosa
Vicia villosa
Vinca minor
Vitis sp.
Vitis sp.
Zea mays
Zea mays
Achillea millefolium
Aconitum napellus
Acorus calamus
Actinidia arguta
Actinidia arguta
Adiantum pedatum
Agrimonia eupatoria
Agropyron rupens
Alchemilla mollis
Alchemilla mollis
Allium ampeloprasum
Allium ampeloprasum
Allium cepa
Allium cepa
Allium sativum
Allium schoenoprasum
Allium tuberosum
Allium tuberosum
Aloe vera
Aloe vera
Althaea officinalis
Amaranthus caudathus
Amaranthus caudathus
Amaranthus retroflexus
angelica archangelica
angelica archangelica
Anthriscus cerefolium
Apium graveolens
Aralia nudicaulis
Aralia nudicaulis
Arctium minus
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Armoracia rusticana
Aronia melanocarpa
Aronia melanocarpa
Artemisia absinthium
Artemisia absinthium
Artemisia dracunculus
Artium lappa
Asclepias incarnata
Asclepias incarnata
Aster
Aster sp
Aster sp
Atropa belladonna
Avena sativa
Beta vulgaris
Beta vulgaris
Borago officinalis
Borago officinalis
Brassica napus
Brassica Napus
Brassica nigra
Brassica oleracea
Bromus inermis
Bromus inermis
Calendula officinalis
Canna edulis
Canna edulis
Capsella bursa-pastoris
Capsella bursa-pastoris
Carex morrowii
Carex morrowii
Carum carvi
Cerastium tomentosum
Chaerophyllum bulbosum
Chaerophyllum bulbosum
Chelidonium majus
Chenopodium quinoa
Chenopodium quinoa
Cicer arietinum
Cicer arietinum
Cichorium endivia subsp endivia
Cichorium endivia subsp endivia
Cichorium intybus
Cichorium intybus
Circium arvense
Circium arvense
Citrullus colocynthis
Citrullus colocynthis
Coriandrum sativum
Coriandrum sativum
Cornus canadensis
Cornus canadensis
Crataegus sp
Crataegus submollis
Cryptotaenia canadensis
Cymbopogon citratus
Cymbopogon citratus
Cyperus esculentus
Cyperus esculentus
Dirca palustris
Dirca palustris
Dryopteris filix-mas
Echinacea purpurea
Eleusine coracana
Erysimum perofskianum
Erysimum perofskianum
Fagopyrum esculentum
Fagopyrum tararicum
Fagopyrum tataricum
Foeniculum vulgare
Fpomoea batatas
Fragaria x ananassa
Galinsoga ciliata
Galinsoga ciliata
Galium odoratum
Galium odoratum
Gaultheria hispidula
Gaultheria hispidula
Gaultheria procumbens
Glechoma hederacea
Glycine max
Glycine max
Glycine max
Glycyrrhiza glabra
Glycyrrhiza glabra
Guizotia abyssinica
Guizotia abyssinica
Hamamelis virginiana
Hamamelis virginiana
Hedeoma pulegioides
Helianthus strumosus
Helianthus strumosus
Helianthus tuberosa
Helianthus tuberosus
Helichrysum angustifolium
Helichrysum angustifolium
Helichrysum thianschanicum
Helleborus niger
Humulus lupulus
Humulus lupulus
Hyoscyamus niger
Hyssopus officinalis
Inula helenium
Juniperus communis
Koeleria glauca
Koeleria glauca
Lactuca sativa
Lathyrus Sativus
Lathyrus Sativus
Lathyrus sylvestris
Laurus nobilis
Laurus nobilis
Lavandula latifolia
Lavendula angustifolia
Ledum groenlandicum
Ledum groenlandicum
Lens culinaris subsp. Culinaris
Lens culinaris subsp. Culinaris
Levisticum officinale
Levisticum officinale
Lotus corniculatus
Lotus corniculatus
Lupinus polyphyllus
Lupinus polyphyllus
Luzula sylvatica
Malus hupehensis
Malus hupehensis
Malus spp.
Malva sylvestris
Medicago sativa
Medicago sativa
Melilotus officinalis
Melissa officinalis
Mentha piperita
Menyanthes trifoliata
Miscanthus sinensis Andress
Miscanthus sinensis Andress
Nepeta cataria
Ocimum Basilicum
Oenothera biennis
Oenothera biennis
Onobrychis viciifolia
Onobrychis viciifolia
Origanum vulgare
Origanum vulgare
Oryza sativa
Oxalis Deppei
Oxalis Deppei
oxyria digyna
oxyria digyna
Panax quinquefolius
Panax quinquefolius
Panicum miliaceum
Passiflora caerulea
Passiflora caerulea
Pastinaca sativa
Pastinaca sativa
Pennisetum alopecuroides
Perilla frutescens
Petasites Japonicus
Petasites Japonicus
Petroselinum crispum
Petroselinum crispum
Petroselinum crispum
Phalaris canariensis
Phalaris canariensis
Phaseolus vulgaris
Physalis pruinosa
Pimpinella anisum
Pimpinella anisum
Pisum sativum
Plantago major
Plectranthus sp.
Podophyllum peltatum
Polygonum aviculare
Polygonum aviculare
Potentilla anserina
Prunella vulgaris
Prunella vulgaris
Pteridium aquilinum
Raphanus raphanistrum
Raphanus raphanistrum
Raphanus sativus
Ribes nigrum
Ribes nigrum
Ribes Sylvestre
Ribes Sylvestre
Ricinus communis
Ricinus communis
Rosa rugosa
Rubus canadensis
Rubus idaeus
Rubus idaeus
Rumes scutatus
Rumex acetosella
Rumex acetosella
Rumex crispus
Rumex crispus
Ruta graveolens
Salix purpurea
Salix purpurea
Salvia officinalis
Salvia officinalis
Sambucus canadensis
Sambucus canadensis
Sanguisorba minor
Santolina
Santolina
Saponaria officinalis
Satureja hortensis
Satureja hortensis
Satureja montana
Satureja montana
Satureja repandra
Satureja repandra
Scorzorera hipanica
Scuttellaria lateriflora
Setaria italica
Silene vulgaris
Sium sisarum
Sium sisarum
Solanum melongens
Solidago sp
Solidago sp
Sonchus oleraceus
Sonchus oleraceus
Sorghum caffrorum
Sorghum caffrorum
Sorghum dochna
Sorghum dochna
Sorghum dochna
Sorghum dochna
Sorghum durra
Sorghum durra
Sorghum sudanense
Stachys affinis
Stachys affinis
Stachys byzantina
Stellaria graminea
Stellaria graminea linne
Stellaria media
Stipa capillata
Symphytum officinale
Tanacetum parthenium
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
Taraxacum officinale
Teucrium chamaedrys
Thymus fragantissimus
Thymus fragantissimus
Thymus praecox subsp arcticus
Thymus pseudolanuginosus
Thymus serpyllum
Thymus x citriodorus
Thymus x citriodorus
Tiarella cordifolia
Tragopogon porrifolius
Tragopogon porrifolius
Triticosecale spp
Triticosecale spp
Triticum aestivum
Triticum aestivum
Tropaeolum majus
Tropaeolum majus
Typha latifolia
Typha latifolia
Urtica dioica
Urtica dioica
Vaccinium angustifolium
Vaccinium macrocarpon
Vaccinium macrocarpon
Veratrum viride
Verbascum thapsus
Viburnum trilobum
Viburnum trilobum
Vicia sativa
Vicia villosa
Vicia villosa
Vinca minor
Vitis sp.
Zea mays
Zea mays
Achillea millefolium
Achillea millefolium
Aconitum napellus
Adiantum pedatum
Agrimonia eupatoria
Agropyron cristatum
Agropyron repens
Agropyron repens
Agropyron repens
Agrostis Stofonifera
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alkanna tinctoria
Allium Tuberosum
Aloe vera
Ambrosia artemisiifolia
Amelanchier sanguinea
Amelanchier sanguinea
Anethum graveolens
Anethum graveolens
Angelica archangelica
Anthemis nobilis
Anthemis nobilis
Anthemis tinctoria
Anthemis tinctoria
Apium graveolens
Arctium minus
Arclostaphylos uva-ursi
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa
Artemisia dracunculus
Aster sp
Beta vulgaris
Beta vulgaris ssp. Maritima
Borago officinalis
Brassica napus
Brassica napus
Brassica nigra
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica rapa
Brassica rapa
Bromus inermis
Bromus inermis
Calamintha nepeta
Canna edulis
Canna edulis
Carum carvi
Chaerophyllum bulbosum
Chenopodium bonus-henricus
Chenopodium bonus-henricus
Chenopodium quinoa
Chrysanthemum coronarium
Cicer arietinum
Cichorium intybus
Citrullus lanatus
Coix Lacryma-Jobi
Cosmos sulphureus
Cosmos sulphureus
Crataegus sp
Crataegus sp
Crataegus sp
Crataegus submollis
Cryptotaenia canadensis
Cucumis anguria
Cucumis Anguria
Cucumis melo
Cucumis sativus
Curcuma zedoaria
Cymbopogon citratus
Datisca cannabina
Daucus carota
Daucus carota
Daucus carota
Digitalis purpurea
Dirca palustris
Dirca palustris
Dolichos Lablab
Dryopteris filix-mas
Dryopteris filix-mas
Echinacea purpurea
Echinacea purpurea
Eleusine coracana
Erigeron canadensis
Fagopyrum esculentum
Fagopyrum tataricum
Foeniculum vulgare
Fragaria x ananassa
Fragaria x ananassa
Fragaria x ananassa
Fragaria x ananassa
Fragaria x ananassa
Galinsoga ciliata
Galium odoratum
Gaultheria hispidula
Gentiana lutea
Glechoma hederacea
Glycine Max
Glycyrrhiza glabra
Glycyrrhiza glabra
Guizotia abyssinica
Hamamelis virginiana
Helianthus Tuberosus
Heliotropium arborescens
Heliotropium arborescens
Helleborus niger
Hordeum vulgare
Hypericum perforatum
Hyssopus officinalis
Hyssopus officinalis
Lactuca serriola
Laurus nobilis
Lavandula latifolia
Lavandula latifolia
Lavandula latifolia
Leonurus cardiaca
Lepidium sativum
Lolium multiflorum
Lolium perenne
Lolium perenne
Lolium perenne
Ludoviciana
Ludoviciana
Malva sylvestris
Matricaria recutita
Melaleuca alternifolia
Melissa officinalis
Mentha piperita
Mentha piperita
Mentha pulegium
Mentha pulegium
Mentha pulegium
Mentha spicata
Oenothera biennis
Oenothera biennis
Origanum majorana
Oxyria digyna
Panicum miliaceum
Peucedanum cervaria
Phalaris arundinacea
Phalaris canariensis
Phaseolus coccineus
Phaseolus mungo
Phaseolus vulgaris
Phaseolus Vulgaris
Phleum pratense
Physalis ixocarpa
Physalis Ixocarpa
Physalis Pruinosa
Phytolacca americana
Plantago coronopus
Plantago coronopus
Plantago major
Plectranthus sp.
Poa pratensis
Polygonum aviculare
Portulaca olevcae
Poterium sanguisorba
Poterium sanguisorba
Poterium sanguisorba
Pteridium aquilinum
Raphanus sativus
Raphanus sativus
Rheum officinale
Ribes nigrum
Ribes nigrum
Ribes nigrum
Ribes rubrum
Ribes Sylvestre
Rosa rugosa
Rosa rugosa
Rosmarinus officinalis
Rubus idaeus
Rubus idaeus
Rubus idaeus
Rubus idaeus
Rumex Acetosa
Rumex crispus
Rumex crispus
Rumex Scutatus
Ruta graveolens
Saccharum officinarum
Saccharum officinarum
Salvia elegans
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia sclarea
Salvia sclarea
Santolina chamaecyparissus
Satureja montana
Satureja montana
Scorzonera hispanica
Scutellaria lateriflora
Senecio vulgaris
Sonchus oleraceus
Sorghum dochna
Sorghum dochna
Sorghum durra
Sorghum durra
Spinacia oleracea
Stellaria graminea
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
Taraxacum officinale
Taraxacum officinale
Teucrium chamaedrys
Thymus fragantissimus
Thymus herba-barona
Thymus vulgaris
Thymus vulgaris
Thymus x citriodorus
Thymus x citriodorus
Trichosanthes kirilowii
Trigonella foenum graecum
Triticum durum
Triticum turgidum
Triticum spelta
Urtica dioica
Vaccinium augustifolium
Vaccinium Corymbosum
Vaccinium Corymbosum
Vaccinium macrocarpon
Vaccinium macrocarpon
Valerianella locusta
Veronica officinalis
Viburnum trilobum Marsh.
Vitis
Vitis
Vitis
Zea Mays
Achillea millefolium
Achillea millefolium
Aconitum napellus
Aconitum napellus
Acorus calamus
Adiantum pedatum
Agastache foeniculum
Ageratum conyzoides
Agropyron cristatum
Agropyron repens
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Allium cepa
Allium sativum
Allium tuberosum
Althaea officinalis
Amaranthus caudatus
Amelanchier sanguinea
Anethum graveolens
Angelica archangelica
Anthemis nobilis
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Armoracia rusticana
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa
Aronia melanocarpa
Artemisia absinthium
Artemisia absinthium
Aster
Beckmannia eruciformis
Beta vulgaris
Betula glandulosa
Borago officinalis
Brassica Napus
Brassica napus
Brassica nigra
Brassica oleracea
Brassica oleracea
Brassica rapa
Calamintha nepeta
Calamintha nepeta
Canna edulis
Capsella bursa-pastoris
Carthamus tinctorius
Chelidonium majus
Chenopodium album
Cichorium endivia subsp. Endivia
Cicer arietinum
Cichorium endivia subsp. Endivia
Cichorium endivia subsp. Endivia
Coix Lacryma-Jobi
Cornus canadensis
Crataegus sp
Cucurbita Pepo
Curcuma zedoaria
Datura metel
Daucus carota
Daucus carrota
Dipsacus sativus
Dirca palustris
Dolichos Lablab
Dryopteris filix-mas
Echinacea purpurea
Elymus junceus
Erigeron canadensis
Erigeron speciosus
Erigeron speciosus
Erysimum perofskianum
Fagopyrum esculentum
Fagopyrum tataricum
Foeniculum vulgare
Foeniculum vulgare
Foeniculum Vulgare
Galinsoga ciliata
Galium odoratum
Gaultheria hispidula
Gaultheria hispidula
Gaultheria procumbens
Glycine max
Glycyrrhiza glabra
Glycyrrhiza glabra
Glycyrrhiza glabra
Glycyrrhiza glabra
Hamamelis virginiana
Hamamelis virginiana
Hedeoma pulegioides
Helenium hoopesii
Helenium hoopesii
Helianthus tuberosus
Helichrysum thianschanicum
Helichrysum thianschanicum
Heliotropium arborescens
Heliotropium arborescens
Helleborus niger
Hordeum vulgare subsp. Vulgare
Hypericum henryi
Hypericum perforatum
Hyssopus officinalis
Hyssopus officinalis
Inula helenium
Ipomola batatas
Lactuca sativa
Laportea canadensis
Laportea canadensis
Laserpitium latifolium
Lathyrus sativus
Lathyrus sativus
Lathyrus sativus
Laurus nobilis
Lavandula angustifolia
Ledum groenlandicum
Leonorus cardiaca
Lepidium sativum
Levisticum officinale
Lolium perenne
Lotus tetragonolobus
Lupinus polyphylius
Malus hupehensis
Medicago sativa
Melaleuca alternifolia
Melissa officinalis
Mentha arvensis
Mentha piperita
Mentha piperita
Mentha piperita
Mentha pulegium
Mentha pulegium
Mentha spicata
Monarda didyma
Nepeta cataria
Nicotiana tabacum
Ocimum basilicum
Ocimum basilicum
Oenothera biennis
Oenothera biennis
Oenothera biennis
Oenothera biennis
Origanum vulgare
Origanum vulgare
Origanum vulgare
Oryza Sativa
Oxalis Deppei Lodd.
Panicum miliaceum
Pastinaca sativa
Petroselinum crispum
Petroselinum crispum
Peucedanum cervaria
Phaseolus coccineus
Phaseolus coccineus
Phaseolus mungo
Phlox paniculata
Physalis pruinosa
Phytolacca americana
Pimpinella anisum
Plantago coronopus
Plantago major
Plantago major
Plantago major
Poa compressa
Poa pratensis
Polygonum aviculare
Polygonum pensylvanicum
Portulaca oleracea
Poterium sanguisorba
Poterium sanguisorba
Prunella vulgaris
Pteridium aquilinum
Reseda odorata
Rhaphanus sativus
Rheum x cultorum
Ribes nidigrolaria
Ribes nidigrolaria
Ribes nigrum
Ribes Silvestre
Ricinus communis
Rosmarinus officinalis
Rubus idaeus
Rubus occidentalis
Rubus occidentalis
Rumex acetosella
Rumex crispus
Rumex patientia
Rumex scutatus
Ruta graveolens
Saccharum officinarum
Salix purpurea
Salvia elegans
Salvia officinalis
Salvia officinalis
Salvia officinalis
Salvia sclarea
Salvia sclarea
Salvia sclarea
Sambucus ebulus
Sambucus ebulus
Sanguisorba officinalis
Santolina chamaecyparissus
Serratula tinctoria
Satureja montana
Scolymus hispanicus
Scutellaria lateriflora
Senecio vulgaris
Solidago sp
Sonchus oleraceus
Sorghum caffrorum
Sorghum dochna
Sorghum dochna
Sorghum sudanense
Sorghum sudanense
Stellaria graminea
Stellaria media
Stellaria media
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
taraxacum officinale
Thymus fragantissimus
Thymus fragantissimus
Thymus herba-barona
Thymus serpyllum
Triticosecale spp.
Triticum durum
Triticum spelta
Triticum spelta
Typha latifolia
Urtica diolca
Vaccinium corymbosum
Vaccinium angustifolium
Vaccinium macrocarpon
Vaccinium macrocarpon
Valerianella locusta
Veratrum viride
Verbascum thapsus
Viburnum trilobum
Viburnum trilobum
Vicia faba
Vigna unguiculata
Vitis
Vitis
Vitis
Vitis
Xanthium sibiricum
Zea mays
Abies lasiocarpa
Achillea millefolium
Aconitum napellus
Acorus calamus
Agaricus bisporatus
Ageratum conyzoides
Agrimonia eupatoria
Agropyron cristatum
Agropyron repens
Agrostis alba
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Alchemilla mollis
Allium ascalonicum
Allium sativum
Allium tuberosum
Alpinia officinarum
Alpinia officinarum
Amaranthus candatus
Amaranthus gangeticus
Ananas comosus
Ananas comosus
Anethum graveolens
angelica archangelica
Anthemis nobilis
Anthemis tinctorium
Anthriscus cerefolium
Arctium minus
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Aronia melanocarpa
Aronia melanocarpa
Aronia prunifolia
Artemisia absinthium
Artemisia dracunulus
Artemisia dracunulus
Aster
Avena sativa
Averrhoa carambola
Beta vulgaris
Beta vulgaris
Beta vulgaris
Betula glandulosa
Boesenbergia rotunda
Boesenbergia rotunda
Boletus edulis
Borago officinalis
Brassica hirta
Brassica juncea
Brassica Napus
Brassica napus
Brassica oleracea
Brassica oleracea
Brassica oleracea
Brassica rapa
Bromus inermis
Canna edulis
Capsicum annuum
Carex morrowii
Carex morrowii
Carya cordiformis
Carya cordiformis
Carya cordiformis
Clematis armandii
Chaerophyllum bulbosum
Chaerophyllum bulbosum
Agaricus bisporatus
Chelidonium majus
Chenopodium bonus-henricus
chrysanthemum coronarium
chrysanthemum coronarium
Cichorium endivia subs. Endivia
Cichorium endivia subs. Endivia
Circium arvense
Citrullus colocynthis
Citrullus colocynthis
Citrus limettoides
Citrus limon
Citrus limon
Citrus reticulata
Citrus reticulata
Citrus sinensis
Coix Lacryma-Jobi
Coix Lacryma-Jobi
Corchorus olitorius
Cornus canadensis
Crataegus sp
Crataegus submollis
Curcuma longa
Curcuma zedoaria
Cydonia oblonga
Cynara scolymus
Cynara scolymus
Dactilis Glomerata
Datura metel
Datura metel
Datura stramonium
Daucus carota
Daucus carota
Dipsacus sativus
Dirca palustris
Dolichos lablab
Dryopteris filix-mas
Echinacea purpurea
Eleusine coracana
Elymus junceus
Erigeron speciosus
Erysimum perofskianum
Erysimum perofskianum
Fagopyrum esculentum
Foeniculum vulgare
Foeniculum vulgare
Foeniculum vulgare
Fragaria x ananassa
Fragaria x ananassa
Fragaria x ananassa
Frangula alnus
Frangula alnus
Fucus vesiculosus
Galinsoga ciliata
Gaultheria hispidula
Gentiana macrophylla
Ginkgo biloba
Glycyrrhiza glabra
Glycyrrhiza glabra
Glycyrrhiza glabra
Gossypium herbaceum
Gossypium herbaceum
Guizotia abyssinica
Hamamelis virginiana
Hamamelis virginiana
Hedeoma pulegioides
Hedeoma pulegioides
Helenium hoopesii
Helenium hoopesii
Helianthus tuberosus
Helichrysum thianschanicum
Helichrysum thianschanicum
Helleborus niger
Hibiscus cannabinus
Hibiscus cannabinus
Humulus lupulus
Humulus lupulus
Hydrastis canadensis
Hypericum henryi
Hypericum perforatum
Hypericum sp
Hypomyces lactifluorum
Iberis amara
Inula helenium
Ipomola batatas
Ipomola batatas
Juniperus communis
Laportea canadensis
Laurus nobilis
Laurus nobilis
Lavandula angustifolia
Lavandula angustifolia
Lavandula latifolia
Lavandula latifolia
Ledum groenlandicum
Lentinus edodes
Leonurus cardiaca
Lepidium sativum
Levisticum officinale
Litchi chinensis
Lolium multiflorum
Lolium perenne
Lonicera ramosissima
Lupinus polyphyllus
Lupinus polyphyllus
Luzula sylvatica
Majorana hortensis
Malus spp.
Malus spp.
Malus hupehensis
Melaleuca alternifolia
Melissa officinalis
mentha arvensis
Mentha piperita
Mentha pulegium
Mentha pulegium
Mentha spicata
Mentha suaveolens
Monarda didyma
Musa paradisiaca
Musa paradisiaca
nasturtium officinale
Nepeta cataria
Nepeta cataria
Nigella sativa
Ocimum Basilicum
Ocimum Basilicum
Ocimum Basilicum
Oenothera biennis
Oenothera biennis
Oenothera biennis
Onobrychis viciifolia
Origanum vulgare
Oryza sativa
Oxalis Deppei
Panicum miliaceum
Passiflora spp.
Passiflora spp.
Passiflora spp.
Pastinaca sativa
Pastinaca sativa
Pastinaca sativa
Petroselinum crispum
Phaseolus coccineus
Phaseolus vulgaris
Phaseolus vulgaris
Phaseolus vulgaris
Phlox paniculata
Physalis pruinosa
Phytolacca americana
Plantago coronopus
Plantago coronopus
Pleurotus spp.
Poa pratensis
Podophyllum peltatum
Polygonum chinense
Polygonum aviculare
Polygonum aviculare
Polygonum pensylvanicum
Polygonum persicaria
Populus incrassata
Populus Tremula
Populus x petrowskyana
Populus x petrowskyana
Populus x petrowskyana
Portulaca oleracera
Poterium sanguisorba
Prunus spp.
Prunus persica
Prunus persica
Psidium guajava
Psidium spp.
Psoralea corylifolia
Pteridium aquilinum
Pteridium aquilinum
Punica granatum
Rehmannia glutinosa
Raphanus sativus
Raphanus sativus
Reseda luteola
Reseda odorata
Rheum officinale
Rheum officinale
Rheum x cultorum
Ricinus communis
Ribes Grossularia
Ribes nidigrolaria
Ribes nigrum
Ribes nigrum
Ribes nigrum
Ribes Sylvestre
Rosa rugosa
Rosmarinus officinalis
Rosmarinus officinalis
Rubus idaeus
Rubus idaeus
Rubus idaeus
Rubus occidentalis
Rubus occidentalis
Rubus occidentalis
Rumex acetosella
Rumex crispus
Rumex crispus
Rumex crispus
Ruta graveolens
Serenoa repens
Salvia officinalis
Salvia officinalis
Salvia officinalis
Sambucus canadensis
Sambucus canadensis
Sambucus canadensis
Sambucus canadensis
Sanguisorba minor
Santolina chamaecyparissus
Santolina chamaecyparissus
Satureja montana
Satureja montana
Satureja repandra
Schizonepeta tenuifolia
Schizonepeta tenuifolia
Scorzorera hispanica
Scorzorera hispanica
Scutellaria lateriflora
Serratula tinctoria
Sium sisarum
Solanum melongena
Solidago sp
Sonchus oleraceus
Sorghum caffrorum
Sorghum dochna
Sorghum dochna
Sorghum durra
Sorghum sudanense
Stachys byzantina
Stellaria graminea
Stellaria graminea
Stellaria media
Stipa capillata
Symphytum officinale
Symphytum officinale
Tanacetum cinerariifolium
Tanacetum vulgare
Tanacetum vulgare
Taraxacum officinale
Thlaspi arvense
Thymus fragantissimus
Thymus fragantissimus
Thymus praecox subsp arcticus
Thymus pseudolanuginosus
Thymus vulgaris
Triticosecale spp.
Triticum aestivum
Triticum turgidum
Triticum spelta
Tropaeofum majus
Tsuga diversifolia
Tsuga mertensiana
Typha latifolia
Urtica dioica
Vaccinium angustifolium
Vaccinium macrocarpon
Vaccinium macrocarpon
Vaccinium macrocarpon
Vaccinium macrocarpon
Valeriana officinalis
Valerianella locusta
Verbascum thapsus
Verbascum thapsus
Veronica officinalis
Vitis
Vitis
Vitis
Vitis
Weigela coraeensis
Weigela hortensis
Xanthium sibiricum
Zea mays
Achillea plarmica
Achillea plarmica
Geranium pratense
Geranium pratense
Geranium pratense
Thalictrum aquilegiifolium
Thalictrum aquilegiifolium
Veronica spicata
Veronica spicata
Veronica spicata
Helenium spp.
Salvia sylvestris
Salvia sylvestris
Salvia sylvestris
Salvia regeliana
Crambe cordifolia
Crambe cordifolia
Rudbeckia maxima
Trollius x cultorum
Trollius x cultorum
Trollius x cultorum
Amsonia tabernaemontana
Oenothera fruticosa spp.
Oenothera fruticosa spp.
Oenothera fruticosa spp.
Oenothera fruticosa spp.
Veronica austriaca ssp teucrium
Veronica austriaca ssp teucrium
Coreopsis verticillata
Coreopsis verticillata
Potentilla fruticosa
Potentilla fruticosa
Lysimachia clethroides
Magnolia x loebneri
Iberis sempervirens
Iberis sempervirens
Filipendula vulgaris
Filipendula vulgaris
Filipendula vulgaris
Geranium sanguineum
Geranium sanguineum
Geranium sanguineum
Geranium sanguineum
Garanium sanguineum
Garanium sanguineum
Philadelphus coronarius
paeonia suffruticosa
paeonia suffruticosa
Paeonia suffruticosa
Paeonia suffruticosa
Paeonia suffruticosa
Paeonia suffruticosa
Dahlia spp.
Begonia convolvulacea
Begonia convolvulacea
Begonia convolvulacea
Begonia eminii
Begonia eminii
Begonia eminii
Begonia glabra
Begonia mannii
Begonia mannii
Begonia polygonoides
Begonia polygonoides
Begonia polygonoides
Fushia spp.
Fushia spp.
Fushia spp.
Butomus umbellatus
Onoclea sensibilis
Onoclea sensibilis
Pinus cembra
Pinus cembra
Cornus sericea
Cornus sericea
Cornus sericea
Cornus sericea
Cornus sericea
Hydrangea quercifolia
Solidago caesia
Solidago caesia
Cornus alba
Cornus alba
Cornus alba
Carpinus caroliniana
Carpinus caroliniana
Carpinus caroliniana
Astilbe chinensis
Astilbe chinensis
Symphoricarpos albus
Euphorbia amygdaloides
Euphorbia amygdaloides
Euphorbia amygdaloides
Viburnum plicatum
Rubus arcticus
Rubus arcticus
Rubus Phoenicolasius
ribes americanum
Passiflora spp.
Rubus occidentalis
Nicotiana tabacum
Beta vulgaris
Oenothera biennis
Alchemilla mollis
Alchemilla mollis
Symphytum officinale
Fragaria x ananassa
Fragaria x ananassa
Vaccinium corymbosum
Vaccinium augustifolium
Vaccinium augustifolium
Vitis
Vitis
Petasites japonicus
Petasites japonicus
Nicotiana rustica
Pysalis ixocarpa
Pteridium aquilinum
Pteridium aquilinum
Pteridium aquilinum
Pteridium aquilinum
Matteuccia pensylvanica
Matteuccia pensylvanica
Ocimum tenuiflorum
Carthamus tinctorius
Carthamus tinctorius
Ligustrum vulgare
Ligustrum vulgare
Ligustrum vulgare
Malva verticillata
Malva verticillata
Malva verticillata
Hamamelis virginiana
Arctostaphylos uva-ursi
Arctostaphylos uva-ursi
Vicia faba
Sempervivum tectorum
Sempervivum tectorum
Sempervivum tectorum
Ajuga reptans
Ajuga reptans
Ajuga reptans
Phlox paniculata
Ligularia dentata
Ligularia dentata
Ligularia dentata
Achillea ptarmica
Potentilla fruticosa
Vernonia gigantea
Vernonia gigantea
Vernonia gigantea
Vernonia gigantea
Penstemon digitalis
Penstemon digitalis
Penstemon digitalis
Penstemon digitalis
Penstemon digitalis
Malus spp.
Malus spp.
Malus spp.
Malus spp.
Hosta sieboldiana
Hamamelis mollis
Hamamelis mollis
Hamamelis mollis
Chaenomeles x superba
Chaenomeles x superba
Chaenomeles x superba
Chaenomeles x superba
Centaurea dealbata
Centaurea dealbata
Paeonia spp.
Paeonia spp.
Paeonia spp.
Paeonia spp.
Paeonia spp.
Paeonia spp.
Lysimachia clethroides
Lysimachia clethroides
Lysimachia clethroides
Viburnum plicatum
Buxus microphylla
Astilboides tabularis
Astilboides tabularis
Astilboides tabularis
Staphylea trifolia
Bergenia x schmidtii
Bergenia x schmidtii
Bergenia x schmidtii
Rodgersia podophylla
Rodgersia podophylla
Rodgersia podophylla
Geranium phaeum
Geranium phaeum
Geranium phaeum
Rubus pubescens
Rubus pubescens
Rubus pubescens
Taxus x media
Taxus x media
Taxus x media
Geranium x cantabrigiense
Geranium x cantabrigiense
Geranium x cantabrigiense
Fuchia magellanica
Fuchia magellanica
Fuchia magellanica
Microbiata decussata
Microbiata decussata
Rhododendron spp.
Stephanandra incisa
Stephanandra incisa
Stephanandra incisa
Corylus maxima
Corylus maxima
Cyperus alternifolius
Soleirolia soleirolii
Soleirolia soleirolii
Strelitzia reginae
Strelitzia reginae
Strelitzia reginae
Hedychium coronarium
Hedychium coronarium
Hedychium coronarium
Strelitzia reginae
Strelitzia reginae
Strelitzia reginae
Symphoricarpos orbiculatus
Rodgersia spp.
Rodgersia spp.
Lamiastrum galeobdolon
Astilbe x arendsii
Clematis alpina
Stewartia pseudocamellia
Stewartia pseudocamellia
Stewartia pseudocamellia
Pinus mugo
Pinus mugo
Pinus mugo
Rubus thibetanus
Rubus thibetanus
Rubus thibetanus
Achidinia arguta
Anthoxanthum odoratum
Apocynum cannabinum
Arctium minus (Hill) Bernhardi
Beckmannia erucaeformis
Beta vulgaris
Brassica rapa
Buddleja davidii
Bupleurum falcatum
Capsicum annuum
Capsicum annuum
Cotinus coggygria
Kolkwitzia amabilis
Laserpitium latifolium
Lindera benzoin
Lolium perenne
Miscanthus sacchariflorus
Ophiopogon japonicus
Phaseolus mungo
Phaseolus Vulgaris
Phaseolus Vulgaris
Plumbago zeylanica
Portulacea oleracea
Salix purpurea F. Gracilis
Solanum melanocerasum
Stellaria media (linné) Cyrillo
Tanacetum vulgare
Tanacetum vulgare
Trifolium incarnatum
Vaccinum augustifolium
Zea Mays
Aframomum melegueta
Allium sativum
Anthemis nobilis
Anthurium guildingii
Astilbe x arendsii
Beta vulgaris
Campanula rapunculus
Cirsium arvense
Cissus discolor
Coccoloba caracasana
Convallaria majalis
Cucurbita pepo
Cucurbita pepo
Errhenatherum elatius
Filipendula rubra
Galium odoratum
Glycyrrhiza glabra
Hedychium sp.
Houttuynia cordata
Lactuca sativa
Lactuca sativa
Lotus tetragonolobus
Lycopersicon esculentum
Lysimachia clethroides
Magnolia stellata
Microlepia plalyphylla
Miscanthus sacchariflorus
Myrica pensylvanica
Nicotiana tabacum
Paeonia
Pastinaca sativa
pastinaca sativa
Phaseolus vulgaris
Pteridium aquilinum
Solidago sp ?
Symphytum officinale
Tanacetum vulgare
Thymus fragantissumus
Urtica dioica
Zea mays
Abies balsamea
Allium ampeloprasum
Allium sativum
Amaranthus gangeticus
Apium graveolens
Aralia cordata
Asclepias tuberosa
Asctinidia chinensis
Baptisia tinctoria
Betula alleghaniensis
Brassica oleracea
Brassica rapa
Caladium sp.
Carica papaya
Chaerophyllum bulbosum
Chrysanthenum coronarium
Clematis chiisanensis
Coccoloba caracasana
Cocos nucifera
Cornus mas
Cucurbita pepo
Cymbopogon citratus
Forsythia x intermedia
Heliotropium arborescens
Lonicera ramosissima
Malus pranifolia
Marrubium vulgare
Miscanthus sinensis Anchess
Nephelium longana ou Euphoria longana
Psoralea corylifolia
Raphanus sativus
Ribes Nigrum
Rubus thibetanus
Rumex acetosella linné
Sechium edule
Stachys macrantha
Tepary
Thymus vulgaris “Argenteus”
Trifolium pratense
Trollius x cultorum
Uvularia perfoliata
Vaccinum macrocarpon
Verbena officinalis
Zea mays
Actaea racemosa
Alchemilla motlis
Borago officinalis
Capsicum annuum
Cornus canadensis L.
Genista multibracteata
Glycine max
Lolium perenne
Matricaria recutita
Phaseolus Vulgaris
Prunus Tomentosa
Scuttellaria lateriflora
Solidago canadensis
Spinacia oleracea
Tanacetum vulgare
Tanacetum vulgare
Typha latifolia L.
Zea mays
Zea Mays
Adiantum pedatum
Cichorium endivia
Cucurbita pepo
Echinacea purpurea
Lactuca sativa
pastinaca sativa
Pastinaca sativa
Ribes nigrum
Symphytum officinale
Urtica dioica
Vitis sp.
Alchemilla mollis
Althacea officinalis
Althaea officinalis
Aralia cordata
Asctinidia chinensis
Astilboides tabularis
Averrhoa carambola
Baptisia tinctoria
Beta vulgaris
Convallaria majalis
Datura stramonium
Dioscorea batatas
Eleusine coracana
Fragaria x ananassa
Ginkgo biloba
Heliotropium arborescens
Hibiscus cannabinus
Hypericum perforatum
Ipomea batalas
Lathyrus sylvestris
Lonicera ramosissima
Lonicera ramosissima
Lonicera syringantha
Madia sativa
Monarda
Ocimum Basilicum
Peucedanum oreaselinum
Psoralea corylifolia
Rahmnus frangula
Raphanus sativus
Rheum rhabarbarum
Ribes Nigrum
Rubus occidentalis
Rumes scutatus
Solidago Hybrida
Tanacetum balsamila
Vaccinum macrocarpon
Xanthium sibiricum
Zea mays
Amaranthus candathus
Ambrosia artemisiifolia
Aronia x prunifolia
Brassica napus
Brassica oleracea
Brassica oleracea
Bromus inermis
Chenopodium quinoa
Citrullus lanatus
Cynara cardunculus
Dolichos lablab
Foeniculum vulgare
Hypomyces
lactifluorum
Lotus corniculatus
Lotus corniculatus
Manihot esculenta
Matricaria recutita
Melilotus albus
Phaseolus vulgaris
Phaseolus vulgaris
Pisum sativum
Raphanus raphanistrum
Ribes sylvestre
Rumex crispus
Rumex crispus
Rumex scutatus
Tanacetum
cinerariifolium
Tropaeolum majus
Tsuga canadensis
Tsuga diversifolia
Vaccinium
angustifolium
Zea mays
Zingiber officinale
1N: no stress; A: stress A; G: stress G.
2EP: Entire plant; Fl: Flower; Fr: Fruit; L: Leaf; R: Root; Se: Seed; St: Stem
Allium tuberosum
Allium tuberosum
Althacea officinalis
Amaranthus candathus
Ambrosia
artemisiifolia
Angelica sinensis
Aronia x prunifolia
Asarum europaeum
Begonia Hannii
Begonia polygonoides
Brassica oleracea
Bromus inermis
Chenopodium quinoa
Conyza canadensis
Cynara cardunculus
Daucus carota
Dolichos lablab
Foeniculum vulgare
Hypomyces
lactifluorum
Iberis sempervirens
Iberis sempervirens
Lotus corniculatus
Lotus corniculatus
Lunaria annua
Melilotus albus
Phaseolus vulgaris
Physostegia virginiana
Pisum sativum
Rheum rhabarbarum
Ribes sylvestre
Rubus occidentalis
Rumex crispus
Rumex crispus
Rumex scutatus
Salvia officinalis
Salvia officinalis
Solidago canadensis
Solidago sp.
Solidago x hybrida
Solidago x hybrida
Solidago x hybrida
Solidago x hybrida
Tanacetum
cinerariifolium
Taraxacum officinale
Tsuga canadensis
Tsuga diversifolia
Zea mays
Zingiber officinale
1N: no stress; A: stress A; G: stress G.
2EP: Entire plant; Fl: Flower; Fr: Fruit; L: Leaf; R: Root; Se: Seed; St: Stem
| Number | Date | Country | Kind |
|---|---|---|---|
| 2400 936 | Aug 2002 | CA | national |
This application is a continuation of U.S. patent application Ser. No. 10/526,387 filed on Oct. 6, 2005, which claims the benefit under 35 U.S.C. § 371 to PCT Application No. PCT/CA2003/001284 filed on Sep. 2, 2003, which claims priority to Canadian Application No. 2,400,936, filed on Aug. 30, 2002, all of which are incorporated herein in their entireties.
| Number | Date | Country | |
|---|---|---|---|
| Parent | 10526387 | Oct 2005 | US |
| Child | 12263114 | US |
