Patent Application
20160001242
The present invention is directed to mixing devices, systems and processes. More particularly, the present invention is directed to plunge-mixing.
Many pharmaceutical solutions and suspensions on an industrial scale rely upon highly-controlled, thorough mixing to achieve desired distribution of ingredients in a final product. Agitator tanks are frequently used to complete the mixing processes. Also mechanical stirrers or impellers are also frequently used. Typically, the mechanical stirrers or impellers are lowered into the fluid through an opening in the top of the vessel and rotated by an external motor to create a mixing action.
Substantial operational procedures are employed to make sure that such techniques do not suffer from drawbacks of contamination and/or leakage during the mixing. Otherwise, the rod carrying the mixing blades or impeller introduced into the vessel would introduce bacteria or other contaminants, which would lead to degradation of the product. Corresponding efforts are employed in applications involving hazardous or toxic fluids, or suspensions of pathogenic organisms.
Consumable bags have been used to further augment such issues. Some known systems rely upon magnetically-driven impellers and/or immobile spurge discs contained within the consumable bags. Further improvements to the design, efficiency and operation of such consumable bags and the features operating in conjunction with such consumable bags continue to be a desirable goal.
A plunge-mixing bag arrangement and a plunge-mixing system that show one or more improvements in comparison to the prior art would be desirable in the art.
In an embodiment, a plunge-mixing bag arrangement includes a flexible mixing bag defining a mixing region, and a shaft extending from outside of the flexible mixing bag into the mixing region, the shaft comprising a sparger within the mixing region. The sparger comprises an interior channel and ports extending from the interior channel. The shaft is capable of axial movement within the bag to fracture gas bubbles being released from the interior channel through the ports.
In another embodiment, a plunge-mixing bag arrangement includes a flexible mixing bag defining a mixing region, a shaft extending from outside of the flexible mixing bag into the mixing region, the shaft comprising a sparger within the mixing region, the sparger comprising an interior channel and ports extending from the interior channel, a porous material between the interior channel and the ports, and a mixing head positioned opposite from where the sparger extends from the outside into the mixing region. The shaft is capable of axial movement within the bag to fracture gas bubbles being released from the interior channel through the ports. The interior channel terminates prior to reaching the mixing head.
In another embodiment, a plunge-mixing system includes a mechanism for raising and lowering, a shaft extending upward from the mechanism and from outside of a flexible mixing bag into a mixing region defined by the flexible mixing bag, the shaft comprising a sparger within the mixing region, the sparger comprising an interior channel and ports extending from the interior channel, and the flexible mixing bag. The shaft is capable of axial movement within the bag to fracture gas bubbles being released from the interior channel through the ports.
In another embodiment, a plunge-mixing process includes raising and lowering a shaft extending upward from a mechanism in a plunge-mixing system and from outside of a flexible mixing bag into a mixing region defined by the flexible mixing bag, releasing gas from a sparger within the mixing region and part of the shaft, and fracturing gas bubbles being released from the interior channel through the ports.
In another embodiment, a fabrication process includes positioning a shaft having an interior channel, forming holes to extend from the interior channel through the shaft to an exterior surface of the shaft, and positioning a porous material between the interior channel and the exterior surface.
In another embodiment, a fabrication process includes positioning a shaft having an interior channel and ports extending from the interior channel through the shaft to an exterior surface of the shaft, and positioning a porous material between the interior channel and the exterior surface.
Other features and advantages of the present invention will be apparent from the following more detailed description, taken in conjunction with the accompanying drawings which illustrate, by way of example, the principles of the invention.
Wherever possible, the same reference numbers will be used throughout the drawings to represent the same parts.
Provided is a plunge-mixing bag arrangement and a plunge-mixing system capable of use in or with the systems describe in detail in U.S. Pat. No. 6,923,567, which issued on Aug. 2, 2005, and is hereby incorporated by specific reference in its entirety. Embodiments of the present disclosure, for example, in comparison to concepts failing to include one or more of the features disclosed herein, permit increases in operational efficiency in the mixing of pharmaceutical materials, fermentation materials, bioreactor materials, permit greater control of bubble size and/or frequency from gas introduced during mixing, permit greater operational flexibility and control during mixing, permit the fracture and/or reduction in size of bubbles released into a mixing region, reduce or eliminate damage to mixing materials (such as cells) through increased uniformity of distribution of bubbles, permit bubbles to be released at a lower velocity, permit other advantages and benefits that will be apparent from the disclosure, or a combination thereof.
Referring to
The shaft 103 includes a sparger 105 within the mixing region 102. The sparger 105 includes an interior channel 107 and ports 109 extending from the interior channel 107, as shown in
The plunge-mixing bag arrangement 100 is capable of being positioned in a plunge-mixing system 119. The plunge-mixing system 119 is configured for the axial movement of the sparger 105 by having a mechanism 117 or drive for raising and lowering the shaft 103. The mechanism 117 is any device capable of repeated movement and controlled movement. The shaft 103 extends upward from the plunge-mixing system 119 and the mechanism 117 for the raising and the lowering. The plunge-mixing system 119 is capable of including any other suitable features for plunge-mixing processes.
The shaft 103 includes features for controlling the release, the fracture, and/or the constriction of gas through the sparger 105 during the axial movement. The sparger 105 includes or is devoid of a porous material 115 (see
The porous material 115 includes properties for selected applications, such as, being hydrophobic to prevent, reduce, or eliminate fluid from travelling from the mixing region 102 into the interior channel 107. The porous material 115 is any suitable material compatible with the sparger 105 and capable of operation during plunge-mixing. Suitable materials include, but are not limited to, a porous polymer (such as, those available from Porex Corporation, Atlanta, Ga.), a foam, a metallic foam, charcoal, pumice, or a combination thereof. The porous material 115 is permanently adhered or secured to the sparger 105 or is removable and/or replaceable.
The sparger 105 includes any suitable geometry and features for the plunge-mixing process. Although the embodiments of the sparger 105 shown in
The sparger 105 includes a polymeric material, a metal material, a metallic material, another suitable material, or a combination thereof. The ports 109 within the sparger 105 are formed within the sparger 105 based upon the material and/or based upon desired properties. For example, in some embodiments, the ports 109 are formed by drilling holes perpendicular, at an angle above perpendicular, or below perpendicular from the interior channel 107. Alternatively, in some embodiments, the sparger 105 is molded to have the ports 109 positioned perpendicular, at an angle above perpendicular, or below perpendicular from the interior channel 107. The ports 109 are arranged concentrically around the sparger 105, with greater frequency on certain portions of the sparger 105 (for example, proximal or distal from the plunge-mixing system 119), with equal frequency throughout the sparger 105, extending from the interior channel 107 in more than a select number of directions (for example, at least three directions, at least four directions, at least five directions, at least six directions, etc.), increasing or decreasing in size as the ports 109 extend from the interior channel 107, in other suitable arrangements, or a combination thereof.
The gas provided from the interior channel 107 and released through the ports 109 is provided from the plunge-mixing system 119. For example, in one embodiment, the interior channel 107, which is enclosed by the shaft 103, extends from beyond the sparger 105 portion of the shaft 103 into the portion of the shaft 103 proximal to the plunge-mixing system 119. Gas is selectively provided to the interior channel 107 during the plunge-mixing process, for example, at a select pressure (for example, above 0 pounds and below 100 pounds) and/or a select temperature (for example, above 0° C. and below 80° C.).
In one embodiment, the interior channel 107 extends in a linear or substantially linear direction and terminates within the shaft 103 proximal to the end of the sparger 105 where a mixing head 121 is positioned. Alternatively, the interior channel 107 extends into the mixing head 121 and a plurality of the ports 109 are positioned in the mixing head 121, for example, around the mixing head 121 and/or below the mixing head 121, which is believed to result in additional mixing uniformity and/or distribution of bubbles. The mixing head 121 includes any suitable mixing apparatus, such as, a substantially planar circle 201 as shown in
While the invention has been described with reference to one or more embodiment, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention will include all embodiments falling within the scope of the appended claims.
