Claims
- 1. A conjugate comprising a polypeptide bound to a chelating agent according to the formula: ##STR2## and when o+p.gtoreq.3 a closed ring structure may be formed.
- 2. A compound according to the formula: ##STR3## and when o+p.gtoreq.2 a closed ring structure may be formed.
- 3. The conjugate according to claim 1, wherein the chelating agent is LiLo2': ##STR4##
- 4. The compound according to claim 2, which has the formula: ##STR5##
- 5. The conjugate according to claim 1, wherein the chelating agent is HETA2: ##STR6##
- 6. The compound according to claim 2, which as the formula: ##STR7##
- 7. A conjugate complex comprising a compound according to claim 2 bound to a metal.
- 8. A conjugate complex comprising a compound according to claim 6 bound to a metal.
- 9. A conjugate complex comprising a compound according to claim 6 bound to a metal.
- 10. A conjugate complex comprising a complex according to claim 1 bound to a metal.
- 11. A conjugate complex comprising a complex according to claim 3 bound to a metal.
- 12. A conjugate complex comprising a complex according to claim 5 bound to a metal.
Parent Case Info
This application is a continuation-in-part of U.S. application Ser. No. 08/044,875, filed Apr.8, 1993, U.S. Pat. No. 5,292,868 which is a continuation of U.S. Ser. No. 07/720,277, filed Jun. 24, 1991, now abandoned, which is a continuation of U.S. Ser. No. 07/438,558, filed Nov. 17, 1989, now abandoned, which is a continuation-in-part of U.S. Ser. No. 07/358,917, filed May 26, 1989, now abandoned, all of which are included herein by reference.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US95/00068 |
1/5/1995 |
|
|
9/18/1996 |
9/18/1996 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO95/18832 |
7/13/1995 |
|
|
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Entry |
Moi et al., Inorganic Chemistry, 26(21) :3458-3463, 1987. |
Brechbeil et al., Inorganic Chemistry, 25:2772-2781, 1986. |
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Continuations (2)
|
Number |
Date |
Country |
Parent |
720277 |
Jun 1991 |
|
Parent |
438558 |
Nov 1989 |
|
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
044875 |
Apr 1993 |
|
Parent |
358917 |
May 1989 |
|