The invention is directed generally to devices and methods for delivering markers to a desired location within a patient's body. In particular, the invention is directed to devices, assemblies, and methods configured to retain a biological marker within a delivery device before delivery of the marker to a desired intracorporeal location.
In diagnosing and treating certain medical conditions, it is often desirable to mark a suspicious body site for the subsequent taking of a biopsy, delivery of medicine, radiation, or other treatment, to mark a location from which a biopsy was taken, or at which some other procedure was performed. As is known, obtaining a tissue sample by biopsy and the subsequent examination are typically employed in the diagnosis of cancers and other malignant tumors, or to confirm that a suspected lesion or tumor is not malignant. The information obtained from these diagnostic tests and/or examinations is frequently used to devise a therapeutic plan for the appropriate surgical procedure or other course of treatment.
In many instances, the suspicious tissue to be sampled is located in a subcutaneous site, such as inside a human breast. To minimize surgical intrusion into patient's body, it is often desirable to insert a small instrument, such as a biopsy needle, into the body for extracting the biopsy specimen while imaging the procedure using fluoroscopy, ultrasonic imaging, x-rays, magnetic resonance imaging (MRI) or any other suitable form of imaging technique. Examination of tissue samples taken by biopsy is of particular significance in the diagnosis and treatment of breast cancer. In the ensuing discussion, the biopsy and treatment site described will generally be the human breast, although the invention is suitable for marking biopsy sites in other parts of the human and other mammalian body as well.
Periodic physical examination of the breasts and mammography are important for early detection of potentially cancerous lesions. In mammography, the breast is compressed between two plates while specialized x-ray images are taken. If an abnormal mass in the breast is found by physical examination or mammography, ultrasound may be used to determine whether the mass is a solid tumor or a fluid-filled cyst. Solid masses are usually subjected to some type of tissue biopsy to determine if the mass is cancerous.
If a solid mass or lesion is large enough to be palpable, a tissue specimen can be removed from the mass by a variety of techniques, including but not limited to open surgical biopsy, a technique known as Fine Needle Aspiration Biopsy (FNAB) and instruments characterized as “vacuum assisted large core biopsy devices”.
If a solid mass of the breast is small and non-palpable (e.g., the type typically discovered through mammography), a biopsy procedure known as stereotactic needle biopsy may be used. In performing a stereotactic needle biopsy of a breast, the patient lies on a special biopsy table with her breast compressed between the plates of a mammography apparatus and two separate x-rays or digital video views are taken from two different points of view. A computer calculates the exact position of the lesion as well as depth of the lesion within the breast. Thereafter, a mechanical stereotactic apparatus is programmed with the coordinates and depth information calculated by the computer, and such apparatus is used to precisely advance the biopsy needle into the small lesion. Depending on the type of biopsy needle(s) used, this stereotactic technique may be used to obtain cytologic specimens, e.g., obtained through FNAB or it may be used to obtain histologic specimens e.g., obtained through coring needle biopsy. Usually at least five separate biopsy specimens are obtained from locations around the small lesion as well as one from the center of the lesion.
The available treatment options for cancerous lesions of the breast include various degrees of mastectomy or lumpectomy and radiation therapy, as well as chemotherapy and combinations of these treatments. However, radiographically visible tissue features, originally observed in a mammogram, may be removed, altered or obscured by the biopsy procedure, and may heal or otherwise become altered following the biopsy. In order for the surgeon or radiation oncologist to direct surgical or radiation treatment to the precise location of the breast lesion several days or weeks after the biopsy procedure was performed, it is desirable that a biopsy site marker be placed in or on the patient's body to serve as a landmark for subsequent location of the lesion site. A biopsy site marker may be a permanent marker (e.g., a metal marker visible under X-ray examination), or a temporary marker (e.g., a bioresorbable marker detectable with ultrasound). While current radiographic type markers may persist at the biopsy site, an additional mammography generally must be performed at the time of follow up treatment or surgery in order to locate the site of the previous surgery or biopsy. In addition, once the site of the previous procedure is located using mammography, the site must usually be marked with a location wire which has a hook on the end which is advanced into site of the previous procedure. The hook is meant to fix the tip of the location wire with respect to the site of the previous procedure so that the patient can then be removed from the confinement of the mammography apparatus and the follow-up procedure performed. However, as the patient is removed from the mammography apparatus, or otherwise transported the position of the location wire can change or shift in relation to the site of the previous procedure. This, in turn, can result in follow-up treatments being misdirected to an undesired portion of the patient's tissue.
As an alternative or adjunct to radiographic imaging, ultrasonic imaging and visualization techniques (herein abbreviated as “USI”) can be used to image the tissue of interest at the site of interest during a surgical or biopsy procedure or follow-up procedure. USI is capable of providing precise location and imaging of suspicious tissue, surrounding tissue and biopsy instruments within the patient's body during a procedure. Such imaging facilitates accurate and controllable removal or sampling of the suspicious tissue so as to minimize trauma to surrounding healthy tissue.
For example, during a breast biopsy procedure, the biopsy device is often imaged with USI while the device is being inserted into the patient's breast and activated to remove a sample of suspicious breast tissue. As USI is often used to image tissue during follow-up treatment, it may be desirable to have a marker, similar to the radiographic markers discussed above, which can be placed in a patient's body at the site of a surgical procedure and which are visible using USI. Such a marker enables a follow-up procedure to be performed without the need for traditional radiographic mammography imaging which, as discussed above, can be subject to inaccuracies as a result of shifting of the location wire as well as being tedious and uncomfortable for the patient.
Placement of a marker or multiple markers at a location within a patient's body requires delivery devices capable of holding markers within the device until the device is properly situated within a breast or other body location. Accordingly, devices and methods for retaining markers within a marker delivery device while allowing their expulsion from the devices at desired intracorporeal locations are desired.
The invention provides devices and systems for delivery of markers to a site within a patient's body. Delivery systems embodying features of the invention include a marker delivery tube with a removable plug. Plugs embodying features of the invention are held within an orifice at the tip of the delivery tube, retaining markers within the delivery tube, until it is desired that the markers be ejected. The plug may then be ejected or removed from the orifice, allowing the delivery of the markers to a desired site within a patient's body. Plugs and delivery tubes embodying features of the invention may have retaining features, such as recesses or protuberances, configured to releasably retain a plug within a delivery tube until ejection of the plug from the delivery tube is desired. The retaining features are typically complementary pairs, such as a plug protuberance configured to fit into a recess in the delivery tube.
Assemblies embodying features of the invention include marker delivery devices having a delivery tube with an orifice at its distal tip, an inner bore leading to an orifice, and at least one marker (preferably more than one) within the bore of the delivery tube. A plug is disposed at least in part within the bore and orifice to prevent markers from prematurely passing through the orifice and to prevent tissue from entering the bore when the delivery tube is advanced through tissue. The plug may itself serve as a marker, and may be the sole marker, although typically the delivery tube contains a plug and at least one other marker. The plug is releasably secured within or adjacent to the orifice in order to retain a marker within the delivery tube bore proximate thereto but to allow passage of the marker out of the orifice when the plug is ejected from the orifice. The plug may partially or completely occlude the orifice, and is configured to retain the marker within the delivery tube before the marker is to be placed at a desired location within a patient's body, and to allow the marker to pass out of the orifice when delivery of the marker is desired. A movable plunger may be slidably disposed within the tube from an initial position accommodating the marker or markers and the plug within the tube, to a delivery position to push a marker against the plug to push the plug out of the orifice and to then eject one or more markers through the orifice.
The plug is preferably configured to be releasably retained within the delivery tube, and may be aligned in a preferred orientation within the delivery tube, to properly orient an inclined face within the orifice. A plug may be configured to fit tightly within a part of the bore of a delivery device so as to be retained by pressure; may have a portion configured to contact a slot, hole, notch, ridge, tab, lip, or other feature of a delivery tube; may be configured to be retained by a tab; may include an internal retention element, such as a coil, a spring, a clip, a loop, an arch, or a resilient core, that is configured to press an outer portion of a plug against a delivery tube wall or to contact a retaining feature such as a tab, slot, notch or hole; may be pressed against at least part of the bore of a delivery tube by an external retention element such as a pin, wedge, clip, spring, coil or other element applied to a plug; or by otherwise engaging a portion of a delivery tube effective to be releasably retained within a delivery tube.
The plug is preferably biocompatible, and may itself be a marker that is detectable within a patient's body visually, tactilely, by imaging (including ultrasound, radiographic, magnetic resonance, or other form of imaging), or is otherwise detectable. A plug may be a bio-resorbable temporary marker made up of bio-resorbable materials, or may be a permanent marker including non-bio-resorbable materials as well. A plug may also include bio-active materials (e.g., hemostatic materials, anesthetic materials, absorbent materials, antibiotic materials, antifungal materials, antiviral materials, chemotherapeutic materials, radioactive materials, and other pharmaceutical materials) as well as biologically inert materials.
Systems and devices embodying features of the invention may have markings or indicators to aid in placement of the delivery tube in a desired location. In addition, methods of using systems and devices embodying features of the invention include guiding the insertion of the delivery tube with the aid of an imaging device, such as an ultrasound imaging device, an x-ray imaging device, and a magnetic resonance imaging device, which may be used to image the plug, a marker retained within the delivery device, a portion of the delivery device, or combinations of these.
The invention provides the advantages of securely retaining markers within a marker delivery device, improving accuracy and avoiding errors in of placement of markers at desired locations within a patient's body, preventing ingress of tissue into the distal tip of the device when it is advanced through tissue, and guiding the device by use of an imaging device. These and other advantages of the invention will become more apparent from the following description when taken in conjunction with the accompanying drawings.
Marker delivery assemblies embodying features of the invention are illustrated in
Plug 26 may substantially fill orifice 34, as shown in
Markers 24 are preferably configured to slide readily within tube bore 16. Plug 26 is configured to be releasably secured within a portion of tube bore 16, such as a distal portion 18 or orifice 34, effective to prevent inadvertent exit or release of markers 24 from delivery tube 14. The engagement of plug 26 with delivery tube 14 is further configured to be readily releasable when desired. For example, plug 26 is configured to release its engagement with delivery tube 14 effective to allow exit of markers 24 upon distal movement of plunger 28. Markers 24 are made with detectable, biocompatible materials, and may include a radiopaque element 40. Plug 26 may be made from the same or similar materials as a marker 24, and may also include a radiopaque element 40.
In
The plug 26 illustrated in
As illustrated by the embodiment of a plug 26 shown in
The embodiments of a plug 26 shown in
A compressible plug 26 as illustrated in
In addition, a further embodiment of a plug 26 embodying features of the invention is illustrated in
A plug 26 may be releasably retained within a bore 16 of a delivery tube 14 upon addition or insertion of an external retention element 62.
A delivery tube 14 may be configured to retain and optionally to align a plug 26. For example, a delivery tube 14 may have a retaining feature 64, illustrated in
Upon expulsion of a plug 26, as may be caused by distal movement of a plunger 28, a retaining feature 64 may become reconfigured to allow passage of a marker 24 out of an orifice 34 for delivery into a patient. For example, where the retaining feature 64 is a tab intruding into a tube bore 16, as shown in
Several examples of alternative embodiments of retaining features 64 are illustrated in
A marker delivery assembly 10 embodying features of the invention may be used to deliver a marker 24 to a desired location within a patient's body. Such a desired location is typically a lesion site from which a biopsy sample has been, or is to be, taken, or a lesion has been or will be removed. Assemblies, devices, and methods embodying features of the invention find use, for example, in marking a breast biopsy site. By way of illustration, the use of assemblies, devices and methods embodying features of the invention will be discussed below in terms of breast biopsies and similar uses involving marking sites within a breast of a human female. It will be understood that the assemblies, devices and methods embodying features of the invention find use in a variety of locations and in a variety of applications, in addition to the human breast.
An assembly 10 or delivery device 12 can be inserted into a breast 66 through a guide cannula 72, as illustrated in
A plug 26 and marker 24 may be introduced into a breast 66 of a patient at a lesion site 74 adjacent or within a biopsy cavity 76, from which a biopsy sample or tissue from a lesion has been taken, as illustrated in
Assemblies, devices and methods embodying features of the invention may be used to deliver a marker to a desired location within a body of a patient, by inserting a delivery device 12 into a patient having markers 24 retained within the bore 16 of the delivery tube 14 by a plug 26, and expelling a marker 24 from the orifice 34 into the desired location. A marker 24 may be expelled, for example, by depressing plunger 28 by moving plunger handle 30. Depression of plunger 28, pushing on a marker 24, is preferably effective to expel plug 26 from the orifice 34, allowing a marker 24 to exit the delivery tube 14 for delivery within a patient.
An operator may grasp a device handle 22 to guide the device 12 during insertion, and to steady the device 12 during depression of the plunger 28. Insertion of a device 12 results in the placement of at least a portion of the device 12 adjacent a desired location. The device 12, in particular the distal tip 36 and orifice 34 of the device 12, may be guided adjacent a desired location such as a lesion site, or a biopsy cavity, or other internal body site where delivery of a marker 24 is desired.
An initial scalpel incision in the skin is typically made in order to introduce a device 12 into the body tissue of a patient, although in many cases the sharp edge 34 or pointed tip 36 tip may be used to gain access to tissue beneath the skin without the use of an incision by a surgical tool. Insertion of the device 12 into a patient, e.g. into a breast 66 of a patient, may be guided by an operator with the aid of an imaging device. A delivery tube 14, and/or markings 44, as well as markers 24 and optionally plug 26, may be detectable by an imaging device, such as an ultrasound imaging device, an X-ray imaging device, a magnetic resonance imaging device, or other imaging device. Alternatively, or additionally, insertion may be visually guided, or may be guided by palpation or by other means.
As illustrated in
A plug 26 may be made with any suitable material. Typically, a plug 26 is made with the same materials as a marker 24. A plug 26 may serve as a marker after its expulsion from orifice 34 and placement into a patient's body. Preferably, a plug 26 is made with a biocompatible material, and provides sufficient structural strength as to retain a marker 24 within a delivery tube 14 and, where insertion of a delivery device embodying features of the invention is performed without the aid of a guide cannula, a material used in making a plug 26 preferably has sufficient structural strength to withstand the forces encountered during insertion into tissue or through skin. Materials suitable for use in making a plug 26 embodying features of the invention include polymers, plastics, resins, waxes, glasses, ceramics, metals, metal oxides, and composites, combinations and mixtures of these materials. For example, a wax such as bone wax, or other biocompatible material is suitable for use in making a plug 26. In presently preferred embodiments, a plug 26 is made with bioresorbable polymers such as poly-lactic acid and poly-glycolic acid. A plug may be made of more than one material, as illustrated, for example, in
A marker 24, including a plug 26 when configured to also serve as a marker 24, is preferably readily visible by ultrasonic imaging (USI), or by conventional imaging methods, such as x-ray and magnetic resonance imaging methods, or by more than one imaging technique. Suitable bio-compatible materials which may be used in a marker 24 or a plug 26 include polyethylene, polytetrafluoroethylene, PEBAX (made by Autochem Corp.), and the like.
Thus, biocompatible plugs 26 or markers 24 embodying features of the invention are preferably made using materials including a bioresorbable material. Some particularly suitable bioresorbable materials include bio-resorbable polymers including, but not limited to, polymers of lactic acid, glycolic acid, caprolactones, and other monomers; thus, for example, suitable bio-resorbable polymers may include poly(esters), poly(hydroxy acids), poly(lactones), poly(amides), poly(ester-amides), poly(amino acids), poly(anhydrides), poly(ortho-esters), poly(carbonates), poly(phosphazines), poly(thioesters), poly(urethanes), poly(ester urethanes), polysaccharides, polylactic acid, polyglycolic acid, polycaproic acid, polybutyric acid, polyvaleric acid, and copolymers, polymer alloys, polymer mixtures, and combinations thereof.
A marker 24 typically should remain in place and detectable within a patient for up to at least 2 weeks to have practical clinical value. Thus, a marker 24, including a plug 26 configured to serve as a marker, is detectable at a biopsy site within a patient for a time period of at least 2 weeks, preferably at least about 6 weeks, and may remain detectable for a time period of up to about 20 weeks, more preferably for a time period of up to about 12 weeks. In some embodiments, a marker material for use in markers 24 and plugs 26 embodying features of the invention is preferably not detectable about 6 months after placement at a biopsy site, and is more preferably not detectable with ultrasound about 12 weeks after placement at a biopsy site. Thus, a preferable in-vivo lifetime for a marker material for use in markers 24 and plugs 26 having features of the invention is between about 6 weeks and about 12 weeks.
In embodiments of the invention, a marker 24, and a plug 26 configured to serve as a marker 24 following expulsion from a delivery tube 14, may be detectable by ultrasound. Ultrasound-detectable markers 24 and plugs 26 may be formed with ultrasound detectable materials, such as stainless steel, titanium, platinum and the like, other bio-compatible metals, ceramics, metal oxides or polymers, or composites or mixtures of these materials. Typically, any material which reflects ultrasound energy may be suitable for use in an ultrasound-detectable marker. For example, materials having bubbles, internal voids, or gas-filled spaces, are detectable by ultrasound. A marker 24 or a plug 26 may be formed so as to include voids, such as cavities, to enhance their detectability by ultrasound. For example, a cavity size of between about 10 microns and about 500 microns, preferably between about 50 microns to about 200 microns, may be suitable to enhance the ultrasound-detectability of a marker 24 or plug 26.
Plugs 26 and markers 24 are configured to fit within a bore 16 of a delivery tube 14. A delivery tube 14 maybe configured to fit within a guide cannula 72, such as a guide cannula sized to accept a Mammotome®, Tru-Cut®, or SenoCor® biopsy device. Typically, a plug 26 or marker 24 will have a diameter determined by the size of a bore 16, typically between about 0.02″ (0.5 mm) and about 0.5″ (12 mm), preferably between about 0.04″ (1 mm) and about 0.3″ (8 mm). In addition, a plug 26 or marker 24 may have a length of between about 0.04″ (1 mm) and about 0.8″ (20 mm), preferably between about 0.1″ (2.5 mm) and about 0.6″ (15 mm).
A radiopaque element 40 may be made with any suitable radiopaque material, including stainless steel, platinum, gold, iridium, tantalum, tungsten, silver, rhodium, nickel, bismuth, other radiopaque metals, alloys and oxides of these metals, barium salts, iodine salts, iodinated materials, and combinations of these. Radiopaque materials and markers may be permanent, or may be temporary and not detectable after a period of time subsequent to their placement within a patient. MRI contrast agents such as gadolinium and gadolinium compounds, for example, are also suitable for use with plugs 26 and/or markers 24 embodying features of the invention. Colorants, such as dyes (e.g., methylene blue and carbon black) and pigments (e.g., barium sulfate), may also be included in markers 24 and/or plugs 26 embodying features of the invention.
Markers 24, and plugs 26 configured to serve as markers, may also include other materials besides marker materials, including anesthetic agents, hemostatic agents, pigments, dyes, materials detectable by magnetic resonance imaging (MRI), inert materials, and other compounds.
In any of the above-described embodiments of the invention, a plug 26 may include an adhesive component to aid the plug 26 to adhere to a delivery tube 14. In addition, an adhesive component may be useful to aid a marker 24 (and a plug 26 after expulsion from a delivery tube 14) to adhere to adjacent tissue within the body of a patient, such as at a biopsy site. The adhesive component may comprise a biocompatible adhesive, such as a polyurethane, polyacrylic compound, polyhydroxymethacrylate, fibrin glue (e.g., Tisseal™), collagen adhesive, or mixtures thereof.
While particular forms of the invention have been illustrated and described, it will be apparent that various modifications can be made without departing from the spirit and scope of the invention. Accordingly, it is not intended that the invention be limited to the specific embodiments illustrated. It is therefore intended that this invention be defined by the scope of the appended claims as broadly as the prior art will permit, and in view of the specification if need be. All patents and patent applications referred to above are hereby incorporated by reference in their entirety.
This application is a continuation of application Ser. No. 12/592,020, filed Nov. 18, 2009, now U.S. Pat. No. 8,177,792, which is a continuation of application Ser. No. 10/174,401, filed Jun. 17, 2002, now U.S. Pat. No. 7,651,505, each of which is incorporated by reference herein in its entirety and from which priority is claimed.
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