The present invention relates to a concentrated plant-protection formulation comprising an active compound selected from azoles, preferably triazoles, for example tebuconazole. The composition comprises at least one solvent. The composition is stable and easy for farmers to use. The present invention further relates to a useful solvent composition particularly suitable for implementing the plant-protection composition.
Agriculture uses many active materials such as fertilizers or pesticides, for example insecticides, herbicides or fungicides. These are referred to as active plant-protection products (or active material). The active plant-protection products are generally produced in pure or highly concentrated form. They should be used on farms in low concentrations. To this end, they are generally formulated with other ingredients in order to allow easy weight dilution by the farmer. These are referred to as plant-protection formulations. The dilution performed by the farmer is generally carried out by mixing the plant-protection formulation with water.
Thus, plant-protection formulations should allow easy weight dilution by the farmer, in order to obtain a product in which the plant-protection product is correctly dispersed, for example in the form of a solution, emulsion, suspension or suspoemulsion. The plant-protection formulations thus allow the transportation of a plant-protection product in relatively concentrated form, easy packaging and/or easy handling for the final user. Various types of plant-protection formulations may be used according to the various plant-protection products. Mention may, for example, be made of emulsifiable concentrates (ECs), concentrated emulsions (emulsions in water EWs), microemulsions (MEs), wettable powders (WPs) and water-dispersible granules (WDGS). The formulations that may be used depend on the physical form of the plant-protection product (for example solid or liquid) and on its physicochemical properties in the presence of other compounds such as water or solvents.
After weight dilution by the farmer, for example by mixing with water, the plant-protection product may be in various physical forms: solution, dispersion of solid particles, dispersion of droplets of the product, droplets of solvent in which the product is dissolved, etc. The plant-protection formulations generally comprise compounds that allow these physical forms to be obtained. They may, for example, be surfactants, solvents, mineral supports and/or dispersants. These compounds quite often have no active nature, but an intermediary nature for aiding formulation. It is thus quite often desired to limit the amount thereof in order to limit the costs and/or any environmental unfriendliness. The plant-protection formulations may in particular be in liquid form or in solid form.
For practical reasons (for example for reasons of easy handling and/or transport), it may sometimes preferably be desired to use plant-protection formulations in solid form, and sometimes to use formulations in liquid form.
In order to prepare plant-protection formulations of solid active plant-protection products, it is known practice to solubilize the product in a solvent. The plant-protection formulation thus comprises a solution of the product in the solvent. The formulation may be in solid form, for example in the form of a wettable powder (WP), where the solution impregnates an inorganic support, for example kaolin and/or silica. The formulation may alternatively be in liquid form, for example in the form of an emulsifiable concentrate (EC) having a single clear liquid phase comprising the solvent and the product in solution, which can form an emulsion when water is added, without stirring or with gentle stirring. It may also be in the form of an emulsion in water (EW), which is turbid, in which the phase dispersed in the water comprises the solvent and the product in solution in the solvent. It may also be in the form of a microemulsion (ME), which is clear, in which the phase dispersed in the water comprises the solvent and the product in solution in the solvent.
Azoles, in particular triazoles, more particularly tebuconazole, are generally solid plant-protection products that are often difficult to formulate. Tebuconazole is a particularly effective fungicide that is widely used for, in particular, soybean cultivation. For these products, it is difficult to produce concentrated formulations that the farmer can easily dilute, that are stable and that do not have any substantial drawbacks (proven or perceived) in terms of safety, toxicity and/or ecotoxicity.
It is known practice to use liquid formulations in which the azoles are solubilized in a solvent or placed in the presence of a solvent (sometimes also called crystallization inhibitor). However, it remains difficult to formulate azoles, in particular triazoles, at relatively high concentrations with sufficient stability. In particular, it is necessary to prevent the appearance of crystals, in particular at low temperature and/or during dilution and/or during storage at high temperature of the diluted composition. The crystals can have negative effects, in particular blocking the filters of the devices used to spread the diluted composition, blocking spraying devices, decreasing the overall activity of the formulation, creating needless problems for waste companies in terms of eliminating the crystals, and/or causing poor distribution of the active product over the agricultural field.
There exists a need for new azole formulations, in particular triazole formulations.
The object of the invention is to meet this need and to prevent at least one of the drawbacks mentioned above. To this effect, the invention proposes a concentrated plant-protection formulation comprising:
The invention also relates to the use of the concentrated formulation (or a method) for preparing a composition of the active plant-protection product, diluted in water, by mixing at least one part by weight of concentrated formulation with at least 10 parts of water, preferably less than 1000 parts. The diluted composition can, of course, comprise other active plant-protection products, that may originate from other plant-protection formulations, thus combined in the composition.
The invention also relates to the use of the solvent in concentrated formulations or in the diluted compositions.
The invention also relates to a solvent composition that is particularly effective and particularly useful for implementing the plant-protection formulation, and that can also be used for other purposes. The solvent composition comprises a mixture of solvents. It comprises:
In the present application, the term “concentrated plant-protection formulation” is intended to mean a formulation intended to be mixed with water (for example, diluted) by the user, as opposed to a diluted plant-protection composition.
In the present application, when concentration ranges or proportions as % are used in a composition or a formulation, the total with, optionally, other ingredients is 100%.
In the present application, when concentration ranges or proportions in g/l are used in a composition or a formulation, the total with, optionally, other ingredients is such that it complies with the density of the composition or of the formulation (for 1 l, the total is equal to the density *1000).
In the present application, the term “solid plant-protection product” is intended to mean a product which has a melting point above 25° C.
The active plant-protection product is an azole, preferably a triazole. The triazole may in particular be a compound other than tebuconazole, or advantageously tebuconazole.
Tebuconazole is the usual name of a compound known to those skilled in the art, the formula of which is the following:
Tebuconazole is a solid plant-protection product.
By way of triazoles other than tebuconazole, mention may in particular be made of the following compounds: azaconazole, bitertanol; bromuconazole; cyproconazole; diclobutrazol; difenoconazole; diniconazole; diniconazole-M; epoxiconazole; etaconazole; fenbuconazole; fluotrimazole; fluquinconazole; flusilazole; flutriafol; furconazole; furconazole-cis; hexaconazole; imibenconazole; ipconazole; metconazole; myclobutanil; penconazole; prochloraz; propiconazole; prothioconazole; quinconazole; strobulurin and analogues, simeconazole; tetraconazole; triadimefon; triadimenol; triazbutil; triflumizole; triticonazole; uniconazole; uniconazole-P.
According to one embodiment, a solid azole, in particular a solid triazole, especially from those mentioned above, is used.
The plant-protection formulation comprises at least one solvent selected from dialkyl alkyl phosphonates. According to an advantageous embodiment, the solvent b) is a mixture of solvents. The expression “mixture of solvents in the concentrated plant-protection formulation” (or in the diluted composition) is intended to mean both a mixture prepared prior to the introduction into the formulation, and a combination, where the solvents are mixed while preparing the formulation, at the time they are brought together with the active plant-protection product.
The invention also relates to a particularly useful solvent composition comprising a mixture of solvents. In the solvent composition, the mixture of solvents is understood to be an effective mixture (as opposed to a combination), which is preferably clear.
The solvent comprises a dialkyl alkyl phosphonate. The dialkyl alkyl phosphonate preferably comprises at least 90% by weight of a compound of formula
R1aP(═O)(—OR2)b
in which:
The dialkyl alkyl phosphonate may comprise less than 10%, preferably less than 95% of impurities such as dialkyl phosphates or trialkyl phosphates.
According to an advantageous embodiment, dibutyl butyl phosphonate (DBBP) is used. Preferably, the dialkyl alkyl phosphonate comprises at least 90% by weight of dibutyl butyl phosphonate (DBBP). The product sold by Rhodia under the name Albrite DBBP may, for example, be used.
Advantageously, use is made of a mixture of solvents, or the solvent composition, comprising at least:
Preferably, the mixture of solvents or the solvent composition comprises:
The organic carbonate may in particular be selected from propylene carbonate, dimethyl carbonate, diethyl carbonate and ethylene carbonate. Propylene carbonate (“4-methyl-1,3-dioxan-2-one”) is most particularly preferred. Such a compound is in particular sold under the name Arconate for Lyondell.
The sulfoxide may in particular be selected from dimethyl sulfoxide (DMSO) and methyl sulfoxide.
A mixture of solvents, or a solvent composition, which is particularly advantageous comprises:
It is specified that, in general, the solvent composition comprises substantially no water (typically less than 5% by weight, preferably less than 1% by weight), and that it comprises substantially no active plant-protection product (typically less than 5% by weight, preferably less than 1% by weight). It is not impossible for it to comprise other solvents (other than water) and/or at least one surfactant.
As other solvents, which are minor solvents, and which it is possible to use in the mixture of solvents of the plant-protection formulation or in the solvent composition, mention may be made of lactate esters, carboxylic acid dimethylamides, fatty acid esters, hydrocarbon fractions, cyclic amides or lactones.
Without wishing to be bound to any theory, it is thought that the sulfoxide and/or the propylene carbonate helps to reduce the viscosity of the formulations comprising the dialkyl alkyl phosphonate. The sulfoxide helps to prevent the appearance of crystals after dilution with water, but promotes the appearance of crystals in the formulation at low temperatures. The propylene carbonate helps to prevent the appearance of crystals in the formulation, but promotes the appearance of crystals after dilution with water. The respective proportions of the various solvents can be refined by means of these indications, according to the desired viscosity, the plant-protection product to be solubilized and the required stability (in particular absence of crystallization)
The plant-protection formulation may comprise an emulsifier, typically and preferably a surfactant. Emulsifiers are agents intended to facilitate emulsification or dispersion after the formulation has been brought into contact with water, and/or to stabilize (over time and/or with respect to temperature) the emulsion or the dispersion, for example by preventing sedimentation.
Surfactants are known compounds which have a molar mass that is generally relatively low, for example less than 1000 g/mol. The surfactant may be an anionic surfactant in salified or acidic form, a nonionic surfactant, preferably polyalkoxylated, a cationic surfactant or an amphoteric surfactant (term also including zwitterionic surfactants). It may be a mixture or a combination of these surfactants. The surfactant may be a surfactant comprising an aromatic group (aromatic surfactant) or a surfactant not comprising an aromatic group (nonaromatic surfactant). It may be a mixture or a combination of these surfactants. In the case of mixtures of surfactants, it may be a mixture comprising at least one aromatic surfactant and at least one nonaromatic surfactant, or a mixture of several aromatic surfactants but no nonaromatic surfactant, or a mixture comprising several nonaromatic surfactants but no nonaromatic surfactant.
By way of examples of anionic surfactants, mention may be made, without wishing to be limited thereto, of:
The anionic surfactants may be in acid form (they are potentially anionic) or in a partially or totally salified form, with a counterion. The counterion may be an alkali metal, such as sodium or potassium, an alkaline earth metal, such as calcium, or an ammonium ion of formula N(R)4+ in which R, which may be identical or different, represent a hydrogen atom or a C1-C4 alkyl radical optionally substituted with an oxygen atom.
By way of examples of nonionic surfactants, mention may be made, without wishing to be limited thereto, of:
Preferably, the surfactant c) comprises at least 50% by weight of an ethoxylated and/or propoxylated di- or tristyrylphenol surfactant. These surfactants have a relatively high HLB. It may be advantageous to combine them with a surfactant having a lower HLB, for example a nonionic surfactant with a lower HLB. Such a combination may help to prevent sedimentation.
The formulation, which is preferably liquid, may typically comprise from 10 to 500 g/l of the active plant-protection product. This proportion may be from 200 to 300 g/l, or even less, for example from 10 to 100 g/l or from 100 to 200 g/l.
According to an advantageous embodiment, the formulation comprises:
The concentrated formulation does not comprise large amounts of water. The water content is typically less than 50% by weight, advantageously less than 25% by weight.
The formulation is preferably a liquid formulation, for example in the form of an emulsifiable concentrate (EC), an emulsion in water (EW) or a microemulsion (ME). In this case, it preferably comprises less than 500 g/l of water, more preferably less than 250 g/l.
The possibility of preparing solid formulations, for example formulations in which a liquid comprising the plant-protection product solubilized in the solvent or the mixture of solvents or the solvent composition is supported by a mineral and/or dispersed in a solid matrix, is not excluded.
The formulation may, of course, comprise ingredients other than the active plant-protection product, the solvent(s), the optional emulsifier(s) and the optional water. It may in particular comprise viscosity modifiers, antifoams, in particular silicone-based antifoams, anti-rebound agents, agents for preventing washing off, inert fillers, in particular inorganic fillers, frost-protection agents, etc.
Conventional methods for preparing plant-protection formulations or mixtures of solvents can be used. The process can be carried out by simple mixing of the constituents.
For the preparation of the plant-protection formulations comprising a mixture or a combination of solvents, the various solvents may in particular be introduced separately. A mixture of solvents prepared beforehand, typically the solvent composition, may also be introduced.
The solvent composition may be prepared by simple mixing of the solvents.
The concentrated plant-protection formulation is intended to be spread over a cultivated field or a field to be cultivated, for example a field of soybean, most commonly after dilution in water, so as to obtain a diluted composition. The dilution is generally performed by the farmer, directly in a tank (“tank-mix”), for example in the tank of a device for spreading the composition. The possibility of the farmer adding other plant-protection products, for example fungicides, herbicides, pesticides, insecticides or fertilizers, is not excluded. Thus, the formulation may be used for preparing a composition of the active plant-protection product, diluted in water, by mixing at least one part by weight of concentrated formulation with at least 10 parts of water, preferably less than 1000 parts. The dilution rate and the amounts to be applied to the field generally depend on the plant-protection product and on the dose desired for treating the field; this can be determined by the farmer.
Other details or advantages of the invention will become apparent in view of the examples which follow and which are not limiting in nature.
The following ingredients are used:
Plant-protection formulations are prepared by mixing the ingredients so as to obtain a tebuconazole concentration of 250 g/l.
The following tests are carried out:
The letter C indicates that it is a comparative example.
The following formulation is prepared:
The density is 1.098.
The pH is 7.2.
The formulations of examples 4 and 5 show excellent properties with regard to noncrystallization, and are particularly favored due to the fact that they have a low danger level and/or low toxicity.
The following formulation, which does not comprise an aromatic surfactant, is prepared:
The formulation of example 6 shows excellent properties with regard to noncrystallization, and is particularly favored due to the fact that it has a low danger level and/or low toxicity.
Number | Date | Country | Kind |
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0504847 | May 2005 | FR | national |
Filing Document | Filing Date | Country | Kind | 371c Date |
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PCT/FR2006/001039 | 5/10/2006 | WO | 00 | 12/17/2007 |