Claims
- 1. The method of inhibiting the growth of gram positive bacteria in a subject in need thereof which comprises administering to said subject a gram positive inhibitory amount of a compound of the following structural Formula II: ##STR18## wherein w is the integer 0 or 1;
- y is the integer 1-6;
- z is the integer 0-3;
- t is the integer 0 or 1; ##STR19## R is hydrogen, lower alkyl, phenyl or when taken together with R.sub.1 forms a saturated monoheterocyclic ring of from 5 to 6 members;
- R.sub.1, R.sub.2 are the same or independently C.sub.1 -C.sub.10 straight or branched chain alkyl which may be substituted by up to 3 substituents selected from 1 to 2 hydroxyl groups and one ##STR20## group, or when taken together form a saturated heterocyclic ring of from 5 to 6 members which may contain a ##STR21## or --O-- linkage; R.sub.3 is methyl, ethyl, benzyl which may be substituted by up to 3 substituents selected from hydroxyl, halogen, methoxy and C.sub.1 -C.sub.6 straight or branched chain alkyl, 1-naphthyl or 2-naphthyl;
- R.sub.4 is a C.sub.1 -C.sub.6 straight or branched chain alkyl which may be substituted by one hydroxyl group;
- R.sub.5, R.sub.6 are the same or independently hydrogen, C.sub.1 -C.sub.4 straight or branched chain alkyl or when taken together form a diheterocyclic ring of from 5 to 6 members;
- R.sub.7, R.sub.8 are the same or independently C.sub.1 -C.sub.6 straight or branched chain alkyl which may be substituted by one hydroxyl group or when taken together with an --O-- linkage form a morpholine ring;
- B is a direct link or a C.sub.1 -C.sub.4 straight or branched chain alkyl;
- n is an integer in the range from about 5 to 500; and
- X.sup.- is an anion forming a pharmaceutically acceptable salt.
- 2. The method of claim 1 where n is in the range of from about 5 to 49.
- 3. The method of claim 1 where n is in the range of 50 to 500.
- 4. The method of claim 2 wherein the compound administered is poly[imino[1-[[[[3-(trimethylammonio)propyl]amino]carbonyl]methyl]-2-oxo-1,2-ethanediyl chloride]].
- 5. The method of claim 2 wherein the compound administered is polyimino[1-[[[[2-[[2-(trimethylammonio)ethyl]dimethylammonio]ethyl]amino]carbonyl]methyl]-2-oxo-1,2-ethanediyl chloride]].
- 6. The method of claim 2 wherein the compound administered is poly[imino[1-[[[[3-[dimethyl(phenylmethyl)ammonio]propyl]aminocarbonyl]methyl]-2-oxo-1,2-ethanediyl chloride]].
- 7. The method of claim 2 wherein the compound administered is polyimino[1-[[[[3-[(aminoiminomethyl)amino]propyl]amino]carbonyl]methyl]-2-oxo-1,2-ethanediyl hydrochloride]].
- 8. The method of claim 2 wherein the compound administered is [S]-poly[imino[1-[[[[3-(trimethylammonio)propyl]amino]-carbonyl]methyl]-2-oxo-1,2-ethanediyl chloride]].
- 9. The method of claim 3 wherein the compound administered is poly[imino[1-[[[[3-(trimethylammonio)propyl]amino]carbonyl]methyl]-2-oxo-1,2-ethanediyl chloride]].
- 10. The method of claim 3 wherein the compound administered is poly[imino[1-[[[[2-[[2-(trimethylammonio)ethyl]dimethylammonio]ethyl]amino]carbonyl]methyl]-2-oxo-1,2-ethanediyl chloride]].
- 11. The method of claim 3 wherein the compound administered is poly[imino[1-[[[[3-[dimethyl(phenylmethyl)ammonio]propyl]aminocarbonyl]-methyl]-2-oxo-1,2-ethanediyl chloride]].
- 12. The method of claim 3 wherein the compound administered is poly[imino[1-[[[[3-[(aminoiminomethyl)amino]propyl]amino]carbonyl]methyl]-2-oxo-1,2-ethanediyl hydrochloride]].
- 13. The method of claim 3 wherein the compound administered is [S]-poly[imino[1-[[[[3-(trimethylammonio)propyl]amino]-carbonyl]methyl]-2-oxo-1,2-ethanediyl chloride]].
- 14. The method of inhibiting the growth of gram-positive bacteria on a surface which comprises contacting the surface with a gram positive inhibitory amount of a compound of the following structural Formula II: ##STR22## wherein w is the integer 0 or 1;
- y is the integer 1-6;
- z is the integer 0-3;
- t is the integer 0 or 1;
- contain a ##STR23## or --O-- linkage; R.sub.3 is methyl, ethyl, benzyl which may be substituted by up to 3 substituents selected from hydroxyl, halogen, methoxy and C.sub.1 -C.sub.6 straight or branched chain alkyl, 1-naphthyl or 2-naphthyl;
- R.sub.4 is a C.sub.1 -C.sub.6 straight or branched chain alkyl which may be substituted by one hydroxyl group;
- R.sub.5, R.sub.6 are the same or independently hydrogen, C.sub.1 -C.sub.4 straight or branched chain alkyl or when taken together form a diheterocyclic ring of from 5 to 6 members;
- R.sub.7, R.sub.8 are the same or independently C.sub.1 -C.sub.6 straight or branched chain alkyl which may be substituted by one hydroxyl group or when taken together with an --O-- linkage form a morpholine ring;
- B is a direct link or a C.sub.1 -C.sub.4 straight or branched chain alkyl;
- n is an integer in the range from about 5 to 500; and
- X.sup.- is an anion forming a pharmaceutically acceptable salt.
Priority Claims (2)
Number |
Date |
Country |
Kind |
90250078 |
Mar 1990 |
EPX |
|
91120988 |
Dec 1991 |
EPX |
|
CROSS-REFERENCE TO RELATED APPLICATIONS
This Application is a continuation-in-part of U.S. Ser. No. 07/716,883, filed Jun. 18, 1991 now abandoned, which is a continuation-in-part of U.S. Ser. No. 07/543,916, filed Jun. 26, 1990 now abandoned, which is a continuation-in-part of U.S. Ser. No. 7/328,014, filed Mar. 23, 1989, now abandoned, all of which are entirely incorporated by reference herein.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4314808 |
Jacquet et al. |
Feb 1982 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
7727769 |
Apr 1979 |
FRX |
Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
716883 |
Jun 1991 |
|
Parent |
543916 |
Jun 1990 |
|
Parent |
328014 |
Mar 1989 |
|