Claims
- 1. A method of inducing regression and/or inhibiting the growth of malignant neoplasms sensitive to treatment with the compound belong in mammals which comprises injecting to said mammals an effective oncolytic amount of a compound of the formula: ##STR13## where R.sub.1 and R.sub.2 are individually hydrogen or alkyl(C.sub.1 -C.sub.6) or R.sub.1 and R.sub.2 taken together are ##STR14## where n is an integer 3-6, ##STR15## where m is an integer 3-6, or ##STR16## and L is --O--, ##STR17## or NH.sub.3 where R.sub.3 is alkyl(C.sub.1 -C.sub.6) or --CH.sub.2 CH.sub.2 OH.
- 2. A method according to claim 1 wherein the compound is cis-(and trans)-1,2-cyclohexanediamine compound with [[2,2'-oxybis[acetato]](2-)-O.sup.1,O.sup.1 ]platinum.
- 3. A method according to claim 1 wherein the compound is (1R-trans)-1,2-cyclohexanediamine compound with [2,2'-oxybis[acetato]](2-)-O.sup.1,O.sup.1 ]platinum.
- 4. A method according to claim 1 wherein the compound is (2,2-dimethyl-1,3-propanediamine-N,N')[[2,2'-oxybis[acetato]]-(2-)-O.sup.1,O.sup.1 ]platinum.
- 5. A method according to claim 1 wherein the compound is trans(-racemic)-(1,2-cyclohexanediamine, N,N',)[[2,2'-oxybis[acetato]](2-)-O.sup.1,O.sup.1 ]platinum.
- 6. A method according to claim 1 wherein the compound is cis-(1,2-cyclohexanediamine-N,N',)[[2,2'-oxybis[acetato]]O.sup.1,O.sup.1 ]platinum.
- 7. A method according to claim 1 wherein the compound is (1,1-cyclopentanedimethanamine, N,N')[[2,2'-oxybis[acetato]](2-)-O.sup.1,O.sup.1 ]platinum.
- 8. A method according to claim 1 wherein the compound is bis-(2-methylpropanamine)[[2,2'-oxybis[acetato]](2-)-O.sup.1,O.sup.1 ]platinum.
- 9. A method according to claim 1 wherein the compound is trans)-(-)(1,2-cyclohexanediamine, N,N')-[[2,2'-sulfonylbis[acetato]](2-)-O.sup.1,O.sup.1 ]platinum.
- 10. A method according to claim 1 wherein the compound is (1,1-cyclobutanedimethanamine-N,N'),[[2,2'-oxybis[acetato]](2-)-O.sup.1,O.sup.1 ]platinum.
- 11. A method according to claim 1 wherein the compound is (1,1-cyclohexanedimethanamine-N,N',)[[2,2'-oxybis[acetato]](2-)-O.sup.1,O.sup.1 ]platinum.
- 12. A method according to claim 1 wherein the compound is diammine[[2,2'-sulfonylbis[acetato]](2-)-O.sup.1,O.sup.1 ]-platinum.
- 13. A method according to claim 1 wherein the compound is trans(racemic)-(1,2-cyclohexanediamine-N,N',)-[[2,2'-sulfonylbis[acetato]](2-)O.sup.1,O.sup.1 ]platinum.
- 14. A method according to claim 1 wherein the compound is cis-(1,2-cyclohexanediamine-N,N',)[[2,2'-sulfonylbis[acetato]](2-)-O.sup.1,O.sup.1 ]platinum.
Parent Case Info
This is a division of application Ser. No. 748,788, filed June 26, 1985 which is now U.S. Pat. No. 4,675,336 (1987).
US Referenced Citations (5)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0130482 |
Sep 1985 |
EPX |
Divisions (1)
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Number |
Date |
Country |
Parent |
748788 |
Jun 1985 |
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