Research Project
10009036
Abstract The goal of this SBIR Phase I project is to develop a portable and affordable cranial x-ray-based Computed Tomography Perfusion (CT-P) device for expedited front-line evaluation and triage of ischemic cerebral stroke victims. CT-P is the gold standard modality for assessment and classifying stroke patients to determine the best candidates for revascularizing procedures; however, CT-P is generally unavailable early in the current acute care treatment model. Unlike existing conventional CT-P equipment which is generally large, expensive, and stationary, the proposed device would be compact, portable, and affordable to be deployed in nursing homes, urgent care centers, hospital ER triage areas, ICUs, and EMS response vehicles, yet also provide sufficient time and contrast resolution for reliable perfusion metrics. Rapidly acquired point-of-care CT and CT-P images showing blood flow, volume, and transit times will enable (1) early classification of hemorrhage or ischemic, and (2) assessment of the recoverable brain tissue volume. This will enable early screening evaluation for appropriate acute stroke patient prioritization and routing. In addition, it may also provide an economical and safe bedside means of assessing cranial perfusion for follow up care in the ICU, recovery room, or even eventually in a residential care setting. Xoran Technologies LLC specializes in point-of-care (POC) medical imaging and has successfully marketed over 750 POC imaging devices in the US.
